-
1
-
-
26444455691
-
Neural progenitor cells from an adult patient with fragile X syndrome
-
Schwartz, P. H. et al. Neural progenitor cells from an adult patient with fragile X syndrome. BMC Med. Genet. 6, 2 (2005).
-
(2005)
BMC Med. Genet.
, vol.6
, pp. 2
-
-
Schwartz, P.H.1
-
2
-
-
80052783545
-
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
-
Haidet-Phillips, A. M. et al. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nature Biotech. 29, 824-828 (2011).
-
(2011)
Nature Biotech.
, vol.29
, pp. 824-828
-
-
Haidet-Phillips, A.M.1
-
3
-
-
35848937244
-
Developmental Study of Fragile X Syndrome Using Human Embryonic Stem Cells Derived from Preimplantation Genetically Diagnosed Embryos
-
DOI 10.1016/j.stem.2007.09.001, PII S1934590907001713
-
Eiges, R. et al. Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos. Cell Stem Cell 1, 568-577 (2007). (Pubitemid 350079966)
-
(2007)
Cell Stem Cell
, vol.1
, Issue.5
, pp. 568-577
-
-
Eiges, R.1
Urbach, A.2
Malcov, M.3
Frumkin, T.4
Schwartz, T.5
Amit, A.6
Yaron, Y.7
Eden, A.8
Yanuka, O.9
Benvenisty, N.10
Ben-Yosef, D.11
-
4
-
-
84875984674
-
Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines
-
Niclis, J. C. et al. Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines. Front. Cell Neurosci. 7, 37 (2013).
-
(2013)
Front. Cell Neurosci.
, vol.7
, pp. 37
-
-
Niclis, J.C.1
-
5
-
-
77958138433
-
Human embryonic stem cells as models for aneuploid chromosomal syndromes
-
Biancotti, J. C. et al. Human embryonic stem cells as models for aneuploid chromosomal syndromes. Stem Cells 28, 1530-1540 (2010).
-
(2010)
Stem Cells
, vol.28
, pp. 1530-1540
-
-
Biancotti, J.C.1
-
6
-
-
31544441632
-
Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders
-
DOI 10.1093/humrep/dei345
-
Mateizel, I. et al. Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders. Hum. Reprod. 21, 503-511 (2006). (Pubitemid 43159929)
-
(2006)
Human Reproduction
, vol.21
, Issue.2
, pp. 503-511
-
-
Mateizel, I.1
De Temmerman, N.2
Ullmann, U.3
Cauffman, G.4
Sermon, K.5
Van De Velde, H.6
De Rycke, M.7
Degreef, E.8
Devroey, P.9
Liebaers, I.10
Van Steirteghem, A.11
-
7
-
-
56549115885
-
Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells
-
Marchetto, M. C. et al. Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-657 (2008).
-
(2008)
Cell Stem Cell
, vol.3
, pp. 649-657
-
-
Marchetto, M.C.1
-
8
-
-
56549096129
-
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
-
Di Giorgio, F. P., Boulting, G. L., Bobrowicz, S. & Eggan, K. C. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3, 637-648 (2008).
-
(2008)
Cell Stem Cell
, vol.3
, pp. 637-648
-
-
Di Giorgio, F.P.1
Boulting, G.L.2
Bobrowicz, S.3
Eggan, K.C.4
-
9
-
-
33747195353
-
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
-
DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
-
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006). (Pubitemid 44233629)
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
10
-
-
36248966518
-
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
-
DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
-
Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007). (Pubitemid 350138099)
-
(2007)
Cell
, vol.131
, Issue.5
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
11
-
-
58249110796
-
Induced pluripotent stem cells from a spinal muscular atrophy patient
-
Ebert, A. D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
-
(2009)
Nature
, vol.457
, pp. 277-280
-
-
Ebert, A.D.1
-
12
-
-
84864628471
-
Huntington's disease show CAG-repeat-expansion-associated phenotypes
-
HD iPSC Consortium. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11, 264-278 (2012).
-
(2012)
Cell Stem Cell
, vol.11
, pp. 264-278
-
-
-
13
-
-
84873337576
-
Characterization of human Huntington's disease cell model from induced pluripotent stem cells
-
Zhang, N., An, M. C., Montoro, D. & Ellerby, L. M. Characterization of human Huntington's disease cell model from induced pluripotent stem cells. PLoS Curr. 2, RRN1193 (2010).
-
(2010)
PLoS Curr.
