메뉴 건너뛰기




Volumn 12, Issue 6, 2013, Pages 890-900

The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LUMINESPIB;

EID: 84878971471     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0998     Document Type: Article
Times cited : (59)

References (49)
  • 1
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005;5:761-72.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 2
    • 45849105629 scopus 로고    scopus 로고
    • Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target
    • Gallegos Ruiz MI, Floor K, Roepman P, Rodriguez JA, Meijer GA, Mooi WJ, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS One 2008;3:e0001722.
    • (2008) PLoS One , vol.3
    • Gallegos Ruiz, M.I.1    Floor, K.2    Roepman, P.3    Rodriguez, J.A.4    Meijer, G.A.5    Mooi, W.J.6
  • 3
    • 0038404927 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
    • Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 2003;63:2139-44.
    • (2003) Cancer Res , vol.63 , pp. 2139-2144
    • Solit, D.B.1    Basso, A.D.2    Olshen, A.B.3    Scher, H.I.4    Rosen, N.5
  • 4
    • 61449261930 scopus 로고    scopus 로고
    • Death by chaperone: Hsp90, HSP70 or both?
    • Powers MV, Clarke PA, Workman P. Death by chaperone: HSP90, HSP70 or both? Cell Cycle 2009;8:518-26.
    • (2009) Cell Cycle , vol.8 , pp. 518-526
    • Powers, M.V.1    Clarke, P.A.2    Workman, P.3
  • 5
    • 50349093362 scopus 로고    scopus 로고
    • A phase I study of 17-allylamino-17-demethox-ygeldanamycin combined with paclitaxel in patients with advanced solid malignancies
    • Ramalingam SS, Egorin MJ, Ramanathan RK, Remick SC, Sikorski RP, Lagattuta TF, et al. A phase I study of 17-allylamino-17-demethox-ygeldanamycin combined with paclitaxel in patients with advanced solid malignancies. Clin Cancer Res 2008;14:3456-61.
    • (2008) Clin Cancer Res , vol.14 , pp. 3456-3461
    • Ramalingam, S.S.1    Egorin, M.J.2    Ramanathan, R.K.3    Remick, S.C.4    Sikorski, R.P.5    Lagattuta, T.F.6
  • 6
    • 58149340657 scopus 로고    scopus 로고
    • Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma
    • Solit DB, Osman I, Polsky D, Panageas KS, Daud A, Goydos JS, et al. Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma. Clin Cancer Res 2008;14:8302-7.
    • (2008) Clin Cancer Res , vol.14 , pp. 8302-8307
    • Solit, D.B.1    Osman, I.2    Polsky, D.3    Panageas, K.S.4    Daud, A.5    Goydos, J.S.6
  • 7
    • 51449118446 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKI) or other sarcomas: Clinical results from a phase I trial
    • Abs 10503
    • Wagner AJ MJ, Chugh R, et al. Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKI) or other sarcomas: clinical results from a phase I trial. J Clin Oncol 2008;26:Abs 10503.
    • (2008) J Clin Oncol , vol.26
    • Wagner, A.J.M.J.1    Chugh, R.2
  • 8
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpres-sing breast cancer: A phase I dose-escalation study
    • Modi S, Stopeck AT, Gordon MS, Mendelson D, Solit DB, Bagatell R, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpres-sing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007;25:5410-7.
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3    Mendelson, D.4    Solit, D.B.5    Bagatell, R.6
  • 9
    • 23044441106 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-allyla-mino, 17-demethoxygeldanamycin in patients with advanced malignancies
    • Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allyla-mino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005;23:4152-61.
    • (2005) J Clin Oncol , vol.23 , pp. 4152-4161
    • Banerji, U.1    O'Donnell, A.2    Scurr, M.3    Pacey, S.4    Stapleton, S.5    Asad, Y.6
  • 10
    • 48949119477 scopus 로고    scopus 로고
    • NVP-AUY922: A small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
    • Jensen MR, Schoepfer J, Radimerski T, Massey A, Guy CT, Brueggen J, et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res 2008;10:R33.
