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Volumn 15, Issue 2, 2013, Pages 126-134

Tracing the cellular origin of cancer

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BETA CATENIN; BRCA1 PROTEIN; MYC PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROBASIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN P53; RETINOBLASTOMA PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; WNT PROTEIN;

EID: 84873406827     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2657     Document Type: Review
Times cited : (223)

References (130)
  • 2
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves, M. & Maley, C. C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 3
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay, J. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127, 2893-2917 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • Stratton, M. R. Exploring the genomes of cancer cells: progress and promise. Science 331, 1553-1558 (2011).
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 6
    • 84862615790 scopus 로고    scopus 로고
    • Tracing epithelial stem cells during development, homeostasis, and repair
    • Van Keymeulen, A. & Blanpain, C. Tracing epithelial stem cells during development, homeostasis, and repair. J. Cell Biol. 197, 575-584 (2012).
    • (2012) J. Cell Biol. , vol.197 , pp. 575-584
    • Van Keymeulen, A.1    Blanpain, C.2
  • 7
    • 60749125436 scopus 로고    scopus 로고
    • Epidermal homeostasis: A balancing act of stem cells in the skin
    • Blanpain, C. & Fuchs, E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev. Mol. Cell Biol. 10, 207-217 (2009).
    • (2009) Nat Rev. Mol. Cell Biol. , vol.10 , pp. 207-217
    • Blanpain, C.1    Fuchs, E.2
  • 8
    • 0347634454 scopus 로고    scopus 로고
    • Defining the epithelial stem cell niche in skin
    • Tumbar, T. et al. Defining the epithelial stem cell niche in skin. Science 303, 359-363 (2004).
    • (2004) Science , vol.303 , pp. 359-363
    • Tumbar, T.1
  • 9
    • 1842529559 scopus 로고    scopus 로고
    • Capturing and profiling adult hair follicle stem cells
    • Morris, R. J. et al. Capturing and profiling adult hair follicle stem cells. Nat Biotechnol. 22, 411-417 (2004).
    • (2004) Nat Biotechnol. , vol.22 , pp. 411-417
    • Morris, R.J.1
  • 10
    • 28444472423 scopus 로고    scopus 로고
    • Distinct stem cell populations regenerate the follicle and interfollicular epidermis
    • Levy, V., Lindon, C., Harfe, B. D. & Morgan, B. A. Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev. Cell 9, 855-861 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 855-861
    • Levy, V.1    Lindon, C.2    Harfe, B.D.3    Morgan, B.A.4
  • 11
    • 77649258546 scopus 로고    scopus 로고
    • Identification of the cell lineage at the origin of basal cell carcinoma
    • Youssef, K. K. et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol. 12, 299-305 (2010).
    • (2010) Nat Cell Biol. , vol.12 , pp. 299-305
    • Youssef, K.K.1
  • 12
    • 55049112939 scopus 로고    scopus 로고
    • Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    • Jaks, V. et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 40, 1291-1299 (2008).
    • (2008) Nat Genet. , vol.40 , pp. 1291-1299
    • Jaks, V.1
  • 13
    • 77949360959 scopus 로고    scopus 로고
    • Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    • Snippert, H. J. et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385-1389 (2010).
    • (2010) Science , vol.327 , pp. 1385-1389
    • Snippert, H.J.1
  • 14
    • 77950407892 scopus 로고    scopus 로고
    • Stem cells: Skin regeneration and repair
    • Blanpain, C. Stem cells: Skin regeneration and repair. Nature 464, 686-687 (2010).
    • (2010) Nature , vol.464 , pp. 686-687
    • Blanpain, C.1
  • 15
    • 33947104197 scopus 로고    scopus 로고
    • A single type of progenitor cell maintains normal epidermis
    • Clayton, E. et al. A single type of progenitor cell maintains normal epidermis. Nature 446, 185-9 (2007).
