Atomistic mechanisms of huntingtin N-terminal fragment insertion on a phospholipid bilayer revealed by molecular dynamics simulations

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 7, 2014, Pages 1409-1427

  Côté, Sébastien ^a   Wei, Guanghong ^b   Mousseau, Normand ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b FUDAN UNIVERSITY   (China)

Author keywords

All atom explicit solvent simulations; HttNTQN monomer; Huntingtin protein; Huntington's disease; Peptide membrane interactions

Indexed keywords

HUNTINGTIN; MOLECULAR SCAFFOLD; PHOSPHOLIPID; SODIUM CHLORIDE; GLUTAMINE; HTT PROTEIN, HUMAN; LIPID BILAYER; NERVE PROTEIN;

ALPHA HELIX; ARTICLE; ATOM; COMPUTER SIMULATION; GENE INSERTION; HYDROGEN BOND; MOLECULAR DYNAMICS; OLIGOMERIZATION; PHASE PARTITIONING; PHOSPHOLIPID BILAYER; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN STRUCTURE; BIOLOGICAL MODEL; CHEMISTRY; HUMAN; LIPID BILAYER; METABOLISM;

GLUTAMINE; HUMANS; LIPID BILAYERS; MODELS, BIOLOGICAL; MOLECULAR DYNAMICS SIMULATION; NERVE TISSUE PROTEINS; PHOSPHOLIPIDS;

EID: 84902164061     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24509     Document Type: Article

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