    • (2008) Breast Cancer Res , vol.10
    • Jensen, M.R.1    Schoepfer, J.2    Radimerski, T.3    Massey, A.4    Guy, C.T.5    Brueggen, J.6
  • 11
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
    • Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res 2008;68:2850-60.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3    Sharp, S.Y.4    Box, G.5    Valenti, M.6
  • 12
    • 77950807945 scopus 로고    scopus 로고
    • Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800
    • Massey AJ, Schoepfer J, Brough PA, Brueggen J, Chene P, Drysdale MJ, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther 2010;9:906-19.
    • (2010) Mol Cancer Ther , vol.9 , pp. 906-919
    • Massey, A.J.1    Schoepfer, J.2    Brough, P.A.3    Brueggen, J.4    Chene, P.5    Drysdale, M.J.6
  • 13
    • 79960983822 scopus 로고    scopus 로고
    • AUY922, a novel HSP90 inhibitor: Final results of a first-in-human study in patients with advanced solid malignancies
    • abstr 2528
    • Samuel TA, Sessa C, Britten C, Milligan KS, Mita MM, Banerji U, et al. AUY922, a novel HSP90 inhibitor: Final results of a first-in-human study in patients with advanced solid malignancies. J Clin Oncol 28:15s, 2010 (suppl; abstr 2528).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Samuel, T.A.1    Sessa, C.2    Britten, C.3    Milligan, K.S.4    Mita, M.M.5    Banerji, U.6
  • 14
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's lung cancer mutation consortium (LCMC)
    • abstr CRA7506
    • Kris MG JB, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Aronson SL, Engelman JA, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's lung cancer mutation consortium (LCMC). J Clin Oncol 2011;29(suppl): abstr CRA7506.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kris, M.G.J.B.1    Kwiatkowski, D.J.2    Iafrate, A.J.3    Wistuba, I.I.4    Aronson, S.L.5    Engelman, J.A.6
  • 15
    • 19844375720 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumor biology
    • Janne PA, Engelman JA, Johnson BE. Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology. J Clin Oncol 2005;23:3227-34.
    • (2005) J Clin Oncol , vol.23 , pp. 3227-3234
    • Janne, P.A.1    Engelman, J.A.2    Johnson, B.E.3
  • 16
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y, Rosell R, Mok T, Massuti B, Zamora L, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 2005;11:5878-85.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3    Mok, T.4    Massuti, B.5    Zamora, L.6
  • 17
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-46.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3    Nomura, M.4    Suzuki, M.5    Wistuba, I.I.6
  • 18
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:6829-37.
    • (2005) J Clin Oncol , vol.23 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3    Tsuta, K.4    Matsuno, Y.5    Tateishi, U.6
  • 19
    • 2642570481 scopus 로고    scopus 로고
    • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    • Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, et al. Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation. Mol Cancer Ther 2004;3: 465-72.
    • (2004) Mol Cancer Ther , vol.3 , pp. 465-472
    • Ono, M.1    Hirata, A.2    Kometani, T.3    Miyagawa, M.4    Ueda, S.5    Kinoshita, H.6
  • 20
    • 19944427851 scopus 로고    scopus 로고
    • Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
    • Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H, et al. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 2005;65:226-35.
    • (2005) Cancer Res , vol.65 , pp. 226-235
    • Amann, J.1    Kalyankrishna, S.2    Massion, P.P.3    Ohm, J.E.4    Girard, L.5    Shigematsu, H.6
  • 21
    • 80455129848 scopus 로고    scopus 로고
    • 18F-FDG PET/CT for monitoring treatment responses to the epidermal growth factor receptor inhibitor erlotinib
    • Benz MR, Herrmann K, Walter F, Garon EB, Reckamp KL, Figlin R, et al. 18F-FDG PET/CT for monitoring treatment responses to the epidermal growth factor receptor inhibitor erlotinib. J Nucl Med 2011;52:1684-9.
