Adverse effects of dietary fructose

Alternative Medicine Review

Volumn 10, Issue 4, 2005, Pages 294-306

  Gaby, Alan R ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; FRUCTOSE; SUCROSE; SWEETENING AGENT;

AGING; ATHEROSCLEROSIS; CALORIC INTAKE; CHRONIC DIARRHEA; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DIETARY INTAKE; DRUG ABSORPTION; DRUG METABOLISM; FRUCTOSE METABOLISM; GLUCOSE BLOOD LEVEL; GLYCATION; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; IRRITABLE COLON; NONALCOHOLIC FATTY LIVER; OBESITY; PREVALENCE; REVIEW; URTICARIA;

DIABETES MELLITUS; DIETARY CARBOHYDRATES; FATTY LIVER; FRUCTOSE; HUMANS; INTESTINAL DISEASES; OBESITY;

EID: 29144456572     PISSN: 10895159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (79)

1. Elliott SS, Keim NL, Stern JS, et al. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76:911-922.
2. Bantle JP, Laine DC, Thomas JW. Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 1986;256:3241-3246.
3. Choi YK, Johlin FC Jr, Summers RW, et al. Fructose intolerance: an under-recognized problem. Am J Gastroenterol 2003;98:1348-1353.
4. Cook GC. Absorption products of D(-) fructose in man. Clin Sci 1969;37:675-687.
5. Rumessen JJ, Gudmand-Hoyer E. Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut 1986;27:1161-1168.
6. Dencker H, Meeuwisse G, Norryd C, et al. Intestinal transport of carbohydrates as measured by portal catheterization in man. Digestion 1973;9:514-524.
7. Michal G, ed. Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology. Wiley. NY: Wiley, John & Sons, Incorporated; 1999:27.
8. Macdonald I, Keyser A, Pacy D. Some effects, in man, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood. Am J Clin Nutr 1978;31:1305-1311.
9. Bohannon NV, Karam JH, Forsham PH. Endocrine responses to sugar ingestion in man. Advantages of fructose over sucrose and glucose. J Am Diet Assoc 1980;76:555-560.
10. Dills WL Jr. Protein fructosylation: fructose and the Maillard reaction. Am J Clin Nutr 1993;58:779S-787S.
11. Brownlee M. Glycosylation products as toxic mediators of diabetic complications. Annu Rev Med 1991;42:159-166.
12. Howard BV, Wylie-Rosett J. Sugar and cardiovascular disease: a statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation 2002;106:523-527.
13. Devamanoharan PS, Ali AH, Varma SD. Prevention of lens protein glycation by taurine. Mol Cell Biochem 1997;177:245-250.
14. Lin YT, Tseng YZ, Chang KC. Aminoguanidine prevents fructose-induced arterial stiffening in Wistar rats: aortic impedance analysis. Exp Biol Med (Maywood) 2004;229:1038-1045.
15. Cerami A, Vlassara H, Brownlee M. Protein glycosylation and the pathogenesis of atherosclerosis. Metabolism 1985;34:37-42.
16. Bunn HF, Higgins PJ. Reaction of monosaccharides with proteins: possible evolutionary significance. Science 1981;213:222-224.
17. McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and cross-linking of proteins. Biochemistry 1988;27:1901-1907.
18. Levi B, Werman MJ. Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J Nutr 1998;128:1442-1449.
19. Vlassara H, Cai W, Crandall J, et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A 2002;99:15596-15601.
20. Zheng F, He C, Cai W, et al. Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev 2002;18:224-237.
21. Goldberg T, Cai W, Peppa M, et al. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004;104:1287-1291.
22. Crapo PA, Kolterman OG, Olefsky JM. Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care 1980;3:575-582.
23. Crapo PA, Scarlett JA, Kolterman OG. Comparison of the metabolic responses to fructose and sucrose sweetened foods. Am J Clin Nutr 1982;36:256-261.
24. Hassinger W, Gaberle E, Schultz G, et al. Blood glucose levels and insulin requirement after fructose as sweetener in diabetic diet. Diabetologia 1980;19:281.
