메뉴 건너뛰기




Volumn 179, Issue 6, 2007, Pages 3881-3887

Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; BUTEIN; ESCULETIN; FISETIN; FLAVONOL; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; JANUS KINASE 1; JANUS KINASE 3; KAEMPFEROL; LUTEOLIN; MORIN; MYRICETIN; PHENETHYLSALICYLIC ACID; PROTEIN TYROSINE KINASE; ROSMARINIC ACID; SALICYLIC ACID DERIVATIVE; STAT6 PROTEIN; UNCLASSIFIED DRUG; JAK1 PROTEIN, HUMAN; JAK3 PROTEIN, HUMAN; KAEMPFEROL DERIVATIVE; PROTEIN KINASE INHIBITOR; STAT6 PROTEIN, HUMAN;

EID: 35748973566     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.3881     Document Type: Article
Times cited : (66)

References (44)
  • 1
    • 0025764757 scopus 로고
    • Interleukin-4: A prototypic immunoregulatory lymphokine
    • Paul, W. E. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77: 1859-1870.
    • (1991) Blood , vol.77 , pp. 1859-1870
    • Paul, W.E.1
  • 2
    • 0030444051 scopus 로고    scopus 로고
    • IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway
    • Zamorano, J., H. Y. Wang, L. M. Wang, J. H. Pierce, and A. D. Keegan. 1996. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J. Immunol. 157: 4926-4934.
    • (1996) J. Immunol , vol.157 , pp. 4926-4934
    • Zamorano, J.1    Wang, H.Y.2    Wang, L.M.3    Pierce, J.H.4    Keegan, A.D.5
  • 3
    • 0036786477 scopus 로고    scopus 로고
    • Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF
    • Lutz, M. B., M. Schnare, M. Menges, S. Rossner, M. Rollinghoff, G. Schuler, and A. Gessner. 2002. Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF. J. Immunol. 169: 3574-3580.
    • (2002) J. Immunol , vol.169 , pp. 3574-3580
    • Lutz, M.B.1    Schnare, M.2    Menges, M.3    Rossner, S.4    Rollinghoff, M.5    Schuler, G.6    Gessner, A.7
  • 4
    • 0028785274 scopus 로고
    • Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells
    • Yanagida, M., H. Fukamachi, K. Ohgami, T. Kuwaki, H. Ishii, H. Uzumaki, K. Amano, T. Tokiwa, H. Mitsui, and H. Saito. 1995. Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Blood 86: 3705-3714.
    • (1995) Blood , vol.86 , pp. 3705-3714
    • Yanagida, M.1    Fukamachi, H.2    Ohgami, K.3    Kuwaki, T.4    Ishii, H.5    Uzumaki, H.6    Amano, K.7    Tokiwa, T.8    Mitsui, H.9    Saito, H.10
  • 5
    • 0032007351 scopus 로고    scopus 로고
    • IL-13, IL-4Ra, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite N. brasiliensis
    • Urban, J. F., N. Noben-Trauth, D. D. Donaldson, K. B. Madden, S. C. Morris, M. Collins, and F. D. Finkelman. 1998. IL-13, IL-4Ra, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite N. brasiliensis. Immunity 8: 255-264.
    • (1998) Immunity , vol.8 , pp. 255-264
    • Urban, J.F.1    Noben-Trauth, N.2    Donaldson, D.D.3    Madden, K.B.4    Morris, S.C.5    Collins, M.6    Finkelman, F.D.7
  • 7
    • 0035340763 scopus 로고    scopus 로고
    • A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness
    • Tomkinson, A., C. Duez, G. Cieslewicz, J. C. Pratt, A. Joetham, M. C. Shanafelt, R. Gundel, and E. W. Gelfand. 2001. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J. Immunol. 166: 5792-5800.