    • (2007) Nature , vol.446 , pp. 185-189
    • Clayton, E.1
  • 16
    • 76249112830 scopus 로고    scopus 로고
    • The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate
    • Doupe, D. P., Klein, A. M., Simons, B. D. & Jones, P. H. The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev. Cell 18, 317-323 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 317-323
    • Doupe, D.P.1    Klein, A.M.2    Simons, B.D.3    Jones, P.H.4
  • 17
    • 84866147372 scopus 로고    scopus 로고
    • Distinct contribution of stem and progenitor cells to epidermal maintenance
    • Mascre, G. et al. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489, 257-262 (2012).
    • (2012) Nature , vol.489 , pp. 257-262
    • Mascre, G.1
  • 18
    • 28644451449 scopus 로고    scopus 로고
    • Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    • Ito, M. et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med. 11, 1351-1354 (2005).
    • (2005) Nat Med. , vol.11 , pp. 1351-1354
    • Ito, M.1
  • 19
    • 34247631592 scopus 로고    scopus 로고
    • Epidermal stem cells arise from the hair follicle after wounding
    • Levy, V., Lindon, C., Zheng, Y., Harfe, B. D. & Morgan, B. A. Epidermal stem cells arise from the hair follicle after wounding. FASEB J. 21, 1358-1366 (2007).
    • (2007) FASEB J. , vol.21 , pp. 1358-1366
    • Levy, V.1    Lindon, C.2    Zheng, Y.3    Harfe, B.D.4    Morgan, B.A.5
  • 20
    • 84863622334 scopus 로고    scopus 로고
    • Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair
    • Lu, C. P. et al. Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell 150, 136-150 (2012).
    • (2012) Cell , vol.150 , pp. 136-150
    • Lu, C.P.1
  • 21
    • 70449729939 scopus 로고    scopus 로고
    • Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
    • Van Keymeulen, A. et al. Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J. Cell Biol. 187, 91-100 (2009).
    • (2009) J. Cell Biol. , vol.187 , pp. 91-100
    • Van Keymeulen, A.1
  • 22
    • 70350622572 scopus 로고    scopus 로고
    • Mammalian Merkel cells are descended from the epidermal lineage
    • Morrison, K. M., Miesegaes, G. R., Lumpkin, E. A. & Maricich, S. M. Mammalian Merkel cells are descended from the epidermal lineage. Dev. Biol. 336, 76-83 (2009).
    • (2009) Dev. Biol. , vol.336 , pp. 76-83
    • Morrison, K.M.1    Miesegaes, G.R.2    Lumpkin, E.A.3    Maricich, S.M.4
  • 23
    • 0038819656 scopus 로고    scopus 로고
    • Contribution of stem cells and differentiated cells to epidermal tumours
    • Owens, D. M. & Watt, F. M. Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev. Cancer 3, 444-451 (2003).
    • (2003) Nat Rev. Cancer , vol.3 , pp. 444-451
    • Owens, D.M.1    Watt, F.M.2
  • 24
    • 0038819885 scopus 로고    scopus 로고
    • Stem-cell hierarchy in skin cancer
    • Perez-Losada, J. & Balmain, A. Stem-cell hierarchy in skin cancer. Nat Rev. Cancer 3, 434-443 (2003).
    • (2003) Nat Rev. Cancer , vol.3 , pp. 434-443
    • Perez-Losada, J.1    Balmain, A.2
  • 25
    • 84860322847 scopus 로고    scopus 로고
    • A systematic review of worldwide incidence of nonmelanoma skin cancer
    • Lomas, A., Leonardi-Bee, J. & Bath-Hextall, F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br. J. Dermatol. 166, 1069-1080 (2012).
    • (2012) Br. J. Dermatol. , vol.166 , pp. 1069-1080
    • Lomas, A.1    Leonardi-Bee, J.2    Bath-Hextall, F.3
  • 26
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: Attack of the hedgehog
    • Epstein, E. H. Basal cell carcinomas: attack of the hedgehog. Nat Rev. Cancer 8, 743-754 (2008).
    • (2008) Nat Rev. Cancer , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 27
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing sonic hedgehog
    • Oro, A. E. et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276, 817-821 (1997).
