Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress

Biochemical Journal

Volumn 370, Issue 3, 2003, Pages 935-943

  Filosa, Stefania ^a   Fico, Annalisa ^a   Paglialunga, Francesca ^a   Balestrieri, Marco ^b   Crooke, Almudena ^a,c   Verde, Pasquale ^a   Abrescia, Paolo ^a,b   Bautista, José M ^c   Martini, Giuseppe ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Apoptosis; Diamide; GSH; NADPH; Thiol

Indexed keywords

CARBOXYLIC ACIDS; CELLS; ENZYMES; GLUCOSE; OXIDATION; PHOSPHATES; STRESS ANALYSIS;

CELL REDOX POTENTIAL;

GENETIC ENGINEERING;

DIAMIDE; GENOMIC DNA; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PENTOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; IMMUNOBLOTTING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ANIMALS; CARBON DIOXIDE; CELL DEATH; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID CYCLE; DIAMIDE; EMBRYO; GENE DELETION; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; HUMANS; INTEGRASES; MALE; MICE; NADP; OXIDANTS; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; RNA; STEM CELLS; SULFHYDRYL REAGENTS; VIRAL PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037444772     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021614     Document Type: Article

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