Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3023-3033

  Ueda, Keisuke ^a   Higashi, Kenjirou ^a   Limwikrant, Waree ^a   Sekine, Shuichi ^a   Horie, Toshiharu ^a   Yamamoto, Keiji ^a   Moribe, Kunikazu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

1H NMR spectroscopy; Caco 2 permeation; HPMC AS; NMR relaxation time; solid dispersion; supersaturated solution

Indexed keywords

CARBAMAZEPINE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; POLOXAMER;

AQUEOUS SOLUTION; ARTICLE; DIALYSIS MEMBRANE; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SPRAY DRYING; VISCOSITY; X RAY POWDER DIFFRACTION;

ANTICONVULSANTS; CACO-2 CELLS; CARBAMAZEPINE; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIALYSIS; DOSAGE FORMS; DRUG COMPOUNDING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES, ARTIFICIAL; METHYLCELLULOSE; PHYSICOCHEMICAL PHENOMENA; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84868554561     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300083e     Document Type: Article

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