Mechanisms for the acute effect of fructose on postprandial lipemia

American Journal of Clinical Nutrition

Volumn 85, Issue 6, 2007, Pages 1511-1520

  Chong, Mary F F ^a   Fielding, Barbara A ^a   Frayn, Keith N ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Carbohydrate oxidation; De novo lipogenesis; Fructose; High carbohydrate diets; Hypertriglyceridemia; Lipoprotein lipase; Mechanisms; Stable isotopes

Indexed keywords

CARBON; CARBON 13; DEUTERIUM; FATTY ACID; FRUCTOSE; GLUCOSE; INSULIN; LIPOPROTEIN LIPASE; PALMITIC ACID; TRIACYLGLYCEROL; URANIUM; VERY LOW DENSITY LIPOPROTEIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; BREATH ANALYSIS; CALORIMETRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; ESTERIFICATION; FAT INTAKE; FATTY ACID SYNTHESIS; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; LIPOGENESIS; LUNG GAS EXCHANGE; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUGAR INTAKE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 34250000890     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/85.6.1511     Document Type: Article

References (53)

1. Donmoyer CM, Ejiofor J, Lacy DB, Chen SS, McGuinness OP. Fructose augments infection-impaired net hepatic glucose uptake during TPN administration. Am J Physiol Endocrinol Metab 2001;280:E703-11.
2. Moore MC, Davis SN, Mann SL, Cherrington AD. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care 2001;24:1882-7.
3. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76:911-22.
4. Truswell AS. Food carbohydrates and plasma lipids - an update. Am J Clin Nutr 1994;59(suppl):710S-8S.
5. Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992;55:851-6.
6. Macdonald I. Influence of fructose and glucose on serum lipid levels in men and pre- and postmenopausal women. Am J Clin Nutr 1966;18:369-72.
7. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000;72:1128-34.
8. Bossetti BM, Kocher LM, Moranz JF, Falko JM. The effects of physiologic amounts of simple sugars on lipoprotein, glucose, and insulin levels in normal subjects. Diabetes Care 1984;7:309-12.
9. Huttunen JK, Makinen KK, Scheinin A. Turku sugar studies XI. Effects of sucrose, fructose and xylitol diets on glucose, lipid and urate metabolism. Acta Odontol Scand 1976;34:345-51.
10. Crapo PA, Kolterman OG. The metabolic effects of 2-week fructose feeding in normal subjects. Am J Clin Nutr 1984;39:525-34.
11. Thorburn AW, Crapo PA, Beltz WF, Wallace P, Witztum JL, Henry RR. Lipid metabolism in non-insulin-dependent diabetes: effects of long-term treatment with fructose-supplemented mixed meals. Am J Clin Nutr 1989;50:1015-22.
12. Reiser S, Powell AS, Scholfield DJ, Panda P, Ellwood KC, Canary JJ. Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch. Am J Clin Nutr 1989;49:832-9.
13. Hallfrisch J, Reiser S, Prather ES. Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose. Am J Clin Nutr 1983;37:740-8.
14. Boquist S, Ruotolo G, Tang R, et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation 1999;100:723-8.
15. Mancini M, Mattock M, Rabaya E, Chait A, Lewis B. Studies of the mechanisms of carbohydrate-induced lipaemia in normal man. Atherosclerosis 1973;17:445-54.
16. Hirano T, Mamo J, Poapst M, Steiner G. Very-low-density lipoprotein triglyceride kinetics in acute and chronic carbohydrate-fed rats. Am J Physiol 1988;255:E236-40.
17. Frayn KN, Kingman SM. Dietary sugars and lipid metabolism in humans. Am J Clin Nutr 1995;62(suppl):250S-61S.
18. Zakim D. Influence of fructose of hepatic synthesis of lipids. Prog Biochem Pharmacol 1973;8:161-88.
19. Carmona A, Freedland RA. Comparison among the lipogenic potential of various substrates in rat hepatocytes: the differential effects of fructose-containing diets on hepatic lipogenesis. J Nutr 1989;119:1304-10.
20. Schwarz JM, Neese R, Turner S, Nguyen C, Hellerstein M. Effect of fructose ingestion on glucose production and de novo lipogenesis in normal and hyperinsulinemic obese humans. Diabetes 1994;43(suppl):52A (abstr).
21. Schwarz JM, Neese R, Shackleton CH, Hellerstein M. De novo lipogenesis during fasting and oral fructose in lean and obese hyperinsulinemic subjects. Diabetes 1993;42(suppl):39A (abstr).
22. Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy L. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 2005;54:1907-13.
