-
1
-
-
0037025173
-
Cancer: Addiction to oncogenes - The Achilles heal of cancer
-
Weinstein IB: Cancer: Addiction to oncogenes - The Achilles heal of cancer. Science 297:63-64, 2002
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
2
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
DOI 10.1056/NEJMoa062867
-
Druker BJ, Guilhot F, O'Brien SG, et al: Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355:2408-2417, 2006 (Pubitemid 44903745)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.23
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
Deininger, M.W.N.7
Silver, R.T.8
Goldman, J.M.9
Stone, R.M.10
Cervantes, F.11
Hochhaus, A.12
Powell, B.L.13
Gabrilove, J.L.14
Rousselot, P.15
Reiffers, J.16
Cornelissen, J.J.17
Hughes, T.18
Agis, H.19
Fischer, T.20
Verhoef, G.21
Shepherd, J.22
Saglio, G.23
Gratwohl, A.24
Nielsen, J.L.25
Radich, J.P.26
Simonsson, B.27
Taylor, K.28
Baccarani, M.29
So, C.30
Letvak, L.31
Larson, R.A.32
more..
-
3
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
DOI 10.1056/NEJMoa020461
-
Demetri GD, von Mehren M, Blanke CD, et al: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472-480, 2002 (Pubitemid 34879334)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.7
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den, A.A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.M.20
Joensuu, H.21
more..
-
4
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al: Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819, 2010
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
5
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516, 2011
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
6
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004 (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
7
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez JG, Jänne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004 (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
8
-
-
35448967331
-
Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
-
Apperley JF: Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 8:1018-1029, 2007
-
(2007)
Lancet Oncol
, vol.8
, pp. 1018-1029
-
-
Apperley, J.F.1
-
9
-
-
73349131387
-
Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors
-
Gramza AW, Corless CL, Heinrich MC: Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors. Clin Cancer Res 15:7510-7518, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7510-7518
-
-
Gramza, A.W.1
Corless, C.L.2
Heinrich, M.C.3
-
10
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N, Emery C, Berger MF, et al: Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 29:3085-3096, 2011
-
(2011)
J Clin Oncol
, vol.29
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
-
11
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
DOI 10.1073/pnas.0405220101
-
Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101:13306-13311, 2004 (Pubitemid 39209661)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
Mardis, E.11
Kupfer, D.12
Wilson, R.13
Kris, M.14
Varmus, H.15
-
12
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma SV, Bell DW, Settleman J, et al: Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7:169-181, 2007
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
-
13
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947-957, 2009
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
14
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362:2380-2388, 2010
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
15
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R, et al: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13:239-246, 2012
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
16
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
Soda M, Choi YL, Enomoto M, et al: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448:561-566, 2007 (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
17
-
-
36849065315
-
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
-
DOI 10.1016/j.cell.2007.11.025, PII S009286740701522X
-
Rikova K, Guo A, Zeng Q, et al: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-1203, 2007 (Pubitemid 350235027)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
Hu, Y.11
Tan, Z.12
Stokes, M.13
Sullivan, L.14
Mitchell, J.15
Wetzel, R.16
MacNeill, J.17
Ren, J.M.18
Yuan, J.19
Bakalarski, C.E.20
Villen, J.21
Kornhauser, J.M.22
Smith, B.23
Li, D.24
Zhou, X.25
Gygi, S.P.26
Gu, T.-L.27
Polakiewicz, R.D.28
Rush, J.29
Comb, M.J.30
more..
-
18
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
Takeuchi K, Choi YL, Soda M, et al: Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res 14:6618-6624, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
-
19
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, et al: EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 14:4275-4283, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
20
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al: Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27:4247-4253, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
21
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al: Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363:1693-1703, 2010
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
22
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
-
Camidge DR, Bang YJ, Kwak EL, et al: Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study. Lancet Oncol 13:1011-1019, 2012
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
23
-
-
84865431278
-
Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
abstr 7533
-
Kim D, Ahn M, Shi Y, et al: Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol 30:488s, 2012 (suppl; abstr 7533)
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Kim, D.1
Ahn, M.2
Shi, Y.3
-
24
-
-
73349122639
-
Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
-
Baccarani M, Cortes J, Pane F, et al: Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 27:6041-6051, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 6041-6051
-
-
Baccarani, M.1
Cortes, J.2
Pane, F.3
-
25
-
-
24944529613
-
Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
-
Van Glabbeke M, Verweij J, Casali PG, et al: Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J Clin Oncol 23:5795-5804, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 5795-5804
-
-
Van Glabbeke, M.1
Verweij, J.2
Casali, P.G.3
-
26
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
Jackman D, Pao W, Riely GJ, et al: Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 28:357-360, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
-
27
-
-
77958478674
-
