-
1
-
-
55049133396
-
Bacteriophage genomics
-
Hatfull G.F. Bacteriophage genomics. Curr. Opin. Microbiol. 2008, 11:447-453.
-
(2008)
Curr. Opin. Microbiol.
, vol.11
, pp. 447-453
-
-
Hatfull, G.F.1
-
2
-
-
77951104433
-
Bacteriophage resistance mechanisms
-
Labrie S.J., et al. Bacteriophage resistance mechanisms. Nat. Rev. Microbiol. 2010, 8:317-327.
-
(2010)
Nat. Rev. Microbiol.
, vol.8
, pp. 317-327
-
-
Labrie, S.J.1
-
3
-
-
78650045540
-
The phage-host arms race: shaping the evolution of microbes
-
Stern A., Sorek R. The phage-host arms race: shaping the evolution of microbes. Bioessays 2011, 33:43-51.
-
(2011)
Bioessays
, vol.33
, pp. 43-51
-
-
Stern, A.1
Sorek, R.2
-
4
-
-
84870180587
-
The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity
-
Westra E.R., et al. The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity. Annu. Rev. Genet. 2012, 46:311-339.
-
(2012)
Annu. Rev. Genet.
, vol.46
, pp. 311-339
-
-
Westra, E.R.1
-
5
-
-
84884286187
-
Revenge of the phages: defeating bacterial defences
-
Samson J.E., et al. Revenge of the phages: defeating bacterial defences. Nat. Rev. Microbiol. 2013, 11:675-687.
-
(2013)
Nat. Rev. Microbiol.
, vol.11
, pp. 675-687
-
-
Samson, J.E.1
-
6
-
-
84878936806
-
CRISPR-mediated adaptive immune systems in bacteria and archaea
-
Sorek R., et al. CRISPR-mediated adaptive immune systems in bacteria and archaea. Annu. Rev. Biochem. 2013, 82:237-266.
-
(2013)
Annu. Rev. Biochem.
, vol.82
, pp. 237-266
-
-
Sorek, R.1
-
8
-
-
80755187812
-
CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation
-
Bhaya D., et al. CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. Annu. Rev. Genet. 2011, 45:273-297.
-
(2011)
Annu. Rev. Genet.
, vol.45
, pp. 273-297
-
-
Bhaya, D.1
-
9
-
-
84857097177
-
RNA-guided genetic silencing systems in bacteria and archaea
-
Wiedenheft B., et al. RNA-guided genetic silencing systems in bacteria and archaea. Nature 2012, 482:331-338.
-
(2012)
Nature
, vol.482
, pp. 331-338
-
-
Wiedenheft, B.1
-
10
-
-
34248400310
-
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
-
Haft D.H., et al. A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput. Biol. 2005, 1:e60.
-
(2005)
PLoS Comput. Biol.
, vol.1
-
-
Haft, D.H.1
-
11
-
-
79956157571
-
Evolution and classification of the CRISPR-Cas systems
-
Makarova K.S., et al. Evolution and classification of the CRISPR-Cas systems. Nat. Rev. Microbiol. 2011, 9:467-477.
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 467-477
-
-
Makarova, K.S.1
-
12
-
-
84878211288
-
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
-
Chylinski K., et al. The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biol. 2013, 10:726-737.
-
(2013)
RNA Biol.
, vol.10
, pp. 726-737
-
-
Chylinski, K.1
-
13
-
-
84895832944
-
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
-
Fonfara I., et al. Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems. Nucleic Acids Res. 2013, 10.1093/nar/gkt1074.
-
(2013)
Nucleic Acids Res.
-
-
Fonfara, I.1
-
14
-
-
34248374277
-
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
-
Makarova K.S., et al. A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol. Direct 2006, 1:7.
-
(2006)
Biol. Direct
, vol.1
, pp. 7
-
-
Makarova, K.S.1
-
15
-
-
57849137502
-
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
-
Marraffini L.A., Sontheimer E.J. CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science 2008, 322:1843-1845.
-
(2008)
Science
, vol.322
, pp. 1843-1845
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
16
-
-
78149261827
-
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau J.E., et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 2010, 468:67-71.
