p16INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer

Clinical Cancer Research

Volumn 8, Issue 12, 2002, Pages 3782-3787

  Bearzatto, Alessandra ^a   Conte, Davide ^a   Frattini, Milo ^a   Zaffaroni, Nadia ^a   Andriani, Francesca ^a   Balestra, Debora ^a   Tavecchio, Luca ^a   Daidone, Maria Grazia ^a   Sozzi, Gabriella ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; PROTEIN P16;

ADULT; ARTICLE; BODY FLUID; CANCER DIAGNOSIS; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FISHER EXACT TEST; FLUORESCENCE; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MALE; METHYLATION; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRECURSOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TUMOR SUPPRESSOR GENE;

CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOMES, HUMAN, PAIR 3; COHORT STUDIES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENES, RAS; HUMANS; LUNG NEOPLASMS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0036898622     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Hirsch, F. R., Franklin, W. A., Gazdar, A. F., and Bunn, P. A., Jr. Early detection of lung cancer: Clinical perspectives of recent advances in biology and radiology. Clin. Cancer Res., 7: 5-22, 2001.
2. Kersting, M., Friedl, C., Kraus, A., Behn, M., Pankow, W., and Schuermann, M. J. Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J. Clin. Oncol., 18: 3221-3229, 2000.
3. Esteller, M., Sanchez-Cespedes, M., Rosell, R., Sidransky, D., Baylin, S. B., and Herman, J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res., 59: 67-70, 1999.
4. Sozzi, G., Conte, D., Mariani, L., Lo Vullo, S., Roz, L., Lombardo, C., Pierotti, M. A., and Tavecchio, L. Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Res., 61: 4675-4678, 2001.
5. Sozzi, G., Musso, K., Ratcliffe, C., Goldstraw, P., Pierotti, M. A., and Pastorino, U. Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: A prospect for early diagnosis. Clin. Cancer Res., 5: 2689-2692, 1999.
6. Coulet, F., Blons, H., Cabelguenne, A., Lecomte, T., Lacourreye, O., Brasnu, D., Beaune, P., Zucman, J., and Laurent-Puig, P. Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis. Cancer Res., 60: 707-711, 2000.
7. Kopreski, M. S., Benko, F. A., Borys, D. J., Khan, A., McGarrity, T. J., and Gocke, C. D. Somatic mutation screening: Identification of individuals harboring K-ras mutations with the use of plasma DNA. J. Natl. Cancer Inst. (Bethesda), 92: 918-923, 2000.
8. Baylin, S. B., and Herman, J. G. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics. Trends Genet., 16: 168-174, 2000.
9. Palmisano, W. A., Divine, K. K., Saccomanno, G., Gilliland, F. D., Baylin, S. B., Herman, J. G., and Belinsky, S. A. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res., 60: 5954-5958, 2000.
10. Ahrendt, S. A., Chow, J. T., Xu, L. H., Yang, S. C., Eisenberger, C. F., Esteller, M., Herman, J. G., Wu, L., Decker, P. A., Jen, J., and Sidransky, D. Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J. Natl. Cancer. Inst. (Bethesda), 91: 332-339, 1999.
11. Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., and Ohyashiki, K. Hypermethylation of p16(INK4a) and p15(INK4b) genes in non-small cell lung cancer. Int. J. Oncol., 19: 277-281, 2001.
12. Belinsky, S. A., Nikula, K. J., Palmisano, W. A., Michels, R., Saccomanno, G., Gabrielson, E., Baylin, S. B., and Herman, J. G. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc. Natl. Acad. Sci. USA, 95: 11891-11896, 1998.
13. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 93: 9821-9826, 1996.
14. Liloglu, T., Maloney, P., Xinarianos, G., Fear, S., and Field, J. K. Sensitivity and limitations of high throughput fluorescent microsatellite analysis for the detection of allelic imbalance: Application in lung tumors. Int. J. Oncol., 16: 5-14, 2000.
15. Nollau, P., Moser, C., Weinland, G., and Wagener, C. Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR. Int. J. Cancer, 66: 332-336, 1996.
16. Goessl, C., Krause, H., Muller, M., Heicappell, R., Schrader, M., Sachsinger, J., and Miller, K. Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids. Cancer Res., 60: 5941-5945, 2000.
17. Esteller, M., Corn, P. G., Baylin, S. B., and Herman, J. G. A gene hypermethylation profile of human cancer. Cancer Res., 61: 3225-3229, 2001.
18. Oshita, F., Nomura, I., Yamada, K., Kato, Y., Tanaka, G., and Noda, K. Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions. Clin. Cancer Res., 5: 617-620, 1999.
19. Dong, S. M., Traverso, G., Johnson, C., Geng, L., Favis, R., Boynton, K., Hibi, K., Goodman, S. N., D'Allessio, M., Paty, P., Hamilton, S. R., Sidransky, D., Barany, F., Levin, B., Shuber, A., Kinzler, K. W., Vogelstein, B., and Jen, J. Detecting colorectal cancer in stool with the use of multiple genetic targets. J. Natl. Cancer Inst. (Bethesda), 93: 858-865, 2001.
20. Sugio, K., Kishimoto, Y., Virmani, A. K., Hung, J. Y., and Gazdar, A. F. K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. Cancer Res., 54: 5811-5815, 1994.