Metabolic alterations in highly tumorigenic glioblastoma cells: Preference for hypoxia and high dependency on glycolysis

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32843-32853

  Zhou, Yunfei ^a   Zhou, Yan ^a   Shingu, Takashi ^a   Feng, Li ^a   Chen, Zhao ^a   Ogasawara, Marcia ^a   Keating, Michael J ^a   Kondo, Seiji ^a   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; DISEASES; ELECTRON TRANSPORT PROPERTIES; MAMMALS; METABOLISM; MITOCHONDRIA; PATHOLOGY; STEM CELLS; TUMORS;

CHEMOTHERAPEUTIC AGENTS; ELECTRON TRANSPORT CHAIN; GLIOBLASTOMA CELLS; GLYCOLYTIC PATHWAYS; HYPOXIA-INDUCIBLE FACTORS; METABOLIC CHARACTERISTICS; MITOCHONDRIAL RESPIRATION; SUCCINATE DEHYDROGENASE;

CYTOLOGY;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CARMUSTINE; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR; PENTYL 3 BROMOPYRUVATE ESTER; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARCINOGENESIS; CARCINOGENICITY; CELL ACTIVITY; CELL FUNCTION; CELL ISOLATION; CELL KILLING; CELL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG RESISTANCE; DRUG SENSITIVITY; ELECTRON TRANSPORT; ENERGY METABOLISM; GLIOBLASTOMA; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; TUMOR XENOGRAFT;

MUS;

EID: 80052722539     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.260935     Document Type: Article

References (39)

1. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., and Clarke, M. F. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3983-3988
2. Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., and Dick, J. E. (1994) Nature 367, 645-648
3. Singh, S. K., Clarke, I. D., Terasaki, M., Bonn, V. E., Hawkins, C., Squire, J., and Dirks, P. B. (2003) Cancer Res. 63, 5821-5828
4. Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A. M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., and Sorrentino, B. P. (2001) Nat. Med. 7, 1028-1034
5. Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R., and Down, J. D. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 5431-5436
6. Guzman, M. L., Swiderski, C. F., Howard, D. S., Grimes, B. A., Rossi, R. M., Szilvassy, S. J., and Jordan, C. T. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 16220-16225
7. Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., and Rich, J. N. (2006) Nature 444, 756-760
8. Al-Hajj, M. (2007) Curr. Opin. Oncol. 19, 61-64
9. Jordan, C. T., Guzman, M. L., and Noble, M. (2006) N. Engl. J. Med. 355, 1253-1261
10. Pardal, R., Clarke, M. F., and Morrison, S. J. (2003) Nat. Rev. Cancer 3, 895-902
11. Spradling, A., Drummond-Barbosa, D., and Kai, T. (2001) Nature 414, 98-104
12. Cipolleschi, M. G., Dello Sbarba, P., and Olivotto, M. (1993) Blood 82, 2031-2037
13. Morrison, S. J., Csete, M., Groves, A. K., Melega, W., Wold, B., and Anderson, D. J. (2000) J. Neurosci. 20, 7370-7376
14. Ezashi, T., Das, P., and Roberts, R. M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 4783-4788
15. Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C. J., Labosky, P. A., Simon, M. C., and Keith, B. (2006) Genes Dev. 20, 557-570
16. Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., and Bondesson, M. (2005) Dev. Cell 9, 617-628
17. DeAngelis, L. M. (2001) N. Engl. J. Med. 344, 114-123
18. Jensen, R. L. (2009) J. Neurooncol. 92, 317-335
19. Hölzer, T., Herholz, K., Jeske, J., and Heiss, W. D. (1993) J. Comput. Assist. Tomogr. 17, 681-687
20. Warburg, O. (1956) Science 123, 309-314
21. Jiang, H., Gomez-Manzano, C., Aoki, H., Alonso, M. M., Kondo, S., Mc- Cormick, F., Xu, J., Kondo, Y., Bekele, B. N., Colman, H., Lang, F. F., and Fueyo, J. (2007) J. Natl. Cancer Inst. 99, 1410-1414
22. Xu, R. H., Pelicano, H., Zhou, Y., Carew, J. S., Feng, L., Bhalla, K. N., Keating, M. J., and Huang, P. (2005) Cancer Res. 65, 613-621
23. Hamburger, A. W., and Salmon, S. E. (1977) Science 197, 461-463
24. Moppett, I. K., and Hardman, J. G. (2007) Anesth. Analg. 105, 1094-1103
25. Reynolds, B. A., Tetzlaff, W., and Weiss, S. (1992) J. Neurosci. 12, 4565-4574
26. Slater, T. F., Sawyer, B., and Straeuli, U. (1963) Biochim. Biophys. Acta 77, 383-393
27. Gottlieb, E., and Tomlinson, I. P. (2005) Nat. Rev. Cancer 5, 857-866
28. Guzy, R. D., Sharma, B., Bell, E., Chandel, N. S., and Schumacker, P. T. (2008) Mol. Cell. Biol. 28, 718-731
29. Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., Lee, L. A., Semenza, G. L., and Dang, C. V. (2007) Cancer Cell 12, 230-238
30. Geschwind, J. F., Ko, Y. H., Torbenson, M. S., Magee, C., and Pedersen, P. L. (2002) Cancer Res. 62, 3909-3913
31. Parker, G. C., Acsadi, G., and Brenner, C. A. (2009) Stem Cells Dev. 18, 803-806
32. Prigione, A., Fauler, B., Lurz, R., Lehrach, H., and Adjaye, J. (2010) Stem Cells 28, 721-733
33. Keith, B., and Simon, M. C. (2007) Cell 129, 465-472
34. Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., and Gottlieb, E. (2005) Cancer Cell 7, 77-85
35. Dahia, P. L., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., Hodin, R., Heitritter, S., Moore, F., Dluhy, R., Sosa, J. A., Ocal, I. T., Benn, D. E., Marsh, D. J., Robinson, B. G., Schneider, K., Garber, J., Arum, S. M., Korbonits, M., Grossman, A., Pigny, P., Toledo, S. P., Nosé, V., Li, C., and Stiles, C. D. (2005) PLoS Genet. 1, 72-80
36. Calabrese, C., Poppleton, H., Kocak, M., Hogg, T. L., Fuller, C., Hamner, B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., Frank, A., Bayazitov, I. T., Zakharenko, S. S., Gajjar, A., Davidoff, A., and Gilbertson, R. J. (2007) Cancer Cell 11, 69-82
37. Zannettino, A. C., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J. M., and Gronthos, S. (2008) J. Cell. Physiol. 214, 413-421
38. Gage, F. H., Ray, J., and Fisher, L. J. (1995) Annu. Rev. Neurosci. 18, 159-192
39. Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., Park, J. K., and Fine, H. A. (2006) Cancer Cell 9, 391-403