Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression

Experimental and Molecular Medicine

Volumn 40, Issue 2, 2008, Pages 208-219

  Byung, Young Kang ^a,b   Kim, Sujong ^b   Lee, Ki Hwan ^c   Yong, Sung Lee ^c   Hong, Il ^a   Lee, Mi Ock ^a   Min, Daejin ^b   Chang, Ihseop ^b   Jae, Sung Hwang ^b   Jun, Seong Park ^b   Duck, Hee Kim ^b   Kim, Byung Gee ^a  

^a Seoul National University   (South Korea)

^b AmorePacific Corporation   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Kaempferol; Keratinocytes; NF B; Oligonucleotide array sequence analysis; Peroxisome proliferator activated receptors; Transcription factors

Indexed keywords

KAEMPFEROL; TRANSCRIPTION FACTOR;

ARTICLE; CELL ADHESION; CELL CYCLE; CONTROLLED STUDY; CYTOSKELETON; DNA MICROARRAY; DNA MODIFICATION; DOWN REGULATION; DRUG EFFECT; DRUG IDENTIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNITY; INTRACELLULAR TRANSPORT; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA PROCESSING; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; UPREGULATION;

EID: 44349159503     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2008.40.2.208     Document Type: Article

References (45)

1. Ahmad N, Mukhtar H. Green tea polyphenols and cancer: Biologic mechanisms and practical implications. Nutr Rev 1999;57:78-83
2. Ahmad N, Mukhtar H. Cutaneous photochemoprotection by green tea: A brief review. Skin Pharmacol Appl Skin Physiol 2001;14:69-76
3. Ahn JI, Lee KH, Shin DM, Shim JW, Lee JS, Chang SY, Lee YS, Brownstein MJ, Lee SH, Lee YS. Comprehensive transcriptome analysis of differentiation of embryonic stem cells into midbrain and hindbrain neurons. Dev Bio 2004;265:491-501
4. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Distinct types of diffuse large B-cell-lymphoma identified by gene expression profiling. Nature 2000;403:503-11
5. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G. Gene ontology: tool for the unification of biology. Nat Genet 2000;25:25-9
6. Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C. Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol 2003;85:267-73
7. Blonska M, Czuba ZP, Krol W. Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. Scand J Immunol 2003;57:162-6
8. Blonska M, Bronikowska J, Pietsz G, Czuba ZP, Scheller S, Krol W. Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages. J Ethnopharmacol 2004;91:25-30
9. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1998;106:761-71
10. Brown PO, Botstein D. Exploring the new world of the genome with DNA microarrays. Nat Genet 1999;21:33-7
11. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet 2006;11:1289-97
12. Chen F, Wang M, O'Connor JP, He M, Tripathi T, Harrison LE. Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-κB. J Cell Biochem 2003;90:732-44
13. Clamp M, Andrews D, Barker D, Bevan P, Cameron G, Chen Y, Clark L, Cox T, Cuff J, Curwen V, Down T, Durbin R, Eyras E, Gilbert J, Hammond M, Hubbard T, Kasprzyk A, Keefe D, Lehvaslaiho H, Iyer V, Melsopp C, Mongin E, Pettett R, Potter S, Rust A, Schmidt E, Searle S, Slater G, Smith J, Spooner W, Stabenau A, Stalker J, Stupka E, Ureta-Vidal A, Vastrik I, Birney E. Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res 2003;31:38-42
14. Comalada M, Ballester I, Bailon E, Sierra S, Xaus J, Galvez J, de Medina FS, Zarzuelo A. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 2006;72:1010-21
15. de Vries JH, Janssen PL, Hollman PC, van Staveren WA, Katan MB. Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. Cancer Lett 1997;114:141-4
16. Dobrzynska MM, Baumgartner A, Anderson D. Antioxidants modulate thyroid hormone- and noradrenaline-induced DNA damage in human sperm, Mutagenesis 2004;19:325-30
17. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998;95:14863-8
18. Gibson DFC, Ratnam AV, Bikle DD. Evidence for separate control mechanisms in the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes. J Invest Dermatol 1996;106:154-61
