-
1
-
-
46449087223
-
Computational models of the heart and their use in assessing the actions of drugs
-
DOI 10.1254/jphs.CR0070042
-
Noble D. Computational models of the heart and their use in assessing the actions of drugs. J Pharmacol Sci. 2008;107:107-117. (Pubitemid 351931011)
-
(2008)
Journal of Pharmacological Sciences
, vol.107
, Issue.2
, pp. 107-117
-
-
Noble, D.1
-
2
-
-
80054994249
-
Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis
-
Sarkar AX, Sobie EA. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm. 2011;8:1749-1755.
-
(2011)
Heart Rhythm
, vol.8
, pp. 1749-1755
-
-
Sarkar, A.X.1
Sobie, E.A.2
-
3
-
-
0036901631
-
Modelling the heart: Insights, failures and progress
-
DOI 10.1002/bies.10186
-
Noble D. Modelling the heart: insights, failures and progress. Bioessays. 2002;24:1155-1163. (Pubitemid 35464945)
-
(2002)
BioEssays
, vol.24
, Issue.12
, pp. 1155-1163
-
-
Noble, D.1
-
4
-
-
33747586784
-
The emergence of a general theory of the initiation and strength of the heartbeat
-
DOI 10.1254/jphs.CR0060018
-
Maltsev VA, Vinogradova TM, Lakatta EG. The emergence of a general theory of the initiation and strength of the heartbeat. J Pharmacol Sci. 2006;100:338-369. (Pubitemid 44609528)
-
(2006)
Journal of Pharmacological Sciences
, vol.100
, Issue.5
, pp. 338-369
-
-
Maltsev, V.A.1
Vinogradovad, T.M.2
Lakatta, E.G.3
-
5
-
-
0012016053
-
Tonus changes in cardiac muscle and their significance for the initiation of impulses
-
Bozler E. Tonus changes in cardiac muscle and their significance for the initiation of impulses. Am J Physiol. 1943;139:477-480.
-
(1943)
Am J Physiol
, vol.139
, pp. 477-480
-
-
Bozler, E.1
-
6
-
-
36949064203
-
Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
-
Noble D. Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations. Nature. 1960;188:495-497.
-
(1960)
Nature
, vol.188
, pp. 495-497
-
-
Noble, D.1
-
7
-
-
0015403041
-
Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions
-
Fabiato A, Fabiato F. Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. Circ Res. 1972;31:293-307.
-
(1972)
Circ Res
, vol.31
, pp. 293-307
-
-
Fabiato, A.1
Fabiato, F.2
-
8
-
-
0018502516
-
Cellular and subcellular mechanisms of cardiac pacemaker oscillations
-
Tsien RW, Kass RS, Weingart R. Cellular and subcellular mechanisms of cardiac pacemaker oscillations. J Exp Biol. 1979;81:205-215.
-
(1979)
J Exp Biol
, vol.81
, pp. 205-215
-
-
Tsien, R.W.1
Kass, R.S.2
Weingart, R.3
-
9
-
-
0024505757
-
Mechanisms of automaticity in subsidiary pacemakers from cat right atrium
-
Rubenstein DS, Lipsius SL. Mechanisms of automaticity in subsidiary pacemakers from cat right atrium. Circ Res. 1989;64:648-657. (Pubitemid 19105301)
-
(1989)
Circulation Research
, vol.64
, Issue.4
, pp. 648-657
-
-
Rubenstein, D.S.1
Lipsius, S.L.2
-
10
-
-
64049083007
-
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model
-
Maltsev VA, Lakatta EG. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am J Physiol Heart Circ Physiol. 2009;296:H594-H615.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.296
-
-
Maltsev, V.A.1
Lakatta, E.G.2
-
11
-
-
77949379471
-
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
-
Lakatta EG, Maltsev VA, Vinogradova TM. A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res. 2010;106:659-673.