25. Crapo PA, Kolterman OG, Henry RR. Metabolic consequence of two-week fructose feeding in diabetic subjects. Diabetes Care 1986;9:111-119.
26. Thorburn AW, Crapo PA, Griver K, et al. Long-term effects of dietary fructose on carbohydrate metabolism in non-insulin-dependent diabetes mellitus. Metabolism 1990;39:58-63.
27. Koivisto VA, Yki-Jarvinen H. Fructose and insulin sensitivity in patients with type 2 diabetes. J Intern Med 1993;233:145-153.
28. Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992;55:851-856.
29. Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care 1992;15:1468-1476.
30. Faeh D, Minehira K, Schwarz JM, et al. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipoeenesis and insulin sensitivity in healthy men. Diabetes 2005;54:1907-1913.
31. Beck-Nielsen H, Pedersen O, Linskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feedins in normal subjects. Am J Clin Nutr 1980;33:273-278.
32. Fields M, Lewis CG, Beal T. Accumulation of sorbitol in copper deficiency: dependency on gender and type of dietary carbohydrate. Metabolism 1989;38:371-375.
33. Boot-Handford R, Heath H. Identification of fructose as the retinopathic agent associated with the ingestion of sucrose-rich diets in the rat. Metabolism 1980;29:1247-1252.
34. Kawasaki T, Ogata N, Akanuma H, et al. Postprandial plasma fructose level is associated with retinopathy in patients with type 2 diabetes. Metabolism 2004;53:583-588.
35. Blakely SR, Hallfrisch J, Reiser S, Prather ES. Long term effects of moderate fructose feeding on glucose tolerance parameters in rats. J Nutr 1981;111:307-314.
36. Cohen AM, Teitelbaum A, Rosenman E. Diabetes induced by a high fructose diet. Metabolism 1977;26:17-24.
37. Schulze MB, Manson JE, Ludwig DS, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in youns and middle-aged women. JAMA 2004;292:927-934.
38. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-1231.
39. Tuovinen CG, Bender AE. Some metabolic effects of prolonged feeding of starch, sucrose, fructose and carbohydrate-free diet in the rat. Nutr Metab 1975;19:161-172.
40. Davail S, Rideau N, Bernadet MD, et al. Effects of dietary fructose on liver steatosis in overfed mule ducks. Horm Metab Res 2005;37:32-35.
41. Nandhini AT, Balakrishnan SD, Anuradha CV. Response of liver antioxidant system to taurine in rats fed high fructose diet. Indian J Exp Biol 2002;40:1016-1019.
42. Kelley GL, Allan G, Azhar S. High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation. Endocrinology 2004;145:548-555.
43. Santer R, Rischewski J, von Weihe M, et al. The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. Hum Mutat 2005;25:594.
44. Esposito G, Santamaria R, Vitagliano L, et al. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. Hum Mutat 2004;24:534.
45. Brooks CC, Tolan DR. A partially active mutant aldolase B from a patient with hereditary fructose intolerance. FASEB J 1994;8:107-113.
46. Porikos KP, Van Itallie TB. Transient elevations of serum transaminases in healthy males on a high sucrose diet. Am J Clin Nutr 1979;32:959.
47. Porikos KP, Van Itallie TB. Diet-induced changes in serum transaminase and triglyceride levels in healthy adult men. Role of sucrose and excess calories. Am J Med 1983;75:624-630.
48. Spurlock M (Director). Super Size Me. Kathbur Pictures, Inc., 2004.
49. Oberhaensli RD, Galloway GJ, Taylor DJ, et al. Assessment of human liver metabolism by phosphorus-31 magnetic resonance spectroscopy. Br J Radiol 1986;59:695-699.
50. Cortez-Pinto H, Chatham J, Chacko VP, et al. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 1999;282:1659-1664.
51. Terrier F, Vock P, Cotting J, et al. Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers. Radiology 1989;171:557-563.
52. Born P, Zech J, Lehn H, et al. Colonic bacterial activity determines the symptoms in people with fructose-malabsorption. Hepatogastroenterology 1995;42:778-785.