19. Ho Sui SJ, Mortimer JR, Arenillas DJ, Brumm J, Walsh CJ, Kennedy BP, Wasserman WW. oPOSSUM: identification of over- represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res 2005;33:3154-64
20. Hsu S. Green tea and the skin. J Am Acad Dermatol 2005;52:1049-59
21. Jung CH, Kim JH, Hong MH, Seog HM, Oh SH, Lee PJ, Kim GJ, Kim HM, Um JY, Ko SG. Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide- induced RAW 264.7 macrophages. J Ethnopharmacol 2007;110:490-7
22. Katiyar SK, Afaq F, Azizuddin K, Mukhtar H. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol 2001;176:110-7
23. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 1999;58:759-65
24. Kim HK, Park HR, Lee JS, Chung TS, Chung HY, Chung J. Down-regulation of iNOS and TNF-α expression by kaempferol via NF-κB inactivation in aged rat gingival tissues. Biogerontology 2007;8:399-408
25. Kim JH, Kim HY, Lee YS. A novel method using edge detection for signal extraction from cDNA microarray image analysis. Exp Mol Med 2001;33:83-8
26. Kim SJ, Park H, Kim HP. Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism. Arch Pharm Res 2004:27:937-43
27. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM. Differential expression and activation of a family of murine peroxisome proliferator- activated receptors. Proc Natl Acad Sci USA 1994;91:7355-9
28. Lee KH, Chang MY, Ahn JI, Yu DH, Jung SS, Choi JH, Noh YH, Lee YS, Ahn MJ. Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells. Biochem Biophys Res Commun 2002a;296:1125-33
29. Lee MO, Kang HJ. Role of coactivators and corepressors in the induction of the RARbeta gene in human colon cancer cells. Biol Pharm Bull 2000;25:1298-302
30. Lee MO, Kang HJ, Kim Y, Oum JH, Park J. Repression of FasL Expression by Retinoic acid Involves a Novel Mechanism of Inhibition of Transactivation Function of the Nuclear Factors of Activated T-cells. Eur J Biochem 2002b;269:1162-70
31. Lewis DA, Hengeltraub SF, Gao FC, Leivant MA, Spandau DF. Aberrant NF-kappaB activity in HaCaT cells alters their response to UVB signaling. J Invest Dermatol 2006;126:1885-92
32. Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY, Lin JK. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett 2001;496:12-8
33. Murota K, Shimizu S, Miyamoto S, Izumi T, Obata A, Kikuchi M, Terao J. Unique uptake and transport of isoflavone aglycones by human intestinal caco-2 cells: comparison of isoflavonoids and flavonoids. J Nutr 2002;132:1956-61
34. Noroozi M, Angerson WJ, Lean ME. Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes, Am J Clin Nutr 1998;67:1210-8
35. Pang JL, Ricupero DA, Huang S, Fatma N, Singh DP, Romero JR, Chattopadhyay N. Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells. Biochem Pharmacol 2006;71:818-26
36. Park AM, Dong Z. Signal transduction pathways: targets for green and black tea polyphenols. J Biochem Mol Biol 2003;36:66-77
37. Park JS, Rho HS, Kim DH, Chang IS. Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity. J Agric Food Chem 2006;54:2951-6
38. Samhan-Arias AK, Martin-Romero FJ, Gutierrez-Merino C. Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Free Radical Biol Med 2004;37:48-61
39. Sekine T, Arita J, Yamaguchi A, Saito K, Okonogi S, Morisaki N, Iwasaki S, Murakoshi I. Two flavonol glycosides from seeds of camellia sinensis. Phytochemistry 1991;30:991-5
40. Selloum L, Reichl S, Muller M, Sebihi L, Arnhold J. Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils. Arch Biochem Biophys 2001;395:49-56
41. The Gene Ontology. http://www.geneontology.org (last accessed May 8, 2006)
42. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-21
43. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999;35:1517-25
44. Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 2001;296:181-7
45. Yamamoto Y, Verma UN, Gaynor RB. Tools to interfere with NF-?B activation. In Nuclear Factor ?B: regulation and role in disease (Beyaert R, ed), 2003;199-219, Kluwer academic publishers, Dordrecht, The Netherlands