-
(2010)
Circ Res
, vol.106
, pp. 659-673
-
-
Lakatta, E.G.1
Maltsev, V.A.2
Vinogradova, T.M.3
-
12
-
-
33750803267
-
Characterization of a TTX-sensitive Na+ current in pacemaker cells isolated from rabbit sinoatrial node
-
Muramatsu H, Zou AR, Berkowitz GA, Nathan RD. Characterization of a TTX-sensitive Na+ current in pacemaker cells isolated from rabbit sinoatrial node. Am J Physiol. 1996;270:H2108-H2119.
-
(1996)
Am J Physiol
, vol.270
-
-
Muramatsu, H.1
Zou, A.R.2
Berkowitz, G.A.3
Nathan, R.D.4
-
13
-
-
0029962743
-
Correlation between electrical activity and the size of rabbit sino-atrial node cells
-
Honjo H, Boyett MR, Kodama I, Toyama J. Correlation between electrical activity and the size of rabbit sino-atrial node cells. J Physiol. 1996;496:795-808. (Pubitemid 26387862)
-
(1996)
Journal of Physiology
, vol.496
, Issue.3
, pp. 795-808
-
-
Honjo, H.1
Boyett, M.R.2
Kodama, I.3
Toyama, J.4
-
14
-
-
0023874297
-
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells
-
Hagiwara N, Irisawa H, Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol. 1988;395:233-253. (Pubitemid 18029194)
-
(1988)
Journal of Physiology
, vol.395
, pp. 233-253
-
-
Hagiwara, N.1
Irisawa, H.2
Kameyama, M.3
-
15
-
-
0022495261
-
Possible functional significance of a novel type of cardiac Ca channel
-
Nilius B. Possible functional significance of a novel type of cardiac Ca channel. Biomed Biochim Acta. 1986;45:K37-K45. (Pubitemid 16010798)
-
(1986)
Biomedica Biochimica Acta
, vol.45
, Issue.8
-
-
Nilius, B.1
-
16
-
-
44349123473
-
Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by R(-)-efonidipine
-
DOI 10.1254/jphs.SC0070405
-
Tanaka H, Komikado C, Namekata I, Nakamura H, Suzuki M, Tsuneoka Y, et al. Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by r(-)- efonidipine. J Pharmacol Sci. 2008;107:99-102. (Pubitemid 351744088)
-
(2008)
Journal of Pharmacological Sciences
, vol.107
, Issue.1
, pp. 99-102
-
-
Tanaka, H.1
Komikado, C.2
Namekata, I.3
Nakamura, H.4
Suzuki, M.5
Tsuneoka, Y.6
Shigenobu, K.7
Takahara, A.8
-
17
-
-
0031754508
-
Regional differences in effects of 4-aminopyridine within the sinoatrial node
-
Boyett MR, Honjo H, Yamamoto M, Nikmaram MR, Niwa R, Kodama I. Regional differences in effects of 4-aminopyridine within the sinoatrial node. Am J Physiol. 1998;275:H1158-H1168.
-
(1998)
Am J Physiol
, vol.275
-
-
Boyett, M.R.1
Honjo, H.2
Yamamoto, M.3
Nikmaram, M.R.4
Niwa, R.5
Kodama, I.6
-
19
-
-
0034077364
-
+ current in rabbit sinoatrial node cells
-
DOI 10.1016/S0008-6363(00)00036-5, PII S0008636300000365
-
Lei M, Honjo H, Kodama I, Boyett MR. Characterisation of the transient outward K+ current in rabbit sinoatrial node cells. Cardiovasc Res. 2000;46:433-441. (Pubitemid 30319329)
-
(2000)
Cardiovascular Research
, vol.46
, Issue.3
, pp. 433-441
-
-
Lei, M.1
Honjo, H.2
Kodama, I.3
Boyett, M.R.4
-
20
-
-
0028837379
-
A rapidly activating delayed rectifier K+ channel in rabbit sinoatrial node cells
-
Ito H, Ono K. A rapidly activating delayed rectifier K+ channel in rabbit sinoatrial node cells. Am J Physiol. 1995;269:H443-H452.
