Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: Challenges and perspectives

OncoTargets and Therapy

Volumn 7, Issue , 2014, Pages 1689-1704

  Cheng, Xinghua ^a   Chen, Haiquan ^a  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Drug resistance; EGFR; NSCLC; TKIs; Tumor heterogeneity

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; AZD 9291; BEVACIZUMAB; CANERTINIB; CARBOPLATIN; CISPLATIN; CRIZOTINIB; DACOMITINIB; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GANETESPIB; GEFITINIB; GEMCITABINE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYL 1 PIPERAZINYL)PHENYL]AMINO] 4 PYRIMIDINYL]OXY]PHENYL]ACRYLAMIDE; NERATINIB; PACLITAXEL; PEMETREXED; PLACEBO; PLATINUM COMPLEX; ROCILETINIB; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER STEM CELL; CANCER SURGERY; CELL HETEROGENEITY; CHROMOSOMAL INSTABILITY; CIRCULATING TUMOR CELL; CLONAL EVOLUTION; DIARRHEA; DNA METHYLATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG RESISTANCE; DRUG SAFETY; DRUG SENSITIVITY; DYSPHAGIA; EPIGENETICS; GASTROINTESTINAL DISEASE; GENE FUSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; MOUTH PAIN; NON SMALL CELL LUNG CANCER; NONHUMAN; PHENOTYPE; PROTEOMICS; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; UNSPECIFIED SIDE EFFECT;

EID: 84908152108     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S66502     Document Type: Article

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