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
-
Pao W, Chmielecki J: Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer 10:760-774, 2010
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 760-774
-
-
Pao, W.1
Chmielecki, J.2
-
28
-
-
84855310079
-
EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
-
Yasuda H, Kobayashi S, Costa DB: EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications. Lancet Oncol 13:e23-e31, 2012
-
(2012)
Lancet Oncol
, vol.13
-
-
Yasuda, H.1
Kobayashi, S.2
Costa, D.B.3
-
29
-
-
51049116207
-
Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
-
Wu JY, Wu SG, Yang CH, et al: Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin Cancer Res 14:4877-4882, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4877-4882
-
-
Wu, J.Y.1
Wu, S.G.2
Yang, C.H.3
-
30
-
-
28444478439
-
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
-
Greulich H, Chen TH, Feng W, et al: Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2:e313, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Greulich, H.1
Chen, T.H.2
Feng, W.3
-
31
-
-
33748074447
-
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
-
DOI 10.1158/0008-5472.CAN-06-1951
-
Inukai M, Toyooka S, Ito S, et al: Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res 66:7854-7858, 2006 (Pubitemid 44299146)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 7854-7858
-
-
Inukai, M.1
Toyooka, S.2
Ito, S.3
Asano, H.4
Ichihara, S.5
Soh, J.6
Suehisa, H.7
Ouchida, M.8
Aoe, K.9
Aoe, M.10
Kiura, K.11
Shimizu, N.12
Date, H.13
-
32
-
-
33744781279
-
Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer
-
DOI 10.1016/j.lungcan.2006.04.008, PII S0169500206001838
-
Tokumo M, Toyooka S, Ichihara S, et al: Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer. Lung Cancer 53:117-121, 2006 (Pubitemid 43831366)
-
(2006)
Lung Cancer
, vol.53
, Issue.1
, pp. 117-121
-
-
Tokumo, M.1
Toyooka, S.2
Ichihara, S.3
Ohashi, K.4
Tsukuda, K.5
Ichimura, K.6
Tabata, M.7
Kiura, K.8
Aoe, M.9
Sano, Y.10
Date, H.11
Shimizu, N.12
-
33
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al: First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 26:2442-2449, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
34
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
-
Turke AB, Zejnullahu K, Wu YL, et al: Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 17:77-88, 2010
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
Zejnullahu, K.2
Wu, Y.L.3
-
35
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316:1039-1043, 2007 (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
36
-
-
84865776102
-
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants
-
Heuckmann JM, Balke-Want H, Malchers F, et al: Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants. Clin Cancer Res 18:4682-4690, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4682-4690
-
-
Heuckmann, J.M.1
Balke-Want, H.2
Malchers, F.3
-
37
-
-
84869462031
-
Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: A success story to usher in the second decade of molecular targeted therapy in oncology
-
Ou SH, Bartlett CH, Mino-Kenudson M, et al: Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: A success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist 17:1351-1375, 2012
-
(2012)
Oncologist
, vol.17
, pp. 1351-1375
-
-
Ou, S.H.1
Bartlett, C.H.2
Mino-Kenudson, M.3
-
39
-
-
78349237453
-
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment
-
Camidge DR, Kono SA, Flacco A, et al: Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res 16:5581-5590, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5581-5590
-
-
Camidge, D.R.1
Kono, S.A.2
Flacco, A.3
-
40
-
-
3042707495
-
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors
-
DOI 10.1128/MCB.24.14.6172-6183.2004
-
Kuribara R, Honda H, Matsui H, et al: Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. Mol Cell Biol 24:6172-6183, 2004 (Pubitemid 38891120)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.14
, pp. 6172-6183
-
-
Kuribara, R.1
Honda, H.2
Matsui, H.3
Shinjyo, T.4
Inukai, T.5
Sugita, K.6
Nakazawa, S.7
Hirai, H.8
Ozawa, K.9
Inaba, T.10
-
41
-
-
33749510073
-
+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
-
DOI 10.1073/pnas.0606176103
-
Kuroda J, Puthalakath H, Cragg MS, et al: Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A 103:14907-14912, 2006 (Pubitemid 44527827)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.40
, pp. 14907-14912
-
-
Kuroda, J.1
Puthalakath, H.2
Cragg, M.S.3
Kelly, P.N.4
Bouillet, P.5
Huang, D.C.S.6
Kimura, S.7
Ottmann, O.G.8
Druker, B.J.9
Villunger, A.10
Roberts, A.W.11
Strasser, A.12
-
42
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
-
discussion 1680
-
Costa DB, Halmos B, Kumar A, et al: BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med 4:1669-1679; discussion 1680, 2007
-
(2007)
PLoS Med
, vol.4
, pp. 1669-1679
-
-
Costa, D.B.1
Halmos, B.2
Kumar, A.3
-
43
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
discussion 1690
-
Cragg MS, Kuroda J, Puthalakath H, et al: Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 4:1681-1689; discussion 1690, 2007
-
(2007)
PLoS Med
, vol.4
, pp. 1681-1689
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
-
44
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong Y, Somwar R, Politi K, et al: Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 4:e294, 2007
-
(2007)
PLoS Med
, vol.4
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
-
45
-
-
84857002194
-
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors
-
Faber AC, Corcoran RB, Ebi H, et al: BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov 1:352-365, 2011
-
(2011)
Cancer Discov
, vol.1
, pp. 352-365
-
-
Faber, A.C.1
Corcoran, R.B.2
Ebi, H.3
-
46
-
-
79954592031
-
Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
-
Takezawa K, Okamoto I, Nishio K, et al: Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. Clin Cancer Res 17:2140-2148, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2140-2148
-
-
Takezawa, K.1
Okamoto, I.2
Nishio, K.3
-
47
-
-
84862777672
-
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
-
Ng KP, Hillmer AM, Chuah CT, et al: A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med 18:521-528, 2012
-
(2012)
Nat Med
, vol.18
, pp. 521-528
-
-
Ng, K.P.1
Hillmer, A.M.2
Chuah, C.T.3
-
48
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
Kobayashi S, Boggon TJ, Dayaram T, et al: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352:786-792, 2005 (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
49
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2:e73, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
50