    • (2011) J Nucl Med , vol.52 , pp. 1684-1689
    • Benz, M.R.1    Herrmann, K.2    Walter, F.3    Garon, E.B.4    Reckamp, K.L.5    Figlin, R.6
  • 22
    • 22244485706 scopus 로고    scopus 로고
    • Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
    • Shimamura T, Lowell AM, Engelman JA, Shapiro GI. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005;65:6401-8.
    • (2005) Cancer Res , vol.65 , pp. 6401-6408
    • Shimamura, T.1    Lowell, A.M.2    Engelman, J.A.3    Shapiro, G.I.4
  • 23
    • 84855459627 scopus 로고    scopus 로고
    • The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyro-sine kinase inhibitor
    • Kobayashi N, Toyooka S, Soh J, Yamamoto H, Dote H, Kawasaki K, et al. The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyro-sine kinase inhibitor. Lung Cancer 2012;75:161-6.
    • (2012) Lung Cancer , vol.75 , pp. 161-166
    • Kobayashi, N.1    Toyooka, S.2    Soh, J.3    Yamamoto, H.4    Dote, H.5    Kawasaki, K.6
  • 24
    • 44649083135 scopus 로고    scopus 로고
    • Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
    • Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res 2008;68: 5827-38.
    • (2008) Cancer Res , vol.68 , pp. 5827-5838
    • Shimamura, T.1    Li, D.2    Ji, H.3    Haringsma, H.J.4    Liniker, E.5    Borgman, C.L.6
  • 25
    • 0037131187 scopus 로고    scopus 로고
    • Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
    • Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 2002;277:39858-66.
    • (2002) J Biol Chem , vol.277 , pp. 39858-39866
    • Basso, A.D.1    Solit, D.B.2    Chiosis, G.3    Giri, B.4    Tsichlis, P.5    Rosen, N.6
  • 26
    • 0036188465 scopus 로고    scopus 로고
    • Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer
    • Maulik G, Kijima T, Ma PC, Ghosh SK, Lin J, Shapiro GI, et al. Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res 2002;8:620-7.
    • (2002) Clin Cancer Res , vol.8 , pp. 620-627
    • Maulik, G.1    Kijima, T.2    Ma, P.C.3    Ghosh, S.K.4    Lin, J.5    Shapiro, G.I.6
  • 27
    • 79955980366 scopus 로고    scopus 로고
    • C-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma
    • Blasco RB, Francoz S, Santamaria D, Canamero M, Dubus P, Charron J, et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 2011;19: 652-63.
    • (2011) Cancer Cell , vol.19 , pp. 652-663
    • Blasco, R.B.1    Francoz, S.2    Santamaria, D.3    Canamero, M.4    Dubus, P.5    Charron, J.6
  • 28
    • 57049153979 scopus 로고    scopus 로고
    • X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
    • Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, et al. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat Cell Biol 2008;10:1447-55.
    • (2008) Nat Cell Biol , vol.10 , pp. 1447-1455
    • Dogan, T.1    Harms, G.S.2    Hekman, M.3    Karreman, C.4    Oberoi, T.K.5    Alnemri, E.S.6
  • 29
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3    Takada, S.4    Yamashita, Y.5    Ishikawa, S.6
  • 31
    • 79951885125 scopus 로고    scopus 로고
    • Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • Sequist LV, Gettinger S, Senzer NN, Martins RG, Janne PA, Lilenbaum R, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 2010;28:4953-60.
