-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science. 2011;331:1553–8.
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
4
-
-
80054046029
-
Aerobic gly-colysis: Meeting the metabolic requirements of cell proliferation
-
Lunt SY, Vander Heiden MG. Aerobic gly-colysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441–64.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
5
-
-
84862615790
-
Tracing epithelial stem cells during development, homeostasis, and repair
-
Van Keymeulen A, Blanpain C. Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol. 2012;197:575–84.
-
(2012)
J Cell Biol
, vol.197
, pp. 575-584
-
-
Van Keymeulen, A.1
Blanpain, C.2
-
6
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122:947-56.
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
Levine, S.S.5
Zucker, J.P.6
Guenther, M.G.7
Kumar, R.M.8
Murray, H.L.9
Jenner, R.G.10
Gifford, D.K.11
Melton, D.A.12
Jaenisch, R.13
Young, R.A.14
-
7
-
-
79958252915
-
Chromatin connections to pluripotency and cellular repro-gramming
-
Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular repro-gramming. Cell. 2011;145:835–50.
-
(2011)
Cell
, vol.145
, pp. 835-850
-
-
Orkin, S.H.1
Hochedlinger, K.2
-
8
-
-
84868351585
-
Metabolic regulation in pluripo-tent stem cells during reprogramming and self-renewal
-
Zhang J, Nuebel E, Daley GQ, Koehler CM, Teitell MA. Metabolic regulation in pluripo-tent stem cells during reprogramming and self-renewal. Cell Stem Cell. 2012;11:589-95.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 589-595
-
-
Zhang, J.1
Nuebel, E.2
Daley, G.Q.3
Koehler, C.M.4
Teitell, M.A.5
-
9
-
-
84875953755
-
Stem cell metabolism in tissue development and aging
-
Shyh-Chang N, Daley GQ, Cantley LC. Stem cell metabolism in tissue development and aging. Development. 2013;140:2535–47.
-
(2013)
Development
, vol.140
, pp. 2535-2547
-
-
Shyh-Chang, N.1
Daley, G.Q.2
Cantley, L.C.3
-
10
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science. 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
11
-
-
0025075721
-
Over-expression of fa-cilitative glucose transporter genes in human cancer
-
Yamamoto T, Seino Y, Fukumoto H, Koh G, Yano H, Inagaki N, Yamada Y, Inoue K, Manabe T, Imura H. Over-expression of fa-cilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun. 1990;170:223–30.
-
(1990)
Biochem Biophys Res Commun
, vol.170
, pp. 223-230
-
-
Yamamoto, T.1
Seino, Y.2
Fukumoto, H.3
Koh, G.4
Yano, H.5
Inagaki, N.6
Yamada, Y.7
Inoue, K.8
Manabe, T.9
Imura, H.10
-
12
-
-
0030023026
-
Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers
-
Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechago J. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res. 1996;56:1164–7.
-
(1996)
Cancer Res
, vol.56
, pp. 1164-1167
-
-
Younes, M.1
Lechago, L.V.2
Somoano, J.R.3
Mosharaf, M.4
Lechago, J.5
-
13
-
-
2542561169
-
Akt stimulates aerobic glycolysis in can-cer cells
-
Elstrom RL, Bauer DE, Buzzai M, Kar-nauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, Thompson CB. Akt stimulates aerobic glycolysis in can-cer cells. Cancer Res. 2004;64:3892–9.
-
(2004)
Cancer Res
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Kar-Nauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
14
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin WG Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer. 2008;8:865–73.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 865-873
-
-
Kaelin, W.G.1
-
15
-
-
70350728803
-
MYC-induced cancer cell energy metabolism and therapeutic opportunities
-
Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009;15:6479-83.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6479-6483
-
-
Dang, C.V.1
Le, A.2
Gao, P.3
-
16
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009;9:563–75.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
17
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
Faubert B, Boily G, Izreig S, Griss T, Sam-borska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, DeBerardinis RJ, Siegel PM, Jones RG. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab. 2013;17:113–24.
-
(2013)
Cell Metab
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Sam-Borska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
Mamer, O.A.11
Avizonis, D.12
Deberardinis, R.J.13
Siegel, P.M.14
Jones, R.G.15
-
19
-
-
75149148563
-
Q’s next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis RJ, Cheng T. Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 2010;29:313–24.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
Deberardinis, R.J.1
Cheng, T.2
-
20
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A. 2008;105:18782–7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
Deberardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
21
-
-
64749116346
-
c-Myc suppression of miR-23a/b enhances mito-chondrial glutaminase expression and gluta-mine metabolism
-
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV. c-Myc suppression of miR-23a/b enhances mito-chondrial glutaminase expression and gluta-mine metabolism. Nature. 2009;458:762–5.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
22
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stepha-nopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2012;481:380–4.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
Kelleher, J.K.11
Vander Heiden, M.G.12
Iliopoulos, O.13
Stepha-Nopoulos, G.14
-
23
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012;481:385–8.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
Deberardinis, R.J.10
-
24
-
-
78650181190
-
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
-
Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Col-ler HA, Thompson CB. The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev. 2010;24:2784–99.
-
(2010)
Genes Dev
, vol.24
, pp. 2784-2799
-
-
Wellen, K.E.1
Lu, C.2
Mancuso, A.3
Lemons, J.M.4
Ryczko, M.5
Dennis, J.W.6
Rabinowitz, J.D.7
Col-Ler, H.A.8
Thompson, C.B.9
-
25
-
-
57049132739
-
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
-
Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol. 2008;10:1477–83.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1477-1483
-
-
Vaughn, A.E.1
Deshmukh, M.2
-
26
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104:19345–50.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19345-19350
-
-
Deberardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
27
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mul-larky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013;496:101–5.