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al: Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 3:75ra26, 2011
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
51
-
-
79952259564
-
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
-
Arcila ME, Oxnard GR, Nafa K, et al: Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 17:1169-1180, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1169-1180
-
-
Arcila, M.E.1
Oxnard, G.R.2
Nafa, K.3
-
52
-
-
33751292685
-
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
-
DOI 10.1158/1078-0432.CCR-06-1570
-
Balak MN, Gong Y, Riely GJ, et al: Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res 12:6494-6501, 2006 (Pubitemid 44799723)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.21
, pp. 6494-6501
-
-
Balak, M.N.1
Gong, Y.2
Riely, G.J.3
Somwar, R.4
Li, A.R.5
Zakowski, M.F.6
Chiang, A.7
Yang, G.8
Ouerfelli, O.9
Kris, M.G.10
Ladanyi, M.11
Miller, V.A.12
Pao, W.13
-
53
-
-
58149333768
-
Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
-
Bean J, Riely GJ, Balak M, et al: Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin Cancer Res 14:7519-7525, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7519-7525
-
-
Bean, J.1
Riely, G.J.2
Balak, M.3
-
54
-
-
84867760241
-
HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
-
Takezawa K, Pirazzoli V, Arcila ME, et al: HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov 2:922-933, 2012
-
(2012)
Cancer Discov
, vol.2
, pp. 922-933
-
-
Takezawa, K.1
Pirazzoli, V.2
Arcila, M.E.3
-
55
-
-
84864524696
-
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
-
Ohashi K, Sequist LV, Arcila ME, et al: Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A 109:E2127-2133, 2012
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Ohashi, K.1
Sequist, L.V.2
Arcila, M.E.3
-
56
-
-
84864621910
-
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers
-
Cheung HW, Du J, Boehm JS, et al: Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov 1:608-625, 2011
-
(2011)
Cancer Discov
, vol.1
, pp. 608-625
-
-
Cheung, H.W.1
Du, J.2
Boehm, J.S.3
-
57
-
-
56449089812
-
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
-
Yano S, Wang W, Li Q, et al: Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res 68:9479-9487, 2008
-
(2008)
Cancer Res
, vol.68
, pp. 9479-9487
-
-
Yano, S.1
Wang, W.2
Li, Q.3
-
58
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi YL, Soda M, Yamashita Y, et al: EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 363:1734-1739, 2010
-
(2010)
N Engl J Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
59
-
-
80052793410
-
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
-
Sasaki T, Koivunen J, Ogino A, et al: A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res 71:6051-6060, 2011
-
(2011)
Cancer Res
, vol.71
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
-
60
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
Katayama R, Shaw AT, Khan TM, et al: Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med 4:120ra17, 2012
-
(2012)
Sci Transl Med
, vol.4
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
61
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, et al: Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 18:1472-1482, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
62
-
-
43749107912
-
Acquired resistance to tyrosine kinase inhibitors during cancer therapy
-
DOI 10.1016/j.gde.2008.01.004, PII S0959437X08000087
-
Engelman JA, Settleman J: Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr Opin Genet Dev 18:73-79, 2008 (Pubitemid 351694445)
-
(2008)
Current Opinion in Genetics and Development
, vol.18
, Issue.1
, pp. 73-79
-
-
Engelman, J.A.1
Settleman, J.2
-
63
-
-
49649127657
-
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Engelman JA, Jänne PA: Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 14:2895-2899, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2895-2899
-
-
Engelman, J.A.1
Jänne, P.A.2
-
64
-
-
77950678272
-
Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
-
Sierra JR, Cepero V, Giordano S: Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer 9:75, 2010
-
(2010)
Mol Cancer
, vol.9
, pp. 75
-
-
Sierra, J.R.1
Cepero, V.2
Giordano, S.3
-
65
-
-
73349105243
-
Resistance to targeted therapies: Refining anticancer therapy in the era of molecular oncology
-
Ellis LM, Hicklin DJ: Resistance to targeted therapies: Refining anticancer therapy in the era of molecular oncology. Clin Cancer Res 15:7471-7478, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7471-7478
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
66
-
-
77749288978
-
Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance
-
Bixby D, Talpaz M: Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematology Am Soc Hematol Educ Program 461-476, 2009
-
(2009)
Hematology Am Soc Hematol Educ Program
, pp. 461-476
-
-
Bixby, D.1
Talpaz, M.2
-
67
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
DOI 10.1126/science.1062538
-
Gorre ME, Mohammed M, Ellwood K, et al: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293:876-880, 2001 (Pubitemid 32743979)
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Nagesh, R.P.6
Sawyers, C.L.7
-
68
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
DOI 10.1182/blood.V100.3.1014
-
Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al: Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100:1014-1018, 2002 (Pubitemid 34832631)
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
Soenen-Cornu, V.2
Grardel-Duflos, N.3
Lai, J.-L.4
Philippe, N.5
Facon, T.6
Fenaux, P.7
Preudhomme, C.8
-
69
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
DOI 10.1073/pnas.0709662105
-
Yun CH, Mengwasser KE, Toms AV, et al: The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 105:2070-2075, 2008 (Pubitemid 351439466)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.6
, pp. 2070-2075
-
-
Yun, C.-H.1
Mengwasser, K.E.2
Toms, A.V.3
Woo, M.S.4
Greulich, H.5
Wong, K.-K.6
Meyerson, M.7
Eck, M.J.8
-
70
-
-
34347208648
-
Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy
-
DOI 10.1016/j.ccr.2007.06.005, PII S1535610807001742
-
Li D, Shimamura T, Ji H, et al: Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell 12:81-93, 2007 (Pubitemid 47001787)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 81-93
-
-
Li, D.1
Shimamura, T.2
Ji, H.3
Chen, L.4
Haringsma, H.J.5
McNamara, K.6
Liang, M.-C.7
Perera, S.A.8
Zaghlul, S.9
Borgman, C.L.10
Kubo, S.11
Takahashi, M.12
Sun, Y.13
Chirieac, L.R.14
Padera, R.F.15
Lindeman, N.I.16
Janne, P.A.17
Thomas, R.K.18
Meyerson, M.L.19
Eck, M.J.20
Engelman, J.A.21
Shapiro, G.I.22
Wong, K.-K.23
more..