    • (2001) J. Immunol , vol.166 , pp. 5792-5800
    • Tomkinson, A.1    Duez, C.2    Cieslewicz, G.3    Pratt, J.C.4    Joetham, A.5    Shanafelt, M.C.6    Gundel, R.7    Gelfand, E.W.8
  • 8
    • 16244370983 scopus 로고    scopus 로고
    • Interleukin-4 enhances proliferation of human pancreatic cancer cells: Evidence for autocrine and paracrine actions
    • Prokopchuk, O., Y. Liu, D. Henne-Bruns, and M. Kornmann. 2005. Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. Brit. J. Cancer 92: 921-928.
    • (2005) Brit. J. Cancer , vol.92 , pp. 921-928
    • Prokopchuk, O.1    Liu, Y.2    Henne-Bruns, D.3    Kornmann, M.4
  • 11
    • 0031015594 scopus 로고    scopus 로고
    • Cloning of the human IL-13Ral chain and reconstitution with the IL4Ra of a functional IL-4/1L-13 receptor complex
    • Miloux, B., P. Laurent, O. Bonnin, J. Lupker, D. Caput, N. Vita, and P. Ferrara. 1997. Cloning of the human IL-13Ral chain and reconstitution with the IL4Ra of a functional IL-4/1L-13 receptor complex. FEBS Lett. 401: 163-166.
    • (1997) FEBS Lett , vol.401 , pp. 163-166
    • Miloux, B.1    Laurent, P.2    Bonnin, O.3    Lupker, J.4    Caput, D.5    Vita, N.6    Ferrara, P.7
  • 12
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signalling pathways: An evolving web
    • Hershey, G. K. 2003. IL-13 receptors and signalling pathways: an evolving web. J. Allergy Clin. Immunol. 111: 677-690.
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 13
    • 0036467550 scopus 로고    scopus 로고
    • Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6
    • Perez-G, M., M. Melo, A. D. Keegan, and J. Zamorano. 2002. Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6. J. Immunol. 168: 1428-1434.
    • (2002) J. Immunol , vol.168 , pp. 1428-1434
    • Perez-G, M.1    Melo, M.2    Keegan, A.D.3    Zamorano, J.4
  • 15
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T., N. Najafian, C. Benou, A. D. Salama, M. J. Grusby, M. H. Sayegh, and S. J. Khoury. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108: 739-747.
    • (2001) J. Clin. Invest , vol.108 , pp. 739-747
    • Chitnis, T.1    Najafian, N.2    Benou, C.3    Salama, A.D.4    Grusby, M.J.5    Sayegh, M.H.6    Khoury, S.J.7
  • 16
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronquial eosinophilic inflamation and airways hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto, T., F. Numata, M. Tamura, Y. Takata, N. Higashida, T. Takashi, K. Takeda, and S. Akira. 1998. Abrogation of bronquial eosinophilic inflamation and airways hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187: 1537-1542.
    • (1998) J. Exp. Med , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7    Akira, S.8
  • 18
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoides on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton, E. Jr., C. Kandaswami, and T. C. Theoharides. 2000. The effects of plant flavonoides on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52: 673-751.
    • (2000) Pharmacol. Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 19
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • Havsteen, B. H. 2002. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96: 67-202.
    • (2002) Pharmacol. Ther , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 22
    • 33646233781 scopus 로고    scopus 로고
    • Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity
    • Lu, J., L. V. Papp, J. Fang, S. Rodriguez-Nieto, B. Zhivotovsky, and A. Holmgren. 2006. Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res. 66: 4410-4418.
    • (2006) Cancer Res , vol.66 , pp. 4410-4418
    • Lu, J.1    Papp, L.V.2    Fang, J.3    Rodriguez-Nieto, S.4    Zhivotovsky, B.5    Holmgren, A.6
  • 23
    • 4944228697 scopus 로고    scopus 로고
    • Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: Structure-activity relationships
    • Chen, C. C., M. P. Chow, W. C. Huang, Y. C. Lin, and Y. J. Chang. 2004. Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships. Mol. Pharmacol. 66: 683-693.