-
(2010)
Nature
, vol.468
, pp. 67-71
-
-
Garneau, J.E.1
-
17
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas G., et al. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2579-E2586.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
-
-
Gasiunas, G.1
-
18
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M., et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012, 337:816-821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
19
-
-
84866951828
-
An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA
-
Fischer S., et al. An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA. J. Biol. Chem. 2012, 287:33351-33363.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 33351-33363
-
-
Fischer, S.1
-
20
-
-
78650244167
-
Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers
-
Gudbergsdottir S., et al. Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers. Mol. Microbiol. 2011, 79:35-49.
-
(2011)
Mol. Microbiol.
, vol.79
, pp. 35-49
-
-
Gudbergsdottir, S.1
-
21
-
-
79953887840
-
In vivo activity of CRISPR-mediated virus defence in a hyperthermophilic archaeon
-
Manica A., et al. In vivo activity of CRISPR-mediated virus defence in a hyperthermophilic archaeon. Mol. Microbiol. 2011, 80:481-491.
-
(2011)
Mol. Microbiol.
, vol.80
, pp. 481-491
-
-
Manica, A.1
-
22
-
-
84856778250
-
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity
-
Zhang J., et al. Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity. Mol. Cell 2012, 45:303-313.
-
(2012)
Mol. Cell
, vol.45
, pp. 303-313
-
-
Zhang, J.1
-
23
-
-
70449753811
-
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex
-
Hale C.R., et al. RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell 2009, 139:945-956.
-
(2009)
Cell
, vol.139
, pp. 945-956
-
-
Hale, C.R.1
-
24
-
-
84856792673
-
Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs
-
Hale C.R., et al. Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Mol. Cell 2012, 45:292-302.
-
(2012)
Mol. Cell
, vol.45
, pp. 292-302
-
-
Hale, C.R.1
-
25
-
-
84885355637
-
Structure of an RNA silencing complex of the CRISPR-Cas immune system
-
Spilman M., et al. Structure of an RNA silencing complex of the CRISPR-Cas immune system. Mol. Cell 2013, 52:146-152.
-
(2013)
Mol. Cell
, vol.52
, pp. 146-152
-
-
Spilman, M.1
-
26
-
-
84885334898
-
Structure and activity of the RNA-targeting type III-B CRISPR-Cas complex of Thermus thermophilus
-
Staals R.H., et al. Structure and activity of the RNA-targeting type III-B CRISPR-Cas complex of Thermus thermophilus. Mol. Cell 2013, 52:135-145.
-
(2013)
Mol. Cell
, vol.52
, pp. 135-145
-
-
Staals, R.H.1
-
27
-
-
34047118522
-
CRISPR provides acquired resistance against viruses in prokaryotes
-
Barrangou R., et al. CRISPR provides acquired resistance against viruses in prokaryotes. Science 2007, 315:1709-1712.
-
(2007)
Science
, vol.315
, pp. 1709-1712
-
-
Barrangou, R.1
-
28
-
-
84864864464
-
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
-
Datsenko K.A., et al. Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system. Nat. Commun. 2012, 3:945.
-
(2012)
Nat. Commun.
, vol.3
, pp. 945
-
-
Datsenko, K.A.1
-
29
-
-
84866023604
-
Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms
-
Erdmann S., Garrett R.A. Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms. Mol. Microbiol. 2012, 85:1044-1056.
-
(2012)
Mol. Microbiol.
, vol.85
, pp. 1044-1056
-
-
Erdmann, S.1
Garrett, R.A.2
-
30
-
-
84860433123
-
CRISPR interference directs strand specific spacer acquisition
-
Swarts D.C., et al. CRISPR interference directs strand specific spacer acquisition. PLoS ONE 2012, 7:e35888.
-
(2012)
PLoS ONE
, vol.7
-
-
Swarts, D.C.1
-
31
-
-
84861639567
-
Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli
-
Yosef I., et al. Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli. Nucleic Acids Res. 2012, 40:5569-5576.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 5569-5576
-
-
Yosef, I.1
-
32
-
-
49649114086
-
Small CRISPR RNAs guide antiviral defense in prokaryotes
-
Brouns S.J., et al. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 2008, 321:960-964.
-
(2008)
Science
, vol.321
, pp. 960-964
-
-
Brouns, S.J.1
-
33
-
-
78149355930
-
Binding and cleavage of CRISPR RNA by Cas6
-
Carte J., et al. Binding and cleavage of CRISPR RNA by Cas6. RNA 2010, 16:2181-2188.