-
(1995)
Am J Physiol
, vol.269
-
-
Ito, H.1
Ono, K.2
-
21
-
-
0029762672
-
Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells
-
Lei M, Brown HF. Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells. Exp Physiol. 1996;81:725-741.
-
(1996)
Exp Physiol
, vol.81
, pp. 725-741
-
-
Lei, M.1
Brown, H.F.2
-
22
-
-
0347624077
-
Sino-Atrial Nodal Cells of Mammalian Hearts: Ionic Currents and Gene Expression of Pacemaker Ionic Channels
-
DOI 10.1540/jsmr.39.175
-
Satoh H. Sino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels. J Smooth Muscle Res. 2003;39:175-193. (Pubitemid 38017644)
-
(2003)
Journal of Smooth Muscle Research
, vol.39
, Issue.5
, pp. 175-193
-
-
Satoh, H.1
-
23
-
-
0018837655
-
Inward current activated during hyperpolarization in the rabbit sinoatrial node cell
-
Yanagihara K, Irisawa H. Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch. 1980;385:11-19. (Pubitemid 10102676)
-
(1980)
Pflugers Archiv European Journal of Physiology
, vol.385
, Issue.1
, pp. 11-19
-
-
Yanagihara, K.1
Irisawa, H.2
-
24
-
-
0019524947
-
A study of pace-marker potential in rabbit sino-atrial node: Measurement of potassium activity under voltage-clamp conditions
-
Maylie J, Morad M, Weiss J. A study of pace-maker potential in rabbit sino-atrial node: measurement of potassium activity under voltage-clamp conditions. J Physiol. 1981;311:161-178. (Pubitemid 11166915)
-
(1981)
Journal of Physiology
, vol.311
, pp. 161-178
-
-
Maylie, J.1
Morad, M.2
Weiss, J.3
-
25
-
-
0025977991
-
The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes
-
DiFrancesco D. The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J Physiol. 1991;434:23-40.
-
(1991)
J Physiol
, vol.434
, pp. 23-40
-
-
DiFrancesco, D.1
-
26
-
-
0028913302
-
A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells
-
Guo J, Ono K, Noma A. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. J Physiol. 1995;483:1-13.
-
(1995)
J Physiol
, vol.483
, pp. 1-13
-
-
Guo, J.1
Ono, K.2
Noma, A.3
-
27
-
-
0028322077
-
Activation of the cloned muscarinic potassium channel by G protein betagamma subunits
-
DOI 10.1038/370143a0
-
Reuveny E, Slesinger PA, Inglese J, Morales JM, Iniguez-Lluhi JA, Lefkowitz RJ, et al. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 1994;370:143-146. (Pubitemid 24229126)
-
(1994)
Nature
, vol.370
, Issue.6485
, pp. 143-146
-
-
Reuveny, E.1
Slesinger, P.A.2
Inglese, J.3
Morales, J.M.4
Iniguez-Lluhi, J.A.5
Lefkowitz, R.J.6
Bourne, H.R.7
Jan, Y.N.8
Jan, L.Y.9
-
28
-
-
34250220683
-
Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node
-
DOI 10.1161/CIRCRESAHA.107.152181
-
Ju YK, Chu Y, Chaulet H, Lai D, Gervasio OL, Graham RM, et al. Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circ Res. 2007;100:1605-1614. (Pubitemid 46897264)
-
(2007)
Circulation Research
, vol.100
, Issue.11
, pp. 1605-1614
-
-
Ju, Y.-K.1
Chu, Y.2
Chaulet, H.3
Lai, D.4
Gervasio, O.L.5
Graham, R.M.6
Cannell, M.B.7
Allen, D.G.8
-
29
-
-
0026530016
-
Background current in sino-atrial node cells of the rabbit heart
-
Hagiwara N, Irisawa H, Kasanuki H, Hosoda S. Background current in sino-atrial node cells of the rabbit heart. J Physiol. 1992;448:53-72.
