메뉴 건너뛰기




Volumn 19, Issue 5, 2014, Pages 363-382

Tracking down the origin of cancer: Metabolic reprogramming as a driver of stemness and tumorigenesis

Author keywords

Cancer cell of origin; Cancer metabolism; Cancer stem cells; Metabolic reprogramming; Stem cells

Indexed keywords

GLUTAMINE; GLYCINE; SERINE;

EID: 84908170488     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.2014011844     Document Type: Article
Times cited : (29)

References (121)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science. 2011;331:1553–8.
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 4
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic gly-colysis: Meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic gly-colysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441–64.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 5
    • 84862615790 scopus 로고    scopus 로고
    • Tracing epithelial stem cells during development, homeostasis, and repair
    • Van Keymeulen A, Blanpain C. Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol. 2012;197:575–84.
    • (2012) J Cell Biol , vol.197 , pp. 575-584
    • Van Keymeulen, A.1    Blanpain, C.2
  • 7
    • 79958252915 scopus 로고    scopus 로고
    • Chromatin connections to pluripotency and cellular repro-gramming
    • Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular repro-gramming. Cell. 2011;145:835–50.
    • (2011) Cell , vol.145 , pp. 835-850
    • Orkin, S.H.1    Hochedlinger, K.2
  • 8
    • 84868351585 scopus 로고    scopus 로고
    • Metabolic regulation in pluripo-tent stem cells during reprogramming and self-renewal
    • Zhang J, Nuebel E, Daley GQ, Koehler CM, Teitell MA. Metabolic regulation in pluripo-tent stem cells during reprogramming and self-renewal. Cell Stem Cell. 2012;11:589-95.
    • (2012) Cell Stem Cell , vol.11 , pp. 589-595
    • Zhang, J.1    Nuebel, E.2    Daley, G.Q.3    Koehler, C.M.4    Teitell, M.A.5
  • 9
    • 84875953755 scopus 로고    scopus 로고
    • Stem cell metabolism in tissue development and aging
    • Shyh-Chang N, Daley GQ, Cantley LC. Stem cell metabolism in tissue development and aging. Development. 2013;140:2535–47.
    • (2013) Development , vol.140 , pp. 2535-2547
    • Shyh-Chang, N.1    Daley, G.Q.2    Cantley, L.C.3
  • 10
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956;123:309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 12
    • 0030023026 scopus 로고    scopus 로고
    • Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers
    • Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechago J. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res. 1996;56:1164–7.
    • (1996) Cancer Res , vol.56 , pp. 1164-1167
    • Younes, M.1    Lechago, L.V.2    Somoano, J.R.3    Mosharaf, M.4    Lechago, J.5
  • 14
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin WG Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer. 2008;8:865–73.
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin, W.G.1
  • 15
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009;15:6479-83.
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 16
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009;9:563–75.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 19
    • 75149148563 scopus 로고    scopus 로고
    • Q’s next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis RJ, Cheng T. Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 2010;29:313–24.
    • (2010) Oncogene , vol.29 , pp. 313-324
    • Deberardinis, R.J.1    Cheng, T.2
  • 25
    • 57049132739 scopus 로고    scopus 로고
    • Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
    • Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol. 2008;10:1477–83.
    • (2008) Nat Cell Biol , vol.10 , pp. 1477-1483
    • Vaughn, A.E.1    Deshmukh, M.2
  • 26
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104:19345–50.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 29
    • 84881177291 scopus 로고    scopus 로고