-
(2010)
RNA
, vol.16
, pp. 2181-2188
-
-
Carte, J.1
-
34
-
-
58049191229
-
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes
-
Carte J., et al. Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes. Genes Dev. 2008, 22:3489-3496.
-
(2008)
Genes Dev.
, vol.22
, pp. 3489-3496
-
-
Carte, J.1
-
35
-
-
79953250082
-
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
-
Deltcheva E., et al. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 2011, 471:602-607.
-
(2011)
Nature
, vol.471
, pp. 602-607
-
-
Deltcheva, E.1
-
36
-
-
84867678349
-
Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases
-
Garside E.L., et al. Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases. RNA 2012, 18:2020-2028.
-
(2012)
RNA
, vol.18
, pp. 2020-2028
-
-
Garside, E.L.1
-
37
-
-
84855475577
-
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
-
Hatoum-Aslan A., et al. Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:21218-21222.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 21218-21222
-
-
Hatoum-Aslan, A.1
-
38
-
-
77956498326
-
Sequence- and structure-specific RNA processing by a CRISPR endonuclease
-
Haurwitz R.E., et al. Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science 2010, 329:1355-1358.
-
(2010)
Science
, vol.329
, pp. 1355-1358
-
-
Haurwitz, R.E.1
-
39
-
-
57049149666
-
Prokaryotic silencing (psi)RNAs in Pyrococcus furiosus
-
Hale C., et al. Prokaryotic silencing (psi)RNAs in Pyrococcus furiosus. RNA 2008, 14:2572-2579.
-
(2008)
RNA
, vol.14
, pp. 2572-2579
-
-
Hale, C.1
-
40
-
-
79958754524
-
Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE)
-
Lintner N.G., et al. Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE). J. Biol. Chem. 2011, 286:21643-21656.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 21643-21656
-
-
Lintner, N.G.1
-
41
-
-
80053169737
-
Structures of the RNA-guided surveillance complex from a bacterial immune system
-
Wiedenheft B., et al. Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature 2011, 477:486-489.
-
(2011)
Nature
, vol.477
, pp. 486-489
-
-
Wiedenheft, B.1
-
42
-
-
79960029056
-
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
-
Wiedenheft B., et al. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:10092-10097.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 10092-10097
-
-
Wiedenheft, B.1
-
43
-
-
79955574254
-
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
-
Jore M.M., et al. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat. Struct. Mol. Biol. 2011, 18:529-536.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 529-536
-
-
Jore, M.M.1
-
44
-
-
81255160844
-
Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference
-
Beloglazova N., et al. Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference. EMBO J. 2011, 30:4616-4627.
-
(2011)
EMBO J.
, vol.30
, pp. 4616-4627
-
-
Beloglazova, N.1
-
45
-
-
79953779608
-
Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system
-
Sinkunas T., et al. Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system. EMBO J. 2011, 30:1335-1342.
-
(2011)
EMBO J.
, vol.30
, pp. 1335-1342
-
-
Sinkunas, T.1
-
46
-
-
80755145195
-
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
-
Sapranauskas R., et al. The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. Nucleic Acids Res. 2011, 39:9275-9282.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 9275-9282
-
-
Sapranauskas, R.1
-
47
-
-
84940100856
-
Applications of the versatile CRISPR-Cas systems
-
Springer-Verlag, R. Barrangou, J. van der Oost (Eds.)
-
Horvath P., et al. Applications of the versatile CRISPR-Cas systems. CRISPR-Cas Systems: RNA-mediated Adative Immunity in Bacteria and Archaea 2012, 267-278. Springer-Verlag. R. Barrangou, J. van der Oost (Eds.).
-
(2012)
CRISPR-Cas Systems: RNA-mediated Adative Immunity in Bacteria and Archaea
, pp. 267-278
-
-
Horvath, P.1
-
48
-
-
84882787078
-
The CRISPR craze
-
Pennisi E. The CRISPR craze. Science 2013, 341:833-836.
-
(2013)
Science
, vol.341
, pp. 833-836
-
-
Pennisi, E.1
-
49
-
-
84880121815
-
Exploiting CRISPR/Cas: interference mechanisms and applications
-
Richter H., et al. Exploiting CRISPR/Cas: interference mechanisms and applications. Int. J. Mol. Sci. 2013, 14:14518-14531.
