Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

Biochemical and Biophysical Research Communications

Volumn 416, Issue 1-2, 2011, Pages 119-124

  Yoshida, Takeshi ^a   Takayama, Kazuo ^a   Kondoh, Masuo ^a   Sakurai, Fuminori ^a   Tani, Hideki ^b   Sakamoto, Naoya ^c   Matsuura, Yoshiharu ^b   Mizuguchi, Hiroyuki ^a   Yagi, Kiyohito ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Experimental model; Hepatitis C virus; Hepatocyte; Induced pluripotent stem cell; Infection; Replication

Indexed keywords

CD81 ANTIGEN; CLAUDIN 1; INTERFERON; OCCLUDIN; SCAVENGER RECEPTOR BI;

ARTICLE; CONTROLLED STUDY; HEPATITIS C; HEPATITIS C VIRUS; HEPATOCYTE LIKE CELL; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; LIVER CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; VIRUS ENTRY; VIRUS GENOME; VIRUS REPLICATION; VIRUS TYPING;

HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; MODELS, BIOLOGICAL; PLURIPOTENT STEM CELLS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

HEPATITIS C VIRUS; IPS; PAN;

EID: 83055191266     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.11.007     Document Type: Article

References (36)

1. Sarbah S.A., Younossi Z.M. Hepatitis C: an update on the silent epidemic. J. Clin. Gastroenterol. 2000, 30:125-143.
2. Schlutter J. Therapeutics: new drugs hit the target. Nature 2011, 474:S5-7.
3. Sakamoto N., Watanabe M. New therapeutic approaches to hepatitis C virus. J. Gastroenterol. 2009, 44:643-649.
4. Sakamoto N., Wu G.Y. Prospects for future therapy of hepatitis C virus infection. Future Virology 2009, 4:453-462.
5. Sarrazin C., Kieffer T.L., Bartels D., Hanzelka B., Muh U., Welker M., Wincheringer D., Zhou Y., Chu H.M., Lin C., Weegink C., Reesink H., Zeuzem S., Kwong A.D. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007, 132:1767-1777.
6. Jopling C.L., Yi M., Lancaster A.M., Lemon S.M., Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 2005, 309:1577-1581.
7. Lanford R.E., Hildebrandt-Eriksen E.S., Petri A., Persson R., Lindow M., Munk M.E., Kauppinen S., Orum H. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010, 327:198-201.
8. Lupberger J., Zeisel M.B., Xiao F., Thumann C., Fofana I., Zona L., Davis C., Mee C.J., Turek M., Gorke S., Royer C., Fischer B., Zahid M.N., Lavillette D., Fresquet J., Cosset F.L., Rothenberg S.M., Pietschmann T., Patel A.H., Pessaux P., Doffoel M., Raffelsberger W., Poch O., McKeating J.A., Brino L., Baumert T.F. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat. Med. 2011, 17:589-595.
9. Bukh J. A critical role for the chimpanzee model in the study of hepatitis C. Hepatology 2004, 39:1469-1475.
10. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
11. Greenbaum L.E. From skin cells to hepatocytes: advances in application of iPS cell technology. J. Clin. Invest. 2010, 120:3102-3105.
12. Kiskinis E., Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J. Clin. Invest. 2010, 120:51-59.
13. Gai H., Nguyen D.M., Moon Y.J., Aguila J.R., Fink L.M., Ward D.C., Ma Y. Generation of murine hepatic lineage cells from induced pluripotent stem cells. Differentiation 2010, 79:171-181.
14. Si-Tayeb K., Noto F.K., Nagaoka M., Li J., Battle M.A., Duris C., North P.E., Dalton S., Duncan S.A. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 2010, 51:297-305.
15. Song Z., Cai J., Liu Y., Zhao D., Yong J., Duo S., Song X., Guo Y., Zhao Y., Qin H., Yin X., Wu C., Che J., Lu S., Ding M., Deng H. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 2009, 19:1233-1242.
16. Sullivan G.J., Hay D.C., Park I.H., Fletcher J., Hannoun Z., Payne C.M., Dalgetty D., Black J.R., Ross J.A., Samuel K., Wang G., Daley G.Q., Lee J.H., Church G.M., Forbes S.J., Iredale J.P., Wilmut I. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 2010, 51:329-335.
17. Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Sakurai F., Hayakawa T., Furue M.K., Mizuguchi H. Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction. PLoS One 2011, 6:e21780.
18. Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y., Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue M.K., Mizuguchi H. Efficient generation of hepatoblasts from human ES cells and iPS cells by transient over-expression of homeobox gene HEX. Mol. Ther. 2011, 19:400-407.
19. K. Takayama, M. Inamura, K. Kawabata, K. Katayama, M. Higuchi, K. Tashiro, A. Nonaka, F. Sakurai, T. Hayakawa, M.K. Furue, H. Mizuguchi, Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction, Mol. Ther. (in press).
20. Makino H., Toyoda M., Matsumoto K., Saito H., Nishino K., Fukawatase Y., Machida M., Akutsu H., Uyama T., Miyagawa Y., Okita H., Kiyokawa N., Fujino T., Ishikawa Y., Nakamura T., Umezawa A. Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS. Exp. Cell Res. 2009, 315:2727-2740.
21. Nagata S., Toyoda M., Yamaguchi S., Hirano K., Makino H., Nishino K., Miyagawa Y., Okita H., Kiyokawa N., Nakagawa M., Yamanaka S., Akutsu H., Umezawa A., Tada T. Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells. Genes Cells 2009, 14:1395-1404.
22. Furue M.K., Na J., Jackson J.P., Okamoto T., Jones M., Baker D., Hata R., Moore H.D., Sato J.D., Andrews P.W. Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proc. Natl. Acad. Sci. USA 2008, 105:13409-13414.
23. Tani H., Komoda Y., Matsuo E., Suzuki K., Hamamoto I., Yamashita T., Moriishi K., Fujiyama K., Kanto T., Hayashi N., Owsianka A., Patel A.H., Whitt M.A., Matsuura Y. Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins. J. Virol. 2007, 81(9):8601-8612.
24. Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K. Adenovirus vector-mediated assay system for hepatitis C virus replication. Nucleic Acids Res. 2011, 39:e64.
25. Mizuguchi H., Hayakawa T. Characteristics of adenovirus-mediated tetracycline-controllable expression system. Biochim. Biophys. Acta 2002, 1568:21-29.
26. Mizuguchi H., Kay M.A. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Hum. Gene Ther. 1998, 9:2577-2583.
27. Besnard N.C., Andre P.M. Automated quantitative determination of hepatitis C virus viremia by reverse transcription-PCR. J. Clin. Microbiol. 1994, 32:1887-1893.
28. Komurian-Pradel F., Perret M., Deiman B., Sodoyer M., Lotteau V., Paranhos-Baccala G., Andre P. Strand specific quantitative real-time PCR to study replication of hepatitis C virus genome. J. Virol. Methods 2004, 116:103-106.
29. Zeisel M.B., Fofana I., Fafi-Kremer S., Baumert T.F. Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. J. Hepatol. 2011, 54:566-576.
30. Moriishi K., Matsuura Y. Evaluation systems for anti-HCV drugs. Adv. Drug Deliv. Rev. 2007, 59:1213-1221.
31. Ek M., Soderdahl T., Kuppers-Munther B., Edsbagge J., Andersson T.B., Bjorquist P., Cotgreave I., Jernstrom B., Ingelman-Sundberg M., Johansson I. Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells. Biochem. Pharmacol. 2007, 74:496-503.
32. Battle M.A., Konopka G., Parviz F., Gaggl A.L., Yang C., Sladek F.M., Duncan S.A. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc. Natl. Acad. Sci. USA 2006, 103:8419-8424.
33. Malerod L., Sporstol M., Juvet L.K., Mousavi A., Gjoen T., Berg T. Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha. Biochem. Biophys. Res. Commun. 2003, 305:557-565.
34. Lagos-Quintana M., Rauhut R., Yalcin A., Meyer J., Lendeckel W., Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 2002, 12:735-739.
35. Kim N., Kim H., Jung I., Kim Y., Kim D., Han Y.M. Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation. Hepatol. Res. 2011, 41:170-183.
36. Gravitz L., Smouldering A. Public-health crisis. Nature 2011, 474:S2-S4.