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Volumn 25, Issue 1, 2013, Pages 76-84

TGF-β signaling and epithelial-mesenchymal transition in cancer progression

Author keywords

Cancer stem cell; EMT; Smad; TGF

Indexed keywords

METALLOPROTEINASE; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA;

EID: 84871948755     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32835b6371     Document Type: Review
Times cited : (694)

References (79)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 80053322515 scopus 로고    scopus 로고
    • Cell communication networks in cancer invasion
    • Calvo F, Sahai E. Cell communication networks in cancer invasion. Curr Opin Cell Biol 2011; 23:621-629
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 621-629
    • Calvo, F.1    Sahai, E.2
  • 3
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: Molecular insights and evolving paradigms. Cell 2011; 147:275-292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 4
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organspecific colonization
    • Nguyen DX, Bos PD, MassaguéJ. Metastasis: From dissemination to organspecific colonization. Nat Rev Cancer 2009; 9:274-284
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massagué, J.3
  • 5
    • 77952902430 scopus 로고    scopus 로고
    • Mechanisms of motility in metastasizing cells
    • Yilmaz M, Christofori G. Mechanisms of motility in metastasizing cells. Mol Cancer Res 2010; 8:629-642
    • (2010) Mol Cancer Res , vol.8 , pp. 629-642
    • Yilmaz, M.1    Christofori, G.2
  • 6
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 7
    • 59449090107 scopus 로고    scopus 로고
    • TGF-b-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-b-induced epithelial to mesenchymal transition. Cell Res 2009; 19:156-172
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 8
    • 77952896646 scopus 로고    scopus 로고
    • TGFb signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. TGFb signalling: A complex web in cancer progression. Nat Rev Cancer 2010; 10:415-424
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 9
    • 47549090432 scopus 로고    scopus 로고
    • TGFb in cancer
    • MassaguéJ. TGFb in cancer. Cell 2008; 134:215-230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 10
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-b signaling from cell membrane to the nucleus
    • Shi Y, MassaguéJ. Mechanisms of TGF-b signaling from cell membrane to the nucleus. Cell 2003; 113:685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 11
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-b signaling through Smads
    • Feng XH, Derynck R. Specificity and versatility in TGF-b signaling through Smads. Annu Rev Cell Dev Biol 2005; 21:659-693
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 12
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-b family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-b family signalling. Nature 2003; 425:577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 13
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-b signals
    • Moustakas A, Heldin CH. Non-Smad TGF-b signals. J Cell Sci 2005; 118:3573-3584
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 14
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 2008; 14:818- 829
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 15
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 16
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial- mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7:131-142
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 17
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7:415-428
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 18
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28:15-33
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 19
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto MA. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 2011; 27:347-376
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 20
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial- mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas A, Heldin CH. Signaling networks guiding epithelial- mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 2007; 98:1512-1520
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 21
    • 84866327767 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition by transforming growth factor beta
    • Moustakas A, Heldin CH. Induction of epithelial-mesenchymal transition by transforming growth factor beta. Semin Cancer Biol 2012; 22:446- 454
    • (2012) Semin Cancer Biol , vol.22 , pp. 446-454
    • Moustakas, A.1    Heldin, C.H.2
  • 22
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-b mediated epithelial-mesenchymal transition
    • Vincent T, Neve EP, Johnson JR, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-b mediated epithelial-mesenchymal transition. Nat Cell Biol 2009; 11:943-950
