Transdifferentiation of cultured tubular cells induced by hypoxia

Kidney International

Volumn 65, Issue 3, 2004, Pages 871-880

  Manotham, Krissanapong ^b   Tanaka, Tetsuhiro ^b   Matsumoto, Makiko ^b   Ohse, Takamoto ^b   Inagi, Reiko ^b   Miyata, Toshio ^b   Kurokawa, Kiyoshi ^b   Fujita, Toshiro ^b   Ingelfinger, Julie R ^b   Nangaku, Masaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE

Author keywords

Epithelial mesenchymal transformation; Hypoxia; Myofibroblast; Smooth muscle actin; Transdifferentiation; Tubuloitnterstitial fibrosis

Indexed keywords

ALPHA ACTIN; COBALT CHLORIDE; COLLAGEN TYPE 1; DESMIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL IMMORTALIZATION; CELL MOTILITY; CELL TRANSFORMATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY CELL CULTURE; KIDNEY EPITHELIUM; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MESENCHYME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE;

EID: 10744229444     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00461.x     Document Type: Article

References (59)

1. NATH KA: Tubulointerstitial changes as a major determinant in progression of renal damage. Am J Kidney Dis 1:1-17, 1992
2. EDDY AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7:2495-508, 1996
3. REMUZZI G, BERTANI T: Pathophysiology of progressive nephropathies. N Engl J Med 339:1448-1456, 1998
4. KLAHR S: Progression of chronic renal disease. Heart Dis 3:205-209, 2001
5. MACPHERSON BR, LESLIE KO, LIZARO KV, SCHWARZ JE: Contractile cells of the kidney in primary glomerular disorders: An immunohistochemical study using anti-alpha-smooth muscle actin monoclonal antibody. Hum Pathol 24:710-6, 1993
6. ALPERS CE, HUDKINS KL, FLOEGE J, JOHNSON RJ: Human renal cortical interstitial cells with some features of smooth muscle cell participate in tubulointerstitial and crecentic glomerular injury. J Am Soc Nephrol 5:201-209, 1994
7. TANG WW, VAN GY, QI M: Myofibroblast and alpha 1(III) collagen expression in experimental tubulointerstitial nephritis. Kidney Int 51:926-931, 1997
8. HOGEMANN B, GILLESSEN A, BOCKER W, et al: Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis. Scand J Gastroenterol 28:591-594, 1993
9. DIAMOND JR, VAN GOOR H, DING G, ENGELMYER E: Myofibroblasts in experimental hydronephrosis. Am J Pathol 146:121-129, 1995
10. HEWITSON TD, WU HL, BECKER GJ: Interstitial myofibroblasts in experimental renal infection and scarring. Am J Nephrol 15:411-417, 1995
11. HEWITSON TD, BECKER GJ: Interstitial myofibroblasts in IgA glomerulonephritis. Am J Nephrol 15:111-117, 1995
12. ROBERTS IS, BURROWS C, SHANKS JH, et al: Interstitial myofibroblasts: Predictors of progression in membranous nephropathy. J Clin Pathol 50:123-127, 1997
13. ESSAWY M, SOYLEMEZOGLU O, MUCHANETA-KUBARA EC, et al: Myofibroblasts and the progression of diabetic nephropathy. Nephrol Dial Transplant 12:43-50, 1997
14. BADID C, VINCENT M, MCGREGOR B, et al: Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 58:51-61, 2000
15. PICHLER RH, HUGO C, SHANKLAND SJ, et al: SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int 50:1978-1989, 1996
16. BUCALA R, SPIEGEL LA, CHESNEY J, et al: Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1:71-81, 1994
17. IWANO M, PLIETH D, DANOFF TM, et al: Evidence that fibroblast derive from epithelium during tissue fibrosis. J Clin Invest 110:341-350, 2001
18. NG YY, HUANG TP, YANG WC, et al: Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54:864-876, 1998
19. PIEK E, MOUSTAKAS A, KURISAKI A, et al: TGF-β type1 receptor/ALK-5 and Smad proteins mediated epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 112:4557-4588, 1999
20. ROCKEY DC: The cell and molecular biology of hepatic fibrogenesis. Clinical and therapeutic implications. Clin Liver Dis 4:329-355, 2000
21. FAN JM, NG YY, HILL PA, et al: Transforming growth factor β regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 56:1455-1467, 1999
22. LI JH, ZHU HJ, HUANG XR, et al: Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cell by blocking Smad2 activation. J Am Soc Nephrol 13:1464-72, 2002
23. STRUTZ F, ZEISBERG M, ZIYADEH FN, et al: Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61:1714-1728, 2002
24. VESEY DA, CHEUNG CW, CUTTLE L, et al: Interleukin 1-β induce human proximal tubule injury, α-smooth muscle actin expressin and fibronectin production. Kidney Int 62:31-40, 2002
25. FINE LG, BANDYOPADHAY D, NORMAN JT: Is there a common mechanism for the progression of different types of renal disease other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 57(Suppl 75) S22-S26, 2000
