Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation

Cell

Volumn 156, Issue 4, 2014, Pages 663-677

  Ohnishi, Kotaro ^a,b   Semi, Katsunori ^a,c   Yamamoto, Takuya ^a,c   Shimizu, Masahito ^b   Tanaka, Akito ^a   Mitsunaga, Kanae ^a   Okita, Keisuke ^a   Osafune, Kenji ^a   Arioka, Yuko ^a   Maeda, Toshiyuki ^d   Soejima, Hidenobu ^d   Moriwaki, Hisataka ^b   Yamanaka, Shinya ^a,c,e   Woltjen, Knut ^a,f   Yamada, Yasuhiro ^a,c,g  

^a KYOTO UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d SAGA UNIVERSITY   (Japan)

^e GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^f KYOTO UNIVERSITY   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; ALKALINE PHOSPHATASE; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 3; SOMATOMEDIN B; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENETICS; CARCINOGENESIS; CONTROLLED STUDY; DISEASE COURSE; DNA METHYLATION; GENETIC REGULATION; GENETIC TRANSFORMATION; KIDNEY CELL; MOUSE; NEOPLASM; NEPHROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; SOMATIC CELL; TRANSIENT EXPRESSION; ANIMAL TISSUE; BLASTOCYST; CANCER CELL; CANCER GROWTH; CELL FATE; EMBRYONIC STEM CELL; EPIGENETICS; GALLBLADDER; GENE EXPRESSION; GLOBAL CHANGE; INTESTINE; KIDNEY; KIDNEY CANCER; KIDNEY TUMOR; MICROARRAY ANALYSIS; PANCREAS; PLURIPOTENT STEM CELL; SKIN; STOMACH;

ANIMALS; DNA METHYLATION; DOXYCYCLINE; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; INDUCED PLURIPOTENT STEM CELLS; KIDNEY NEOPLASMS; MICE; MICE, TRANSGENIC; NUCLEAR REPROGRAMMING; TRANSCRIPTION FACTORS;

EID: 84894109473     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.01.005     Document Type: Article

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