, vol.2
-
-
Zhang, N.1
An, M.C.2
Montoro, D.3
Ellerby, L.M.4
-
14
-
-
84865592653
-
Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient
-
Chae, J. I. et al. Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient. Biochem. J. 446, 359-371 (2012).
-
(2012)
Biochem. J.
, vol.446
, pp. 359-371
-
-
Chae, J.I.1
-
15
-
-
84863230167
-
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity
-
Camnasio, S. et al. The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol. Dis. 46, 41-51 (2012).
-
(2012)
Neurobiol. Dis.
, vol.46
, pp. 41-51
-
-
Camnasio, S.1
-
16
-
-
84864601969
-
Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells
-
Jeon, I. et al. Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells. Stem Cells 30, 2054-2062 (2012).
-
(2012)
Stem Cells
, vol.30
, pp. 2054-2062
-
-
Jeon, I.1
-
17
-
-
77957729169
-
Patient-specific induced pluripotent stem-cell models for long-QT syndrome
-
Moretti, A. et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N. Engl. J. Med. 363, 1397-1409 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1397-1409
-
-
Moretti, A.1
-
18
-
-
79952446402
-
Modelling the long QT syndrome with induced pluripotent stem cells
-
Itzhaki, I. et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 471, 225-229 (2011).
-
(2011)
Nature
, vol.471
, pp. 225-229
-
-
Itzhaki, I.1
-
19
-
-
79960831061
-
Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin
-
Zhang, S. et al. Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Hum. Mol. Genet. 20, 3176-3187 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 3176-3187
-
-
Zhang, S.1
-
20
-
-
84883394324
-
Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy
-
Eggenschwiler, R. et al. Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy. Stem Cells Transl. Med. 2, 641-654 (2013).
-
(2013)
Stem Cells Transl. Med.
, vol.2
, pp. 641-654
-
-
Eggenschwiler, R.1
-
21
-
-
70450247528
-
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
-
Ye, Z. et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114, 5473-5480 (2009).
-
(2009)
Blood
, vol.114
, pp. 5473-5480
-
-
Ye, Z.1
-
22
-
-
84879798872
-
An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
-
Kim, J. et al. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep. 3, 2088-2099 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 2088-2099
-
-
Kim, J.1
-
23
-
-
76149134717
-
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
-
Li, X. et al. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J. Neurosci. 30, 1788-1797 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 1788-1797
-
-
Li, X.1
-
24
-
-
50049104725
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: A case-control study
-
Healy, D. G. et al. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol. 7, 583-590 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, pp. 583-590
-
-
Healy, D.G.1
-
25
-
-
84893770183
-
A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism
-
Trinh, J. et al. A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism. Neurobiol. Aging 35, 1125-1131 (2013).
-
(2013)
Neurobiol. Aging
, vol.35
, pp. 1125-1131
-
-
Trinh, J.1
-
26
-
-
79952172335
-
LRRK2 mutant iPSC-derived da neurons demonstrate increased susceptibility to oxidative stress
-
Nguyen, H. N. et al. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 267-280 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 267-280
-
-
Nguyen, H.N.1
-
27
-
-
84860510280
-
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
-
Sanchez-Danes, A. et al. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol. Med. 4, 380-395 (2012).
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 380-395
-
-
Sanchez-Danes, A.1
-
28
-
-
84875916922
-
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness
-
Kondo, T. et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness. Cell Stem Cell 12, 487-496 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 487-496
-
-
Kondo, T.1
-
29
-
-
84875140407
-
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
-
Reinhardt, P. et al. Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell Stem Cell 12, 354-367 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 354-367
-
-
Reinhardt, P.1
-
30
-
-
84869877601
-
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
-
Liu, G. H. et al. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 491, 603-607 (2012).
-
(2012)
Nature
, vol.491
, pp. 603-607
-
-
Liu, G.H.1
-
31
-
-
84890109489
-
Human iPSC-based modeling of late-onset disease via progerin-induced aging
-
Miller, J. D. et al. Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell 13, 691-705 (2013).
-
(2013)
Cell Stem Cell
, vol.13
, pp. 691-705
-
-
Miller, J.D.1
-
32
-
-
84860124221
-
Chronic inhibition of the respiratory chain in human fibroblast cultures: Differential responses related to subject chronological and biological age
-
Dekker, P. et al. Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age. J. Gerontol. A Biol. Sci. Med. Sci. 67, 456-464 (2012).