-
71
-
-
34547625913
-
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
-
DOI 10.1158/0008-5472.CAN-06-4625
-
Godin-Heymann N, Bryant I, Rivera MN, et al: Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res 67:7319-7326, 2007 (Pubitemid 47206561)
-
(2007)
Cancer Research
, vol.67
, Issue.15
, pp. 7319-7326
-
-
Godin-Heymann, N.1
Bryant, I.2
Rivera, M.N.3
Ulkus, L.4
Bell, D.W.5
Riese II, D.J.6
Settleman, J.7
Haber, D.A.8
-
72
-
-
33947287270
-
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
-
DOI 10.1158/0008-5472.CAN-06-4293
-
Mulloy R, Ferrand A, Kim Y, et al: Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res 67:2325-2330, 2007 (Pubitemid 46424253)
-
(2007)
Cancer Research
, vol.67
, Issue.5
, pp. 2325-2330
-
-
Mulloy, R.1
Ferrand, A.2
Kim, Y.3
Sordella, R.4
Bell, D.W.5
Haber, D.A.6
Anderson, K.S.7
Settleman, J.8
-
73
-
-
79960085862
-
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
-
Chmielecki J, Foo J, Oxnard GR, et al: Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med 3:90ra59, 2011
-
(2011)
Sci Transl Med
, vol.3
-
-
Chmielecki, J.1
Foo, J.2
Oxnard, G.R.3
-
74
-
-
79952711946
-
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation
-
Oxnard GR, Arcila ME, Sima CS, et al: Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 17:1616-1622, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1616-1622
-
-
Oxnard, G.R.1
Arcila, M.E.2
Sima, C.S.3
-
75
-
-
84857027931
-
Escaping ALK inhibition: Mechanisms of and strategies to overcome resistance
-
Lovly CM, Pao W: Escaping ALK inhibition: Mechanisms of and strategies to overcome resistance. Sci Transl Med 4:120ps2, 2012
-
(2012)
Sci Transl Med
, vol.4
-
-
Lovly, C.M.1
Pao, W.2
-
76
-
-
81355124049
-
Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen
-
Zhang S, Wang F, Keats J, et al: Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des 78:999-1005, 2011
-
(2011)
Chem Biol Drug des
, vol.78
, pp. 999-1005
-
-
Zhang, S.1
Wang, F.2
Keats, J.3
-
77
-
-
78649475696
-
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
-
Sasaki T, Okuda K, Zheng W, et al: The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res 70:10038-10043, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 10038-10043
-
-
Sasaki, T.1
Okuda, K.2
Zheng, W.3
-
78
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
George RE, Sanda T, Hanna M, et al: Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 455:975-978, 2008
-
(2008)
Nature
, vol.455
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
-
79
-
-
54049122600
-
Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations
-
Avizienyte E, Ward RA, Garner AP: Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations. Biochem J 415:197-206, 2008
-
(2008)
Biochem J
, vol.415
, pp. 197-206
-
-
Avizienyte, E.1
Ward, R.A.2
Garner, A.P.3
-
80
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, et al: Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 108:7535-7540, 2011
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
-
81
-
-
77951643141
-
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
-
Ercan D, Zejnullahu K, Yonesaka K, et al: Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 29:2346-2356, 2010
-
(2010)
Oncogene
, vol.29
, pp. 2346-2356
-
-
Ercan, D.1
Zejnullahu, K.2
Yonesaka, K.3
-
82
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al: MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932-20937, 2007
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
83
-
-
74949142595
-
Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer
-
Yamada T, Matsumoto K, Wang W, et al: Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer. Clin Cancer Res 16:174-183, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 174-183
-
-
Yamada, T.1
Matsumoto, K.2
Wang, W.3
-
84
-
-
33749435816
-
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
-
DOI 10.1172/JCI28656
-
Engelman JA, Mukohara T, Zejnullahu K, et al: Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 116:2695-2706, 2006 (Pubitemid 44511633)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.10
, pp. 2695-2706
-
-
Engelman, J.A.1
Mukohara, T.2
Zejnullahu, K.3
Lifshits, E.4
Borras, A.M.5
Gale, C.-M.6
Naumov, G.N.7
Yeap, B.Y.8
Jarrell, E.9
Sun, J.10
Tracy, S.11
Zhao, X.12
Heymach, J.V.13
Johnson, B.E.14
Cantley, L.C.15
Janne, P.A.16
-
85
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ, et al: KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2:e17, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
86
-
-
84869211206
-
Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer
-
Tanizaki J, Okamoto I, Okabe T, et al: Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer. Clin Cancer Res 18:6219-6226, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6219-6226
-
-
Tanizaki, J.1
Okamoto, I.2
Okabe, T.3
-
87
-
-
33745913034
-
EGFR mutations in small-cell lung cancers in patients who have never smoked [18]
-
DOI 10.1056/NEJMc053610
-
Zakowski MF, Ladanyi M, Kris MG, et al: EGFR mutations in small-cell lung cancers in patients who have never smoked. N Engl J Med 355:213-215, 2006 (Pubitemid 44050422)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.2
, pp. 213-215
-
-
Zakowski, M.F.1
Ladanyi, M.2
Kris, M.G.3
-
88
-
-
35748973894
-
Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation
-
DOI 10.1016/j.lungcan.2007.05.014, PII S0169500207003170
-
Morinaga R, Okamoto I, Furuta K, et al: Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation. Lung Cancer 58:411-413, 2007 (Pubitemid 350051499)
-
(2007)
Lung Cancer
, vol.58
, Issue.3
, pp. 411-413
-
-
Morinaga, R.1
Okamoto, I.2
Furuta, K.3
Kawano, Y.4
Sekijima, M.5
Dote, K.6
Satou, T.7
Nishio, K.8
Fukuoka, M.9
Nakagawa, K.10
-
89
-
-
77955819939
-
Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma
-
Uramoto H, Iwata T, Onitsuka T, et al: Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma. Anticancer Res 30:2513-2517, 2010
-
(2010)
Anticancer Res
, vol.30
, pp. 2513-2517
-
-
Uramoto, H.1
Iwata, T.2
Onitsuka, T.3
-
90
-
-
79953121435
-
Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs
-
Chung JH, Rho JK, Xu X, et al: Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs. Lung Cancer 73:176-182, 2011
-
(2011)
Lung Cancer
, vol.73
, pp. 176-182
-
-
Chung, J.H.1
Rho, J.K.2
Xu, X.3
-
91
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442-454, 2002
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
92
-
-
27144477683
-
Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
-
DOI 10.1158/0008-5472.CAN-05-1058
-
Thomson S, Buck E, Petti F, et al: Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 65:9455-9462, 2005 (Pubitemid 41508014)
-
(2005)
Cancer Research
, vol.65
, Issue.20
, pp. 9455-9462
-
-
Thomson, S.1
Buck, E.2
Petti, F.3
Griffin, G.4
Brown, E.5
Ramnarine, N.6
Iwata, K.K.7
Gibson, N.8
Haley, J.D.9
-
93
-
-
58049200145
-
Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
-
Rho JK, Choi YJ, Lee JK, et al: Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line. Lung Cancer 63:219-226, 2009
-
(2009)
Lung Cancer
, vol.63
, pp. 219-226
-
-
Rho, J.K.1
Choi, Y.J.2
Lee, J.K.3
-
94
-
-
79959872399
-
Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib
-
Suda K, Tomizawa K, Fujii M, et al: Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib. J Thorac Oncol 6:1152-1161, 2011
-
(2011)
J Thorac Oncol
, vol.6
, pp. 1152-1161
-
-
Suda, K.1
Tomizawa, K.2
Fujii, M.3
-
95
-
-
46749156706
-
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
-
DOI 10.1172/JC134588
-
Guix M, Faber AC, Wang SE, et al: Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 118:2609-2619, 2008 (Pubitemid 351949788)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.7
, pp. 2609-2619
-
-
Guix, M.1
Faber, A.C.2
Wang, S.E.3
Olivares, M.G.4
Song, Y.5
Qu, S.6
Rinehart, C.7
Seidel, B.8
Yee, D.9
Arteaga, C.L.10
Engelman, J.A.11
-
96
-
-
70350218696
-
High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)
-
Gong Y, Yao E, Shen R, et al: High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). PLoS One 4:e7273, 2009
-
(2009)
PLoS One
, vol.4
-
-
Gong, Y.1
Yao, E.2
Shen, R.3
-
97
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma SV, Lee DY, Li B, et al: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141:69-80, 2010
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
-
98
-
-
79953046542
-
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR
-
Bivona TG, Hieronymus H, Parker J, et al: FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471:523-526, 2011
-
(2011)
Nature
, vol.471
, pp. 523-526
-
-
Bivona, T.G.1
Hieronymus, H.2
Parker, J.3
-
99
-
-
34250898667
-
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt
-
DOI 10.1158/0008-5472.CAN-06-3020
-
Yamasaki F, Johansen MJ, Zhang D, et al: Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt. Cancer Res 67:5779-5788, 2007 (Pubitemid 46985011)
-
(2007)
Cancer Research
, vol.67
, Issue.12
, pp. 5779-5788
-
-
Yamasaki, F.1
Johansen, M.J.2
Zhang, D.3
Krishnamurthy, S.4
Felix, E.5
Bartholomeusz, C.6
Aguilar, R.J.7
Kurisu, K.8
Mills, G.B.9
Hortobagyi, G.N.10
Ueno, N.T.11
-
100
-
-
43249083718
-
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: A subanalysis of the IRIS study
-
Larson RA, Druker BJ, Guilhot F, et al: Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: A subanalysis of the IRIS study. Blood 111:4022-4028, 2008
-
(2008)
Blood
, vol.111
, pp. 4022-4028
-
-
Larson, R.A.1
Druker, B.J.2
Guilhot, F.3
-
101
-
-
34147174980
-
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
-
DOI 10.1182/blood-2006-07-036012
-
Picard S, Titier K, Etienne G, et al: Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 109:3496-3499, 2007 (Pubitemid 46572540)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3496-3499
-
-
Picard, S.1
Titier, K.2
Etienne, G.3
Teilhet, E.4
Ducint, D.5
Bernard, M.-A.6
Lassalle, R.7
Marit, G.8
Reiffers, J.9
Begaud, B.10
Moore, N.11
Molimard, M.12
Mahon, F.-X.13
-
102
-
-
68849113721
-
Drug monitoring of imatinib levels in patients undergoing therapy for chronic myeloid leukaemia: Comparing plasma levels of responders and non-responders
-
Singh N, Kumar L, Meena R, et al: Drug monitoring of imatinib levels in patients undergoing therapy for chronic myeloid leukaemia: Comparing plasma levels of responders and non-responders. Eur J Clin Pharmacol 65:545-549, 2009
-
(2009)
Eur J Clin Pharmacol
, vol.65
, pp. 545-549
-
-
Singh, N.1
Kumar, L.2
Meena, R.3
-
103
-
-
77952467377
-
Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
-
