Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 16017-16028

  Nucifora, Leslie G ^a   Burke, Kathleen A ^b   Feng, Xia ^a,d   Arbez, Nicolas ^a   Zhu, Shanshan ^a   Miller, Jason ^c   Yang, Guocheng ^c   Ratovitski, Tamara ^a   Delannoy, Michael ^a   Muchowski, Paul J ^c   Finkbeiner, Steven ^c   Legleiter, Justin ^b   Ross, Christopher A ^a   Poiriera, Michelle A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROCESS; AMYLOID-LIKE FIBRIL; CORTICAL NEURONS; GEL ANALYSIS; GENE PRODUCTS; HAIRPIN CONFORMATION; HUNTINGTIN; HUNTINGTON DISEASE; IN-VITRO; MAMMALIAN CELL LINES; MAMMALIAN CELLS; MUTANT HUNTINGTIN; N-TERMINALS; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS; POLYGLUTAMINE; POLYGLUTAMINE PROTEINS; TOXIC SPECIES; TRANSGENIC MICE;

AGGLOMERATION; AMINO ACIDS; ANTIBODIES; CELL CULTURE; GENES; MAMMALS; NEURODEGENERATIVE DISEASES;

OLIGOMERS;

AMINO TERMINAL TELOPEPTIDE; HUNTINGTIN; HUNTINGTIN EXON 1; OLIGOMER; PEPTIDE FRAGMENT; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXONS; GLUTATHIONE TRANSFERASE; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; MICE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRINUCLEOTIDE REPEAT EXPANSION;

MAMMALIA; MUS MUSCULUS;

EID: 84860879196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.252577     Document Type: Article

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