Combined therapy with mutant-selective EGFR inhibitor and met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer

Molecular Cancer Therapeutics

Volumn 11, Issue 10, 2012, Pages 2149-2157

  Nakagawa, Takayuki ^a,c   Takeuchi, Shinji ^a   Yamada, Tadaaki ^a   Nanjo, Shigeki ^a   Ishikawa, Daisuke ^a   Sano, Takako ^a   Kita, Kenji ^a   Nakamura, Takahiro ^a   Matsumoto, Kunio ^a   Suda, Kenichi ^b   Mitsudomi, Tetsuya ^b   Sekido, Yoshitaka ^b   Uenaka, Toshimitsu ^c   Yano, Seiji ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; GOLVATINIB; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; WZ4002;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EXON; GENE DELETION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ACRYLAMIDES; AMINOPYRIDINES; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; HEPATOCYTE GROWTH FACTOR; HUMANS; LUNG NEOPLASMS; MICE; MICE, SCID; MICROVESSELS; MUTATION; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867406340     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0195     Document Type: Article

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