Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

Nature Communications

Volumn 3, Issue , 2012, Pages

  Jiang, Houbo ^a   Ren, Yong ^a   Yuen, Eunice Y ^a   Zhong, Ping ^a   Ghaedi, Mahboobe ^a   Hu, Zhixing ^a   Azabdaftari, Gissou ^b   Nakaso, Kazuhiro ^c   Yan, Zhen ^a   Feng, Jian ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; MONOAMINE OXIDASE INHIBITOR; PARKIN; AMINE OXIDASE (FLAVIN CONTAINING); OXYGEN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; LENTIVIRUS INFECTION; MESENCEPHALON; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PLURIPOTENT STEM CELL; POINT MUTATION; PROTEIN EXPRESSION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; BIOSYNTHESIS; BRAIN; CHEMISTRY; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; MUTATION; NERVE CELL; PARKINSON DISEASE; PRENATAL DEVELOPMENT; SKIN; TIME;

MUS;

ANIMALS; BINDING SITES; BRAIN; DOPAMINE; DOPAMINERGIC NEURONS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MONOAMINE OXIDASE; MUTATION; NEURONS; OXIDATIVE STRESS; OXYGEN; PARKINSON DISEASE; PHENOTYPE; SKIN; TIME FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 84863393846     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1669     Document Type: Article

References (39)

1. Lang, A. E. & Lozano, A. M. Parkinson's disease. First of two parts. N. Engl. J. Med. 339, 1044-1053 (1998). (Pubitemid 28457867)
2. Hardy, J. Genetic analysis of pathways to Parkinson disease. Neuron 68, 201-206 (2010).
3. Nuytemans, K., Theuns, J., Cruts, M. & Van Broeckhoven, C. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. H um. Mutat. 31, 763-780 (2010).
4. Shimura, H. et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25, 302-305 (2000). (Pubitemid 30437317)
5. Dawson, T. M. & Dawson, V. L. The role of parkin in familial and sporadic Parkinson's disease. Mov. Disord. 2 5 (Suppl 1), S32-S39 (2010).
6. Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998). (Pubitemid 28207717)
7. Perez, F. A. & Palmiter, R. D. Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl Acad. Sci. USA 102, 2174-2179 (2005). (Pubitemid 40262031)
8. Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007). (Pubitemid 350138099)
9. Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
10. Maherali, N. et al. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 3, 340-345 (2008).
11. Yan, Y. et al. Directed diff erentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-790 (2005). (Pubitemid 40791793)
12. Chambers, S. M., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280 (2009).
13. Danielian, P. S. & McMahon, A. P. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334 (1996). (Pubitemid 26321761)
14. Rhee, Y. H. et al. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J. Clin. Invest. 121, 2326-2335 (2011).
15. Takenaga, M., Fukumoto, M. & Hori, Y. Regulated Nodal signaling promotes diff erentiation of the definitive endoderm and mesoderm from ES cells. J. Cell Sci. 120, 2078-2090 (2007). (Pubitemid 47010003)
16. Boulting, G. L. et al. A functionally characterized test set of human induced pluripotent stem cells. Nat. Biotechnol. 29, 279-286 (2011).
17. Jiang, H., Jiang, Q., Liu, W. & Feng, J. Parkin suppresses the expression of monoamine oxidases. J. Biol. Chem. 281, 8591-8599 (2006). (Pubitemid 43847962)
18. Jiang, H., Jiang, Q. & Feng, J. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J. Biol. Chem. 279, 54380-54386 (2004). (Pubitemid 40053177)
19. Giros, B. et al. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42, 383-390 (1992). (Pubitemid 23024654)
20. Lee, F. J., Pristupa, Z. B., Ciliax, B. J., Levey, A. I. & Niznik, H. B. The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. J. Biol. Chem. 271, 20885-20894 (1996). (Pubitemid 26281877)
21. Torres, G. E. et al. Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. J. Biol. Chem. 278, 2731-2739 (2003). (Pubitemid 36801354)
22. Jenner, P. & Olanow, C. W. Oxidative stress and the pathogenesis of Parkinson's disease. N eurology 47, S161-S170 (1996). (Pubitemid 26422582)
23. Shih, J. C., Chen, K. & Ridd, M. J. Monoamine oxidase: from genes to behavior. Annu. Rev. Neurosci. 22, 197-217 (1999). (Pubitemid 29144886)
24. Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803 (2008).
25. Dawson, T. M., Ko, H. S. & Dawson, V. L. Genetic animal models of Parkinson's disease. N euron 66, 646-661 (2010).
26. 2+ dependence and time course of somatodendritic dopamine release: substantia nigra versus striatum. J. Neurosci. 21, 7841-7847 (2001). (Pubitemid 32904984)
27. Patel, J. C., Witkovsky, P., Avshalumov, M. V. & Rice, M. E. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J. Neurosci. 29, 6568-6579 (2009).
28. Fallon, L. et al. A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat. Cell Biol. 8, 834-842 (2006). (Pubitemid 44151586)
29. Best, J. A., Nijhout, H. F. & Reed, M. C. Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theor. Biol. Med. Model. 6, 21 (2009).
30. Pavese, N. et al. In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study. Exp. Neurol. 222, 120-124 (2010).
31. Ribeiro, M. J. et al. A multitracer dopaminergic PET study of young-onset parkinsonian patients with and without parkin gene mutations. J. Nucl. Med. 50, 1244-1250 (2009).
32. Olanow, C. W. et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N. Engl. J. Med. 361, 1268-1278 (2009).
33. Ren, Y., Jiang, H., Ma, D., Nakaso, K. & Feng, J. Parkin degrades estrogenrelated receptors to limit the expression of monoamine oxidases. Hum. Mol. Genet. 20, 1074-1083 (2011).
34. Willy, P. J. et al. Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc. Natl Acad. Sci. USA 101, 8912-8917 (2004). (Pubitemid 38781585)
35. da Costa, C. A. et al. Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat. Cell Biol. 11, 1370-1375 (2009).
36. Hu, B. Y. et al. Neural diff erentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc. Natl Acad. Sci. USA 107, 4335-4340 (2010).
37. Zhang, X. Q. & Zhang, S. C. Diff erentiation of neural precursors and dopaminergic neurons from human embryonic stem cells. Methods Mol. Biol. 584, 355-366 (2010).
38. Jiang, H., Ren, Y., Zhao, J. & Feng, J. Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum. Mol. Genet. 13, 1745-1754 (2004). (Pubitemid 39173443)
39. Yuen, E. Y. et al. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol. Psychiatry 16, 156-170 (2011).