Marin D, Bazeos A, Mahon FX, et al: Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 28:2381-2388, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 2381-2388
-
-
Marin, D.1
Bazeos, A.2
Mahon, F.X.3
-
104
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al: Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 19:2240-2247, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
105
-
-
80053531654
-
Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: Implications for clinical trial design
-
Chaft JE, Oxnard GR, Sima CS, et al: Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: Implications for clinical trial design. Clin Cancer Res 17:6298-6303, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6298-6303
-
-
Chaft, J.E.1
Oxnard, G.R.2
Sima, C.S.3
-
106
-
-
84863827626
-
Disease flare after treatment discontinuation in a patient with EML4-ALK lung cancer and acquired resistance to crizotinib
-
Pop O, Pirvu A, Toffart AC, et al: Disease flare after treatment discontinuation in a patient with EML4-ALK lung cancer and acquired resistance to crizotinib. J Thorac Oncol 7:e1-e2, 2012
-
(2012)
J Thorac Oncol
, vol.7
-
-
Pop, O.1
Pirvu, A.2
Toffart, A.C.3
-
107
-
-
84871756952
-
Use of research biopsies in clinical trials: Are risks and benefits adequately discussed?
-
Overman MJ, Modak J, Kopetz S, et al: Use of research biopsies in clinical trials: Are risks and benefits adequately discussed? J Clin Oncol 31:17-22, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 17-22
-
-
Overman, M.J.1
Modak, J.2
Kopetz, S.3
-
108
-
-
84871780523
-
Toward improved understanding of the ethical and clinical issues surrounding mandatory research biopsies
-
Peppercorn J: Toward improved understanding of the ethical and clinical issues surrounding mandatory research biopsies. J Clin Oncol 31:1-2, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 1-2
-
-
Peppercorn, J.1
-
109
-
-
65249127504
-
Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small cell lung cancer
-
Kuang Y, Rogers A, Yeap BY, et al: Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small cell lung cancer. Clin Cancer Res 15:2630-2636, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2630-2636
-
-
Kuang, Y.1
Rogers, A.2
Yeap, B.Y.3
-
110
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S, Sequist LV, Nagrath S, et al: Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359:366-377, 2008
-
(2008)
N Engl J Med
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
-
111
-
-
84870317390
-
Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
-
Weickhardt AJ, Scheier B, Burke JM, et al: Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol 7:1807-1814, 2012
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1807-1814
-
-
Weickhardt, A.J.1
Scheier, B.2
Burke, J.M.3
-
112
-
-
80054766947
-
Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure
-
Shukuya T, Takahashi T, Naito T, et al: Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure. Lung Cancer 74:457-461, 2011
-
(2011)
Lung Cancer
, vol.74
, pp. 457-461
-
-
Shukuya, T.1
Takahashi, T.2
Naito, T.3
-
113
-
-
84871495757
-
Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors
-
abstr 7527
-
Yu H, Sima C, Drilon A, et al: Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors. J Clin Oncol 30:486s, 2012 (suppl; abstr 7527)
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Yu, H.1
Sima, C.2
Drilon, A.3
-
114
-
-
84866751861
-
Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR-mutant lung cancer
-
abstr 7547
-
Oxnard G, Lo P, Jackman D, et al: Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR-mutant lung cancer. J Clin Oncol 30:491s, 2012 (suppl; abstr 7547)
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Oxnard, G.1
Lo, P.2
Jackman, D.3
-
115
-
-
0037438467
-
Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
-
DOI 10.1182/blood-2002-05-1451
-
Kantarjian HM, Talpaz M, O'Brien S, et al: Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood 101:473-475, 2003 (Pubitemid 36077567)
-
(2003)
Blood
, vol.101
, Issue.2
, pp. 473-475
-
-
Kantarjian, H.M.1
Talpaz, M.2
O'Brien, S.3
Giles, F.4
Garcia-Manero, G.5
Faded, S.6
Thomas, D.7
Shan, J.8
Rios, M.B.9
Cortes, J.10
-
116
-
-
39149127634
-
Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
-
DOI 10.1200/JCO.2007.13.4452
-
Blanke CD, Rankin C, Demetri GD, et al: Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 26:626-632, 2008 (Pubitemid 351264358)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.4
, pp. 626-632
-
-
Blanke, C.D.1
Rankin, C.2
Demetri, G.D.3
Ryan, C.W.4
Von Mehren, M.5
Benjamin, R.S.6
Raymond, A.K.7
Bramwell, V.H.C.8
Baker, L.H.9
Maki, R.G.10
Tanaka, M.11
Hecht, J.R.12
Heinrich, M.C.13
Fletcher, C.D.M.14
Crowley, J.J.15
Borden, E.C.16
-
117
-
-
84866600466
-
Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer
-
Foo J, Chmielecki J, Pao W, et al: Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer. J Thorac Oncol 7:1583-1593, 2012
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1583-1593
-
-
Foo, J.1
Chmielecki, J.2
Pao, W.3
-
118
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
DOI 10.1056/NEJMoa055229
-
Talpaz M, Shah NP, Kantarjian H, et al: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354:2531-2541, 2006 (Pubitemid 43882349)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
119
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
