Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion?

International Journal of Pharmaceutics

Volumn 395, Issue 1-2, 2010, Pages 232-235

  Qian, Feng ^a   Huang, Jun ^a   Zhu, Qing ^b   Haddadin, Raja ^a   Gawel, John ^a   Garmise, Robert ^a   Hussain, Munir ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Purdue University   (United States)

Author keywords

Amorphous solid dispersion; Confocal Raman microscopy; Homogeneity; Hot melt extrusion; Tg

Indexed keywords

BMS A; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; POLY(VINYLPYRROLIDONE CO VINYLACETATE); POLYMER; UNCLASSIFIED DRUG; DRUG; POLY(VINYLPYRROLIDONE CO VINYL ACETATE); POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); PYRROLIDINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; CONFOCAL MICROSCOPY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG STABILITY; GLASS TRANSITION TEMPERATURE; PRIORITY JOURNAL; SOLID; X RAY POWDER DIFFRACTION; CHEMICAL MODEL; CHEMISTRY; DRUG FORMULATION; METHODOLOGY; PHARMACEUTICS; POWDER DIFFRACTION; RAMAN SPECTROMETRY; TIME; TRANSITION TEMPERATURE; X RAY CRYSTALLOGRAPHY;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; DRUG STABILITY; MICROSCOPY, CONFOCAL; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; POWDER DIFFRACTION; PYRROLIDINES; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; TRANSITION TEMPERATURE; VINYL COMPOUNDS;

EID: 77954314844     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.05.033     Document Type: Article

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