    • (2009) Nat Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3
  • 23
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial- mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial- mesenchymal transition. Cancer Res 2008; 68:7846-7854
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3
  • 24
    • 84865169224 scopus 로고    scopus 로고
    • Epigenetic reprogramming and posttranscriptional regulation during the epithelial-mesenchymal transition
    • Wu CY, Tsai YP, Wu MZ, et al. Epigenetic reprogramming and posttranscriptional regulation during the epithelial-mesenchymal transition. Trends Genet 2012; 28:454-463
    • (2012) Trends Genet , vol.28 , pp. 454-463
    • Wu, C.Y.1    Tsai, Y.P.2    Wu, M.Z.3
  • 25
    • 84863203049 scopus 로고    scopus 로고
    • TGF-b drives epithelial- mesenchymal transition through deltaEF1-mediated downregulation of ESRP
    • Horiguchi K, Sakamoto K, Koinuma D, et al. TGF-b drives epithelial- mesenchymal transition through deltaEF1-mediated downregulation of ESRP. Oncogene 2012; 31:3190-3201
    • (2012) Oncogene , vol.31 , pp. 3190-3201
    • Horiguchi, K.1    Sakamoto, K.2    Koinuma, D.3
  • 26
    • 79951813692 scopus 로고    scopus 로고
    • TGF-b regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
    • Shirakihara T, Horiguchi K, Miyazawa K, et al. TGF-b regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J 2011; 30:783-795
    • (2011) EMBO J , vol.30 , pp. 783-795
    • Shirakihara, T.1    Horiguchi, K.2    Miyazawa, K.3
  • 27
    • 77956338683 scopus 로고    scopus 로고
    • Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    • Lin T, Ponn A, Hu X, et al. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 2010; 29:4896-4904
    • (2010) Oncogene , vol.29 , pp. 4896-4904
    • Lin, T.1    Ponn, A.2    Hu, X.3
  • 28
    • 84879414983 scopus 로고    scopus 로고
    • The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
    • doi: 10. 1038/onc.2012.297
    • Ezponda T, Popovic R, Shah MY, et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene 2012 doi: 10. 1038/onc.2012.297
    • Oncogene 2012
    • Ezponda, T.1    Popovic, R.2    Shah, M.Y.3
  • 29
    • 78649815150 scopus 로고    scopus 로고
    • Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
    • Hayami S, Kelly JD, Cho HS, et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011; 128:574-586
    • (2011) Int J Cancer , vol.128 , pp. 574-586
    • Hayami, S.1    Kelly, J.D.2    Cho, H.S.3
  • 30
    • 79955506975 scopus 로고    scopus 로고
    • The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors
    • Hudlebusch HR, Santoni-Rugiu E, Simon R, et al. The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res 2011; 17:2919-2933
    • (2011) Clin Cancer Res , vol.17 , pp. 2919-2933
    • Hudlebusch, H.R.1    Santoni-Rugiu, E.2    Simon, R.3
  • 31
    • 84859731270 scopus 로고    scopus 로고
    • G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
    • Dong C, Wu Y, Yao J, et al. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest 2012; 122:1469-1486
    • (2012) J Clin Invest , vol.122 , pp. 1469-1486
    • Dong, C.1    Wu, Y.2    Yao, J.3
  • 32
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong W, Yang H, He L, et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008; 28:6773-6784
    • (2008) Mol Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3
  • 33
    • 78650038626 scopus 로고    scopus 로고
    • TGF-b-induced miR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells
    • Zhou Q, Fan J, Ding X, et al. TGF-b-induced miR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells. J Biol Chem 2010; 285:40019-40027
    • (2010) J Biol Chem , vol.285 , pp. 40019-40027
    • Zhou, Q.1    Fan, J.2    Ding, X.3
  • 34
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam D, Lamouille S, Judson RL, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011; 29:443-448
    • (2011) Nat Biotechnol , vol.29 , pp. 443-448
    • Subramanyam, D.1    Lamouille, S.2    Judson, R.L.3
  • 35
    • 77952307133 scopus 로고    scopus 로고
    • MicroRNA-204/211 alters epithelial physiology
    • Wang FE, Zhang C, Maminishkis A, et al. MicroRNA-204/211 alters epithelial physiology. FASEB J 2010; 24:1552-1571
    • (2010) FASEB J , vol.24 , pp. 1552-1571
    • Wang, F.E.1    Zhang, C.2    Maminishkis, A.3
  • 36
    • 84868000009 scopus 로고    scopus 로고
    • MicroRNA control of epithelial-mesenchymal transition and metastasis
    • Zhang J, Ma L. MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Rev 2012; 31:653-662
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 653-662
    • Zhang, J.1    Ma, L.2
  • 37
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-b-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille S, Derynck R. Cell size and invasion in TGF-b-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 2007; 178:437-451
    • (2007) J Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 38
    • 84861448736 scopus 로고    scopus 로고
    • TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    • Lamouille S, Connolly E, Smyth JW, et al. TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci 2012; 125:1259-1273
    • (2012) J Cell Sci , vol.125 , pp. 1259-1273
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3
  • 39
    • 77649261101 scopus 로고    scopus 로고
    • TGF-b-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
    • Chaudhury A, Hussey GS, Ray PS, et al. TGF-b-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 2010; 12:286-293
    • (2010) Nat Cell Biol , vol.12 , pp. 286-293
    • Chaudhury, A.1    Hussey, G.S.2    Ray, P.S.3
  • 40
    • 79951472098 scopus 로고    scopus 로고
    • Identification of an mRNP complex regulating tumorigenesis at the translational elongation step
    • Hussey GS, Chaudhury A, Dawson AE, et al. Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell 2011; 41:419-431
    • (2011) Mol Cell , vol.41 , pp. 419-431
    • Hussey, G.S.1    Chaudhury, A.2    Dawson, A.E.3
  • 41
    • 77950505906 scopus 로고    scopus 로고
    • The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation
    • Vinas-Castells R, Beltran M, Valls G, et al. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem 2010; 285:3794-3805
    • (2010) J Biol Chem , vol.285 , pp. 3794-3805
    • Vinas-Castells, R.1    Beltran, M.2    Valls, G.3
  • 42
    • 79960283982 scopus 로고    scopus 로고
    • The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
    • Lander R, Nordin K, LaBonne C. The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol 2011; 194: 17-25
    • (2011) J Cell Biol , vol.194 , pp. 17-25
    • Lander, R.1    Nordin, K.2    LaBonne, C.3
  • 43
    • 74949132577 scopus 로고    scopus 로고
    • TGF-b1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
    • Araki S, Eitel JA, Batuello CN, et al. TGF-b1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest 2010; 120:290-302
    • (2010) J Clin Invest , vol.120 , pp. 290-302
    • Araki, S.1    Eitel, J.A.2    Batuello, C.N.3
  • 44
    • 78649731470 scopus 로고    scopus 로고
    • Suppression of TGFb-induced epithelial- mesenchymal transition like phenotype by a PIAS1 regulated sumoylation pathway in NMuMG epithelial cells
    • Netherton SJ, Bonni S. Suppression of TGFb-induced epithelial- mesenchymal transition like phenotype by a PIAS1 regulated sumoylation pathway in NMuMG epithelial cells. PLoS One 2010; 5:e13971
    • (2010) PLoS One , vol.5
    • Netherton, S.J.1    Bonni, S.2
  • 45
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9:265-273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 46
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-715
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 47
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008; 3:e2888
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3
  • 48
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011; 145:926-940
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3
  • 49
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003; 3:921-930
    • (2003) Nat Rev Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 50
    • 57049128693 scopus 로고    scopus 로고
    • Intravital imaging of metastatic behavior through a mammary imaging window
    • Kedrin D, Gligorijevic B, Wyckoff J, et al. Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods 2008; 5:1019- 1021
    • (2008) Nat Methods , vol.5 , pp. 1019-1021
    • Kedrin, D.1    Gligorijevic, B.2    Wyckoff, J.3
  • 51
    • 1642282882 scopus 로고    scopus 로고
    • Prespecification and plasticity: Shifting mechanisms of cell migration
    • Friedl P. Prespecification and plasticity: Shifting mechanisms of cell migration. Curr Opin Cell Biol 2004; 16:14-23
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 14-23
    • Friedl, P.1
  • 52
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: A multiscale tuning model
    • Friedl P, Wolf K. Plasticity of cell migration: A multiscale tuning model. J Cell Biol 2010; 188:11-19
    • (2010) J Cell Biol , vol.188 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 53
    • 67649528138 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis, regeneration and cancer
    • Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009; 10:445-457
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 445-457
    • Friedl, P.1    Gilmour, D.2
  • 54
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFb signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri S, Manning C, Hooper S, et al. Localized and reversible TGFb signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol 2009; 11:1287-1296
    • (2009) Nat Cell Biol , vol.11 , pp. 1287-1296
    • Giampieri, S.1    Manning, C.2    Hooper, S.3
  • 55
    • 79952499030 scopus 로고    scopus 로고
    • Twist1-induced invadopodia formation promotes tumor metastasis
    • Eckert MA, Lwin TM, Chang AT, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011; 19:372-386.
