A critical role for eosinophils in allergic airways remodeling

Science

Volumn 305, Issue 5691, 2004, Pages 1776-1779

  Humbles, Alison A ^a   Lloyd, Clare M ^b   McMillan, Sarah J ^b   Friend, Daniel S ^c   Xanthou, Georgina ^b   McKenna, Erin E ^a   Ghiran, Sorina ^a   Gerard, Norma P ^a   Yu, Channing ^d   Orkin, Stuart H ^a   Gerard, Craig ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIES; COLLAGEN; DISEASES; MUSCLE; PATIENT TREATMENT; SOCIAL SCIENCES;

AIRWAY REMODELLING; DYSFUNCTION; EOSINOPHILS;

CELLS;

COLLAGEN; INTERLEUKIN DERIVATIVE; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

MEDICINE;

ALLERGIC ASTHMA; ALLERGY; ANIMAL CELL; ARTICLE; ASTHMA; CELL FUNCTION; CELL LINEAGE; EOSINOPHIL; LUNG DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BRONCHUS; CELL DIVISION; IMMUNOLOGY; LEUKOCYTE COUNT; LUNG; LUNG FUNCTION TEST; METABOLISM; MUCUS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT ALLERGY; SECRETION; TH2 CELL;

ANIMALIA;

ANIMALS; ASTHMA; BRONCHI; CELL DIVISION; COLLAGEN; EOSINOPHILS; INTERLEUKINS; LEUKOCYTE COUNT; LUNG; MICE; MICE, INBRED BALB C; MUCUS; MUSCLE, SMOOTH; RESPIRATORY FUNCTION TESTS; RESPIRATORY HYPERSENSITIVITY; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 4544274172     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1100283     Document Type: Article

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31. We thank J. Brewer for technical assistance and the staff of Animal Resources Children's Hospital for animal care. This work was supported by the NIH (grants AI39759 and HL10463). C.M.L. and S.J.M. were supported by the Wellcome Trust (award 057704) and G.X. by the European Molecular Biology Foundation.