-
(2012)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.67
, pp. 456-464
-
-
Dekker, P.1
-
33
-
-
71049171763
-
Rapid flow cytometric method for measuring senescence associated β-galactosidase activity in human fibroblasts
-
Noppe, G. et al. Rapid flow cytometric method for measuring senescence associated β-galactosidase activity in human fibroblasts. Cytometry A 75, 910-916 (2009).
-
(2009)
Cytometry A
, vol.75
, pp. 910-916
-
-
Noppe, G.1
-
34
-
-
84355161952
-
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
-
Koch, P. et al. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480, 543-546 (2011).
-
(2011)
Nature
, vol.480
, pp. 543-546
-
-
Koch, P.1
-
35
-
-
80054987997
-
Targeted gene correction of ?1-antitrypsin deficiency in induced pluripotent stem cells
-
Yusa, K. et al. Targeted gene correction of ?1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478, 391-394 (2011).
-
(2011)
Nature
, vol.478
, pp. 391-394
-
-
Yusa, K.1
-
36
-
-
84879116702
-
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
-
Choi, S. M. et al. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology 57, 2458-2468 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 2458-2468
-
-
Choi, S.M.1
-
37
-
-
80055069793
-
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
-
Zou, J., Mali, P., Huang, X., Dowey, S. N. & Cheng, L. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood 118, 4599-4608 (2011).
-
(2011)
Blood
, vol.118
, pp. 4599-4608
-
-
Zou, J.1
Mali, P.2
Huang, X.3
Dowey, S.N.4
Cheng, L.5
-
38
-
-
84862776968
-
Genetic correction of beta-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice
-
Wang, Y. et al. Genetic correction of beta-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. Cell Res. 22, 637-648 (2012).
-
(2012)
Cell Res.
, vol.22
, pp. 637-648
-
-
Wang, Y.1
-
39
-
-
84883857778
-
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells
-
Fong, H. et al. Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Rep. 1, 226-234 (2013).
-
(2013)
Stem Cell Rep.
, vol.1
, pp. 226-234
-
-
Fong, H.1
-
40
-
-
84864631163
-
Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells
-
An, M. C. et al. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell 11, 253-263 (2012).
-
(2012)
Cell Stem Cell
, vol.11
, pp. 253-263
-
-
An, M.C.1
-
41
-
-
84871529372
-
Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy
-
Corti, S. et al. Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy. Sci. Transl Med. 4, 165ra162 (2012).
-
(2012)
Sci. Transl Med.
, vol.4
-
-
Corti, S.1
-
42
-
-
84906321073
-
Press release: Data from ISIS-SMN Rx Phase 1 study in children with spinal muscular atrophy
-
ISIS Pharmaceuticals [online]
-
ISIS Pharmaceuticals. Press release: Data from ISIS-SMN Rx Phase 1 study in children with spinal muscular atrophy presented at the American Academy of Neurology Meeting [online], http://ir.isispharm.com/ phoenix.zhtml?c= 222170&p=irol-newsArticle&ID=1798657 (2014).
-
(2014)
American Academy of Neurology Meeting
-
-
-
43
-
-
84890115517
-
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1? Transcription
-
Ryan, S. D. et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1? transcription. Cell 155, 1351-1364 (2013).
-
(2013)
Cell
, vol.155
, pp. 1351-1364
-
-
Ryan, S.D.1
-
44
-
-
84873733109
-
A TALEN genome-editing system for generating human stem cell-based disease models
-
Ding, Q. et al. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell 12, 238-251 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 238-251
-
-
Ding, Q.1
-
45
-
-
84863982020
-
Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
-
Roelandt, P. et al. Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus. J. Hepatol 57, 246-251 (2012).
-
(2012)
J. Hepatol
, vol.57
, pp. 246-251
-
-
Roelandt, P.1
-
46
-
-
84861206498
-
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
-
Wu, X. et al. Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog. 8, e1002617 (2012).
-
(2012)
PLoS Pathog.
, vol.8
-
-
Wu, X.1
-
47
-
-
83055191266
-
Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection
-
Yoshida, T. et al. Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection. Biochem. Biophys. Res. Commun. 416, 119-124 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.416
, pp. 119-124
-
-
Yoshida, T.1
-
48
-
-
84857125662
-
Modeling hepatitis C virus infection using human induced pluripotent stem cells
-
Schwartz, R. E. et al. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc. Natl Acad. Sci. USA 109, 2544-2548 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 2544-2548
-
-
Schwartz, R.E.1
-
49
-
-
84879559567
-
Human embryonic stem cell lines model experimental human cytomegalovirus latency
-
Penkert, R. R. & Kalejta, R. F. Human embryonic stem cell lines model experimental human cytomegalovirus latency. MBio 4, e00298-00213 (2013).