    • (1997) Science , vol.276 , pp. 817-821
    • Oro, A.E.1
  • 28
    • 0031913524 scopus 로고    scopus 로고
    • Activating Smoothened mutations in sporadic basal-cell carcinoma
    • Xie, J. et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391, 90-92 (1998).
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1
  • 29
    • 0034091805 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing Gli2 in skin
    • Grachtchouk, M. et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet. 24, 216-217 (2000).
    • (2000) Nat Genet. , vol.24 , pp. 216-217
    • Grachtchouk, M.1
  • 30
    • 0034724219 scopus 로고    scopus 로고
    • Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
    • Nilsson, M. et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc. Natl Acad. Sci. USA 97, 3438-3443 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 3438-3443
    • Nilsson, M.1
  • 31
    • 33750543972 scopus 로고    scopus 로고
    • A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
    • Mao, J. et al. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 66, 10171-10178 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 10171-10178
    • Mao, J.1
  • 32
    • 84870583964 scopus 로고    scopus 로고
    • Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    • Youseff, K. K. et al. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 14, 1282-1294 (2012).
    • (2012) Nat Cell Biol. , vol.14 , pp. 1282-1294
    • Youseff, K.K.1
  • 33
    • 33746128113 scopus 로고    scopus 로고
    • Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation
    • Mancuso, M. et al. Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation. Cancer Res. 66, 6606-6614 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6606-6614
    • Mancuso, M.1
  • 34
    • 33644509505 scopus 로고    scopus 로고
    • Patched1 functions as a gatekeeper by promoting cell cycle progression
    • Adolphe, C., Hetherington, R., Ellis, T. & Wainwright, B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66, 2081-2088 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 2081-2088
    • Adolphe, C.1    Hetherington, R.2    Ellis, T.3    Wainwright, B.4
  • 35
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in Ptch1(±) mice
    • Wang, G. Y., Wang, J., Mancianti, M. L. & Epstein, E. H., Jr. Basal cell carcinomas arise from hair follicle stem cells in Ptch1(±) mice. Cancer Cell 19, 114-124 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3    Epstein Jr., E.H.4
  • 36
    • 79956317899 scopus 로고    scopus 로고
    • Identifying the cellular origin of squamous skin tumors
    • Lapouge, G. et al. Identifying the cellular origin of squamous skin tumors. Proc. Natl Acad. Sci. USA 108, 7431-7436 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7431-7436
    • Lapouge, G.1
  • 37
    • 77953121698 scopus 로고    scopus 로고
    • Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    • Sotiropoulou, P. A. et al. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol. 12, 572-582 (2010).
    • (2010) Nat Cell Biol. , vol.12 , pp. 572-582
    • Sotiropoulou, P.A.1
  • 38
    • 79952741709 scopus 로고    scopus 로고
    • Wounding mobilizes hair follicle stem cells to form tumors
    • Wong, S. Y. & Reiter, J. F. Wounding mobilizes hair follicle stem cells to form tumors. Proc. Natl Acad. Sci. USA 108, 4093-4098 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4093-4098
    • Wong, S.Y.1    Reiter, J.F.2
  • 39
    • 79952745374 scopus 로고    scopus 로고
    • Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
    • Kasper, M. et al. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc. Natl Acad. Sci. USA 108, 4099-104 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4099-4104
    • Kasper, M.1
  • 40
    • 34249106502 scopus 로고    scopus 로고
    • Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    • Ito, M. et al. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447, 316-320 (2007).
    • (2007) Nature , vol.447 , pp. 316-320
    • Ito, M.1
  • 41
    • 79955508675 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
    • Grachtchouk, M. et al. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J. Clin. Invest. 121, 1768-1781 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1768-1781
    • Grachtchouk, M.1
  • 42
    • 0035967241 scopus 로고    scopus 로고
    • Cutaneous squamous-cell carcinoma
    • Alam, M. & Ratner, D. Cutaneous squamous-cell carcinoma. N. Engl. J. Med. 344, 975-983 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 975-983
    • Alam, M.1    Ratner, D.2
  • 43
    • 24944535307 scopus 로고    scopus 로고
    • Multistep skin cancer in mice as a model to study the evolution of cancer cells
    • Kemp, C. J. Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin. Cancer Biol. 15, 460-473 (2005).