DOI 10.1182/blood-2006-09-047266
-
Hochhaus A, Kantarjian HM, Baccarani M, et al: Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 109:2303-2309, 2007 (Pubitemid 46425867)
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.M.2
Baccarani, M.3
Lipton, J.H.4
Apperley, J.F.5
Druker, B.J.6
Facon, T.7
Goldberg, S.L.8
Cervantes, F.9
Niederwieser, D.10
Silver, R.T.11
Stone, R.M.12
Hughes, T.P.13
Muller, M.C.14
Ezzeddine, R.15
Countouriotis, A.M.16
Shah, N.P.17
-
120
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
DOI 10.1056/NEJMoa055104
-
Kantarjian H, Giles F, Wunderle L, et al: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354:2542-2551, 2006 (Pubitemid 43882350)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
Bhalla, K.4
O'Brien, S.5
Wassmann, B.6
Tanaka, C.7
Manley, P.8
Rae, P.9
Mietlowski, W.10
Bochinski, K.11
Hochhaus, A.12
Griffin, J.D.13
Hoelzer, D.14
Albitar, M.15
Dugan, M.16
Cortes, J.17
Alland, L.18
Ottmann, O.G.19
-
121
-
-
36348968931
-
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
-
DOI 10.1182/blood-2007-03-080689
-
Kantarjian HM, Giles F, Gattermann N, et al: Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 110:3540-3546, 2007 (Pubitemid 350159618)
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3540-3546
-
-
Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
Bhalla, K.4
Alimena, G.5
Palandri, F.6
Ossenkoppele, G.J.7
Nicolini, F.-E.8
O'Brien, S.G.9
Litzow, M.10
Bhatia, R.11
Cervantes, F.12
Haque, A.13
Shou, Y.14
Resta, D.J.15
Weitzman, A.16
Hochhaus, A.17
Le, C.P.18
-
122
-
-
80055070888
-
Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
-
Cortes JE, Kantarjian HM, Brümmendorf TH, et al: Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood 118:4567-4576, 2011
-
(2011)
Blood
, vol.118
, pp. 4567-4576
-
-
Cortes, J.E.1
Kantarjian, H.M.2
Brümmendorf, T.H.3
-
123
-
-
84870012939
-
Ponatinib in refractory Philadelphia chromosome-positive leukemias
-
Cortes JE, Kantarjian H, Shah NP, et al: Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med 367:2075-2088, 2012
-
(2012)
N Engl J Med
, vol.367
, pp. 2075-2088
-
-
Cortes, J.E.1
Kantarjian, H.2
Shah, N.P.3
-
124
-
-
84858669035
-
Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence
-
Ou SH: Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence. Crit Rev Oncol Hematol 83:407-421, 2012
-
(2012)
Crit Rev Oncol Hematol
, vol.83
, pp. 407-421
-
-
Ou, S.H.1
-
125
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
DOI 10.1073/pnas.0502860102
-
Kwak EL, Sordella R, Bell DW, et al: Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A 102:7665-7670, 2005 (Pubitemid 40741028)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.21
, pp. 7665-7670
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
Godin-Heymann, N.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Driscoll, D.R.8
Fidias, P.9
Lynch, T.J.10
Rabindran, S.K.11
McGinnis, J.P.12
Wissner, A.13
Sharma, S.V.14
Isselbacher, K.J.15
Settleman, J.16
Haber, D.A.17
-
126
-
-
37549061078
-
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
-
Engelman JA, Zejnullahu K, Gale CM, et al: PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 67:11924-11932, 2007
-
(2007)
Cancer Res
, vol.67
, pp. 11924-11932
-
-
Engelman, J.A.1
Zejnullahu, K.2
Gale, C.M.3
-
127
-
-
77954584507
-
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a phase II trial in patients with advanced non-small-cell lung cancer
-
Sequist LV, Besse B, Lynch TJ, et al: Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 28:3076-3083, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
-
128
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, et al: Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial. Lancet Oncol 13:528-538, 2012
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
129
-
-
72949092456
-
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
-
Zhou W, Ercan D, Chen L, et al: Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462:1070-1074, 2009
-
(2009)
Nature
, vol.462
, pp. 1070-1074
-
-
Zhou, W.1
Ercan, D.2
Chen, L.3
-
130
-
-
84872217794
-
CO-1686, an orally available, mutant-slective inhibitor of the epidermal growth factor receptor (EGFR), causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations
-
Presented at the
-
Walter A, Tjin R, Haringsma H, et al: CO-1686, an orally available, mutant-slective inhibitor of the epidermal growth factor receptor (EGFR), causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations. Presented at the International Conference of the American Association for Cancer Res-National Cancer Institute-European Organization for Research and Treatment of Cancer, San Francisco, CA, November 12-16, 2011
-
International Conference of the American Association for Cancer Res-National Cancer Institute-European Organization for Research and Treatment of Cancer, San Francisco, CA, November 12-16, 2011
-
-
Walter, A.1
Tjin, R.2
Haringsma, H.3
-
131
-
-
84878370168
-
Results of a first-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumors
-
abstr 440O
-
Shaw A, Camidge R, Felip E, et al: Results of a first-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumors. Ann Oncol 23:153, 2012 (suppl; abstr 440O)
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL.