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
Perera, R.M.7
Ferrone, C.R.8
Mul-Larky, E.9
Shyh-Chang, N.10
Kang, Y.11
Fleming, J.B.12
Bardeesy, N.13
Asara, J.M.14
Haigis, M.C.15
Depinho, R.A.16
Cantley, L.C.17
Kimmelman, A.C.18
-
28
-
-
80051866908
-
Oncogen-ic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
-
Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogen-ic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol. 2011;7:523.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 523
-
-
Gaglio, D.1
Metallo, C.M.2
Gameiro, P.A.3
Hiller, K.4
Danna, L.S.5
Balestrieri, C.6
Alberghina, L.7
Stephanopoulos, G.8
Chiaradonna, F.9
-
29
-
-
84881177291
-
Serine, glycine and one-carbon units: Cancer metabolism in full circle
-
Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer. 2013;13:572–83.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
30
-
-
80052258995
-
Phosphoglycer-ate dehydrogenase diverts glycolytic fux and contributes to oncogenesis
-
Locasale JW, Grassian AR, Melman T, Lys-siotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharf H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Li-gon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycer-ate dehydrogenase diverts glycolytic fux and contributes to oncogenesis. Nat Genet. 2011;43:869–74.
-
(2011)
Nat Genet
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lys-Siotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharf, H.10
Sasaki, A.T.11
Anastasiou, D.12
Mullarky, E.13
Vokes, N.I.14
Sasaki, M.15
Beroukhim, R.16
Stephanopoulos, G.17
Li-Gon, A.H.18
Meyerson, M.19
Richardson, A.L.20
Chin, L.21
Wagner, G.22
Asara, J.M.23
Brugge, J.S.24
Cantley, L.C.25
Vander Heiden, M.G.26
more..
-
31
-
-
80051923932
-
Functional ge-nomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R, Marks KM, Shaul YD, Pa-cold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ot-tina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional ge-nomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011;476:346–50.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pa-Cold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
Chen, W.W.11
Barrett, F.G.12
Stransky, N.13
Tsun, Z.Y.14
Cowley, G.S.15
Barretina, J.16
Kalaany, N.Y.17
Hsu, P.P.18
Ot-Tina, K.19
Chan, A.M.20
Yuan, B.21
Garraway, L.A.22
Root, D.E.23
Mino-Kenudson, M.24
Brachtel, E.F.25
Driggers, E.M.26
Sabatini, D.M.27
more..
-
32
-
-
78650996423
-
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
-
Pollari S, Kakonen SM, Edgren H, Wolf M, Kohonen P, Sara H, Guise T, Nees M, Kal-lioniemi O. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat. 2011;125:421–30.
-
(2011)
Breast Cancer Res Treat
, vol.125
, pp. 421-430
-
-
Pollari, S.1
Kakonen, S.M.2
Edgren, H.3
Wolf, M.4
Kohonen, P.5
Sara, H.6
Guise, T.7
Nees, M.8
Kal-Lioniemi, O.9
-
33
-
-
77049254154
-
The biosynthesis of free glycine and serine by tumors
-
Kit S. The biosynthesis of free glycine and serine by tumors. Cancer Res. 1955;15:715-8.
-
(1955)
Cancer Res
, vol.15
, pp. 715-718
-
-
Kit, S.1
-
34
-
-
0021191196
-
Enzymes of serine metabolism in normal, developing and neoplastic rat tissues
-
Snell K. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv Enzyme Regul. 1984;22:325–400.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 325-400
-
-
Snell, K.1
-
35
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O’Reilly M, Gottlieb E. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature. 2012;491:458-62.
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
Frezza, C.11
O’reilly, M.12
Gottlieb, E.13
-
36
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012;109:6904–9.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
Mancuso, A.2
Tong, X.3
Ward, P.S.4
Fan, J.5
Rabinowitz, J.D.6
Thompson, C.B.7
-
37
-
-
84873318679
-
Control of nutrient stress-induced metabolic reprogram-ming by PKCzeta in tumorigenesis
-
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J. Control of nutrient stress-induced metabolic reprogram-ming by PKCzeta in tumorigenesis. Cell. 2013;152:599–611.
-
(2013)
Cell
, vol.152
, pp. 599-611
-
-
Ma, L.1
Tao, Y.2
Duran, A.3
Llado, V.4
Galvez, A.5
Barger, J.F.6
Castilla, E.A.7
Chen, J.8
Yajima, T.9
Porollo, A.10
Medvedovic, M.11
Brill, L.M.12
Plas, D.R.13
Riedl, S.J.14
Leitges, M.15
Diaz-Meco, M.T.16
Richardson, A.D.17
Moscat, J.18
-
38
-
-
84889684498
-
The histone H3 methyltransfer-ase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
-
Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L, Zha Y, Dong Z, Huang S, Asara JM, Cui H, Ding HF. The histone H3 methyltransfer-ase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013;18:896–907.
-
(2013)
Cell Metab
, vol.18
, pp. 896-907
-
-
Ding, J.1
Li, T.2
Wang, X.3
Zhao, E.4
Choi, J.H.5
Yang, L.6
Zha, Y.7
Dong, Z.8
Huang, S.9
Asara, J.M.10
Cui, H.11
Ding, H.F.12
-
39
-
-
84971646528
-
p73 regulates ser-ine biosynthesis in cancer
-
Nov 4 [Epub ahead of print
-
Amelio I, Markert EK, Rufni A, Antonov AV, Sayan BS, Tucci P, Agostini M, Mineo TC, Levine AJ, Melino G. p73 regulates ser-ine biosynthesis in cancer. Oncogene. 2013 Nov 4 [Epub ahead of print]
-
(2013)
Oncogene
-
-
Amelio, I.1
Markert, E.K.2
Rufni, A.3
Antonov, A.V.4
Sayan, B.S.5
Tucci, P.6
Agostini, M.7
Mineo, T.C.8
Levine, A.J.9
Melino, G.10
-
40
-
-
84861420588
-
Metabolite profling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012;336:1040–4.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
41
-
-
84856087055
-
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
-
Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012;148:259–72.
