Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 671-683

  Niestroy, Jeanette ^a,c   Barbara, Alfonso ^b   Herbst, Kathrin ^a   Rode, Sandra ^a   van Liempt, Manuela ^a   Roos, Peter H ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b Centro Interdisciplinario de Ciencias de la Salud   (Mexico)

^c CINVESTAV Coapa sede sur   (Mexico)

Author keywords

Aryl hydrocarbon receptor; Benzo a pyrene; Caco 2; CYP1A1; Kaempferol; Nrf2; Quercetin

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN; BENZO[A]PYRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE P1; HYPOXIA INDUCIBLE FACTOR 1BETA; KAEMPFEROL; MESSENGER RNA; QUERCETIN; RECEPTOR PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

ADENOCARCINOMA; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BENZO(A)PYRENE; CACO-2 CELLS; CARCINOGENS; CELL SURVIVAL; COLONIC NEOPLASMS; CYTOCHROME P-450 CYP1A1; DRUG ANTAGONISM; DRUG COMBINATIONS; DRUG SCREENING ASSAYS, ANTITUMOR; ENTEROCYTES; FLAVONOLS; GENE EXPRESSION; HUMANS; KAEMPFEROLS; MICROSOMES, LIVER; NF-E2-RELATED FACTOR 2; QUERCETIN; RATS; RECEPTORS, ARYL HYDROCARBON;

EID: 79952037796     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.008     Document Type: Article

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