-
(2013)
Int. J. Mol. Sci.
, vol.14
, pp. 14518-14531
-
-
Richter, H.1
-
50
-
-
44449133775
-
Virus population dynamics and acquired virus resistance in natural microbial communities
-
Andersson A.F., Banfield J.F. Virus population dynamics and acquired virus resistance in natural microbial communities. Science 2008, 320:1047-1050.
-
(2008)
Science
, vol.320
, pp. 1047-1050
-
-
Andersson, A.F.1
Banfield, J.F.2
-
51
-
-
84862657238
-
CRISPR: new horizons in phage resistance and strain identification
-
Barrangou R., Horvath P. CRISPR: new horizons in phage resistance and strain identification. Annu. Rev. Food Sci. Technol. 2012, 3:143-162.
-
(2012)
Annu. Rev. Food Sci. Technol.
, vol.3
, pp. 143-162
-
-
Barrangou, R.1
Horvath, P.2
-
52
-
-
84872243390
-
The combination of CRISPR-MVLST and PFGE provides increased discriminatory power for differentiating human clinical isolates of Salmonella enterica subsp. enterica serovar Enteritidis
-
Shariat N., et al. The combination of CRISPR-MVLST and PFGE provides increased discriminatory power for differentiating human clinical isolates of Salmonella enterica subsp. enterica serovar Enteritidis. Food Microbiol. 2013, 34:164-173.
-
(2013)
Food Microbiol.
, vol.34
, pp. 164-173
-
-
Shariat, N.1
-
53
-
-
84869231487
-
Use of clustered regularly interspaced short palindromic repeat sequence polymorphisms for specific detection of enterohemorrhagic Escherichia coli strains of serotypes O26:H11, O45:H2, O103:H2, O111:H8, O121:H19, O145:H28, and O157:H7 by real-time PCR
-
Delannoy S., et al. Use of clustered regularly interspaced short palindromic repeat sequence polymorphisms for specific detection of enterohemorrhagic Escherichia coli strains of serotypes O26:H11, O45:H2, O103:H2, O111:H8, O121:H19, O145:H28, and O157:H7 by real-time PCR. J. Clin. Microbiol. 2012, 50:4035-4040.
-
(2012)
J. Clin. Microbiol.
, vol.50
, pp. 4035-4040
-
-
Delannoy, S.1
-
54
-
-
84865169354
-
CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome
-
Stern A., et al. CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome. Genome Res. 2012, 22:1985-1994.
-
(2012)
Genome Res.
, vol.22
, pp. 1985-1994
-
-
Stern, A.1
-
55
-
-
84892453591
-
CRISPRs: molecular signatures used for pathogen subtyping
-
Shariat N., Dudley E.G. CRISPRs: molecular signatures used for pathogen subtyping. Appl. Environ. Microbiol. 2014, 80:430-439.
-
(2014)
Appl. Environ. Microbiol.
, vol.80
, pp. 430-439
-
-
Shariat, N.1
Dudley, E.G.2
-
56
-
-
84879028690
-
Programmable plasmid interference by the CRISPR-Cas system in Thermococcus kodakarensis
-
Elmore J.R., et al. Programmable plasmid interference by the CRISPR-Cas system in Thermococcus kodakarensis. RNA Biol. 2013, 10:828-840.
-
(2013)
RNA Biol.
, vol.10
, pp. 828-840
-
-
Elmore, J.R.1
-
57
-
-
77956628107
-
Transcription, processing and function of CRISPR cassettes in Escherichia coli
-
Pougach K., et al. Transcription, processing and function of CRISPR cassettes in Escherichia coli. Mol. Microbiol. 2010, 77:1367-1379.
-
(2010)
Mol. Microbiol.
, vol.77
, pp. 1367-1379
-
-
Pougach, K.1
-
58
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov F.D., et al. Genome editing with engineered zinc finger nucleases. Nat. Rev. Genet. 2010, 11:636-646.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
-
59
-
-
84865297223
-
Advances in targeted genome editing
-
Perez-Pinera P., et al. Advances in targeted genome editing. Curr. Opin. Chem. Biol. 2012, 16:268-277.
-
(2012)
Curr. Opin. Chem. Biol.