-
(2012)
Cell
, vol.148
, pp. 259-272
-
-
Zhang, W.C.1
Shyh-Chang, N.2
Yang, H.3
Rai, A.4
Umashankar, S.5
Ma, S.6
Soh, B.S.7
Sun, L.L.8
Tai, B.C.9
Nga, M.E.10
Bhakoo, K.K.11
Jayapal, S.R.12
Nichane, M.13
Yu, Q.14
Ahmed, D.A.15
Tan, C.16
Sing, W.P.17
Tam, J.18
Thirugananam, A.19
Noghabi, M.S.20
Pang, Y.H.21
Ang, H.S.22
Mitchell, W.23
Robson, P.24
Kaldis, P.25
Soo, R.A.26
Swarup, S.27
Lim, E.H.28
Lim, B.29
more..
-
42
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PE, Rubinstein WS, Myers EN, Richard CWIII, Cornelisse CJ, Devilee P, Devlin B. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science. 2000;287:848–51.
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
Van Der Mey, A.7
Taschner, P.E.8
Rubinstein, W.S.9
Myers, E.N.10
Richard, C.W.11
Cornelisse, C.J.12
Devilee, P.13
Devlin, B.14
-
43
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fbroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aitto-maki K, Hietala M, Sistonen P, Paetau A, Sa-lovaara R, Herva R, Launonen V, Aaltonen LA. Germline mutations in FH predispose to dominantly inherited uterine fbroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406–10.
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.5
Kelsell, D.6
Leigh, I.7
Gorman, P.8
Lamlum, H.9
Rahman, S.10
Roylance, R.R.11
Olpin, S.12
Bevan, S.13
Barker, K.14
Hearle, N.15
Houlston, R.S.16
Kiuru, M.17
Lehtonen, R.18
Karhu, A.19
Vilkki, S.20
Laiho, P.21
Eklund, C.22
Vierimaa, O.23
Aitto-Maki, K.24
Hietala, M.25
Sistonen, P.26
Paetau, A.27
Sa-Lovaara, R.28
Herva, R.29
Launonen, V.30
Aaltonen, L.A.31
more..
-
44
-
-
33746930794
-
Succinate de-hydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
King A, Selak MA, Gottlieb E. Succinate de-hydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Onco-gene. 2006;25:4675–82.
-
(2006)
Onco-gene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
45
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinow-itz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462:739–44.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinow-Itz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
46
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate de-hydrogenase 1 and 2 mutations
-
Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, Sasaki M, Jin S, Schenkein DP, Su SM, Dang L, Fantin VR, Mak TW. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate de-hydrogenase 1 and 2 mutations. J Exp Med. 2010;207:339–44.
-
(2010)
J Exp Med
, vol.207
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
Sasaki, M.7
Jin, S.8
Schenkein, D.P.9
Su, S.M.10
Dang, L.11
Fantin, V.R.12
Mak, T.W.13
-
47
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, Rohle D, Tur-can S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O’Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012;483:474–8.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Tur-Can, S.5
Abdel-Wahab, O.6
Edwards, C.R.7
Khanin, R.8
Figueroa, M.E.9
Melnick, A.10
Wellen, K.E.11
O’rourke, D.M.12
Berger, S.L.13
Chan, T.A.14
Levine, R.L.15
Mellinghoff, I.K.16
Thompson, C.B.17
-
48
-
-
78650019179
-
Leu-kemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vas-anthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Lowenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Leu-kemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18:553–67.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vas-Anthakumar, A.9
Fernandez, H.F.10
Tallman, M.S.11
Sun, Z.12
Wolniak, K.13
Peeters, J.K.14
Liu, W.15
Choe, S.E.16
Fantin, V.R.17
Paietta, E.18
Lowenberg, B.19
Licht, J.D.20
Godley, L.A.21
Delwel, R.22
Valk, P.J.23
Thompson, C.B.24
Levine, R.L.25
Melnick, A.26
more..
-
49
-
-
84884545211
-
Induction of sarcomas by mutant IDH2
-
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Induction of sarcomas by mutant IDH2. Genes Dev. 2013;27:1986–98.
-
(2013)
Genes Dev
, vol.27
, pp. 1986-1998
-
-
Lu, C.1
Venneti, S.2
Akalin, A.3
Fang, F.4
Ward, P.S.5
Dematteo, R.G.6
Intlekofer, A.M.7
Chen, C.8
Ye, J.9
Hameed, M.10
Nafa, K.11
Agaram, N.P.12
Cross, J.R.13
Khanin, R.14
Mason, C.E.15
Healey, J.H.16
Lowe, S.W.17
Schwartz, G.K.18
Melnick, A.19
Thompson, C.B.20
more..
-
50
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, True-love J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guc-cione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012;151:1185–99.
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
Ram, O.7
True-Love, J.8
Guimaraes, A.R.9
Toiber, D.10
Cosentino, C.11
Greenson, J.K.12
Macdonald, A.I.13
McGlynn, L.14
Maxwell, F.15
Edwards, J.16
Giacosa, S.17
Guc-Cione, E.18
Weissleder, R.19
Bernstein, B.E.20
Regev, A.21
Shiels, P.G.22
Lombard, D.B.23
Mostoslavsky, R.24
more..
-
51
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeo-stasis via Hif1alpha
-
Zhong L, D’Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeo-stasis via Hif1alpha. Cell. 2010;140:280–93.
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D’urso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
Guimaraes, A.7
Marinelli, B.8
Wikstrom, J.D.9
Nir, T.10
Clish, C.B.11
Vaitheesvaran, B.12
Iliopoulos, O.13
Kurland, I.14
Dor, Y.15
Weissleder, R.16
Shirihai, O.S.17
Ellisen, L.W.18
Espinosa, J.M.19
Mostoslavsky, R.20
more..
-
52
-
-
84870907452
-
SIRT6 puts cancer metabolism in the driver’s seat
-
Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver’s seat. Cell. 2012;151:1155–6.
-
(2012)
Cell
, vol.151
, pp. 1155-1156
-
-
Lyssiotis, C.A.1
Cantley, L.C.2
-
53
-
-
84892909254
-
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
-
Onodera Y, Nam JM, Bissell MJ. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014;124:367–84.