53. Ledochowski M, Widner B, Bair H, et al. Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances in fructose malabsorbers. Scand J Gastroenterol 2000;35:1048-1052.
54. Rumessen JJ, Gudmand-Hoyer E. Functional bowel disease: malabsorption and abdominal distress after ingestion of fructose, sorbitol, and fructose-sorbitol mixtures. Gastroenterology 1988;95:694-700.
55. Andersson DE, Nygren A. Four cases of long-standing diarrhoea and colic pains cured by fructose-free diet - a pathogenetic discussion. Acta Med Scand 1978;203:87-92.
56. Fernandez-Banares F, Esteve-Pardo M, de Leon R, et al. Sugar malabsorption in functional bowel disease: clinical implications. Am J Gastroenterol 1993;88:2044-2050.
57. Ament ME. Malabsorption of apple juice and pear nectar in infants and children: clinical implications. J Am Coll Nutr 1996;15:26S-29S.
58. Rumessen JJ, Gudmand-Hoyer E. Malabsorption of fructose-sorbitol mixtures. Interactions causing abdominal distress. Scand J Gastroenterol 1987;22:431-436.
59. Lifshitz F, Ament ME, Kleinman RE, et al. Role of juice carbohydrate malabsorption in chronic nonspecific diarrhea in children. J Pediatr 1992;120:825-829.
60. Hyams JS, Leichtner AM. Apple juice. An unappreciated cause of chronic diarrhea. Am J Dis Child 1985;139:503-505.
61. Duro D, Rising R, Cedillo M, Lifshitz F. Association between infantile colic and carbohydrate malabsorption from fruit juices in infancy. Pediatrics 2002;109:797-805.
62. Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 2001;357:505-508.
63. Allen RJ, Brook M, Lister RE, et al. Metabolic differences between dietary liquid glucose and sucrose. Nature 1966;211:1104.
64. Nagata R, Nishio Y, Sekine O, et al. Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis. J Biol Chem 2004;279:29031-29042.
65. James J, Thomas P, Cavan D, Kerr D. Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial. BMJ 2004;328:1237.
66. Cooper JT. Dr. Cooper's Fabulous Fructose Diet. M. Evans and Co., Inc.; New York, NY: 1979.
67. Rodin J, Reed D, Jamner L. Metabolic effects of fructose and glucose: implications for food intake. Am J Clin Nutr 1988;47:683-689.
68. Simko V. Increase in serum lipids on feeding sucrose: the role of fructose and glucose. Am J Clin Nutr 1980;33:2217.
69. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000;72:1128-1134.
70. Hallfrisch J, Reiser S, Prather ES. Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose. Am J Clin Nutr 1983;37:740-748.
71. Reiser S, Powell AS, Scholfield DJ, et al. Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch. Am J Clin Nutr 1989;49:832-839.
72. Emmerson BT. Effect of oral fructose on urate production. Ann Rheum Dis 1974;33:276-280.
73. Crapo PA, Kolterman OG. The metabolic effects of 2-week fructose feeding in normal subjects. Am J Clin Nutr 1984;39:525-534.
74. Kelsay JL, Behall KM, Moser PB, Prather ES. The effect of kind of carbohydrate in the diet and use of oral contraceptives on metabolism of young women. I. Blood and urinary lactate, uric acid, and phosphorus. Am J Clin Nutr 1977;30:2016-2022.
75. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000;283:2404-2410.
76. Reiser S, Ferretti RJ, Fields M, Smith JC Jr. Role of dietary fructose in the enhancement of mortality and biochemical changes associated with copper deficiency in rats. Am J Clin Nutr 1983;38:214-222.
77. Fields M, Ferretti RJ, Reiser S, Smith JC Jr. The severity of copper deficiency in rats is determined by the type of dietary carbohydrate. Proc Soc Exp Biol Med 1984;175:530-537.
78. Baker DH. Cupric oxide should not be used as a copper supplement for either animals or humans. J Nutr 1999;129:2278-2279.
79. Nishioka K, Katayama I, Sano S. Urticaria induced by D-psicose. Lancet 1983;2:1417-1418.