Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation

PLoS Pathogens

Volumn 8, Issue 4, 2012, Pages

  Wu, Xianfang ^a   Robotham, Jason M ^a   Lee, Emily ^a   Dalton, Stephen ^b   Kneteman, Norman M ^c   Gilbert, David M ^a   Tang, Hengli ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b University of Georgia ^*  (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CD81 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOKERATIN 7; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MICRORNA 122; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SMALL INTERFERING RNA; MICRORNA; MIRN122 MICRORNA, HUMAN;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL THERAPY; CULTURE MEDIUM; DNA MODIFICATION; ENDODERM; HEPATITIS C; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER; LIVER CELL; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; RNA INTERFERENCE; STEM CELL; VIRUS GENE; VIRUS REPLICATION; VIRUS TRANSMISSION; BIOLOGICAL MODEL; CELL LINE; HEPATITIS C VIRUS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

HEPATITIS C VIRUS;

CELL DIFFERENTIATION; CELL LINE; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; MICRORNAS; MODELS, BIOLOGICAL; PLURIPOTENT STEM CELLS;

EID: 84861206498     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002617     Document Type: Article

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