-
(2014)
J Clin Invest
, vol.124
, pp. 367-384
-
-
Onodera, Y.1
Nam, J.M.2
Bissell, M.J.3
-
54
-
-
72949096792
-
Senescence in tumours: Evidence from mice and humans
-
Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer. 2010;10:51–7.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
55
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh H, Lleonart ME, Gil J, Wang J, Degan P, Peters G, Martinez D, Carnero A, Beach D. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005;65:177-85.
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
56
-
-
84896797170
-
Glucose metabolism and hexos-amine pathway regulate oncogene-induced senescence
-
Gitenay D, Wiel C, Lallet-Daher H, Vin-drieux D, Aubert S, Payen L, Simonnet H, Bernard D. Glucose metabolism and hexos-amine pathway regulate oncogene-induced senescence. Cell Death Dis. 2014;5:e1089.
-
(2014)
Cell Death Dis
, vol.5
-
-
Gitenay, D.1
Wiel, C.2
Lallet-Daher, H.3
Vin-Drieux, D.4
Aubert, S.5
Payen, L.6
Simonnet, H.7
Bernard, D.8
-
57
-
-
84878679199
-
A key role for mitochon-drial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
-
Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov VA, Mackay G, van der Burg SH, Verdegaal EM, Cascante M, Shlomi T, Gottlieb E, Peeper DS. A key role for mitochon-drial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature. 2013;498:109–12.
-
(2013)
Nature
, vol.498
, pp. 109-112
-
-
Kaplon, J.1
Zheng, L.2
Meissl, K.3
Chaneton, B.4
Selivanov, V.A.5
Mackay, G.6
Van Der Burg, S.H.7
Verdegaal, E.M.8
Cascante, M.9
Shlomi, T.10
Gottlieb, E.11
Peeper, D.S.12
-
58
-
-
84868347607
-
Metabolic plasticity in stem cell homeo-stasis and differentiation
-
Folmes CD, Dzeja PP, Nelson TJ, Terzic A. Metabolic plasticity in stem cell homeo-stasis and differentiation. Cell Stem Cell. 2012;11:596–606.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 596-606
-
-
Folmes, C.D.1
Dzeja, P.P.2
Nelson, T.J.3
Terzic, A.4
-
59
-
-
84872493778
-
Exploring metabolic pathways that contribute to the stem cell phenotype
-
Vacanti NM, Metallo CM. Exploring metabolic pathways that contribute to the stem cell phenotype. Biochim Biophys Acta. 2013;1830:2361–9.
-
(2013)
Biochim Biophys Acta
, vol.1830
, pp. 2361-2369
-
-
Vacanti, N.M.1
Metallo, C.M.2
-
60
-
-
33846420629
-
A high glycolytic fux supports the prolif-erative potential of murine embryonic stem cells
-
Kondoh H, Lleonart ME, Nakashima Y, Yo-kode M, Tanaka M, Bernard D, Gil J, Beach D. A high glycolytic fux supports the prolif-erative potential of murine embryonic stem cells. Antioxid Redox Signal. 2007;9:293–9.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 293-299
-
-
Kondoh, H.1
Lleonart, M.E.2
Nakashima, Y.3
Yo-Kode, M.4
Tanaka, M.5
Bernard, D.6
Gil, J.7
Beach, D.8
-
61
-
-
79959221064
-
Energy metabolism in human pluripotent stem cells and their differentiated counterparts
-
Varum S, Rodrigues AS, Moura MB, Mom-cilovic O, Easley CAIIII, Ramalho-Santos J, Van Houten B, Schatten G. Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One. 2011;6:e20914.
-
(2011)
PLoS One
, vol.6
-
-
Varum, S.1
Rodrigues, A.S.2
Moura, M.B.3
Mom-Cilovic, O.4
Easley, C.A.5
Ramalho-Santos, J.6
Van Houten, B.7
Schatten, G.8
-
62
-
-
83455235489
-
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
-
Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setogu-chi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 2011;30:4860–73.
-
(2011)
EMBO J
, vol.30
, pp. 4860-4873
-
-
Zhang, J.1
Khvorostov, I.2
Hong, J.S.3
Oktay, Y.4
Vergnes, L.5
Nuebel, E.6
Wahjudi, P.N.7
Setogu-Chi, K.8
Wang, G.9
Do, A.10
Jung, H.J.11
McCaffery, J.M.12
Kurland, I.J.13
Reue, K.14
Lee, W.N.15
Koehler, C.M.16
Teitell, M.A.17
-
63
-
-
16344380951
-
Low O2 tensions and the prevention of differentiation of hES cells
-
Ezashi T, Das P, Roberts RM. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci U S A. 2005;102:4783–8.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4783-4788
-
-
Ezashi, T.1
Das, P.2
Roberts, R.M.3
-
64
-
-
77956224494
-
Oxygen in stem cell biology: A critical component of the stem cell niche
-
Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010;7:150–61.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 150-161
-
-
Mohyeldin, A.1
Garzon-Muvdi, T.2
Quinones-Hinojosa, A.3
-
65
-
-
70349860263
-
Enhancement of human embryonic stem cell pluripotency through inhibition of the mito-chondrial respiratory chain
-
Varum S, Momcilovic O, Castro C, Ben-Yehudah A, Ramalho-Santos J, Navara CS. Enhancement of human embryonic stem cell pluripotency through inhibition of the mito-chondrial respiratory chain. Stem Cell Res. 2009;3:142–56.
-
(2009)
Stem Cell Res
, vol.3
, pp. 142-156
-
-
Varum, S.1
Momcilovic, O.2
Castro, C.3
Ben-Yehudah, A.4
Ramalho-Santos, J.5
Navara, C.S.6
-
66
-
-
0037444772
-
Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxi-dative stress
-
Filosa S, Fico A, Paglialunga F, Balestrieri M, Crooke A, Verde P, Abrescia P, Bautista JM, Martini G. Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxi-dative stress. Biochem J. 2003;370:935–43.