-
(2013)
MBio
, vol.4
-
-
Penkert, R.R.1
Kalejta, R.F.2
-
50
-
-
84870274844
-
Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells
-
D'Aiuto, L. et al. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS ONE 7, e49700 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
D'aiuto, L.1
-
51
-
-
84868506826
-
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay
-
Hoing, S. et al. Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. Cell Stem Cell 11, 620-632 (2012).
-
(2012)
Cell Stem Cell
, vol.11
, pp. 620-632
-
-
Hoing, S.1
-
52
-
-
84878883307
-
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS
-
Yang, Y. M. et al. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell 12, 713-726 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 713-726
-
-
Yang, Y.M.1
-
53
-
-
76749151845
-
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
-
Braam, S. R. et al. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res. 4, 107-116 (2010).
-
(2010)
Stem Cell Res.
, vol.4
, pp. 107-116
-
-
Braam, S.R.1
-
54
-
-
84876526111
-
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
-
Liang, P. et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 127, 1677-1691 (2013).
-
(2013)
Circulation
, vol.127
, pp. 1677-1691
-
-
Liang, P.1
-
55
-
-
84879756120
-
Somatic mutation, genomic variation, and neurological disease
-
Poduri, A., Evrony, G. D., Cai, X. & Walsh, C. A. Somatic mutation, genomic variation, and neurological disease. Science 341, 1237758 (2013).
-
(2013)
Science
, vol.341
, pp. 1237758
-
-
Poduri, A.1
Evrony, G.D.2
Cai, X.3
Walsh, C.A.4
-
56
-
-
79952258224
-
Somatic coding mutations in human induced pluripotent stem cells
-
Gore, A. et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 471, 63-67 (2011).
-
(2011)
Nature
, vol.471
, pp. 63-67
-
-
Gore, A.1
-
57
-
-
84878759743
-
Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors
-
Theka, I. et al. Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors. Stem Cells Transl. Med. 2, 473-479 (2013).
-
(2013)
Stem Cells Transl. Med.
, vol.2
, pp. 473-479
-
-
Theka, I.1
-
58
-
-
84862777308
-
Direct reprogramming of fibroblasts into neural stem cells by defined factors
-
Han, D. W. et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10, 465-472 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 465-472
-
-
Han, D.W.1
-
59
-
-
0037336820
-
Homologous recombination in human embryonic stem cells
-
DOI 10.1038/nbt788
-
Zwaka, T. P. & Thomson, J. A. Homologous recombination in human embryonic stem cells. Nature Biotech. 21, 319-321 (2003). (Pubitemid 36314818)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.3
, pp. 319-321
-
-
Zwaka, T.P.1
Thomson, J.A.2
-
60
-
-
2642513868
-
Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells
-
DOI 10.1016/j.ygeno.2003.12.015, PII S0888754304000217
-
Heaney, J. D., Rettew, A. N. & Bronson, S. K. Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics 83, 1072-1082 (2004). (Pubitemid 38726055)
-
(2004)
Genomics
, vol.83
, Issue.6
, pp. 1072-1082
-
-
Heaney, J.D.1
Rettew, A.N.2
Bronson, S.K.3
-
61
-
-
69249138761
-
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells
-
Xue, H. et al. A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells 27, 1836-1846 (2009).
-
(2009)
Stem Cells
, vol.27
, pp. 1836-1846
-
-
Xue, H.1
-
62
-
-
73049105546
-
Modeling disease in human ESCs using an efficient BAC-based homologous recombination system
-
Song, H., Chung, S. K. & Xu, Y. Modeling disease in human ESCs using an efficient BAC-based homologous recombination system. Cell Stem Cell 6, 80-89 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 80-89
-
-
Song, H.1
Chung, S.K.2
Xu, Y.3
-
63
-
-
79953001332
-
A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives
-
Goulburn, A. L. et al. A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells 29, 462-473 (2011).
-
(2011)
Stem Cells
, vol.29
, pp. 462-473
-
-
Goulburn, A.L.1
-
64
-
-
84856529668
-
Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors
-
Aizawa, E. et al. Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors. Mol. Ther. 20, 424-431 (2012).
-
(2012)
Mol. Ther.
, vol.20
, pp. 424-431
-
-
Aizawa, E.1
-
65
-
-
70249114821
-
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
-
Hockemeyer, D. et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotech. 27, 851-857 (2009).
-
(2009)
Nature Biotech.