    • (2004) Mol. Pharmacol , vol.66 , pp. 683-693
    • Chen, C.C.1    Chow, M.P.2    Huang, W.C.3    Lin, Y.C.4    Chang, Y.J.5
  • 24
    • 33846026738 scopus 로고    scopus 로고
    • Dietary flavonoids attenuate tumor necrosis factor α-induced adhesion molecule expression in human aortic endothelial cells: Structure-function relationships and activity after first pass metabolism
    • Lolito, S. B., and B. Frei. 2006. Dietary flavonoids attenuate tumor necrosis factor α-induced adhesion molecule expression in human aortic endothelial cells: structure-function relationships and activity after first pass metabolism. J. Biol. Chem. 281: 37102-37110.
    • (2006) J. Biol. Chem , vol.281 , pp. 37102-37110
    • Lolito, S.B.1    Frei, B.2
  • 25
    • 18144417435 scopus 로고    scopus 로고
    • Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-κ-independent mechanism
    • Birrell, M. A., K. McCluskie, S. Wong, L. E. Donnelly, P. J. Barnes, and M. G. Belvisi. 2005. Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-κ-independent mechanism. FASEB J. 19: 840-841.
    • (2005) FASEB J , vol.19 , pp. 840-841
    • Birrell, M.A.1    McCluskie, K.2    Wong, S.3    Donnelly, L.E.4    Barnes, P.J.5    Belvisi, M.G.6
  • 26
    • 0029974563 scopus 로고    scopus 로고
    • IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor a chain
    • Wang, H. Y., W. E. Paul, and A. Keegan. 1996. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor a chain. Immunity 4: 113-121.
    • (1996) Immunity , vol.4 , pp. 113-121
    • Wang, H.Y.1    Paul, W.E.2    Keegan, A.3
  • 27
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano, P., C. Montgomery, R. Geske, and A. Bradley. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 29
    • 0022445670 scopus 로고
    • Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
    • Denizot, F., and R. Lang. 1986. Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 22: 271-277.
    • (1986) J. Immunol. Methods , vol.22 , pp. 271-277
    • Denizot, F.1    Lang, R.2
  • 30
    • 0001606677 scopus 로고    scopus 로고
    • Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signalling molecules
    • Chen, X. H., B. K. Patel, L. M. Wang, M. Frankel, N. Ellmore, R. A. Flavell, W. J. LaRochelle, and J. H. Pierce. 1997. Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signalling molecules. J. Biol. Chem. 272: 6556-6560.
    • (1997) J. Biol. Chem , vol.272 , pp. 6556-6560
    • Chen, X.H.1    Patel, B.K.2    Wang, L.M.3    Frankel, M.4    Ellmore, N.5    Flavell, R.A.6    LaRochelle, W.J.7    Pierce, J.H.8
  • 31
    • 0034640404 scopus 로고    scopus 로고
    • A gain-of-function mutation in STAT6
    • Daniel, C., A. Salvekar, and U. Schindler. 2000. A gain-of-function mutation in STAT6. J. Biol. Chem. 275: 14255-14259.
    • (2000) J. Biol. Chem , vol.275 , pp. 14255-14259
    • Daniel, C.1    Salvekar, A.2    Schindler, U.3
  • 33
    • 0034657447 scopus 로고    scopus 로고
    • IL-3 signalling and the role of Src kinases, JAKs and STATs: A cover liaison unveiled
    • Reddy, E. P., A. Korapati, P. Chaturvedi, and S. Rane. 2000. IL-3 signalling and the role of Src kinases, JAKs and STATs: a cover liaison unveiled. Oncogene 19: 2532-2547.
    • (2000) Oncogene , vol.19 , pp. 2532-2547
    • Reddy, E.P.1    Korapati, A.2    Chaturvedi, P.3    Rane, S.4
  • 34
    • 0032055611 scopus 로고    scopus 로고
    • Regulation of cell growth by IL-2: Role of STAT5 in protection from apoptosis but not in cell cycle progression
    • Zamorano, J., H. Y. Wang, R. X. Wang, Y. Shi, G. D. Longmore, and A.D. Keegan. 1998. Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. J. Immunol. 160: 3502-3512.
