An N-terminal nuclear export signal regulates trafficking and aggregation of huntingtin (Htt) protein exon 1

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6063-6071

  Zheng, Zhiqiang ^a   Li, Aimin ^a   Holmes, Brandon B ^a   Marasa, Jayne C ^b   Diamond, Marc I ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSERVED RESIDUES; CULTURED NEURONS; HEK293 CELLS; HUNTINGTIN; HUNTINGTON DISEASE; LEPTOMYCIN; N TERMINUS; N-TERMINALS; NEURODEGENERATIVE; NUCLEAR ACCUMULATION; NUCLEAR EXPORT; NUCLEAR EXPORT SIGNALS; NUCLEAR INCLUSIONS; POLYGLUTAMINE; PROTEIN AGGREGATION; TO EFFECT; YELLOW FLUORESCENT PROTEINS;

AMINO ACIDS; CYTOLOGY; TOXICITY;

PROTEINS;

EXPORTIN 1; HISTONE H1; HUNTINGTIN; LEPTOMYCIN B; LYSINE; POLYGLUTAMINE; SERINE; SMALL INTERFERING RNA; THREONINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL FRACTIONATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOPLASM; EXON; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NERVE CELL CULTURE; NUCLEAR EXPORT SIGNAL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIBIOTICS, ANTINEOPLASTIC; CELL NUCLEUS; CYTOPLASM; EXONS; FATTY ACIDS, UNSATURATED; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; KARYOPHERINS; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR EXPORT SIGNALS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84874787234     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.413575     Document Type: Article

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