-
(1992)
J Physiol
, vol.448
, pp. 53-72
-
-
Hagiwara, N.1
Irisawa, H.2
Kasanuki, H.3
Hosoda, S.4
-
30
-
-
0016746593
-
Contribution of an electrogenic sodium pump to the membrane potential in rabbit sinoatrial node cells
-
Noma A, Irisawa H. Contribution of an electrogenic sodium pump to the membrane potential in rabbit sinoatrial node cells. Pflugers Arch. 1975;358:289-301.
-
(1975)
Pflugers Arch
, vol.358
, pp. 289-301
-
-
Noma, A.1
Irisawa, H.2
-
31
-
-
0030048158
-
Sodium-potassium pump current in rabbit sino-atrial node cells
-
Sakai R, Hagiwara N, Matsuda N, Kassanuki H, Hosoda S. Sodium--potassium pump current in rabbit sino-atrial node cells. J Physiol. 1996;490:51-62. (Pubitemid 26020130)
-
(1996)
Journal of Physiology
, vol.490
, Issue.1
, pp. 51-62
-
-
Sakai, R.1
Hagiwara, N.2
Matsuda, N.3
Kasanuki, H.4
Hosoda, S.5
-
32
-
-
0029741590
-
Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node
-
Rigg L, Terrar DA. Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node. Exp Physiol. 1996;81:877-880. (Pubitemid 26332086)
-
(1996)
Experimental Physiology
, vol.81
, Issue.5
, pp. 877-880
-
-
Rigg, L.1
Terrar, D.A.2
-
33
-
-
33745344579
-
Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node
-
Li J, Qu J, Nathan RD. Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node. Am J Physiol. 1997;273:H2481-H2489.
-
(1997)
Am J Physiol
, vol.273
-
-
Li, J.1
Qu, J.2
Nathan, R.D.3
-
34
-
-
0031012374
-
Electrophysiological actions of ryanodine on single rabbit sinoatrial nodal cells
-
DOI 10.1016/S0306-3623(96)00182-6, PII S0306362396001826
-
Satoh H. Electrophysiological actions of ryanodine on single rabbit sinoatrial nodal cells. Gen Pharmacol. 1997;28:31-38. (Pubitemid 27016056)
-
(1997)
General Pharmacology
, vol.28
, Issue.1
, pp. 31-38
-
-
Satoh, H.1
-
35
-
-
0035933474
-
2+ exchanger: Molecular partners in peacemaker regulation
-
Bogdanov KY, Vinogradova TM, Lakatta EG. Sinoatrial nodal cell ryanodine receptor and Na+-Ca2+ exchanger: molecular partners in pacemaker regulation. Circ Res. 2001;88:1254-1258. (Pubitemid 32587841)
-
(2001)
Circulation Research
, vol.88
, Issue.12
, pp. 1254-1258
-
-
Bogdanov, K.Y.1
Vinogradova, T.M.2
Lakatta, E.G.3
-
36
-
-
0003222194
-
Na-Ca exchange current in sinoatrial node cell of rabbit
-
Hagiwara N, Irisawa H. Na-Ca exchange current in sinoatrial node cell of rabbit. Circulation. 1988;Suppl 78:490a.
-
(1988)
Circulation
, Issue.SUPPL. 78
-
-
Hagiwara, N.1
Irisawa, H.2
-
37
-
-
0036554705
-
- current in rabbit sinoatrial node cells
-
DOI 10.1113/jphysiol.2001.013184
-
Verkerk AO, Wilders R, Zegers JG, van Borren MM, Ravesloot JH, Verheijck EE. Ca2+-activated Cl- current in rabbit sinoatrial node cells. J Physiol. 2002;540:105-117. (Pubitemid 35174989)
-
(2002)
Journal of Physiology
, vol.540
, Issue.1
, pp. 105-117
-
-
Verkerk, A.O.1
Wilders, R.2
Zegers, J.G.3
Van Borren, M.M.G.J.4
Ravesloot, J.H.5
Verheijck, E.E.6
-
38
-
-
0029864476
-
Ionic mechanisms of the cardiac pacemaker potential
-
Noma A. Ionic mechanisms of the cardiac pacemaker potential. Jpn Heart J. 1996;37:673-682. (Pubitemid 26358659)
-
(1996)
Japanese Heart Journal
, vol.37
, Issue.5
, pp. 673-682
-
-
Noma, A.1
-
39
-
-
50349096521
-
Genesis and regulation of the heart automaticity
-
Mangoni ME, Nargeot J. Genesis and regulation of the heart automaticity. Physiol Rev. 2008;88:919-982.
