Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

Journal of Clinical Investigation

Volumn 110, Issue 10, 2002, Pages 1441-1448

  Constant, Stephanie L ^a,b   Brogdon, Jennifer L ^a   Piggott, Damani A ^a   Herrick, Christina A ^a   Visintin, Irene ^a   Ruddle, Nancy H ^a   Bottomly, Kim ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 6;

ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL MIGRATION; CYTOKINE PRODUCTION; LUNG PARENCHYMA; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY SYSTEM; TH1 CELL; TH2 CELL;

EID: 0036853910     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0216109     Document Type: Article

References (23)

1. Wills-Karp, M. 1999. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17:255-281.
2. Herrick, C.A., MacLeod, H., Glusac, E., Tigelaar, R.E. and Bottomly, K. 2000. Th2 responses induced by epicutaneous versus inhalational protein exposure are differentially dependent on IL-4. J. Clin. Invest. 105:765-775.
3. Constant, S.L., Lee, K.S., and Bottomly, K. 2000. Site of antigen delivery can influence T cell priming: Pulmonary environment promotes preferential Th2-type pe differentiation. Eur. J. Immunol. 30:840-847.
4. Jones, H.P., et al. 2001. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J. Immunol. 167:4518-4526.
5. Reiner, S.L., and Locksley, R.M. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177
6. + T cell responses: The alternative approaches. Annu. Rev. Immunol. 15:297-322.
7. Lyons, A.B., and Parish, C.P. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods. 171:131-137.
8. Hume, D.A., Robinson, A.P., MacPherson, G.G., and Gordon, S. 1983. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J. Exp. Med. 158:1522-1536.
9. Kraal, G., Breel, M., Janse, M., and Bruin, G. 1986. Langerhans' cells, veiled cells, and interdigitiating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163:981-997.
10. Roake, J.A., et al. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181:2237-2247.
11. De Togni, P., et al. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 264:703-707.
12. Banks, T., et al. 1995. Lymphotoxin-α-deficient mice: Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1685-1693.
13. Fu, Y.-X., et al. 1997. Lymphotoxin-α (LTα) supports development of splenic follicular structure that is required for IgG responses. J. Exp. Med. 185:2111-2120.
14. Akbari, O., DeKruyff, R.H., and Umetsu, D.T. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725-731.
15. Riacon, M., Anguita, J., Nakamura, T., Fikrig, E., and Flaveli, R.A. 1997. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185:461-469.
16. Diehl, S., et al. 2000. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity. 13:805-815.
17. Vermaelen, K.Y., Carro-Muino, I., Lambrecht, B.N., and Pauwels, R.A. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:51-60.
18. Byersdorfer, C.A., and Chaplin, D.D. 2001. Visualization of early APC/T cell interactions in the mouse lung following intranasal challenge. J. Immunol. 167:6756-6764.
19. Julia, V., et al. 2002. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity. 16:271-283.
20. Demangel, C., Bertolino, P., and Britton, W.J. 2002. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur. J. Immunol. 32:994-1002.
21. McSorley, S.J., Asch, S., Costalonga, M., Reinhardt, R.L., and Jenkins, M.K. 2002. Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity. 16:365-377.
22. Ruddle, N.H. 1999. Lymphoid neo-organogenesis: Lymphotoxin's role in inflammation and development. Immunol Res. 19:119-125.
23. Kelsall, B.L., Biron, C.A., Sharma O., and Kaye, P.M. 2002. Dendritic cells at the host-pathogen interface. Nat. Immunol. 3:699-702.