Miscibility of nifedipine and hydrophilic polymers as measured by 1H-NMR spin-lattice relaxation

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 8, 2007, Pages 1227-1231

  Aso, Yukio ^a   Yoshioka, Sumie ^a   Miyazaki, Tamaki ^a   Kawanishi, Tohru ^a   Tanaka, Kazuyuki ^b   Kitamura, Satoshi ^b   Takakura, Asako ^c   Hayashi, Takashi ^c   Muranushi, Noriyuki ^c  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

Author keywords

Amorphous; Miscibility; Solid dispersion; Spin diffusion; Spin lattice relaxation time

Indexed keywords

ALPHA,BETA POLY(N 5 HYDROXYPENTYL)ASPARTAMIDE; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; NIFEDIPINE; POLYMER; POVIDONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FEASIBILITY STUDY; HYDROPHILICITY; LABORATORY; MATHEMATICAL ANALYSIS; MISCIBILITY; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID; SPRAY DRYING; TEMPERATURE;

CALCIUM CHANNEL BLOCKERS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; METHYLCELLULOSE; NIFEDIPINE; PHENOBARBITAL; POLYMERS; POVIDONE; SOLUBILITY;

EID: 34548297155     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.1227     Document Type: Article

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