-
(2003)
Biochem J
, vol.370
, pp. 935-943
-
-
Filosa, S.1
Fico, A.2
Paglialunga, F.3
Balestrieri, M.4
Crooke, A.5
Verde, P.6
Abrescia, P.7
Bautista, J.M.8
Martini, G.9
-
67
-
-
84855759349
-
Modulation of the pentose phosphate pathway induces en-dodermal differentiation in embryonic stem cells
-
Manganelli G, Fico A, Masullo U, Pizzolon-go F, Cimmino A, Filosa S. Modulation of the pentose phosphate pathway induces en-dodermal differentiation in embryonic stem cells. PLoS One. 2012;7:e29321.
-
(2012)
PLoS One
, vol.7
-
-
Manganelli, G.1
Fico, A.2
Masullo, U.3
Pizzolon-Go, F.4
Cimmino, A.5
Filosa, S.6
-
68
-
-
83455169174
-
Human pluripotent stem cells decouple respiration from energy production
-
Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. EMBO J. 2011;30:4851–2.
-
(2011)
EMBO J
, vol.30
, pp. 4851-4852
-
-
Shyh-Chang, N.1
Zheng, Y.2
Locasale, J.W.3
Cantley, L.C.4
-
69
-
-
77954822251
-
Mitochondrial reactive oxygen species mediate cardiomyocyte formation from embryonic stem cells in high glucose
-
Crespo FL, Sobrado VR, Gomez L, Cervera AM, McCreath KJ. Mitochondrial reactive oxygen species mediate cardiomyocyte formation from embryonic stem cells in high glucose. Stem Cells. 2010;28:1132–42.
-
(2010)
Stem Cells
, vol.28
, pp. 1132-1142
-
-
Crespo, F.L.1
Sobrado, V.R.2
Gomez, L.3
Cervera, A.M.4
McCreath, K.J.5
-
70
-
-
40949088547
-
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells
-
Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M. Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells. 2008;26:455–64.
-
(2008)
Stem Cells
, vol.26
, pp. 455-464
-
-
Saretzki, G.1
Walter, T.2
Atkinson, S.3
Passos, J.F.4
Bareth, B.5
Keith, W.N.6
Stewart, R.7
Hoare, S.8
Stojkovic, M.9
Armstrong, L.10
Von Zglinicki, T.11
Lako, M.12
-
71
-
-
79960945131
-
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear re-programming
-
Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP, Ikeda Y, Perez-Terzic C, Terzic A. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear re-programming. Cell Metab. 2011;14:264–71.
-
(2011)
Cell Metab
, vol.14
, pp. 264-271
-
-
Folmes, C.D.1
Nelson, T.J.2
Martinez-Fernandez, A.3
Arrell, D.K.4
Lindor, J.Z.5
Dzeja, P.P.6
Ikeda, Y.7
Perez-Terzic, C.8
Terzic, A.9
-
72
-
-
84855490988
-
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell re-programming
-
Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerias A, Batch-elder EM, Plongthongkum N, Lutz M, Berg-gren WT, Zhang K, Evans RM., Siuzdak G, Izpisua Belmonte JC. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell re-programming. Cell Res. 2012;22:168–77.
-
(2012)
Cell Res
, vol.22
, pp. 168-177
-
-
Panopoulos, A.D.1
Yanes, O.2
Ruiz, S.3
Kida, Y.S.4
Diep, D.5
Tautenhahn, R.6
Herrerias, A.7
Batch-Elder, E.M.8
Plongthongkum, N.9
Lutz, M.10
Berg-Gren, W.T.11
Zhang, K.12
Evans, R.M.13
Siuzdak, G.14
Izpisua Belmonte, J.C.15
-
73
-
-
69249210977
-
Hypoxia enhances the generation of induced pluripotent stem cells
-
Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell. 2009;5:237–41.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 237-241
-
-
Yoshida, Y.1
Takahashi, K.2
Okita, K.3
Ichisaka, T.4
Yamanaka, S.5
-
74
-
-
78649647814
-
Reprogramm-ing of human primary somatic cells by OCT4 and chemical compounds
-
Zhu S, Li W, Zhou H, Wei W, Ambasudhan R, Lin T, Kim J, Zhang K, Ding S. Reprogramm-ing of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 2010;7:651–5.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 651-655
-
-
Zhu, S.1
Li, W.2
Zhou, H.3
Wei, W.4
Ambasudhan, R.5
Lin, T.6
Kim, J.7
Zhang, K.8
Ding, S.9
-
75
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Go-vindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133:1106–17.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhang, W.9
Jiang, J.10
Loh, Y.H.11
Yeo, H.C.12
Yeo, Z.X.13
Narang, V.14
Go-Vindarajan, K.R.15
Leong, B.16
Shahab, A.17
Ruan, Y.18
Bourque, G.19
Sung, W.K.20
Clarke, N.D.21
Wei, C.L.22
Ng, H.H.23
more..
-
76
-
-
70349338871
-
Stem cells, stress, metabolism and cancer: A drama in two Octs
-
Kang J, Shakya A, Tantin D. Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends Biochem Sci. 2009;34:491–9.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 491-499
-
-
Kang, J.1
Shakya, A.2
Tantin, D.3
-
77
-
-
61849161672
-
Oct1 loss of function indu-ces a coordinate metabolic shift that opposes tumorigenicity
-
Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. Oct1 loss of function indu-ces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol. 2009;11:320–7.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 320-327
-
-
Shakya, A.1
Cooksey, R.2
Cox, J.E.3
Wang, V.4
McClain, D.A.5
Tantin, D.6
-
78
-
-
80053481600
-
The Lin28/let-7 axis regulates glucose metabolism
-
Zhu H, Shyh-Chang N, Segre AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011;147:81–94.
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
Shyh-Chang, N.2
Segre, A.V.3
Shinoda, G.4
Shah, S.P.5
Einhorn, W.S.6
Takeuchi, A.7
Engreitz, J.M.8
Hagan, J.P.9
Kharas, M.G.10
Urbach, A.11
Thornton, J.E.12
Triboulet, R.13
Gregory, R.I.14
Altshuler, D.15
Daley, G.Q.16
-
79
-
-
33644747418
-
HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
-
Covello KL, Kehler J, Yu H, Gordan JD, Ar-sham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006;20:557–70.