23. Humphreys SM, Frayn KN. Micro-method for preparing perchloric extracts of blood. Clin Chem 1988;34:1657.
24. Bickerton AST, Roberts R, Fielding BA, et al. Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period. Diabetes 2007;56:168-76.
25. Roe JH. A colorimetric method for the determination of fructose in blood and urine. J Biol Chem 1934;107:15-22.
26. Truswell AS, Seach JM, Thorburn AW. Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose. Am J Clin Nutr 1988;48:1424-30.
27. Fisher RM, Coppack SW, Humphreys SM, Gibbons GF, Frayn KN. Human triacylglycerol-rich lipoprotein subfractions as substrates for lipoprotein lipase. Clin Chim Acta 1995;236:7-17.
28. Evans K, Burdge GC, Wootton SA, Clark ML, Frayn KN. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 2002;51:2684-90.
29. Gibney J, Healy ML, Stolinski M, et al. Effect of growth hormone (GH) on glycerol and free fatty acid metabolism during exhaustive exercise in GH-deficient adults. J Clin Endocrinol Metab 2003;88:1792-7.
30. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983;55:628-34.
31. Snyder WS for the International Commission on Radiological Protection. Report of the task force on reference man. Oxford, United Kingdom: Pergamon Press, 1975.
32. Holdsworth CD, Dawson AM. Absorption of fructose in man. Proc Soc Exp Biol Med 1965;118:142-5.
33. Teff KL, Elliott SS, Tschop M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004;89:2963-72.
34. Abraha A, Humphreys SM, Clark ML, Matthews DR, Frayn KN. Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects. Br J Nutr 1998;80:169-75.
35. Frayn KN, Coppack SW, Fielding BA, Humphreys SM. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv Enzyme Regul 1995;35:163-78.
36. Sadur CN, Eckel RH. Insulin stimulation of adipose tissue lipoprotein lipase. Use of the euglycemic clamp technique. J Clin Invest 1982;69:1119-25.
37. Vrana A, Fabry P, Slabochova Z, Kazdova L. Effect of dietary fructose on free fatty acid release from adipose tissue and serum free fatty acid concentration in the rat. Nutr Metab 1974;17:74-83.
38. Brunzell JD, Hazzard WR, Porte D, Jr., Bierman EL. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J Clin Invest 1973;52:1578-85.
39. Mamo JC, Hirano T, James L, Szeto L, Steiner G. Partial characterization of the fructose-induced defect in very-low-density lipoprotein triglyceride metabolism. Metabolism 1991;40:888-93.
40. 13C fructose to glucose appearance in humans. Diabetologia 1993;36:338-45.
41. Pagliassotti MJ, Cherrington AD. Regulation of net hepatic glucose uptake in vivo. Annu Rev Physiol 1992;54:847-60.
42. Moore MC, Flakoll PJ, Hsieh PS, et al. Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. Am J Physiol 1998;274:E893-902.
43. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, Klein S. Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res 2002;43:223-33.
44. Daly ME, Vale C, Walker M, Littlefield A, Alberti KGMM, Mathers J. Acute fuel selection in response to high-sucrose and high-starch meals in healthy men. Am J Clin Nutr 2000;71:1516-24.
45. Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr 1993;58(suppl):754S-65S.
46. Nilsson LH, Hultman E. Liver and muscle glycogen in man after glucose and fructose infusion. Scand J Clin Lab Invest 1974;33:5-10.
47. Le KA, Tappy L. Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 2006;9:469-75.
48. Schwarz JM, Neese RA, Basinger A, Hellerstein MK. Effect of oral lipogenesis on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis using mass isotopomer distribution analysis (MIDA). FASEB J 1993;7:A867 (abstr).
49. McGarry JD, Leatherman GF, Foster DW. Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. J Biol Chem 1978;253:4128-36.
50. 14C into glycerol and fatty acids of serum triglyceride in patients with myocardial infarction. Metabolism 1970;19:1085-93.
51. Aarsland A, Wolfe RR. Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. J Lipid Res 1998;39:1280-6.
52. Hudgins LC, Hellerstein MK, Seidman CE, Neese RA, Tremaroli JD, Hirsch J. Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res 2000;41:595-604.
53. Timlin MT, Parks EJ. Temporal pattern of de novo lipogenesis in the postprandial state in healthy men. Am J Clin Nutr 2005;81:35-42.