, vol.16
, pp. 268-277
-
-
Perez-Pinera, P.1
-
60
-
-
84871519181
-
TALENs: a widely applicable technology for targeted genome editing
-
Joung J.K., Sander J.D. TALENs: a widely applicable technology for targeted genome editing. Nat. Rev. Mol. Cell Biol. 2013, 14:49-55.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 49-55
-
-
Joung, J.K.1
Sander, J.D.2
-
61
-
-
84887018028
-
RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?
-
Gasiunas G., Siksnys V. RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?. Trends Microbiol. 2013, 21:562-567.
-
(2013)
Trends Microbiol.
, vol.21
, pp. 562-567
-
-
Gasiunas, G.1
Siksnys, V.2
-
62
-
-
84884856342
-
Cas9 as a versatile tool for engineering biology
-
Mali P., et al. Cas9 as a versatile tool for engineering biology. Nat. Methods 2013, 10:957-963.
-
(2013)
Nat. Methods
, vol.10
, pp. 957-963
-
-
Mali, P.1
-
63
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
Jinek M., et al. RNA-programmed genome editing in human cells. eLife 2013, 2:e00471.
-
(2013)
eLife
, vol.2
-
-
Jinek, M.1
-
64
-
-
84874624936
-
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
-
Cho S.W., et al. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 2013, 31:230-232.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
-
65
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
66
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali P., et al. RNA-guided human genome engineering via Cas9. Science 2013, 339:823-826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
67
-
-
84884663630
-
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
-
Hou Z., et al. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:15644-15649.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 15644-15649
-
-
Hou, Z.1
-
68
-
-
84883305437
-
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
-
Ebina H., et al. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci. Rep. 2013, 3:2510.
-
(2013)
Sci. Rep.
, vol.3
, pp. 2510
-
-
Ebina, H.1
-
69
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran F.A., et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 2013, 154:1380-1389.
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
70
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu Y., et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 2013, 31:822-826.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
71
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Hsu P.D., et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 2013, 31:827-832.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
-
72
-
-
84884950106
-
CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
-
Cradick T.J., et al. CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res. 2013, 41:9584-9592.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 9584-9592
-
-
Cradick, T.J.1
-
73
-
-
84890033064
-
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
-
Schwank G., et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013, 13:653-658.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 653-658
-
-
Schwank, G.1
-
74
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem O., et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 2014, 343:84-87.
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
-
75
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang T., et al. Genetic screens in human cells using the CRISPR-Cas9 system. Science 2014, 343:80-84.
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
-
76
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Li W., et al. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol. 2013, 31:684-686.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 684-686
-
-
Li, W.1
-
77
-
-
84883819602
-
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
-
Li D., et al. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat. Biotechnol. 2013, 31:681-683.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 681-683
-
-
Li, D.1
-
78
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang H., et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 2013, 154:1370-1379.
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
-
79
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang H., et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013, 153:910-918.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
-
80
-
-
84890050551
-
Correction of a genetic disease in mouse via use of CRISPR-Cas9
-
Wu Y., et al. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell 2013, 13:659-662.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 659-662
-
-
Wu, Y.1
-
81
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang W.Y., et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 2013, 31:227-229.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
-
82
-
-
84876409836
-
Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
-
Chang N., et al. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res. 2013, 23:465-472.
-
(2013)
Cell Res.
, vol.23
, pp. 465-472
-
-
Chang, N.1
-
83
-
-
84882788354
-
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
-
Jao L.E., et al. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:13904-13909.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 13904-13909
-
-
Jao, L.E.1
-
84
-
-
84880117972
-
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
-
Xiao A., et al. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic Acids Res. 2013, 41:e141.
-
(2013)
Nucleic Acids Res.
, vol.41
-
-
Xiao, A.1
-
85
-
-
84890787845
-
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis
-
Nakayama T., et al. Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. Genesis 2013, 51:835-843.
-
(2013)
Genesis
, vol.51
, pp. 835-843
-
-
Nakayama, T.1
-
86
-
-
84890805562
-
Biallelic genome modification in F0 Xenopus tropicalis embryos using the CRISPR/Cas system
-
Blitz I.L., et al. Biallelic genome modification in F0 Xenopus tropicalis embryos using the CRISPR/Cas system. Genesis 2013, 51:827-834.