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 460-473
    • Kemp, C.J.1
  • 44
    • 70249123827 scopus 로고    scopus 로고
    • Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications
    • Abel, E. L., Angel, J. M., Kiguchi, K. & DiGiovanni, J. Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat Protoc. 4, 1350-1362 (2009).
    • (2009) Nat Protoc. , vol.4 , pp. 1350-1362
    • Abel, E.L.1    Angel, J.M.2    Kiguchi, K.3    Digiovanni, J.4
  • 45
    • 0022527161 scopus 로고
    • Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
    • Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322, 78-80 (1986).
    • (1986) Nature , vol.322 , pp. 78-80
    • Quintanilla, M.1    Brown, K.2    Ramsden, M.3    Balmain, A.4
  • 46
    • 0029073913 scopus 로고
    • Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas
    • Spencer, J. M., Kahn, S. M., Jiang, W., DeLeo, V. A. & Weinstein, I. B. Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas. Arch. Dermatol. 131, 796-800 (1995).
    • (1995) Arch. Dermatol. , vol.131 , pp. 796-800
    • Spencer, J.M.1    Kahn, S.M.2    Jiang, W.3    Deleo, V.A.4    Weinstein, I.B.5
  • 47
    • 0025374041 scopus 로고
    • Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin
    • van der Schroeff, J. G., Evers, L. M., Boot, A. J. & Bos, J. L. Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. J. Invest. Dermatol. 94, 423-5 (1990).
    • (1990) J. Invest. Dermatol. , vol.94 , pp. 423-425
    • Van Der Schroeff, J.G.1    Evers, L.M.2    Boot, A.J.3    Bos, J.L.4
  • 48
    • 0027225781 scopus 로고
    • Ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation-induced epidermal neoplasias of mouse skin
    • Sutter, C. et al. Ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation-induced epidermal neoplasias of mouse skin. Mol. Carcinogen. 8, 13-9 (1993).
    • (1993) Mol. Carcinogen. , vol.8 , pp. 13-19
    • Sutter, C.1
  • 49
    • 0022537060 scopus 로고
    • Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen
    • Morris, R. J., Fischer, S. M. & Slaga, T. J. Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen. Cancer Res. 46, 3061-3066 (1986).
    • (1986) Cancer Res. , vol.46 , pp. 3061-3066
    • Morris, R.J.1    Fischer, S.M.2    Slaga, T.J.3
  • 50
    • 0030816210 scopus 로고    scopus 로고
    • Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling
    • Morris, R. J., Coulter, K., Tryson, K. & Steinberg, S. R. Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling. Cancer Res. 57, 3436-3443 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 3436-3443
    • Morris, R.J.1    Coulter, K.2    Tryson, K.3    Steinberg, S.R.4
  • 51
    • 0033933043 scopus 로고    scopus 로고
    • Keratinocyte stem cells: Targets for cutaneous carcinogens
    • Morris, R. J. Keratinocyte stem cells: targets for cutaneous carcinogens. J. Clin. Invest. 106, 3-8 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 3-8
    • Morris, R.J.1
  • 52
    • 0019787422 scopus 로고
    • Promotion of carcinomas by repeated abrasion in initiated skin of mice
    • Argyris, T. S. & Slaga, T. J. Promotion of carcinomas by repeated abrasion in initiated skin of mice. Cancer Res. 41, 5193-5195 (1981).
    • (1981) Cancer Res. , vol.41 , pp. 5193-5195
    • Argyris, T.S.1    Slaga, T.J.2
  • 53
    • 0141502120 scopus 로고    scopus 로고
    • Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling
    • Owens, D. M., Romero, M. R., Gardner, C. & Watt, F. M. Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling. J. Cell Sci. 116, 3783-3791 (2003).