, pp. 153
-
-
Shaw, A.1
Camidge, R.2
Felip, E.3
-
132
-
-
84878371081
-
A first-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies
-
abstr 439O
-
Gettinger S, Weiss G, Salgia R, et al: A first-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies. Ann Oncol 23:152, 2012 (suppl; abstr 439O)
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL.
, pp. 152
-
-
Gettinger, S.1
Weiss, G.2
Salgia, R.3
-
133
-
-
84896996800
-
Antitumor activities of ASP3026 against EML4-ALK-dependent tumor models
-
Presented at the
-
Kuromitsu S, Mori M, Shimada I, et al: Antitumor activities of ASP3026 against EML4-ALK-dependent tumor models. Presented at the International Conference of the American Association for Cancer Res-National Cancer Institute-European Organization for Research and Treatment of Cancer, San Francisco, CA, November 12-16, 2011
-
International Conference of the American Association for Cancer Res-National Cancer Institute-European Organization for Research and Treatment of Cancer, San Francisco, CA, November 12-16, 2011
-
-
Kuromitsu, S.1
Mori, M.2
Shimada, I.3
-
134
-
-
79955964568
-
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
-
Sakamoto H, Tsukaguchi T, Hiroshima S, et al: CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell 19:679-690, 2011
-
(2011)
Cancer Cell
, vol.19
, pp. 679-690
-
-
Sakamoto, H.1
Tsukaguchi, T.2
Hiroshima, S.3
-
135
-
-
84878348064
-
A phase I/II study of ALK inhibitor CH5424802 in patients with ALK-positive NSCLC; safety and efficacy interim results of the phase II portion
-
abstr 441O
-
Nishio M, Kiura K, Nakagawa K, et al: A phase I/II study of ALK inhibitor CH5424802 in patients with ALK-positive NSCLC; safety and efficacy interim results of the phase II portion. Ann Oncol 23:153, 2012 (suppl; abstr 441O)
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL.
, pp. 153
-
-
Nishio, M.1
Kiura, K.2
Nakagawa, K.3
-
136
-
-
84863600752
-
Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET
-
Xu L, Kikuchi E, Xu C, et al: Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET. Cancer Res 72:3302-3311, 2012
-
(2012)
Cancer Res
, vol.72
, pp. 3302-3311
-
-
Xu, L.1
Kikuchi, E.2
Xu, C.3
-
137
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
Regales L, Gong Y, Shen R, et al: Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 119:3000-3010, 2009
-
(2009)
J Clin Invest
, vol.119
, pp. 3000-3010
-
-
Regales, L.1
Gong, Y.2
Shen, R.3
-
138
-
-
84873677937
-
Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors
-
abstr 12270
-
Janjigian Y, Smit E, Horn L, et al: Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors. Ann Oncol 23:401, 2012 (suppl; abstr 12270)
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL.
, pp. 401
-
-
Janjigian, Y.1
Smit, E.2
Horn, L.3
-
139
-
-
44649083135
-
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
-
Shimamura T, Li D, Ji H, et al: Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res 68:5827-5838, 2008
-
(2008)
Cancer Res
, vol.68
, pp. 5827-5838
-
-
Shimamura, T.1
Li, D.2
Ji, H.3
-
140
-
-
84866382273
-
Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC)
-
abstr 7543
-
Garon E, Moran T, Barlesi F, et al: Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC). J Clin Oncol 30:490s, 2012 (suppl; abstr 7543)
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Garon, E.1
Moran, T.2
Barlesi, F.3
-
141
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
-
Chen Z, Sasaki T, Tan X, et al: Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res 70:9827-9836, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
-
142
-
-
79957896979
-
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models
-
Normant E, Paez G, West KA, et al: The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models. Oncogene 30:2581-2586, 2011
-
(2011)
Oncogene
, vol.30
, pp. 2581-2586
-
-
Normant, E.1
Paez, G.2
West, K.A.3
-
143
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
Sequist LV, Gettinger S, Senzer NN, et al: Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 28:4953-4960, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
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