    • (1998) J. Immunol , vol.160 , pp. 3502-3512
    • Zamorano, J.1    Wang, H.Y.2    Wang, R.X.3    Shi, Y.4    Longmore, G.D.5    Keegan, A.D.6
  • 35
    • 13144260650 scopus 로고    scopus 로고
    • Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs
    • Pesu, M., F. Candotti, M. Husa, S. R. Hofmann, L. D. Notarangelo, and J. J. O'Shea. 2005. Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs. Immunol. Rev. 203: 127-142.
    • (2005) Immunol. Rev , vol.203 , pp. 127-142
    • Pesu, M.1    Candotti, F.2    Husa, M.3    Hofmann, S.R.4    Notarangelo, L.D.5    O'Shea, J.J.6
  • 37
    • 0034103630 scopus 로고    scopus 로고
    • Th1 and Th2 mediate acute graft-versus-host-disease, each with distinct end-organ targets
    • Nikolic, B., S. Lee, R. T. Bronson, M. J. Grusby, and M. Sykes. 2000. Th1 and Th2 mediate acute graft-versus-host-disease, each with distinct end-organ targets. J. Clin. Invest. 105: 1289-1298.
    • (2000) J. Clin. Invest , vol.105 , pp. 1289-1298
    • Nikolic, B.1    Lee, S.2    Bronson, R.T.3    Grusby, M.J.4    Sykes, M.5
  • 38
    • 0034801108 scopus 로고    scopus 로고
    • Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice
    • Oku, H., and K. Ishiguro. 2001. Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice. Phytother. Res. 15: 506-510.
    • (2001) Phytother. Res , vol.15 , pp. 506-510
    • Oku, H.1    Ishiguro, K.2
  • 39
    • 0036549821 scopus 로고    scopus 로고
    • Preventive effects of Impatiens balsamina on the hen egg-white lysozyme (HEL)-induced decrease in blood flow
    • Ishiguro, K., Y. Ohira, and H. Oku. 2002. Preventive effects of Impatiens balsamina on the hen egg-white lysozyme (HEL)-induced decrease in blood flow. Biol. Pharm. Bull. 25: 505-508.
    • (2002) Biol. Pharm. Bull , vol.25 , pp. 505-508
    • Ishiguro, K.1    Ohira, Y.2    Oku, H.3
  • 40
    • 27644479966 scopus 로고    scopus 로고
    • Jak3 negatively regulates dendritic-cell cytokine production and survival
    • Yamaoka, K., B. Min, Y. J. Zhou, W. E. Paul, and J. J. O'Shea. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106: 3227-3233.
    • (2005) Blood , vol.106 , pp. 3227-3233
    • Yamaoka, K.1    Min, B.2    Zhou, Y.J.3    Paul, W.E.4    O'Shea, J.J.5
  • 41
    • 16244375571 scopus 로고    scopus 로고
    • Augmentation of differentiation and gap function by kaempferol in partially differentiated colon cancer cells
    • Nakamura, Y., C. Chang, T. Mori, K. Sato, K. Ohtsuki, B. L. Upham, and J. E. Trosko. 2005. Augmentation of differentiation and gap function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis 26: 665-671.
    • (2005) Carcinogenesis , vol.26 , pp. 665-671
    • Nakamura, Y.1    Chang, C.2    Mori, T.3    Sato, K.4    Ohtsuki, K.5    Upham, B.L.6    Trosko, J.E.7
  • 42
    • 0034327770 scopus 로고    scopus 로고
    • Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukaemia virus type 1-transformed human T cells
    • Kirken, R. A., R. A. Erwin, L. Wang, Y. Wang, H. Rui, and W. L. Farrar. 2000. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukaemia virus type 1-transformed human T cells. J. Immunol. 165: 5097-5104.
    • (2000) J. Immunol , vol.165 , pp. 5097-5104
    • Kirken, R.A.1    Erwin, R.A.2    Wang, L.3    Wang, Y.4    Rui, H.5    Farrar, W.L.6
  • 43
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
    • Sudbeck, E. A., X. P. Liu, R. K. Narla, S. Mahajan, S. Ghosh, C. Mao, and F. M. Uckun. 1999. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin. Cancer Res. 5: 1569-1582.
    • (1999) Clin. Cancer Res , vol.5 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6    Uckun, F.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.