, vol.27
, pp. 851-857
-
-
Hockemeyer, D.1
-
66
-
-
79960836456
-
Genetic engineering of human pluripotent cells using TALE nucleases
-
Hockemeyer, D. et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nature Biotech. 29, 731-734 (2011).
-
(2011)
Nature Biotech.
, vol.29
, pp. 731-734
-
-
Hockemeyer, D.1
-
67
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nature Biotech. 31, 822-826 (2013).
-
(2013)
Nature Biotech.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
68
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran, F. A. et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389 (2013).
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
69
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotech. 31, 833-838 (2013).
-
(2013)
Nature Biotech.
, vol.31
, pp. 833-838
-
-
Mali, P.1
-
70
-
-
84875963894
-
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs
-
Ding, Q. et al. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Cell Stem Cell 12, 393-394 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 393-394
-
-
Ding, Q.1
-
71
-
-
84869054109
-
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A
-
Kelly, R. D., Mahmud, A., McKenzie, M., Trounce, I. A. & St John, J. C. Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res. 40, 10124-10138 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 10124-10138
-
-
Kelly, R.D.1
Mahmud, A.2
McKenzie, M.3
Trounce, I.A.4
St John, J.C.5
-
72
-
-
0031728072
-
Mitochondrial transfer between oocytes: Potential applications of mitochondrial donation and the issue of heteroplasmy
-
Van Blerkom, J., Sinclair, J. & Davis, P. Mitochondrial transfer between oocytes: potential applications of mitochondrial donation and the issue of heteroplasmy. Hum. Reprod. 13, 2857-2868 (1998). (Pubitemid 28482742)
-
(1998)
Human Reproduction
, vol.13
, Issue.10
, pp. 2857-2868
-
-
Van Blerkom, J.1
Sinclair, J.2
Davis, P.3
-
73
-
-
0033825206
-
Mitochondrial DNA heteroplasmy after human ooplasmic transplantation
-
Brenner, C. A., Barritt, J. A., Willadsen, S. & Cohen, J. Mitochondrial DNA heteroplasmy after human ooplasmic transplantation. Fertil. Steril. 74, 573-578 (2000).
-
(2000)
Fertil. Steril.
, vol.74
, pp. 573-578
-
-
Brenner, C.A.1
Barritt, J.A.2
Willadsen, S.3
Cohen, J.4
-
74
-
-
84878838747
-
Human embryonic stem cells derived by somatic cell nuclear transfer
-
Tachibana, M. et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell 153, 1228-1238 (2013).
-
(2013)
Cell
, vol.153
, pp. 1228-1238
-
-
Tachibana, M.1
-
75
-
-
84873088209
-
Towards germline gene therapy of inherited mitochondrial diseases
-
Tachibana, M. et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature 493, 627-631 (2013).
-
(2013)
Nature
, vol.493
, pp. 627-631
-
-
Tachibana, M.1
-
76
-
-
84355166561
-
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
-
Kriks, S. et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 480, 547-551 (2011).
-
(2011)
Nature
, vol.480
, pp. 547-551
-
-
Kriks, S.1
-
77
-
-
84875284468
-
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling
-
Reinhardt, P. et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE 8, e59252 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Reinhardt, P.1
-
78
-
-
62549127853
-
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
-
Koch, P., Opitz, T., Steinbeck, J. A., Ladewig, J. & Brustle, O. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc. Natl Acad. Sci. USA 106, 3225-3230 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3225-3230
-
-
Koch, P.1
Opitz, T.2
Steinbeck, J.A.3
Ladewig, J.4
Brustle, O.5
-
79
-
-
79957777958
-
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
-
Li, W. et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc. Natl Acad. Sci. USA 108, 8299-8304 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 8299-8304
-
-
Li, W.1
-
80
-
-
84883465408
-
Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions
-
Cao, N. et al. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 23, 1119-1132 (2013).
-
(2013)
Cell Res.
, vol.23
, pp. 1119-1132
-
-
Cao, N.1
-
81
-
-
84859527233
-
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells
-
Cheng, X. et al. Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell 10, 371-384 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 371-384
-
-
Cheng, X.1
-
82
-
-
84886094902
-
Generation of multipotent foregut stem cells from human pluripotent stem cells
-
Hannan, N. R. et al. Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Rep. 1, 293-306 (2013).
-
(2013)
Stem Cell Rep.
, vol.1
, pp. 293-306
-
-
Hannan, N.R.1
-
83
-
-
84864243791
-
Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview
-
Mummery, C. L. et al. Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circ. Res. 111, 344-358 (2012).
