NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4421-4431

  Zhang, Junying ^a   Tozuka, Yuichi ^b   Uchiyama, Hiromasa ^b   Higashi, Kenjirou ^a   Moribe, Kunikazu ^a   Takeuchi, Hirofumi ^b   Yamamoto, Keiji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Excipients; Interaction; Micelle; NMR; NOESY; Solubilization; Spray drying; glucosylhesperidin

Indexed keywords

ALPHA GLUCOSYLHESPERIDIN; FLAVANONE; FLURBIPROFEN; NARINGENIN; SURFACTANT; UNCLASSIFIED DRUG; DRUG; EXCIPIENT; FLAVANONE DERIVATIVE; GLUCOSIDE; GLUCOSYL HESPERIDIN; HESPERIDIN; MICELLE; WATER;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; DRUG SOLUBILITY; HYDROPHOBICITY; LIGHT SCATTERING; MICELLE; MICELLIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SURFACE TENSION; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; FLAVANONES; FLURBIPROFEN; GLUCOSIDES; HESPERIDIN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SURFACE TENSION; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 80052272614     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22606     Document Type: Article

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