    • (2010) J Clin Oncol , vol.28 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3    Martins, R.G.4    Janne, P.A.5    Lilenbaum, R.6
  • 32
    • 82555180241 scopus 로고    scopus 로고
    • An open-label phase II study of the Hsp90 inhibitor gane-tespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC)
    • abstr 7500
    • Wong K KM, Goldman JW, Paschold EH, Horn L, Lufkin JM, Blackman RK, et al. An open-label phase II study of the Hsp90 inhibitor gane-tespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 29, 2011(suppl; abstr 7500).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Wong, K.K.M.1    Goldman, J.W.2    Paschold, E.H.3    Horn, L.4    Lufkin, J.M.5    Blackman, R.K.6
  • 33
    • 84866382273 scopus 로고    scopus 로고
    • Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC)
    • abstr 7543
    • Garon EB, Moran T, Barlesi F, Gandhi L, Sequist LV, Kim SW, et al. Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC). J Clin Oncol 30, 2012 (suppl; abstr 7543).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Garon, E.B.1    Moran, T.2    Barlesi, F.3    Gandhi, L.4    Sequist, L.V.5    Kim, S.W.6
  • 34
    • 84878358097 scopus 로고    scopus 로고
    • Phase II activity of the HSP90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC)
    • Felip E, Carcereny E, Barlesi F, Gandhi L, Sequist LV, Kim SW, et al. Phase II activity of the HSP90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC). Annals of Onc 23[suppl 9].
    • Annals of Onc , vol.23 , Issue.SUPPL. 9
    • Felip, E.1    Carcereny, E.2    Barlesi, F.3    Gandhi, L.4    Sequist, L.V.5    Kim, S.W.6
  • 35
    • 77954572215 scopus 로고    scopus 로고
    • Cell differentiation and dominant signaling pathway signatures in the molecular classification of human breast cancer cell lines
    • Wilson CA DJ, Bernardo G, Rong HM, Ginther C, Ferdman R, Cook AM, et al. Cell differentiation and dominant signaling pathway signatures in the molecular classification of human breast cancer cell lines. Breast Cancer Res 2005;7(Suppl 2):S 4.25.
    • (2005) Breast Cancer Res , vol.7 , Issue.SUPPL. 2 , pp. 425
    • Wilson, C.A.D.J.1    Bernardo, G.2    Rong, H.M.3    Ginther, C.4    Ferdman, R.5    Cook, A.M.6
  • 36
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"Triple-neg- ative" breast cancer cell lines growing in vitro
    • Finn RS, Dering J, Ginther C, Wilson CA, Glaspy P, Tchekmedyian N, et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-neg-ative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat 2007;105:319-26.
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 319-326
    • Finn, R.S.1    Dering, J.2    Ginther, C.3    Wilson, C.A.4    Glaspy, P.5    Tchekmedyian, N.6
  • 37
    • 77954592048 scopus 로고    scopus 로고
    • Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines
    • Garon EB, Finn RS, Hosmer W, Dering J, Ginther C, Adhami S, et al. Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines. Mol Cancer Ther 2010; 9:1985-94.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1985-1994
    • Garon, E.B.1    Finn, R.S.2    Hosmer, W.3    Dering, J.4    Ginther, C.5    Adhami, S.6
  • 38
    • 0037249501 scopus 로고    scopus 로고
    • PANTHER: A browsable database of gene products organized by biological function, using curated protein family and subfamily classification
    • Thomas PD, Kejariwal A, Campbell MJ, Mi H, Diemer K, Guo N, et al. PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res 2003;31:334-41.
    • (2003) Nucleic Acids Res , vol.31 , pp. 334-341
    • Thomas, P.D.1    Kejariwal, A.2    Campbell, M.J.3    Mi, H.4    Diemer, K.5    Guo, N.6
  • 39
    • 84858009160 scopus 로고    scopus 로고
    • Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer
    • Ueno T, Tsukuda K, Toyooka S, Ando M, Takaoka M, Soh J, et al. Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer. Lung cancer 2012;76:26-31.
    • (2012) Lung Cancer , vol.76 , pp. 26-31
    • Ueno, T.1    Tsukuda, K.2    Toyooka, S.3    Ando, M.4    Takaoka, M.5    Soh, J.6
  • 40
    • 84866414082 scopus 로고    scopus 로고
    • Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer
    • Shimamura T, Perera SA, Foley KP, Sang J, Rodig SJ, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin cancer res 2012;18:4973-85.
    • (2012) Clin Cancer Res , vol.18 , pp. 4973-4985
    • Shimamura, T.1    Perera, S.A.2    Foley, K.P.3    Sang, J.4    Rodig, S.J.5    Inoue, T.6
  • 41
    • 0034710542 scopus 로고    scopus 로고
    • Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygel-danamycin, an inhibitor of the hsp90 molecular chaperone
    • Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, et al. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygel-danamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene 2000;19:4125-33.
