Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 21, 2005, Pages 7665-7670

  Kwak, Eunice L ^a   Sordella, Raffaella ^a   Bell, Daphne W ^a   Godin Heymann, Nadia ^a   Okimoto, Ross A ^a   Brannigan, Brian W ^a   Harris, Patricia L ^a   Driscoll, David R ^a   Fidias, Panos ^a   Lynch, Thomas J ^a   Rabindran, Sridhar K ^b   McGinnis, John P ^b   Wissner, Allan ^b   Sharma, Sreenath V ^a   Isselbacher, Kurt J ^a   Settleman, Jeffrey ^a   Haber, Daniel A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

Drug resistance; Molecular targeted therapy; Non small cell lung cancer; Tyrosine kinase inhibitor

Indexed keywords

ANILINOQUINAZOLINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; HKI 272; HKI 357; MUTANT PROTEIN; PELITINIB; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER RECURRENCE; CELL VIABILITY; CLONING; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESISTANCE; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; LUNG NON SMALL CELL CANCER; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR CELL;

BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; DRUG RESISTANCE; HUMANS; IMMUNOBLOTTING; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM RECURRENCE, LOCAL; ORGANIC CHEMICALS; PHOSPHORYLATION; QUINAZOLINES; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 21144439000     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502860102     Document Type: Article

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