-
(2008)
Physiol Rev
, vol.88
, pp. 919-982
-
-
Mangoni, M.E.1
Nargeot, J.2
-
41
-
-
0019172427
-
2) in Purkinje fibres
-
DiFrancesco D, Ojeda C. Properties of the current if in the sino-atrial node of the rabbit compared with those of the current iK, in Purkinje fibres. J Physiol. 1980;308:353-367. (Pubitemid 11252755)
-
(1980)
Journal of Physiology
, vol.308
, pp. 353-367
-
-
DiFrancesco, D.1
Ojeda, C.2
-
42
-
-
84880914083
-
Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells
-
Verkerk AO, Wilders R. Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells. Biomed Res Int. 2013;2013:872454.
-
(2013)
Biomed Res Int
, vol.2013
, pp. 872454
-
-
Verkerk, A.O.1
Wilders, R.2
-
43
-
-
77952609567
-
A novel quantitative explanation for autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins
-
Maltsev VA, Lakatta EG. A novel quantitative explanation for autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins. Am J Physiol Heart Circ Physiol. 2010;298:H2010-H2023.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Maltsev, V.A.1
Lakatta, E.G.2
-
44
-
-
84876178392
-
Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca clock generate robust, flexible, and energy-efficient cardiac pacemaking
-
Maltsev VA, Lakatta EG. Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca clock generate robust, flexible, and energy-efficient cardiac pacemaking. J Mol Cell Cardiol. 2013;59:181-195.
-
(2013)
J Mol Cell Cardiol
, vol.59
, pp. 181-195
-
-
Maltsev, V.A.1
Lakatta, E.G.2
-
45
-
-
0032056007
-
2+ exchange current in isolated toad pacemaker cells
-
Ju YK, Allen DG. Intracellular calcium and Na+-Ca2+ exchange current in isolated toad pacemaker cells. J Physiol. 1998;508:153-166. (Pubitemid 28167578)
-
(1998)
Journal of Physiology
, vol.508
, Issue.1
, pp. 153-166
-
-
Ju, Y.-K.1
Allen, D.G.2
-
46
-
-
0034721798
-
Sinoatrial node pacemaker activity requires Ca2+/calmodulin-dependent protein kinase II activation
-
Vinogradova TM, Zhou YY, Bogdanov KY, Yang D, Kuschel M, Cheng H, et al. Sinoatrial node pacemaker activity requires Ca2+/calmodulin-dependent protein kinase II activation. Circ Res. 2000;87:760-767.
-
(2000)
Circ Res
, vol.87
, pp. 760-767
-
-
Vinogradova, T.M.1
Zhou, Y.Y.2
Bogdanov, K.Y.3
Yang, D.4
Kuschel, M.5
Cheng, H.6
-
47
-
-
33645324479
-
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells
-
Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, et al. High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res. 2006; 98:505-514.