-
(2006)
Genes Dev
, vol.20
, pp. 557-570
-
-
Covello, K.L.1
Kehler, J.2
Yu, H.3
Gordan, J.D.4
Ar-Sham, A.M.5
Hu, C.J.6
Labosky, P.A.7
Simon, M.C.8
Keith, B.9
-
80
-
-
67749140110
-
Dependence of mouse embryonic stem cells on threonine ca-tabolism
-
Wang J, Alexander P, Wu L, Hammer R, Cleaver O, McKnight SL. Dependence of mouse embryonic stem cells on threonine ca-tabolism. Science. 2009;325:435–9.
-
(2009)
Science
, vol.325
, pp. 435-439
-
-
Wang, J.1
Alexander, P.2
Wu, L.3
Hammer, R.4
Cleaver, O.5
McKnight, S.L.6
-
81
-
-
77956205122
-
The distinct metabolic profle of hematopoietic stem cells refects their location in a hypoxic niche
-
Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. The distinct metabolic profle of hematopoietic stem cells refects their location in a hypoxic niche. Cell Stem Cell. 2010;7:380–90.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
Kocabas, F.2
Zheng, J.3
Deberardinis, R.J.4
Mahmoud, A.I.5
Olson, E.N.6
Schneider, J.W.7
Zhang, C.C.8
Sadek, H.A.9
-
82
-
-
80053916176
-
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
-
Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011;9:298-310.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 298-310
-
-
Suda, T.1
Takubo, K.2
Semenza, G.L.3
-
83
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegue E, DePinho RA, Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325-39.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
Armstrong, S.A.11
Passegue, E.12
Depinho, R.A.13
Gilliland, D.G.14
-
84
-
-
84872011926
-
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
-
Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12:49–61.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 49-61
-
-
Takubo, K.1
Nagamatsu, G.2
Kobayashi, C.I.3
Nakamura-Ishizu, A.4
Kobayashi, H.5
Ikeda, E.6
Goda, N.7
Rahimi, Y.8
Johnson, R.S.9
Soga, T.10
Hirao, A.11
Suematsu, M.12
Suda, T.13
-
85
-
-
84864805939
-
Proteomic cornerstones of hematopoietic stem cell differentiation: Distinct signatures of multipo-tent progenitors and myeloid committed cells
-
Klimmeck D, Hansson J, Raffel S, Vakhru-shev SY, Trumpp A, Krijgsveld J. Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipo-tent progenitors and myeloid committed cells. Mol Cell Proteomics. 2012;11:286–302.
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 286-302
-
-
Klimmeck, D.1
Hansson, J.2
Raffel, S.3
Vakhru-Shev, S.Y.4
Trumpp, A.5
Krijgsveld, J.6
-
86
-
-
49249086654
-
Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesen-chymal stem cells
-
Chen CT, Shih YR, Kuo TK, Lee OK, Wei YH. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesen-chymal stem cells. Stem Cells. 2008;26:960-8.
-
(2008)
Stem Cells
, vol.26
, pp. 960-968
-
-
Chen, C.T.1
Shih, Y.R.2
Kuo, T.K.3
Lee, O.K.4
Wei, Y.H.5
-
87
-
-
70350506802
-
FoxO3 regulates neural stem cell homeostasis
-
Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thek-kat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009;5:527–39.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 527-539
-
-
Renault, V.M.1
Rafalski, V.A.2
Morgan, A.A.3
Salih, D.A.4
Brett, J.O.5
Webb, A.E.6
Villeda, S.A.7
Thek-Kat, P.U.8
Guillerey, C.9
Denko, N.C.10
Palmer, T.D.11
Butte, A.J.12
Brunet, A.13
-
88
-
-
84866061103
-
Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH
-
Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012;2:568.
-
(2012)
Sci Rep
, vol.2
, pp. 568
-
-
Stringari, C.1
Edwards, R.A.2
Pate, K.T.3
Waterman, M.L.4
Donovan, P.J.5
Gratton, E.6
-
89
-
-
84878981053
-
TIGAR is required for effcient intestinal regeneration and tu-morigenesis
-
Cheung EC, Athineos D, Lee P, Ridgway RA, Lambie W, Nixon C, Strathdee D, Blyth K, Sansom OJ, Vousden KH. TIGAR is required for effcient intestinal regeneration and tu-morigenesis. Dev Cell. 2013;25:463–77.
-
(2013)
Dev Cell
, vol.25
, pp. 463-477
-
-
Cheung, E.C.1
Athineos, D.2
Lee, P.3
Ridgway, R.A.4
Lambie, W.5
Nixon, C.6
Strathdee, D.7
Blyth, K.8
Sansom, O.J.9
Vousden, K.H.10
-
90
-
-
0017718628
-
Primary bioassay of human myeloma stem cells
-
Hamburger A, Salmon SE. Primary bioassay of human myeloma stem cells. J Clin Invest. 1977;60:846–54.
-
(1977)
J Clin Invest
, vol.60
, pp. 846-854
-
-
Hamburger, A.1
Salmon, S.E.2
-
91
-
-
0017785769
-
Primary bio-assay of human tumor stem cells
-
Hamburger AW, Salmon SE. Primary bio-assay of human tumor stem cells. Science. 1977;197:461–3.
-
(1977)
Science
, vol.197
, pp. 461-463
-
-
Hamburger, A.W.1
Salmon, S.E.2
-
92
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–8.
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
93
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730–7.
-
(1997)
Nat Med
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
94
-
-
84858608410
-
Cancer stem cells: Impact, heterogeneity, and uncertainty
-
Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21:283–96.
-
(2012)
Cancer Cell
, vol.21
, pp. 283-296
-
-
Magee, J.A.1
Piskounova, E.2
Morrison, S.J.3
-
95
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 2008;40:499–507.