26. LIEBERTHAL W, NIGAM SK: Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. Am J Physiol 275:F623-F632, 1998
27. 1 cell proliferation and dedifferentiation by the activation of protein kinase C. Am J Physiol 272:F809-F815, 1997
28. ORPHANIDES C, FINE LG, NORMAN JT: Hypoxia stimulates proximal tubular cell matrix production via TGF-β1 independent mechanism. Kidney Int 52:637-647, 1997
29. NORMAN JT, CLARK IM, GARCIA P: Regulation of TIMP-1 expression by hypoxia in kidney fibroblast. Ann NY Acad Sci 878:503-505, 1999
30. TANG SS, JUNG F, DIAMANT D, et al: Temperature sensitive SV40 immortalized rat proximal tubule cell line has functional reninangiotensin system. Am J Physiol 268:F435-F446, 1995
31. GONG P, HU B, STEWART D, et al: Cobalt induces heme oxygenase-1 expression by hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells regulation by Nrf2 and MafG transcription factors. Biol Chem 276:27018-27025, 2001
32. SHAO J, MIYATA T, YAMADA K, et al: Protective role of nitric oxide in a model of thrombotic microangiopathy in rats. J Am Soc Nephrol 12:2088-2097, 2001
33. MATSUMOTO M, MAKINO Y, TANAKA T, et ai: Induction of renoprotective gene expression by cobalt ameliorate ischemic injury of the kidney in rats. J Am Soc Nephrol 14:1825-1832, 2003
34. ROSENBERGER C, MANDRIOTAS S, JURGENSEN JS, et al: Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 13:1721-1732, 2002
35. POWELL DW, MIFFLIN RC, VALENTICH JD: Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 277: C1-C19, 1999
36. BRADFORD MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
37. NORMAN JT, CLARK IM, GARCIA P: Hypoxia promotes fibrogenesis in human renal fibroblast. Kidney Int 58:2351-2366, 2000
38. NANGAKU M, QUIGG RJ, SHANKLAND SJ, et al: Over expression of Crry protects mesangial cells from complement-mediated injury. J Am Soc Nephrol 8:223-233, 1997
39. PREST SJ, MAY FE, WESTLEY BR: The estrogen-regulated protein TFF-1, stimulates migration of human breast cancer cells. FASEB 16:592-594, 2002
40. TRUONG LD, FARHOOD A, TASBY J, GILLUM D: Experimental chronic renal ischemia: Morphological and immunohistochemical studies. Kidney Int 41:1676-1689, 1992
41. NANGAKU M, ALPERS CE, PIPPIN J, et al: A new model of renal microvascular endothelial injury. Kidney Int 52:182-194, 1997
42. B receptor protects the tubulointerstitium in experimental thrombotic microangiopathy. Kidney Int 62:922-928, 2002
43. KANG DH, JOLY AH, OH SW, et al: Impaired angiogenesis in the remnant kidney model. I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 12:1434-1447, 2001
44. OHASHI R, SHIMIZU A, MASUDA Y, et al: Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol 13:1795-805, 2002
45. OHASHI R, KITAMURA H, YAMANAKA N: Peritubular capillary injury during the progression of experimental glomerulonephritis in rats. J Am Soc Nephrol 11:47-56, 2000
46. STUTZ F, MULLER GA: Transdifferentiation comes of age. Nephrol Dial Transplant 15:1729-1731, 2000
47. 2- regulated gene expression. FASEB J 16:1151-1162, 2002
48. SAED GM, ZHANG W, DIMOND MP: Effect of hypoxia on stimulation effect of TGF-β1 on MMP-2 and MMP-9 activities in mouse fibroblast. J Soc Gynecol Invest 7:348-354, 2000
49. FALANGA V, ZHOU L, YUFIT T: Low oxygen tension stimulates collagen synthesis and COL1A1 transcription though the action of TGF-β1 J Cell Physiol 191:42-50, 2002
50. HOCHACHKA PW, LUTZ PL: Mechanism, origin, and evolution of hypoxia tolerance. Comp Biochem Physiol B Biochem Mol Biol 130:435-459, 2001
51. YANG J, LIU Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159:1465-1475, 2001
52. YANG J, SHULTZ RW, MARS WM, et al: Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 110:1525-1538, 2002
53. ZHANG K, REKHTER MD, GORDON D, PHAN SH: Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. Am J Pathol 145:114-125, 1994
54. HAY ED, ZUK A: Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced. Am J Kidney Dis 26:678-690, 1995
55. ZUK A, MATLIN KS, HAY ED: Type I collagen gel induces Madin-Darby canine kidney cells to become fusiform in shape and lose apical-basal polarity. J Cell Biol 108:903-919, 1989
56. OKADA H, INOUE T, KANNO Y, et al: Renal fibroblast-like cells in Goodpasture's syndrome rats. Kidney Int 60:597-606, 2001
57. OKADA H, BAN S, NAGAO S, et al: Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation. Kidney Int 58:587-597, 2000
58. ABBATE M, ZOJA C, ROTTOLI D, et al: Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts. Kidney Int 61:2066-2077, 2002
59. KANG DH, KANELLIS J, HUGO C, et al: Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol 13:806-816, 2002