-
(2006)
Circ Res
, vol.98
, pp. 505-514
-
-
Vinogradova, T.M.1
Lyashkov, A.E.2
Zhu, W.3
Ruknudin, A.M.4
Sirenko, S.5
Yang, D.6
-
48
-
-
1842507527
-
2+ Releases during Diastolic Depolarization of Sinoatrial Pacemaker Cells Do Not Require Membrane Depolarization
-
DOI 10.1161/01.RES.0000122045.55331.0F
-
Vinogradova TM, Zhou YY, Maltsev V, Lyashkov A, Stern M, Lakatta EG. Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ Res. 2004;94:802-809. (Pubitemid 38451742)
-
(2004)
Circulation Research
, vol.94
, Issue.6
, pp. 802-809
-
-
Vinogradova, T.M.1
Zhou, Y.-Y.2
Maltsev, V.3
Lyashkov, A.4
Stern, M.5
Lakatta, E.G.6
-
49
-
-
0141653536
-
2+ release contributes to automaticity in cat atrial pacemaker cells
-
Huser J, Blatter LA, Lipsius SL. Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol. 2000;524:415-422. (Pubitemid 30229507)
-
(2000)
Journal of Physiology
, vol.524
, Issue.2
, pp. 415-422
-
-
Huser, J.1
Blatter, L.A.2
Lipsius, S.L.3
-
50
-
-
84879548903
-
Beat-to-beat variation in periodicity of local calcium releases contributes to intrinsic variations of spontaneous cycle length in isolated single sinoatrial node cells
-
Monfredi O, Maltseva LA, Spurgeon HA, Boyett MR, Lakatta EG, Maltsev VA. Beat-to-beat variation in periodicity of local calcium releases contributes to intrinsic variations of spontaneous cycle length in isolated single sinoatrial node cells. PLoS One. 2013;8:e67247.
-
(2013)
PLoS One
, vol.8
-
-
Monfredi, O.1
Maltseva, L.A.2
Spurgeon, H.A.3
Boyett, M.R.4
Lakatta, E.G.5
Maltsev, V.A.6
-
51
-
-
0033779053
-
Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node
-
Rigg L, Heath BM, Cui Y, Terrar DA. Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node. Cardiovasc Res. 2000;48:254-264.
-
(2000)
Cardiovasc Res
, vol.48
, pp. 254-264
-
-
Rigg, L.1
Heath, B.M.2
Cui, Y.3
Terrar, D.A.4
-
52
-
-
0034495269
-
The distribution of calcium in toad cardiac pacemaker cells during spontaneous firing
-
DOI 10.1007/s004240000418
-
Ju YK, Allen DG. The distribution of calcium in toad cardiac pacemaker cells during spontaneous firing. Pflugers Arch. 2000; 441:219-227. (Pubitemid 32128160)
-
(2000)
Pflugers Archiv European Journal of Physiology
, vol.441
, Issue.2-3
, pp. 219-227
-
-
Ju, Y.-K.1
Allen, D.G.2
-
53
-
-
0037458671
-
Cyclic variation of intracellular calcium: A critical factor for cardiac pacemaker cell dominance
-
Lakatta EG, Maltsev VA, Bogdanov KY, Stern MD, Vinogradova TM. Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res. 2003;92:e45-e50.
-
(2003)
Circ Res
, vol.92
-
-
Lakatta, E.G.1
Maltsev, V.A.2
Bogdanov, K.Y.3
Stern, M.D.4
Vinogradova, T.M.5
-
54
-
-
1942487269
-
Diastolic Calcium Release Controls the Beating Rate of Rabbit Sinoatrial Node Cells: Numerical Modeling of the Coupling Process
-
Maltsev VA, Vinogradova TM, Bogdanov KY, Lakatta EG, Stern MD. Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process. Biophys J. 2004;86:2596-2605. (Pubitemid 38524445)
-
(2004)
Biophysical Journal
, vol.86
, Issue.4
, pp. 2596-2605
-
-
Maltsev, V.A.1
Vinogradova, T.M.2
Bogdanov, K.Y.3
Lakatta, E.G.4
Stern, M.D.5
-
55
-
-
72449157040
-
Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells
-
van Borren MM, Verkerk AO, Wilders R, Hajji N, Zegers JG, Bourier J, et al. Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells. Basic Res Cardiol. 2010;105:73-87.
-
(2010)
Basic Res Cardiol
, vol.105
, pp. 73-87
-
-
Van Borren, M.M.1
Verkerk, A.O.2
Wilders, R.3
Hajji, N.4
Zegers, J.G.5
Bourier, J.6
-
56
-
-
61949243173
-
Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation
-
Joung B, Tang L, Maruyama M, Han S, Chen Z, Stucky M, et al. Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation. 2009;119:788-796.