-
(2008)
Nat Genet
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
Thomson, M.W.2
Carey, V.J.3
Ge, R.4
Bell, G.W.5
Regev, A.6
Weinberg, R.A.7
-
96
-
-
84873406827
-
Tracing the cellular origin of cancer
-
Blanpain C. Tracing the cellular origin of cancer. Nat Cell Biol. 2013;15:126–34.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 126-134
-
-
Blanpain, C.1
-
97
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clev-ers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608-11.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
Van Es, J.H.3
Van De Wetering, M.4
Begthel, H.5
Van Den Born, M.6
Danenberg, E.7
Clarke, A.R.8
Sansom, O.J.9
Clev-Ers, H.10
-
98
-
-
59049087696
-
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
-
Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009;457:603–7.
-
(2009)
Nature
, vol.457
, pp. 603-607
-
-
Zhu, L.1
Gibson, P.2
Currle, D.S.3
Tong, Y.4
Richardson, R.J.5
Bayazitov, I.T.6
Poppleton, H.7
Zakharenko, S.8
Ellison, D.W.9
Gilbertson, R.J.10
-
99
-
-
79955681163
-
The intestinal stem cell signature identifes colorectal cancer stem cells and predicts disease relapse
-
Merlos-Suarez A, Barriga FM, Jung P, Igle-sias M, Cespedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Munoz P, Clevers H, Sancho E, Mangues R, Batlle E. The intestinal stem cell signature identifes colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 2011;8:511–24.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 511-524
-
-
Merlos-Suarez, A.1
Barriga, F.M.2
Jung, P.3
Igle-Sias, M.4
Cespedes, M.V.5
Rossell, D.6
Sevillano, M.7
Hernando-Momblona, X.8
Da Silva-Diz, V.9
Munoz, P.10
Clevers, H.11
Sancho, E.12
Mangues, R.13
Batlle, E.14
-
101
-
-
33747195353
-
Induction of plu-ripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors
-
Takahashi K, Yamanaka S. Induction of plu-ripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors. Cell. 2006;126:663–76.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
102
-
-
41449118521
-
Module map of stem cell genes guides creation of epithelial cancer stem cells
-
Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. 2008;2:333–44.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 333-344
-
-
Wong, D.J.1
Liu, H.2
Ridky, T.W.3
Cassarino, D.4
Segal, E.5
Chang, H.Y.6
-
103
-
-
84872600554
-
Intestinal tumori-genesis initiated by dedifferentiation and acquisition of stem-cell-like properties
-
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Ru-pec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. Intestinal tumori-genesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013;152:25–38.
-
(2013)
Cell
, vol.152
, pp. 25-38
-
-
Schwitalla, S.1
Fingerle, A.A.2
Cammareri, P.3
Nebelsiek, T.4
Goktuna, S.I.5
Ziegler, P.K.6
Canli, O.7
Heijmans, J.8
Huels, D.J.9
Moreaux, G.10
Ru-Pec, R.A.11
Gerhard, M.12
Schmid, R.13
Barker, N.14
Clevers, H.15
Lang, R.16
Neumann, J.17
Kirchner, T.18
Taketo, M.M.19
Van Den Brink, G.R.20
Sansom, O.J.21
Arkan, M.C.22
Greten, F.R.23
more..
-
104
-
-
84885834573
-
Reprogramming in vivo produces teratomas and iPS cells with totipo-tency features
-
Abad M, Mosteiro L, Pantoja C, Canam-ero M, Rayon T, Ors I, Grana O, Megias D, Dominguez O, Martinez D, Manzanares M, Ortega S, Serrano M. Reprogramming in vivo produces teratomas and iPS cells with totipo-tency features. Nature. 2013;502:340–5.
-
(2013)
Nature
, vol.502
, pp. 340-345
-
-
Abad, M.1
Mosteiro, L.2
Pantoja, C.3
Canam-Ero, M.4
Rayon, T.5
Ors, I.6
Grana, O.7
Megias, D.8
Dominguez, O.9
Martinez, D.10
Manzanares, M.11
Ortega, S.12
Serrano, M.13
-
105
-
-
84894109473
-
Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation
-
Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 2014;156:663-77.
-
(2014)
Cell
, vol.156
, pp. 663-677
-
-
Ohnishi, K.1
Semi, K.2
Yamamoto, T.3
Shimizu, M.4
Tanaka, A.5
Mitsunaga, K.6
Okita, K.7
Osafune, K.8
Arioka, Y.9
Maeda, T.10
Soejima, H.11
Moriwaki, H.12
Yamanaka, S.13
Woltjen, K.14
Yamada, Y.15
-
106
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009;69:7507–11.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
107
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;63:5821–8.
-
(2003)
Cancer Res
, vol.63
, pp. 5821-5828
-
-
Singh, S.K.1
Clarke, I.D.2
Terasaki, M.3
Bonn, V.E.4
Hawkins, C.5
Squire, J.6
Dirks, P.B.7
-
108
-
-
84866950193
-
Com-parison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
-
Morfouace M, Lalier L, Bahut M, Bonna-main V, Naveilhan P, Guette C, Oliver L, Gueguen N, Reynier P, Vallette FM. Com-parison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. J Biol Chem. 2012;287:33664–74.