    • (2003) J. Cell Sci. , vol.116 , pp. 3783-3791
    • Owens, D.M.1    Romero, M.R.2    Gardner, C.3    Watt, F.M.4
  • 54
    • 4143073758 scopus 로고    scopus 로고
    • Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions
    • Hobbs, R. M., Silva-Vargas, V., Groves, R. & Watt, F. M. Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J. Invest. Dermatol. 123, 503-515 (2004).
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 503-515
    • Hobbs, R.M.1    Silva-Vargas, V.2    Groves, R.3    Watt, F.M.4
  • 55
    • 78650573907 scopus 로고    scopus 로고
    • Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate
    • Arwert, E. N. et al. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc. Natl Acad. Sci. USA 107, 19903-19908 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 19903-19908
    • Arwert, E.N.1
  • 56
    • 0025041030 scopus 로고
    • Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter
    • Bailleul, B. et al. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell 62, 697-708 (1990).
    • (1990) Cell , vol.62 , pp. 697-708
    • Bailleul, B.1
  • 57
    • 0032559976 scopus 로고    scopus 로고
    • The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
    • Brown, K., Strathdee, D., Bryson, S., Lambie, W. & Balmain, A. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr. Biol. 8, 516-524 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 516-524
    • Brown, K.1    Strathdee, D.2    Bryson, S.3    Lambie, W.4    Balmain, A.5
  • 58
    • 11144356354 scopus 로고    scopus 로고
    • Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
    • Tuveson, D. A. et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5, 375-387 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 375-387
    • Tuveson, D.A.1
  • 59
    • 79956317166 scopus 로고    scopus 로고
    • Defining the origins of Ras/p53-mediated squamous cell carcinoma
    • White, A. C. et al. Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc. Natl Acad. Sci. USA 108, 7425-7430 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7425-7430
    • White, A.C.1
  • 60
    • 84884817124 scopus 로고    scopus 로고
    • A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse
    • Li, S. et al. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse. Mol. Carcinogen. http://dx.doi.org/10.1002/mc.21896 (2012).
    • (2012) Mol. Carcinogen
    • Li, S.1
  • 61
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp, C. J., Donehower, L. A., Bradley, A. & Balmain, A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822 (1993).
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 62
    • 34447130136 scopus 로고    scopus 로고
    • An inducible mouse model for skin cancer reveals distinct roles for gain-and loss-of-function p53 mutations
    • Caulin, C. et al. An inducible mouse model for skin cancer reveals distinct roles for gain-and loss-of-function p53 mutations. J. Clin. Invest. 117, 1893-1901 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1893-1901
    • Caulin, C.1
  • 63
    • 84860821444 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: The current consensus
    • Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123, 465-472 (2012).
    • (2012) Acta Neuropathol. , vol.123 , pp. 465-472
    • Taylor, M.D.1
  • 64
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang, Z. J. et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14, 135-45 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1
  • 65
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • Schuller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123-134 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1
  • 66
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • Gibson, P. et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 468, 1095-1099 (2010).
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1
  • 67
    • 84857013044 scopus 로고    scopus 로고
    • A mouse model of the most aggressive subgroup of human medulloblastoma
    • Kawauchi, D. et al. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21, 168-180 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 168-180
    • Kawauchi, D.1
  • 68
    • 84863012675 scopus 로고    scopus 로고
    • An animal model of MYC-driven medulloblastoma
    • Pei, Y. et al. An animal model of MYC-driven medulloblastoma. Cancer Cell 21, 155-167 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 155-167
    • Pei, Y.1
  • 69
    • 84861399134 scopus 로고    scopus 로고
    • Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    • Swartling, F. J. et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 21, 601-613 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 601-613
    • Swartling, F.J.1
  • 70
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488, 100-105 (2012).
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1
  • 71
    • 84864444165 scopus 로고    scopus 로고
    • Novel mutations target distinct subgroups of medulloblastoma
    • Robinson, G. et al. Novel mutations target distinct subgroups of medulloblastoma. Nature 488, 43-48 (2012).