-
(2013)
Genesis
, vol.51
, pp. 827-834
-
-
Blitz, I.L.1
-
87
-
-
85042815594
-
Targeted genome modification of crop plants using a CRISPR-Cas system
-
Shan Q., et al. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat. Biotechnol. 2013, 31:686-688.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 686-688
-
-
Shan, Q.1
-
88
-
-
84883785822
-
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
-
Li J.F., et al. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat. Biotechnol. 2013, 31:688-691.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 688-691
-
-
Li, J.F.1
-
89
-
-
84885181396
-
Efficient genome editing in plants using a CRISPR/Cas system
-
Feng Z., et al. Efficient genome editing in plants using a CRISPR/Cas system. Cell Res. 2013, 23:1229-1232.
-
(2013)
Cell Res.
, vol.23
, pp. 1229-1232
-
-
Feng, Z.1
-
90
-
-
84885180177
-
Targeted mutagenesis in rice using CRISPR-Cas system
-
Miao J., et al. Targeted mutagenesis in rice using CRISPR-Cas system. Cell Res. 2013, 23:1233-1236.
-
(2013)
Cell Res.
, vol.23
, pp. 1233-1236
-
-
Miao, J.1
-
91
-
-
84886926151
-
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
-
Jiang W., et al. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res. 2013, 41:e188.
-
(2013)
Nucleic Acids Res.
, vol.41
-
-
Jiang, W.1
-
92
-
-
84883828590
-
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease
-
Nekrasov V., et al. Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat. Biotechnol. 2013, 31:691-693.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 691-693
-
-
Nekrasov, V.1
-
93
-
-
84890831873
-
RNA-guided genome editing for target gene mutations in wheat
-
Upadhyay S.K., et al. RNA-guided genome editing for target gene mutations in wheat. G3 2013, 3:2233-2238.
-
(2013)
G3
, vol.3
, pp. 2233-2238
-
-
Upadhyay, S.K.1
-
94
-
-
84892437994
-
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 System
-
Bassett A.R., et al. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 System. Cell Rep. 2013, 4:220-228.
-
(2013)
Cell Rep.
, vol.4
, pp. 220-228
-
-
Bassett, A.R.1
-
95
-
-
84887478758
-
CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand
-
Gratz S.J., et al. CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand. Fly 2013, 7:249-255.
-
(2013)
Fly
, vol.7
, pp. 249-255
-
-
Gratz, S.J.1
-
96
-
-
84880088705
-
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
-
Gratz S.J., et al. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 2013, 194:1029-1035.
-
(2013)
Genetics
, vol.194
, pp. 1029-1035
-
-
Gratz, S.J.1
-
97
-
-
84883809403
-
Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila
-
Yu Z., et al. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics 2013, 195:289-291.
-
(2013)
Genetics
, vol.195
, pp. 289-291
-
-
Yu, Z.1
-
98
-
-
84884925278
-
Highly improved gene targeting by germline-specific Cas9 expression in Drosophila
-
Kondo S., Ueda R. Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics 2013, 195:715-721.
-
(2013)
Genetics
, vol.195
, pp. 715-721
-
-
Kondo, S.1
Ueda, R.2
-
99
-
-
84893684718
-
A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering
-
Sebo Z.L., et al. A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering. Fly 2013, 8:1-6.
-
(2013)
Fly
, vol.8
, pp. 1-6
-
-
Sebo, Z.L.1
-
100
-
-
84881475586
-
Heritable genome editing in C. elegans via a CRISPR-Cas9 system
-
Friedland A.E., et al. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat. Methods 2013, 10:741-743.
-
(2013)
Nat. Methods
, vol.10
, pp. 741-743
-
-
Friedland, A.E.1
-
101
-
-
84884922656
-
Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions
-
Lo T.W., et al. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics 2013, 195:331-348.
-
(2013)
Genetics
, vol.195
, pp. 331-348
-
-
Lo, T.W.1
-
102
-
-
84884930591
-
CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans
-
Waaijers S., et al. CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans. Genetics 2013, 195:1187-1191.
-
(2013)
Genetics
, vol.195
, pp. 1187-1191
-
-
Waaijers, S.1
-
103
-
-
84884968656
-
Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system
-
Tzur Y.B., et al. Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics 2013, 195:1181-1185.