    • Serine, glycine and one-carbon units: Cancer metabolism in full circle
    • Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer. 2013;13:572–83.
    • (2013) Nat Rev Cancer , vol.13 , pp. 572-583
    • Locasale, J.W.1
  • 33
    • 77049254154 scopus 로고
    • The biosynthesis of free glycine and serine by tumors
    • Kit S. The biosynthesis of free glycine and serine by tumors. Cancer Res. 1955;15:715-8.
    • (1955) Cancer Res , vol.15 , pp. 715-718
    • Kit, S.1
  • 34
    • 0021191196 scopus 로고
    • Enzymes of serine metabolism in normal, developing and neoplastic rat tissues
    • Snell K. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv Enzyme Regul. 1984;22:325–400.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 325-400
    • Snell, K.1
  • 38
    • 84889684498 scopus 로고    scopus 로고
    • The histone H3 methyltransfer-ase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
    • Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L, Zha Y, Dong Z, Huang S, Asara JM, Cui H, Ding HF. The histone H3 methyltransfer-ase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013;18:896–907.
    • (2013) Cell Metab , vol.18 , pp. 896-907
    • Ding, J.1    Li, T.2    Wang, X.3    Zhao, E.4    Choi, J.H.5    Yang, L.6    Zha, Y.7    Dong, Z.8    Huang, S.9    Asara, J.M.10    Cui, H.11    Ding, H.F.12
  • 44
    • 33746930794 scopus 로고    scopus 로고
    • Succinate de-hydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
    • King A, Selak MA, Gottlieb E. Succinate de-hydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Onco-gene. 2006;25:4675–82.
    • (2006) Onco-gene , vol.25 , pp. 4675-4682
    • King, A.1    Selak, M.A.2    Gottlieb, E.3
  • 52
    • 84870907452 scopus 로고    scopus 로고
    • SIRT6 puts cancer metabolism in the driver’s seat
    • Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver’s seat. Cell. 2012;151:1155–6.
    • (2012) Cell , vol.151 , pp. 1155-1156
    • Lyssiotis, C.A.1    Cantley, L.C.2
  • 53
    • 84892909254 scopus 로고    scopus 로고
    • Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
    • Onodera Y, Nam JM, Bissell MJ. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014;124:367–84.
    • (2014) J Clin Invest , vol.124 , pp. 367-384
    • Onodera, Y.1    Nam, J.M.2    Bissell, M.J.3
  • 54
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer. 2010;10:51–7.
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 58
    • 84868347607 scopus 로고    scopus 로고
    • Metabolic plasticity in stem cell homeo-stasis and differentiation
    • Folmes CD, Dzeja PP, Nelson TJ, Terzic A. Metabolic plasticity in stem cell homeo-stasis and differentiation. Cell Stem Cell. 2012;11:596–606.
    • (2012) Cell Stem Cell , vol.11 , pp. 596-606
    • Folmes, C.D.1    Dzeja, P.P.2    Nelson, T.J.3    Terzic, A.4
  • 59
    • 84872493778 scopus 로고    scopus 로고
    • Exploring metabolic pathways that contribute to the stem cell phenotype
    • Vacanti NM, Metallo CM. Exploring metabolic pathways that contribute to the stem cell phenotype. Biochim Biophys Acta. 2013;1830:2361–9.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2361-2369
    • Vacanti, N.M.1    Metallo, C.M.2
  • 63
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • Ezashi T, Das P, Roberts RM. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci U S A. 2005;102:4783–8.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 64
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010;7:150–61.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 65
    • 70349860263 scopus 로고    scopus 로고
    • Enhancement of human embryonic stem cell pluripotency through inhibition of the mito-chondrial respiratory chain
    • Varum S, Momcilovic O, Castro C, Ben-Yehudah A, Ramalho-Santos J, Navara CS. Enhancement of human embryonic stem cell pluripotency through inhibition of the mito-chondrial respiratory chain. Stem Cell Res. 2009;3:142–56.
    • (2009) Stem Cell Res , vol.3 , pp. 142-156