    • (2012) Nature , vol.488 , pp. 43-48
    • Robinson, G.1
  • 72
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012).
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1
  • 73
    • 34250887474 scopus 로고    scopus 로고
    • Taking gene-expression profiling to the clinic: When will molecular signatures become relevant to patient care? Nat Rev
    • Sotiriou, C. & Piccart, M. J. Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Nat Rev. Cancer 7, 545-553 (2007).
    • (2007) Cancer , vol.7 , pp. 545-553
    • Sotiriou, C.1    Piccart, M.J.2
  • 74
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader, J. E. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 23, 2563-2577 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 75
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl, J. et al. Purification and unique properties of mammary epithelial stem cells. Nature 439, 993-997 (2006).
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1
  • 76
    • 30144433093 scopus 로고    scopus 로고
    • Generation of a functional mammary gland from a single stem cell
    • Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
    • (2006) Nature , vol.439 , pp. 84-88
    • Shackleton, M.1
  • 77
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen, A. et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479, 189-93 (2011).
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1
  • 78
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/beta-catenin- responsive stem cells in the mammary gland
    • Van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • Van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 79
    • 84867575877 scopus 로고    scopus 로고
    • Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland
    • De Visser, K. E. et al. Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland. J. Pathol. 228, 300-309 (2012).
    • (2012) J. Pathol. , vol.228 , pp. 300-309
    • De Visser, K.E.1
  • 80
    • 20144387584 scopus 로고    scopus 로고
    • Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers
    • Palacios, J. et al. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast Cancer Res. Treat 90, 5-14 (2005).
    • (2005) Breast Cancer Res. Treat , vol.90 , pp. 5-14
    • Palacios, J.1
  • 81
    • 34547496282 scopus 로고    scopus 로고
    • Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
    • Liu, X. et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc. Natl Acad. Sci. USA 104, 12111-12116 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12111-12116
    • Liu, X.1
  • 82
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux, G. et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7, 403-417 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 403-417
    • Molyneux, G.1
  • 83
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim, E. et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 15, 907-913 (2009).
    • (2009) Nat Med. , vol.15 , pp. 907-913
    • Lim, E.1
  • 84
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia, T. A. et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 8, 149-163 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 149-163
    • Proia, T.A.1
  • 85
    • 77956793432 scopus 로고    scopus 로고
    • Molecular genetics of prostate cancer: New prospects for old challenges
    • Shen, M. M. & Abate-Shen, C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 24, 1967-2000 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1967-2000
    • Shen, M.M.1    Abate-Shen, C.2
  • 86
    • 18844424692 scopus 로고    scopus 로고
    • Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue
    • Burger, P. E. et al. Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc. Natl Acad. Sci. USA 102, 7180-7185 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 7180-7185
    • Burger, P.E.1
  • 87
    • 77955121375 scopus 로고    scopus 로고
    • Identification of a cell of origin for human prostate cancer
    • Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P. & Witte, O. N. Identification of a cell of origin for human prostate cancer. Science 329, 568-571 (2010).
    • (2010) Science , vol.329 , pp. 568-571
    • Goldstein, A.S.1    Huang, J.2    Guo, C.3    Garraway, I.P.4    Witte, O.N.5
  • 88
  • 89
    • 57649140583 scopus 로고    scopus 로고
    • Generation of a prostate from a single adult stem cell
    • Leong, K. G., Wang, B. E., Johnson, L. & Gao, W. Q. Generation of a prostate from a single adult stem cell. Nature 456, 804-808 (2008).
    • (2008) Nature , vol.456 , pp. 804-808
    • Leong, K.G.1    Wang, B.E.2    Johnson, L.3    Gao, W.Q.4
  • 90
    • 18744377702 scopus 로고    scopus 로고
    • The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
    • Xin, L., Lawson, D. A. & Witte, O. N. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc. Natl Acad. Sci. USA 102, 6942-6247 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 6942-6247
    • Xin, L.1    Lawson, D.A.2    Witte, O.N.3
  • 91
    • 36249006969 scopus 로고    scopus 로고
    • Self-renewal and multilineage differentiation in vitro from murine prostate stem cells
    • Xin, L., Lukacs, R. U., Lawson, D. A., Cheng, D. & Witte, O. N. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells 25, 2760-2769 (2007).