-
(2012)
J Biol Chem
, vol.287
, pp. 33664-33674
-
-
Morfouace, M.1
Lalier, L.2
Bahut, M.3
Bonna-Main, V.4
Naveilhan, P.5
Guette, C.6
Oliver, L.7
Gueguen, N.8
Reynier, P.9
Vallette, F.M.10
-
109
-
-
77957016401
-
Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma
-
Pistollato F, Abbadi S, Rampazzo E, Viola G, Della Puppa A, Cavallini L, Frasson C, Per-sano L, Panchision DM, Basso G. Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma. Biochem Pharmacol. 2010;80:1517–27.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1517-1527
-
-
Pistollato, F.1
Abbadi, S.2
Rampazzo, E.3
Viola, G.4
Della Puppa, A.5
Cavallini, L.6
Frasson, C.7
Per-Sano, L.8
Panchision, D.M.9
Basso, G.10
-
110
-
-
80053166769
-
Metabolic state of glioma stem cells and nontumorigenic cells
-
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A. 2011;108:16062-7.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16062-16067
-
-
Vlashi, E.1
Lagadec, C.2
Vergnes, L.3
Matsutani, T.4
Masui, K.5
Poulou, M.6
Popescu, R.7
Della Donna, L.8
Evers, P.9
Dekmezian, C.10
Reue, K.11
Christofk, H.12
Mischel, P.S.13
Pajonk, F.14
-
111
-
-
80052722539
-
Metabolic alterations in highly tumorigen-ic glioblastoma cells: Preference for hypoxia and high dependency on glycolysis
-
Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, Ogasawara M, Keating MJ, Kondo S, Huang P. Metabolic alterations in highly tumorigen-ic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011;286:32843–53.
-
(2011)
J Biol Chem
, vol.286
, pp. 32843-32853
-
-
Zhou, Y.1
Zhou, Y.2
Shingu, T.3
Feng, L.4
Chen, Z.5
Ogasawara, M.6
Keating, M.J.7
Kondo, S.8
Huang, P.9
-
112
-
-
84865300414
-
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism
-
Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WAIII, Peters EC, Driggers EM, Hsieh-Wilson LC. Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science. 2012;337:975–80.
-
(2012)
Science
, vol.337
, pp. 975-980
-
-
Yi, W.1
Clark, P.M.2
Mason, D.E.3
Keenan, M.C.4
Hill, C.5
Goddard, W.A.6
Peters, E.C.7
Driggers, E.M.8
Hsieh-Wilson, L.C.9
-
113
-
-
77952995998
-
Metabolic modulation of glioblasto- ma with dichloroacetate
-
Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Ma-guire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, Petruk KC. Metabolic modulation of glioblasto- ma with dichloroacetate. Sci Transl Med. 2010;2:31-34.
-
(2010)
Sci Transl Med
, vol.2
, pp. 31-34
-
-
Michelakis, E.D.1
Sutendra, G.2
Dromparis, P.3
Webster, L.4
Haromy, A.5
Niven, E.6
Ma-Guire, C.7
Gammer, T.L.8
Mackey, J.R.9
Fulton, D.10
Abdulkarim, B.11
McMurtry, M.S.12
Petruk, K.C.13
-
114
-
-
84863721201
-
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
-
Goidts V, Bageritz J, Puccio L, Nakata S, Zapatka M, Barbus S, Toedt G, Campos B, Korshunov A, Momma S, Van Schaftingen E, Reifenberger G, Herold-Mende C, Lich-ter P, Radlwimmer B. RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival. Oncogene. 2012;31:3235–43.
-
(2012)
Oncogene
, vol.31
, pp. 3235-3243
-
-
Goidts, V.1
Bageritz, J.2
Puccio, L.3
Nakata, S.4
Zapatka, M.5
Barbus, S.6
Toedt, G.7
Campos, B.8
Korshunov, A.9
Momma, S.10
Van Schaftingen, E.11
Reifenberger, G.12
Herold-Mende, C.13
Lich-Ter, P.14
Radlwimmer, B.15
-
115
-
-
84876737635
-
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells
-
Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, Chen X, Yang G, Zhao L, Che H, Bi Y, Wang H, Peng F, Ai J. miR-143 inhibits glycolysis and depletes stemness of glioblastoma stemlike cells. Cancer Lett. 2013;333:253–60.
-
(2013)
Cancer Lett
, vol.333
, pp. 253-260
-
-
Zhao, S.1
Liu, H.2
Liu, Y.3
Wu, J.4
Wang, C.5
Hou, X.6
Chen, X.7
Yang, G.8
Zhao, L.9
Che, H.10
Bi, Y.11
Wang, H.12
Peng, F.13
Ai, J.14
-
116
-
-
84875143073
-
BCL-2 inhibition targets oxidative phosphor-ylation and selectively eradicates quiescent human leukemia stem cells
-
Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O’Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. BCL-2 inhibition targets oxidative phosphor-ylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 2013;12:329–41.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 329-341
-
-
Lagadinou, E.D.1
Sach, A.2
Callahan, K.3
Rossi, R.M.4
Neering, S.J.5
Minhajuddin, M.6
Ashton, J.M.7
Pei, S.8
Grose, V.9
O’dwyer, K.M.10
Liesveld, J.L.11
Brookes, P.S.12
Becker, M.W.13
Jordan, C.T.14
-
117
-
-
84866324123
-
Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
-
Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol. 2012;22:396–403.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 396-403
-
-
Scheel, C.1
Weinberg, R.A.2
-
118
-
-
84876434755
-
Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer
-
Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013;23:316–31.
-
(2013)
Cancer Cell
, vol.23
, pp. 316-331
-
-
Dong, C.1
Yuan, T.2
Wu, Y.3
Wang, Y.4
Fan, T.W.5
Miriyala, S.6
Lin, Y.7
Yao, J.8
Shi, J.9
Kang, T.10
Lorkiewicz, P.11
St Clair, D.12
Hung, M.C.13
Evers, B.M.14
Zhou, B.P.15
-
119
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
Hatzivassiliou G, Zhao F, Bauer DE, An-dreadis C, Shaw AN, Dhanak D, Hingorani SR, Tuveson DA, Thompson CB. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell. 2005;8:311–21.
-
(2005)
Cancer Cell
, vol.8
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
An-Dreadis, C.4
Shaw, A.N.5
Dhanak, D.6
Hingorani, S.R.7
Tuveson, D.A.8
Thompson, C.B.9
-
120
-
-
30544433533
-
ATP citrate lyase is an important component of cell growth and transformation
-
Bauer DE, Hatzivassiliou G, Zhao F, An-dreadis C, Thompson CB. ATP citrate lyase is an important component of cell growth and transformation. Oncogene. 2005;24:6314–22.
-
(2005)
Oncogene
, vol.24
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
An-Dreadis, C.4
Thompson, C.B.5
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