    • Varum, S.1    Momcilovic, O.2    Castro, C.3    Ben-Yehudah, A.4    Ramalho-Santos, J.5    Navara, C.S.6
  • 66
    • 0037444772 scopus 로고    scopus 로고
    • Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxi-dative stress
    • Filosa S, Fico A, Paglialunga F, Balestrieri M, Crooke A, Verde P, Abrescia P, Bautista JM, Martini G. Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxi-dative stress. Biochem J. 2003;370:935–43.
    • (2003) Biochem J , vol.370 , pp. 935-943
    • Filosa, S.1    Fico, A.2    Paglialunga, F.3    Balestrieri, M.4    Crooke, A.5    Verde, P.6    Abrescia, P.7    Bautista, J.M.8    Martini, G.9
  • 67
    • 84855759349 scopus 로고    scopus 로고
    • Modulation of the pentose phosphate pathway induces en-dodermal differentiation in embryonic stem cells
    • Manganelli G, Fico A, Masullo U, Pizzolon-go F, Cimmino A, Filosa S. Modulation of the pentose phosphate pathway induces en-dodermal differentiation in embryonic stem cells. PLoS One. 2012;7:e29321.
    • (2012) PLoS One , vol.7
    • Manganelli, G.1    Fico, A.2    Masullo, U.3    Pizzolon-Go, F.4    Cimmino, A.5    Filosa, S.6
  • 68
    • 83455169174 scopus 로고    scopus 로고
    • Human pluripotent stem cells decouple respiration from energy production
    • Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. EMBO J. 2011;30:4851–2.
    • (2011) EMBO J , vol.30 , pp. 4851-4852
    • Shyh-Chang, N.1    Zheng, Y.2    Locasale, J.W.3    Cantley, L.C.4
  • 69
    • 77954822251 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species mediate cardiomyocyte formation from embryonic stem cells in high glucose
    • Crespo FL, Sobrado VR, Gomez L, Cervera AM, McCreath KJ. Mitochondrial reactive oxygen species mediate cardiomyocyte formation from embryonic stem cells in high glucose. Stem Cells. 2010;28:1132–42.
    • (2010) Stem Cells , vol.28 , pp. 1132-1142
    • Crespo, F.L.1    Sobrado, V.R.2    Gomez, L.3    Cervera, A.M.4    McCreath, K.J.5
  • 76
    • 70349338871 scopus 로고    scopus 로고
    • Stem cells, stress, metabolism and cancer: A drama in two Octs
    • Kang J, Shakya A, Tantin D. Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends Biochem Sci. 2009;34:491–9.
    • (2009) Trends Biochem Sci , vol.34 , pp. 491-499
    • Kang, J.1    Shakya, A.2    Tantin, D.3
  • 77
    • 61849161672 scopus 로고    scopus 로고
    • Oct1 loss of function indu-ces a coordinate metabolic shift that opposes tumorigenicity
    • Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. Oct1 loss of function indu-ces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol. 2009;11:320–7.
    • (2009) Nat Cell Biol , vol.11 , pp. 320-327
    • Shakya, A.1    Cooksey, R.2    Cox, J.E.3    Wang, V.4    McClain, D.A.5    Tantin, D.6
  • 82
    • 80053916176 scopus 로고    scopus 로고
    • Metabolic regulation of hematopoietic stem cells in the hypoxic niche
    • Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011;9:298-310.
    • (2011) Cell Stem Cell , vol.9 , pp. 298-310
    • Suda, T.1    Takubo, K.2    Semenza, G.L.3
  • 85
    • 84864805939 scopus 로고    scopus 로고
    • Proteomic cornerstones of hematopoietic stem cell differentiation: Distinct signatures of multipo-tent progenitors and myeloid committed cells
    • Klimmeck D, Hansson J, Raffel S, Vakhru-shev SY, Trumpp A, Krijgsveld J. Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipo-tent progenitors and myeloid committed cells. Mol Cell Proteomics. 2012;11:286–302.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 286-302
    • Klimmeck, D.1    Hansson, J.2    Raffel, S.3    Vakhru-Shev, S.Y.4    Trumpp, A.5    Krijgsveld, J.6
  • 86
    • 49249086654 scopus 로고    scopus 로고
    • Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesen-chymal stem cells
    • Chen CT, Shih YR, Kuo TK, Lee OK, Wei YH. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesen-chymal stem cells. Stem Cells. 2008;26:960-8.
    • (2008) Stem Cells , vol.26 , pp. 960-968
    • Chen, C.T.1    Shih, Y.R.2    Kuo, T.K.3    Lee, O.K.4    Wei, Y.H.5