    • (2007) Stem Cells , vol.25 , pp. 2760-2769
    • Xin, L.1    Lukacs, R.U.2    Lawson, D.A.3    Cheng, D.4    Witte, O.N.5
  • 92
    • 79953153425 scopus 로고    scopus 로고
    • ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency
    • Zhang, L. et al. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS ONE 6, e18271 (2011).
    • (2011) PLoS ONE , vol.6
    • Zhang, L.1
  • 93
    • 70349438989 scopus 로고    scopus 로고
    • A luminal epithelial stem cell that is a cell of origin for prostate cancer
    • Wang, X. et al. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461, 495-500 (2009).
    • (2009) Nature , vol.461 , pp. 495-500
    • Wang, X.1
  • 94
    • 80054987127 scopus 로고    scopus 로고
    • Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate
    • Liu, J. et al. Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. Mol. Endocrinol. 25, 1849-1857 (2011).
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1849-1857
    • Liu, J.1
  • 95
    • 84863078902 scopus 로고    scopus 로고
    • Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation
    • Choi, N., Zhang, B., Zhang, L., Ittmann, M. & Xin, L. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell 21, 253-265 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 253-265
    • Choi, N.1    Zhang, B.2    Zhang, L.3    Ittmann, M.4    Xin, L.5
  • 96
    • 72249113369 scopus 로고    scopus 로고
    • Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model
    • Mulholland, D. J. et al. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 69, 8555-8562 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8555-8562
    • Mulholland, D.J.1
  • 97
    • 77249178726 scopus 로고    scopus 로고
    • Basal epithelial stem cells are efficient targets for prostate cancer initiation
    • Lawson, D. A. et al. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc. Natl Acad. Sci. USA 107, 2610-2615 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2610-2615
    • Lawson, D.A.1
  • 98
    • 40649121309 scopus 로고    scopus 로고
    • Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
    • Ratnacaram, C. K. et al. Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc. Natl Acad. Sci. USA 105, 2521-2526 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2521-2526
    • Ratnacaram, C.K.1
  • 99
    • 4243110417 scopus 로고    scopus 로고
    • Pten dose dictates cancer progression in the prostate
    • Trotman, L. C. et al. Pten dose dictates cancer progression in the prostate. PLoS Biol 1, E59 (2003).
    • (2003) PLoS Biol , vol.1
    • Trotman, L.C.1
  • 100
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang, S. et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4, 209-221 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1
  • 101
    • 78649639492 scopus 로고    scopus 로고
    • Tissue-resident adult stem cell populations of rapidly self-renewing organs
    • Barker, N., Bartfeld, S. & Clevers, H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 7, 656-670 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 656-670
    • Barker, N.1    Bartfeld, S.2    Clevers, H.3
  • 102
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 103
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi, E. & Capecchi, M. R. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 40, 915-920 (2008).
    • (2008) Nat Genet. , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 104
    • 78651067425 scopus 로고    scopus 로고
    • Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
    • Montgomery, R. K. et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc. Natl Acad. Sci. USA 108, 179-184 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 179-184
    • Montgomery, R.K.1
  • 105
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • Takeda, N. et al. Interconversion between intestinal stem cell populations in distinct niches. Science 334, 1420-1424 (2011).
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1
  • 106
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian, H. et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478, 255-259 (2011).
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1
  • 107
    • 84864131103 scopus 로고    scopus 로고
    • The Lgr5 intestinal stem cell signature: Robust expression of proposed quiescent '+4' cell markers
    • Munoz, J. et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J. 31, 3079-3091 (2012).