    • (2000) Oncogene , vol.19 , pp. 4125-4133
    • Clarke, P.A.1    Hostein, I.2    Banerji, U.3    Stefano, F.D.4    Maloney, A.5    Walton, M.6
  • 42
    • 34147150867 scopus 로고    scopus 로고
    • Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin
    • Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman JO, Akpan A, et al. Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2007;67:3239-53.
    • (2007) Cancer Res , vol.67 , pp. 3239-3253
    • Maloney, A.1    Clarke, P.A.2    Naaby-Hansen, S.3    Stein, R.4    Koopman, J.O.5    Akpan, A.6
  • 43
    • 77955092334 scopus 로고    scopus 로고
    • Genetic determinants of pemetrexed responsiveness and nonrespon-siveness in non-small cell lung cancer cells
    • Wu MF, Hsiao YM, Huang CF, Huang YH, Yang WJ, Chan HW, et al. Genetic determinants of pemetrexed responsiveness and nonrespon-siveness in non-small cell lung cancer cells. J Thorac Oncol 2010;5: 1143-51.
    • (2010) J Thorac Oncol , vol.5 , pp. 1143-1151
    • Wu, M.F.1    Hsiao, Y.M.2    Huang, C.F.3    Huang, Y.H.4    Yang, W.J.5    Chan, H.W.6
  • 44
    • 79960835886 scopus 로고    scopus 로고
    • Establishment of pemetrexed-resistant non-small cell lung cancer cell lines
    • Zhang D, Ochi N, Takigawa N, Tanimoto Y, Chen Y, Ichihara E, et al. Establishment of pemetrexed-resistant non-small cell lung cancer cell lines. Cancer Lett 2011;309:228-35.
    • (2011) Cancer Lett , vol.309 , pp. 228-235
    • Zhang, D.1    Ochi, N.2    Takigawa, N.3    Tanimoto, Y.4    Chen, Y.5    Ichihara, E.6
  • 45
    • 0037593900 scopus 로고    scopus 로고
    • Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
    • Lotz GP, Lin H, Harst A, Obermann WM. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J Biol Chem 2003;278:17228-35.
    • (2003) J Biol Chem , vol.278 , pp. 17228-17235
    • Lotz, G.P.1    Lin, H.2    Harst, A.3    Obermann, W.M.4
  • 46
    • 40449089789 scopus 로고    scopus 로고
    • Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin
    • Holmes JL, Sharp SY, Hobbs S, Workman P. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2008;68:1188-97.
    • (2008) Cancer Res , vol.68 , pp. 1188-1197
    • Holmes, J.L.1    Sharp, S.Y.2    Hobbs, S.3    Workman, P.4
  • 47
    • 0037208893 scopus 로고    scopus 로고
    • Genomic structure of the human mitochondrial chaperonin genes: Hsp60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter
    • Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, Bor-glum AD, et al. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum Genet 2003;112:71-7.
    • (2003) Hum Genet , vol.112 , pp. 71-77
    • Hansen, J.J.1    Bross, P.2    Westergaard, M.3    Nielsen, M.N.4    Eiberg, H.5    Bor-Glum, A.D.6
  • 49
    • 84879320768 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the HSP90 inhibitor AUY922 and erlotinib for patients with EGFR mutant lung cancer with acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs)
    • Abstract nr 3083
    • Johnson ML YH, Hart EM, Worden R, Rademaker F, Gupta R, Miller C, et al. A phase I dose-escalation study of the HSP90 inhibitor AUY922 and erlotinib for patients with EGFR mutant lung cancer with acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs). Am Soc Clin Oncol 2012. Abstract nr 3083.
    • (2012) Am Soc Clin Oncol
    • Johnson, M.L.Y.H.1    Hart, E.M.2    Worden, R.3    Rademaker, F.4    Gupta, R.5    Miller, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.