  • 88
    • 84866061103 scopus 로고    scopus 로고
    • Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH
    • Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012;2:568.
    • (2012) Sci Rep , vol.2 , pp. 568
    • Stringari, C.1    Edwards, R.A.2    Pate, K.T.3    Waterman, M.L.4    Donovan, P.J.5    Gratton, E.6
  • 90
    • 0017718628 scopus 로고
    • Primary bioassay of human myeloma stem cells
    • Hamburger A, Salmon SE. Primary bioassay of human myeloma stem cells. J Clin Invest. 1977;60:846–54.
    • (1977) J Clin Invest , vol.60 , pp. 846-854
    • Hamburger, A.1    Salmon, S.E.2
  • 91
    • 0017785769 scopus 로고
    • Primary bio-assay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primary bio-assay of human tumor stem cells. Science. 1977;197:461–3.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 93
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730–7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 94
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21:283–96.
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 95
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 2008;40:499–507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 96
    • 84873406827 scopus 로고    scopus 로고
    • Tracing the cellular origin of cancer
    • Blanpain C. Tracing the cellular origin of cancer. Nat Cell Biol. 2013;15:126–34.
    • (2013) Nat Cell Biol , vol.15 , pp. 126-134
    • Blanpain, C.1
  • 101
    • 33747195353 scopus 로고    scopus 로고
    • Induction of plu-ripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors
    • Takahashi K, Yamanaka S. Induction of plu-ripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors. Cell. 2006;126:663–76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 106
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009;69:7507–11.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 108
    • 84866950193 scopus 로고    scopus 로고
    • Com-parison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
    • Morfouace M, Lalier L, Bahut M, Bonna-main V, Naveilhan P, Guette C, Oliver L, Gueguen N, Reynier P, Vallette FM. Com-parison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. J Biol Chem. 2012;287:33664–74.
    • (2012) J Biol Chem , vol.287 , pp. 33664-33674
    • Morfouace, M.1    Lalier, L.2    Bahut, M.3    Bonna-Main, V.4    Naveilhan, P.5    Guette, C.6    Oliver, L.7    Gueguen, N.8    Reynier, P.9    Vallette, F.M.10
  • 111
    • 80052722539 scopus 로고    scopus 로고
    • Metabolic alterations in highly tumorigen-ic glioblastoma cells: Preference for hypoxia and high dependency on glycolysis
    • Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, Ogasawara M, Keating MJ, Kondo S, Huang P. Metabolic alterations in highly tumorigen-ic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011;286:32843–53.
    • (2011) J Biol Chem , vol.286 , pp. 32843-32853
    • Zhou, Y.1    Zhou, Y.2    Shingu, T.3    Feng, L.4    Chen, Z.5    Ogasawara, M.6    Keating, M.J.7    Kondo, S.8    Huang, P.9
  • 117
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
    • Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol. 2012;22:396–403.
    • (2012) Semin Cancer Biol , vol.22 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 120
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer DE, Hatzivassiliou G, Zhao F, An-dreadis C, Thompson CB. ATP citrate lyase is an important component of cell growth and transformation. Oncogene. 2005;24:6314–22.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    An-Dreadis, C.4    Thompson, C.B.5
  • 121
    • 84894465269 scopus 로고    scopus 로고
    • ATP citrate lyase knockdown impacts cancer stem cells in vitro
    • Hanai JI, Doro N, Seth P, Sukhatme VP. ATP citrate lyase knockdown impacts cancer stem cells in vitro. Cell Death Dis. 2013;4:e696.
    • (2013) Cell Death Dis , vol.4
    • Hanai, J.I.1    Doro, N.2    Seth, P.3    Sukhatme, V.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.