-
(2012)
Circ. Res.
, vol.111
, pp. 344-358
-
-
Mummery, C.L.1
-
84
-
-
84881184980
-
Vascularized and functional human liver from an iPSC-derived organ bud transplant
-
Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484 (2013).
-
(2013)
Nature
, vol.499
, pp. 481-484
-
-
Takebe, T.1
-
85
-
-
84884414984
-
Cerebral organoids model human brain development and microcephaly
-
Lancaster, M. A. et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373-379 (2013).
-
(2013)
Nature
, vol.501
, pp. 373-379
-
-
Lancaster, M.A.1
-
86
-
-
79953749322
-
Self-organizing optic-cup morphogenesis in three-dimensional culture
-
Eiraku, M. et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51-56 (2011).
-
(2011)
Nature
, vol.472
, pp. 51-56
-
-
Eiraku, M.1
-
87
-
-
84862526635
-
Self-formation of optic cups and storable stratified neural retina from human ESCs
-
Nakano, T. et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10, 771-785 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 771-785
-
-
Nakano, T.1
-
88
-
-
84879397416
-
Small intestinal submucosa segments as matrix for tissue engineering: Review
-
Andr?e, B., Bor, A., Haverich, A. & Hilfiker, A. Small intestinal submucosa segments as matrix for tissue engineering: review. Tissue Eng. Part B Rev. 19, 279-291 (2013).
-
(2013)
Tissue Eng. Part B Rev.
, vol.19
, pp. 279-291
-
-
Andre, B.1
Bor, A.2
Haverich, A.3
Hilfiker, A.4
-
89
-
-
84906781892
-
Organ-on - A-chip platforms for studying drug delivery systems
-
http://dx.doi.org/10.1016/j.jconrel.2014.05.004
-
Bhise, N. S. et al. Organ-on-a-chip platforms for studying drug delivery systems. J. Control Release http://dx.doi.org/10.1016/j.jconrel.2014.05.004 (2014).
-
(2014)
J. Control Release
-
-
Bhise, N.S.1
-
90
-
-
84865107641
-
Age at onset in LRRK2-associated PD is modified by SNCA variants
-
Botta-Orfila, T. et al. Age at onset in LRRK2-associated PD is modified by SNCA variants. J. Mol. Neurosci. 48, 245-247 (2012).
-
(2012)
J. Mol. Neurosci.
, vol.48
, pp. 245-247
-
-
Botta-Orfila, T.1
-
91
-
-
77956354416
-
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
-
Rashid, S. T. et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J. Clin. Invest. 120, 3127-3136 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3127-3136
-
-
Rashid, S.T.1
-
92
-
-
84870401656
-
Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects
-
Almeida, S. et al. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2, 789-798 (2012).
-
(2012)
Cell Rep.
, vol.2
, pp. 789-798
-
-
Almeida, S.1
-
93
-
-
84886389563
-
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
-
Sareen, D. et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci. Transl Med. 5, 208ra149 (2013).
-
(2013)
Sci. Transl Med.
, vol.5
-
-
Sareen, D.1
-
94
-
-
84883465132
-
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
-
Almeida, S. et al. Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. Acta Neuropathol. 126, 385-399 (2013).
-
(2013)
Acta Neuropathol.
, vol.126
, pp. 385-399
-
-
Almeida, S.1
-
95
-
-
84885808774
-
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
-
Donnelly, C. J. et al. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80, 415-428 (2013).
-
(2013)
Neuron
, vol.80
, pp. 415-428
-
-
Donnelly, C.J.1
-
96
-
-
84902134581
-
Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons
-
Chen, H. et al. Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14, 796-809 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 796-809
-
-
Chen, H.1
-
97
-
-
84902191691
-
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1
-
Kiskinis, E. et al. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell 14, 781-795 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 781-795
-
-
Kiskinis, E.1
-
98
-
-
84898034713
-
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
-
Wainger, B. J. et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 7, 1-11 (2014).
-
(2014)
Cell Rep.
, vol.7
, pp. 1-11
-
-
Wainger, B.J.1
-
99
-
-
84864542080
-
Drug screening for ALS using patient-specific induced pluripotent stem cells
-
Egawa, N. et al. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci. Transl Med. 4, 145ra104 (2012).
-
(2012)
Sci. Transl Med.
