Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 20, 2006, Pages 7817-7822

  Ji, Hongbin ^a   Zhao, Xiaojun ^a   Yuza, Yuki ^a   Shimamura, Takeshi ^a   Li, Danan ^a   Protopopov, Alexei ^a   Jung, Boonim L ^a   McNamara, Kate ^a   Xia, Huili ^a   Glatt, Karen A ^a   Thomas, Roman K ^a,d   Sasaki, Hidefumi ^c   Horner, James W ^a   Eck, Michael ^a   Mitchell, Albert ^b   Sun, Yangping ^b   Al Hashem, Ruqayyah ^b   Bronson, Roderick T ^d   Rabindran, Sridhar K ^e   Discafani, Carolyn M ^e   Maher, Elizabeth ^a,b   Shapiro, Geoffrey I ^a,b   Meyerson, Matthew ^a,d,f   Wong, Kwok Kin ^a,b,f   more..

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

^e WYETH RESEARCH   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Irreversible inhibitor; Lung cancer; Lung squamous cell carcinoma

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERLOTINIB; GEFITINIB; PROTEIN TYROSINE KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL TRANSFORMATION; ENZYME INHIBITION; GENE DELETION; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG TUMOR; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC MUTATION; SQUAMOUS CELL CARCINOMA; TISSUE SPECIFICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MUTATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; QUINAZOLINES; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR SUPPRESSOR PROTEIN P14ARF;

MURINAE;

EID: 33646716077     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510284103     Document Type: Article

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