Structural and dynamic properties of amorphous solid dispersions: The role of solid-state nuclear magnetic resonance spectroscopy and relaxometry

Journal of Pharmaceutical Sciences

Volumn 103, Issue 9, 2014, Pages 2635-2662

  Paudel, Amrit ^a,c   Geppi, Marco ^b   Van Den Mooter, Guy ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

^c RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

Author keywords

amorphous; characterization; crystallinity; dissolution; hydrogen bonding; miscibility; molecular mobility; phase separation; physical stability; solid state NMR

Indexed keywords

DRUG CARRIER; DRUG;

AMORPHOUS SOLID DISPERSION; ANALYTIC METHOD; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISPERSION; DISSOLUTION; MISCIBILITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MONITORING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; SOLID STATE NUCLEAR MAGNETIC RESONANCE RELAXOMETRY; SOLID STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ANALYSIS; BIOAVAILABILITY; CHEMISTRY; DRUG STABILITY; MEDICINAL CHEMISTRY; PROCEDURES;

BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; PHARMACEUTICAL PREPARATIONS;

EID: 84906315462     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23966     Document Type: Review

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