, vol.4
-
-
Egawa, N.1
-
100
-
-
84859569070
-
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
-
Bilican, B. et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc. Natl Acad. Sci. USA 109, 5803-5808 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 5803-5808
-
-
Bilican, B.1
-
101
-
-
84875275232
-
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
-
Serio, A. et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc. Natl Acad. Sci. USA 110, 4697-4702 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 4697-4702
-
-
Serio, A.1
-
102
-
-
84856956771
-
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
-
Israel, M. A. et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482, 216-220 (2012).
-
(2012)
Nature
, vol.482
, pp. 216-220
-
-
Israel, M.A.1
-
103
-
-
84891025045
-
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation
-
Mertens, J. et al. APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation. Stem Cell Rep. 1, 491-498 (2013).
-
(2013)
Stem Cell Rep.
, vol.1
, pp. 491-498
-
-
Mertens, J.1
-
104
-
-
81255169342
-
Modeling familial Alzheimer's disease with induced pluripotent stem cells
-
Yagi, T. et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum. Mol. Genet. 20, 4530-4539 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4530-4539
-
-
Yagi, T.1
-
105
-
-
84863229339
-
A human stem cell model of early Alzheimer's disease pathology in Down syndrome
-
Shi, Y. et al. A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci. Transl Med. 4, 124ra29 (2012).
-
(2012)
Sci. Transl Med.
, vol.4
-
-
Shi, Y.1
-
106
-
-
84859482750
-
Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease
-
Jiang, Y. et al. Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease. Stem Cells 30, 599-611 (2012).
-
(2012)
Stem Cells
, vol.30
, pp. 599-611
-
-
Jiang, Y.1
-
107
-
-
84857547828
-
Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation
-
Novak, A. et al. Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation. J. Cell. Mol. Med. 16, 468-482 (2012).
-
(2012)
J. Cell. Mol. Med.
, vol.16
, pp. 468-482
-
-
Novak, A.1
-
108
-
-
83755195408
-
In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells
-
Fatima, A. et al. In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol. Biochem. 28, 579-592 (2011).
-
(2011)
Cell Physiol. Biochem.
, vol.28
, pp. 579-592
-
-
Fatima, A.1
-
109
-
-
84866033059
-
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations
-
Kujala, K. et al. Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. PLoS ONE 7, e44660 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Kujala, K.1
-
110
-
-
84880513096
-
2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects
-
2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. Cell Calcium 54, 57-70 (2013).
-
(2013)
Cell Calcium
, vol.54
, pp. 57-70
-
-
Zhang, X.H.1
-
111
-
-
84858129398
-
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
-
Jung, C. B. et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol. Med. 4, 180-191 (2012).
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 180-191
-
-
Jung, C.B.1
-
112
-
-
80053948646
-
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
-
Sheridan, S. D. et al. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS ONE 6, e26203 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Sheridan, S.D.1
-
113
-
-
79954523845
-
Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
-
Matsa, E. et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur. Heart J. 32, 952-962 (2011).
-
(2011)
Eur. Heart J.
, vol.32
, pp. 952-962
-
-
Matsa, E.1
-
114
-
-
84858040591
-
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
-
Lahti, A. L. et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis. Model. Mech. 5, 220-230 (2012).
-
(2012)
Dis. Model. Mech.
, vol.5
, pp. 220-230
-
-
Lahti, A.L.1
-
115
-
-
84890563877
-
Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome
-
Bellin, M. et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J. 32, 3161-3175 (2013).
-
(2013)
EMBO J.
, vol.32
, pp. 3161-3175
-
-
Bellin, M.1
-
116
-
-
84865254838
-
Disease characterization using LQTS-specific induced pluripotent stem cells
-
Egashira, T. et al. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc. Res. 95, 419-429 (2012).
-
(2012)
Cardiovasc. Res.
, vol.95
, pp. 419-429
-
-
Egashira, T.1
-
117
-
-
84872238836
-
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
-
Terrenoire, C. et al. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J. Gen. Physiol. 141, 61-72 (2013).
-
(2013)
J. Gen. Physiol.
, vol.141
, pp. 61-72
-
-
Terrenoire, C.1
-
118
-
-
84863213874
-
Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease
-
Davis, R. P. et al. Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation 125, 3079-3091 (2012).
-
(2012)
Circulation
, vol.125
, pp. 3079-3091
-
-
Davis, R.P.1
-
119
-
-
84887150722
-
Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
-
Ma, D. et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells. Int. J. Cardiol 168, 5277-5286 (2013).
-
(2013)
Int. J. Cardiol
, vol.168
, pp. 5277-5286
-
-
Ma, D.1
-
120
-
-
84862929910
-
Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells
-
Quarto, N. et al. Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells. Proc. Natl Acad. Sci. USA 109, 215-220 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 215-220
-
-
Quarto, N.1
-
121
-
-
84863584524
-
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
-
Cooper, O. et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci. Transl Med. 4, 141ra90 (2012).