-
(2009)
Circulation
, vol.119
, pp. 788-796
-
-
Joung, B.1
Tang, L.2
Maruyama, M.3
Han, S.4
Chen, Z.5
Stucky, M.6
-
57
-
-
65249100171
-
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
-
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, et al. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009;106:5972-5977.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5972-5977
-
-
Wu, Y.1
Gao, Z.2
Chen, B.3
Koval, O.M.4
Singh, M.V.5
Guan, X.6
-
58
-
-
33845667862
-
The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker
-
Lakatta EG, Vinogradova T, Lyashkov A, Sirenko S, Zhu W, Ruknudin A, et al. The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker. Ann N Y Acad Sci. 2006;1080:178-206.
-
(2006)
Ann N Y Acad Sci
, vol.1080
, pp. 178-206
-
-
Lakatta, E.G.1
Vinogradova, T.2
Lyashkov, A.3
Sirenko, S.4
Zhu, W.5
Ruknudin, A.6
-
59
-
-
84889589464
-
Sarcoplasmic reticulum Ca cycling protein phosphorylation in a physiologic Ca milieu unleashes a high-power, rhythmic Ca clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design
-
Sirenko S, Maltsev VA, Maltseva LA, Yang D, Lukyanenko Y, Vinogradova TM, et al. Sarcoplasmic reticulum Ca cycling protein phosphorylation in a physiologic Ca milieu unleashes a high-power, rhythmic Ca clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design. J Mol Cell Cardiol. 2014;66C:106-115.
-
(2014)
J Mol Cell Cardiol
, vol.66 C
, pp. 106-115
-
-
Sirenko, S.1
Maltsev, V.A.2
Maltseva, L.A.3
Yang, D.4
Lukyanenko, Y.5
Vinogradova, T.M.6
-
60
-
-
34447510936
-
2+ regulation of adenylyl cyclases in cAMP microdomains
-
DOI 10.1152/physrev.00049.2006
-
Willoughby D, Cooper DM. Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev. 2007; 87:965-1010. (Pubitemid 47084674)
-
(2007)
Physiological Reviews
, vol.87
, Issue.3
, pp. 965-1010
-
-
Willoughby, D.1
Cooper, D.M.F.2
-
61
-
-
34547107585
-
f pacemaker current
-
DOI 10.1113/jphysiol.2007.133439
-
Mattick P, Parrington J, Odia E, Simpson A, Collins T, Terrar D. Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the If pacemaker current. J Physiol. 2007;582:1195-1203. (Pubitemid 47104348)
-
(2007)
Journal of Physiology
, vol.582
, Issue.3
, pp. 1195-1203
-
-
Mattick, P.1
Parrington, J.2
Odia, E.3
Simpson, A.4
Collins, T.5
Terrar, D.6
-
62
-
-
47249125756
-
Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
-
Younes A, Lyashkov AE, Graham D, Sheydina A, Volkova MV, Mitsak M, et al. Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J Biol Chem. 2008;283:14461-14468.
-
(2008)
J Biol Chem
, vol.283
, pp. 14461-14468
-
-
Younes, A.1
Lyashkov, A.E.2
Graham, D.3
Sheydina, A.4
Volkova, M.V.5
Mitsak, M.6
-
63
-
-
42049095908
-
2+ releases
-
DOI 10.1161/CIRCRESAHA.107.161679
-
Vinogradova TM, Sirenko S, Lyashkov AE, Younes A, Li Y, Zhu W, et al. Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. Circ Res. 2008;102:761-769. (Pubitemid 351521586)
-
(2008)
Circulation Research
, vol.102
, Issue.7
, pp. 761-769
-
-
Vinogradova, T.M.1
Sirenko, S.2
Lyashkov, A.E.3
Younes, A.4
Li, Y.5
Zhu, W.6
Yang, D.7
Ruknudin, A.M.8
Spurgeon, H.9
Lakatta, E.G.10
-
64
-
-
84874637410
-
Protein phosphatase 1 regulates normal automaticity of the heart's pacemaker node cells by site-specific modulation of phospholamban phosphorylation that regulates spontaneous subsarcolemmal local Ca2+ releases
-
Zahanich I, Li Y, Lyashkov AE, Lukyanenko YO, Vinogradova TM, Younes A, et al. Protein phosphatase 1 regulates normal automaticity of the heart's pacemaker node cells by site-specific modulation of phospholamban phosphorylation that regulates spontaneous subsarcolemmal local Ca2+ releases. Circulation. 2010;122:A21546.