    • (2011) Cancer Cell , vol.19 , pp. 372-386
    • Eckert, M.A.1    Lwin, T.M.2    Chang, A.T.3
  • 56
    • 13444301091 scopus 로고    scopus 로고
    • Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin
    • Yamaguchi H, Lorenz M, Kempiak S, et al. Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 2005; 168:441-452
    • (2005) J Cell Biol , vol.168 , pp. 441-452
    • Yamaguchi, H.1    Lorenz, M.2    Kempiak, S.3
  • 57
    • 84863246877 scopus 로고    scopus 로고
    • N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors
    • Gligorijevic B, Wyckoff J, Yamaguchi H, et al. N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci 2012; 125:724-734
    • (2012) J Cell Sci , vol.125 , pp. 724-734
    • Gligorijevic, B.1    Wyckoff, J.2    Yamaguchi, H.3
  • 58
    • 84862629472 scopus 로고    scopus 로고
    • Hic-5 promotes invadopodia formation and invasion during TGF-b-induced epithelial-mesenchymal transition
    • Pignatelli J, Tumbarello DA, Schmidt RP, Turner CE. Hic-5 promotes invadopodia formation and invasion during TGF-b-induced epithelial-mesenchymal transition. J Cell Biol 2012; 197:421-437
    • (2012) J Cell Biol , vol.197 , pp. 421-437
    • Pignatelli, J.1    Tumbarello, D.A.2    Schmidt, R.P.3    Turner, C.E.4
  • 59
    • 81055126288 scopus 로고    scopus 로고
    • Myosin II isoform switching mediates invasiveness after TGF-b-induced epithelial-mesenchymal transition
    • Beach JR, Hussey GS, Miller TE, et al. Myosin II isoform switching mediates invasiveness after TGF-b-induced epithelial-mesenchymal transition. Proc Natl Acad Sci USA 2011; 108:17991-17996
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17991-17996
    • Beach, J.R.1    Hussey, G.S.2    Miller, T.E.3
  • 60
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8:755- 768
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 62
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells
    • Scheel C, Weinberg RA. Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer 2011; 129:2310- 2314
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 63
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983- 3988
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3
  • 64
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M, Campbell LL, Argani P, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 2007; 11:259-273
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1    Campbell, L.L.2    Argani, P.3
  • 65
    • 84860314217 scopus 로고    scopus 로고
    • The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
    • Buijs JT, van der Horst G, van den Hoogen C, et al. The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation. Oncogene 2012; 31:2164-2174
    • (2012) Oncogene , vol.31 , pp. 2164-2174
    • Buijs, J.T.1    Van Der Horst, G.2    Van Den Hoogen, C.3
  • 66
    • 84865767219 scopus 로고    scopus 로고
    • SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression
    • Zhang J, Liang Q, Lei Y, et al. SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Res 2012; 72:4597-4608
    • (2012) Cancer Res , vol.72 , pp. 4597-4608
    • Zhang, J.1    Liang, Q.2    Lei, Y.3
  • 67
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, et al. Opinion: Migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5:744-749
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3
  • 68
    • 84861344069 scopus 로고    scopus 로고
    • Tissue transglutaminase links TGF-b, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
    • Cao L, Shao M, Schilder J, et al. Tissue transglutaminase links TGF-b, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene 2012; 31:2521-2534
    • (2012) Oncogene , vol.31 , pp. 2521-2534
    • Cao, L.1    Shao, M.2    Schilder, J.3
  • 69
    • 84871246002 scopus 로고    scopus 로고