-
(2012)
Sci. Transl Med.
, vol.4
-
-
Cooper, O.1
-
122
-
-
84875640261
-
Interplay of LRRK2 with chaperone-mediated autophagy
-
Orenstein, S. J. et al. Interplay of LRRK2 with chaperone-mediated autophagy. Nature Neurosci. 16, 394-406 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 394-406
-
-
Orenstein, S.J.1
-
123
-
-
84887506882
-
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
-
Sanders, L. H. et al. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol. Dis. 62, 381-386 (2014).
-
(2014)
Neurobiol. Dis.
, vol.62
, pp. 381-386
-
-
Sanders, L.H.1
-
124
-
-
84863393846
-
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
-
Jiang, H. et al. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Commun. 3, 668 (2012).
-
(2012)
Nature Commun.
, vol.3
, pp. 668
-
-
Jiang, H.1
-
125
-
-
84867031150
-
Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
-
Imaizumi, Y. et al. Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol. Brain 5, 35 (2012).
-
(2012)
Mol. Brain
, vol.5
, pp. 35
-
-
Imaizumi, Y.1
-
126
-
-
79955786943
-
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
-
Seibler, P. et al. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. J. Neurosci. 31, 5970-5976 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 5970-5976
-
-
Seibler, P.1
-
127
-
-
81155131691
-
SNCA triplication Parkinson's patient's iPSC-derived da neurons accumulate ?-synuclein and are susceptible to oxidative stress
-
Byers, B. et al. SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate ?-synuclein and are susceptible to oxidative stress. PLoS ONE 6, e26159 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Byers, B.1
-
128
-
-
84864330048
-
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research
-
Yagi, T. et al. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS ONE 7, e41572 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Yagi, T.1
-
129
-
-
81855172517
-
Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification
-
Huang, H. P. et al. Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum. Mol. Genet. 20, 4851-4864 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4851-4864
-
-
Huang, H.P.1
-
130
-
-
84892645746
-
Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis
-
Suzuki, T. et al. Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis. Am. J. Respir. Crit. Care Med. 189, 183-193 (2014).
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.189
, pp. 183-193
-
-
Suzuki, T.1
-
131
-
-
84892666915
-
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis
-
Lachmann, N. et al. Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am. J. Respir. Crit. Care Med. 189, 167-182 (2014).
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.189
, pp. 167-182
-
-
Lachmann, N.1
-
132
-
-
80053143413
-
Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
-
Ananiev, G., Williams, E. C., Li, H. & Chang, Q. Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model. PLoS ONE 6, e25255 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Ananiev, G.1
Williams, E.C.2
Li, H.3
Chang, Q.4
-
133
-
-
79955602167
-
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
-
Cheung, A. Y. et al. Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum. Mol. Genet. 20, 2103-2115 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 2103-2115
-
-
Cheung, A.Y.1
-
134
-
-
80052155858
-
Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
-
Kim, K. Y., Hysolli, E. & Park, I. H. Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc. Natl Acad. Sci. USA 108, 14169-14174 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14169-14174
-
-
Kim, K.Y.1
Hysolli, E.2
Park, I.H.3
-
135
-
-
79955884485
-
Modelling schizophrenia using human induced pluripotent stem cells
-
Brennand, K. J. et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221-225 (2011).
-
(2011)
Nature
, vol.473
, pp. 221-225
-
-
Brennand, K.J.1
-
136
-
-
84862518720
-
Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy
-
Sareen, D. et al. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. PLoS ONE 7, e39113 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Sareen, D.1
-
137
-
-
81855206164
-
Brief report: Phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient
-
Chang, T. et al. Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient. Stem Cells 29, 2090-2093 (2011).
-
(2011)
Stem Cells
, vol.29
, pp. 2090-2093
-
-
Chang, T.1
-
138
-
-
84856088804
-
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
-
Pasca, S. P. et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nature Med. 17, 1657-1662 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1657-1662
-
-
Pasca, S.P.1
-
139
-
-
79952438377
-
Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
-
Yazawa, M. et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471, 230-234 (2011).
-
(2011)
Nature
, vol.471
, pp. 230-234
-
-
Yazawa, M.1
-
140
-
-
84873097224
-
Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons
-
Krey, J. F. et al. Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Nature Neurosci. 16, 201-209 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 201-209
-
-
Krey, J.F.1
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