Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Zhang, Yun ^a   Luo, Yin ^a   Deng, Yonghua ^a   Mu, Yuguang ^b   Wei, Guanghong ^a  

^a FUDAN UNIVERSITY   (China)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; ARGININE; DIMER; GLYCEROPHOSPHOLIPID; LYSINE; MONOMER; PALMITOYLOLEOLYOPHOSPHATIDYLGLYCEROL; UNCLASSIFIED DRUG; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; PEPTIDE FRAGMENT; PHOSPHATIDYLCHOLINE; SOLVENT;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CELL MEMBRANE; CYTOTOXICITY; DIMERIZATION; LIPID BILAYER; MEMBRANE DAMAGE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PANCREAS ISLET BETA CELL; PROTEIN AGGREGATION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY; SURFACE CHARGE; AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; LIPID METABOLISM; METABOLISM; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; CELL MEMBRANE; HUMANS; ISLET AMYLOID POLYPEPTIDE; LIPID BILAYERS; LIPID METABOLISM; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHATIDYLCHOLINES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SOLVENTS; STATIC ELECTRICITY;

EID: 84861707850     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038191     Document Type: Article

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