-
(2013)
Genetics
, vol.195
, pp. 1181-1185
-
-
Tzur, Y.B.1
-
104
-
-
84884943528
-
Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans
-
Katic I., Grosshans H. Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans. Genetics 2013, 195:1173-1176.
-
(2013)
Genetics
, vol.195
, pp. 1173-1176
-
-
Katic, I.1
Grosshans, H.2
-
105
-
-
84884923061
-
Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas
-
Chiu H., et al. Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas. Genetics 2013, 195:1167-1171.
-
(2013)
Genetics
, vol.195
, pp. 1167-1171
-
-
Chiu, H.1
-
106
-
-
84884904381
-
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
-
Dickinson D.J., et al. Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat. Methods 2013, 10:1028-1034.
-
(2013)
Nat. Methods
, vol.10
, pp. 1028-1034
-
-
Dickinson, D.J.1
-
107
-
-
84885102270
-
Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination
-
Chen C., et al. Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination. Nucleic Acids Res. 2013, 41:e193.
-
(2013)
Nucleic Acids Res.
, vol.41
-
-
Chen, C.1
-
108
-
-
84889080192
-
The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori
-
Wang Y., et al. The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori. Cell Res. 2013, 23:1414-1416.
-
(2013)
Cell Res.
, vol.23
, pp. 1414-1416
-
-
Wang, Y.1
-
109
-
-
84876575031
-
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
-
DiCarlo J.E., et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res. 2013, 41:4336-4343.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 4336-4343
-
-
DiCarlo, J.E.1
-
110
-
-
84874608929
-
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
-
Jiang W., et al. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotechnol. 2013, 31:233-239.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 233-239
-
-
Jiang, W.1
-
111
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali P., et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 2013, 31:833-838.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 833-838
-
-
Mali, P.1
-
112
-
-
38949123143
-
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus
-
Deveau H., et al. Phage response to CRISPR-encoded resistance in Streptococcus thermophilus. J. Bacteriol. 2008, 190:1390-1400.
-
(2008)
J. Bacteriol.
, vol.190
, pp. 1390-1400
-
-
Deveau, H.1
-
113
-
-
84887104139
-
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
-
Esvelt K.M., et al. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat. Methods 2013, 10:1116-1121.
-
(2013)
Nat. Methods
, vol.10
, pp. 1116-1121
-
-
Esvelt, K.M.1
-
114
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi L.S., et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 2013, 152:1173-1183.
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
-
115
-
-
84885180675
-
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
-
Cheng A.W., et al. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res. 2013, 23:1163-1171.
-
(2013)
Cell Res.
, vol.23
, pp. 1163-1171
-
-
Cheng, A.W.1
-
116
-
-
84886488970
-
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
-
Farzadfard F., et al. Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. ACS Synth. Biol. 2013, 13:604-613.
-
(2013)
ACS Synth. Biol.
, vol.13
, pp. 604-613
-
-
Farzadfard, F.1
-
117
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert L.A., et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 2013, 154:442-451.
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
118
-
-
84882986957
-
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
-
Bikard D., et al. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res. 2013, 41:7429-7437.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 7429-7437
-
-
Bikard, D.1
-
119
-
-
84884155038
-
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
Pattanayak V., et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat. Biotechnol. 2013, 31:839-843.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 839-843
-
-
Pattanayak, V.1
-
120
-
-
84867389802
-
RNA processing enables predictable programming of gene expression
-
Qi L., et al. RNA processing enables predictable programming of gene expression. Nat. Biotechnol. 2012, 30:1002-1006.
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 1002-1006
-
-
Qi, L.1
-
121
-
-
84875832964
-
RNA-protein analysis using a conditional CRISPR nuclease
-
Lee H.Y., et al. RNA-protein analysis using a conditional CRISPR nuclease. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:5416-5421.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 5416-5421
-
-
Lee, H.Y.1
-
122
-
-
84879323584
-
Affinity purification of T7 RNA transcripts with homogeneous ends using ARiBo and CRISPR tags
-
Salvail-Lacoste A., et al. Affinity purification of T7 RNA transcripts with homogeneous ends using ARiBo and CRISPR tags. RNA 2013, 19:1003-1014.
-
(2013)
RNA
, vol.19
, pp. 1003-1014
-
-
Salvail-Lacoste, A.1
|