    • (2012) EMBO J. , vol.31 , pp. 3079-3091
    • Munoz, J.1
  • 108
    • 84355162740 scopus 로고    scopus 로고
    • Single-molecule transcript counting of stem-cell markers in the mouse intestine
    • Itzkovitz, S. et al. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol. 14, 106-114 (2012).
    • (2012) Nat Cell Biol. , vol.14 , pp. 106-114
    • Itzkovitz, S.1
  • 109
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 110
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin, P. J. et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275, 1787-1790 (1997).
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1
  • 111
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma
    • Korinek, V. et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science 275, 1784-1787 (1997).
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1
  • 112
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 113
    • 59049087696 scopus 로고    scopus 로고
    • Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    • Zhu, L. et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457, 603-607 (2009).
    • (2009) Nature , vol.457 , pp. 603-607
    • Zhu, L.1
  • 114
    • 80054030182 scopus 로고    scopus 로고
    • Epithelial progenitor cells in lung development, maintenance, repair, and disease
    • Rock, J. R. & Hogan, B. L. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu. Rev. Cell Dev. Biol. 27, 493-512 (2011).
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 493-512
    • Rock, J.R.1    Hogan, B.L.2
  • 115
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • Rock, J. R. et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc. Natl Acad. Sci. USA 106, 12771-12775 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12771-12775
    • Rock, J.R.1
  • 116
    • 66049083441 scopus 로고    scopus 로고
    • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    • Rawlins, E. L. et al. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 4, 525-534 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 525-534
    • Rawlins, E.L.1
  • 117
    • 80455123686 scopus 로고    scopus 로고
    • Pathology of lung cancer
    • Travis, W. D. Pathology of lung cancer. Clin. Chest Med. 32, 669-692 (2011).
    • (2011) Clin. Chest Med. , vol.32 , pp. 669-692
    • Travis, W.D.1
  • 118
    • 0037330728 scopus 로고    scopus 로고
    • The P16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung
    • Beasley, M. B. et al. The P16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum. Pathol. 34, 136-142 (2003).
    • (2003) Hum. Pathol. , vol.34 , pp. 136-142
    • Beasley, M.B.1
  • 119
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen, R. et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 4, 181-189 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1
  • 120
    • 79958761641 scopus 로고    scopus 로고
    • Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung
    • Sutherland, K. D. et al. Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19, 754-764 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 754-764
    • Sutherland, K.D.1
  • 121
    • 80051725013 scopus 로고    scopus 로고
    • Characterization of the cell of origin for small cell lung cancer
    • Park, K. S. et al. Characterization of the cell of origin for small cell lung cancer. Cell Cycle 10, 2806-2815 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 2806-2815
    • Park, K.S.1
  • 122
  • 123
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3243-3248
    • Jackson, E.L.1
  • 124
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim, C. F. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823-835 (2005).
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1
  • 125
    • 33645518095 scopus 로고    scopus 로고
    • K-ras activation generates an inflammatory response in lung tumors
    • Ji, H. et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene 25, 2105-2112 (2006).
    • (2006) Oncogene , vol.25 , pp. 2105-2112
    • Ji, H.1
  • 126
    • 0033615034 scopus 로고    scopus 로고
    • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms
    • Sunday, M. E. et al. Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. Oncogene 18, 4336-47 (1999).
    • (1999) Oncogene , vol.18 , pp. 4336-4347
    • Sunday, M.E.1
  • 127
    • 84859476198 scopus 로고    scopus 로고
    • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma
    • Xu, X. et al. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc. Natl Acad. Sci. US.A 109, 4910-4915 (2012).
    • (2012) Proc. Natl Acad. Sci. US.A , vol.109 , pp. 4910-4915
    • Xu, X.1
  • 128
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • Driessens, G., Beck, B., Caauwe, A., Simons, B. D. & Blanpain, C. Defining the mode of tumour growth by clonal analysis. Nature 488, 527-530 (2012).
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3    Simons, B.D.4    Blanpain, C.5
  • 129
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • Schepers, A. G. et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337, 730-735 (2012).
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1
  • 130
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J. et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522-526 (2012).
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1


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