    • The miR-106b-25 cluster targets Smad7, activates TGF-b signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
    • doi: 10.1038/onc.2012.11
    • Smith AL, Iwanaga R, Drasin DJ, et al. The miR-106b-25 cluster targets Smad7, activates TGF-b signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 2012 doi: 10.1038/onc.2012.11
    • Oncogene 2012
    • Smith, A.L.1    Iwanaga, R.2    Drasin, D.J.3
  • 70
    • 34548706039 scopus 로고    scopus 로고
    • Transforming growth factor-b can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model
    • Tang B, Yoo N, Vu M, et al. Transforming growth factor-b can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. Cancer Res 2007; 67:8643-8652
    • (2007) Cancer Res , vol.67 , pp. 8643-8652
    • Tang, B.1    Yoo, N.2    Vu, M.3
  • 71
    • 79953788906 scopus 로고    scopus 로고
    • Transforming growth factor-b decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells
    • Ehata S, Johansson E, Katayama R, et al. Transforming growth factor-b decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. Oncogene 2011; 30:1693-1705
    • (2011) Oncogene , vol.30 , pp. 1693-1705
    • Ehata, S.1    Johansson, E.2    Katayama, R.3
  • 72
    • 84867575420 scopus 로고    scopus 로고
    • Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffusetype gastric carcinoma-initiating cells is inhibited by TGF-b
    • Katsuno Y, Ehata S, Yashiro M, et al. Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffusetype gastric carcinoma-initiating cells is inhibited by TGF-b. J Pathol 2012; 228:391-404
    • (2012) J Pathol , vol.228 , pp. 391-404
    • Katsuno, Y.1    Ehata, S.2    Yashiro, M.3
  • 73
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200:429-447
    • (2003) J Pathol , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 74
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-b and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y, Acar A, Eaton EN, et al. Autocrine TGF-b and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 2010; 107:20009-20014
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20009-20014
    • Kojima, Y.1    Acar, A.2    Eaton, E.N.3
  • 75
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg EM, Potenta S, Xie L, et al. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 2007; 67:10123-10128
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3
  • 76
    • 79952721477 scopus 로고    scopus 로고
    • Transdifferentiation of glioblastoma cells into vascular endothelial cells
    • Soda Y, Marumoto T, Friedmann-Morvinski D, et al. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci USA 2011; 108:4274-4280
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4274-4280
    • Soda, Y.1    Marumoto, T.2    Friedmann-Morvinski, D.3
  • 77
    • 77950804823 scopus 로고    scopus 로고
    • A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry
    • El Hallani S, Boisselier B, Peglion F, et al. A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry. Brain 2010; 133:973-982
    • (2010) Brain , vol.133 , pp. 973-982
    • El Hallani, S.1    Boisselier, B.2    Peglion, F.3
  • 78
    • 78650153633 scopus 로고    scopus 로고
    • Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
    • Ricci-Vitiani L, Pallini R, Biffoni M, et al. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 2010; 468:824-828
    • (2010) Nature , vol.468 , pp. 824-828
    • Ricci-Vitiani, L.1    Pallini, R.2    Biffoni, M.3
  • 79
    • 78650098659 scopus 로고    scopus 로고
    • Glioblastoma stem-like cells give rise to tumour endothelium
    • Wang R, Chadalavada K, Wilshire J, et al. Glioblastoma stem-like cells give rise to tumour endothelium. Nature 2010; 468:829-833.
    • (2010) Nature , vol.468 , pp. 829-833
    • Wang, R.1    Chadalavada, K.2    Wilshire, J.3


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