Adsorption and orientation of human islet amyloid polypeptide (hIAPP) Monomer at anionic lipid bilayers: Implications for membrane-mediated aggregation

International Journal of Molecular Sciences

Volumn 14, Issue 3, 2013, Pages 6241-6258

  Jia, Yan ^a   Qian, Zhenyu ^a   Zhang, Yun ^a   Wei, Guanghong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Adsorption dynamics; Anionic palmitoyl oleolyohosphatidyl glycerol (POPG) bilayer; Binding orientation; Human islet amyloid polypeptide; Molecular dynamics simulations; Peptide lipid interaction; Type 2 diabetes

Indexed keywords

AMYLIN; PALMITOYLOLEOYLPHOSPHATIDYLGLYCEROL; PHOSPHATIDYLGLYCEROL; UNCLASSIFIED DRUG;

ADSORPTION KINETICS; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; MEMBRANE BINDING; MOLECULAR DYNAMICS; PHOSPHOLIPID BILAYER; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN STABILITY; SOLVENT EFFECT; STATIC ELECTRICITY; SURFACE CHARGE;

EID: 84875495915     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14036241     Document Type: Article

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