-
(2010)
Circulation
, vol.122
-
-
Zahanich, I.1
Li, Y.2
Lyashkov, A.E.3
Lukyanenko, Y.O.4
Vinogradova, T.M.5
Younes, A.6
-
65
-
-
33750450141
-
Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state
-
DOI 10.1161/01.RES.0000247933.66532.0b, PII 0000301220061027000011
-
Bogdanov KY, Maltsev VA, Vinogradova TM, Lyashkov AE, Spurgeon HA, Stern MD, et al. Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ Res. 2006;99:979-987. (Pubitemid 44657801)
-
(2006)
Circulation Research
, vol.99
, Issue.9
, pp. 979-987
-
-
Bogdanov, K.Y.1
Maltsev, V.A.2
Vinogradova, T.M.3
Lyashkov, A.E.4
Spurgeon, H.A.5
Stern, M.D.6
Lakatta, E.G.7
-
67
-
-
16344373083
-
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
-
DOI 10.1529/biophysj.104.047449
-
Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J. 2004;87:3351-3371. (Pubitemid 40468590)
-
(2004)
Biophysical Journal
, vol.87
, Issue.5
, pp. 3351-3371
-
-
Shannon, T.R.1
Wang, F.2
Puglisi, J.3
Weber, C.4
Bers, D.M.5
-
69
-
-
77957283607
-
Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells
-
Vinogradova TM, Brochet DX, Sirenko S, Li Y, Spurgeon H, Lakatta EG. Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells. Circ Res. 2010;107:767-775.
-
(2010)
Circ Res
, vol.107
, pp. 767-775
-
-
Vinogradova, T.M.1
Brochet, D.X.2
Sirenko, S.3
Li, Y.4
Spurgeon, H.5
Lakatta, E.G.6
-
70
-
-
84864614802
-
The "Funny" current (If) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells
-
Yaniv Y, Maltsev VA, Ziman BD, Spurgeon HA, Lakatta EG. The "Funny" current (If) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells. Molecules. 2012;17:8241-8254.
-
(2012)
Molecules
, vol.17
, pp. 8241-8254
-
-
Yaniv, Y.1
Maltsev, V.A.2
Ziman, B.D.3
Spurgeon, H.A.4
Lakatta, E.G.5
-
71
-
-
84880888765
-
New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca cycling
-
Yaniv Y, Sirenko S, Ziman BD, Spurgeon HA, Maltsev VA, Lakatta EG. New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca cycling. J Mol Cell Cardiol. 2013;62C:80-89.
-
(2013)
J Mol Cell Cardiol
, vol.62 C
, pp. 80-89
-
-
Yaniv, Y.1
Sirenko, S.2
Ziman, B.D.3
Spurgeon, H.A.4
Maltsev, V.A.5
Lakatta, E.G.6
-
72
-
-
0029744373
-
Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells
-
Bois P, Bescond J, Renaudon B, Lenfant J. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol. 1996;118:1051-1057. (Pubitemid 26261281)
-
(1996)
British Journal of Pharmacology
, vol.118
, Issue.4
, pp. 1051-1057
-
-
Bois, P.1
Bescond, J.2
Renaudon, B.3
Lenfant, J.4
-
73
-
-
84867095585
-
Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: A prospective, randomized, placebo-controlled, double-blind, crossover evaluation
-
Cappato R, Castelvecchio S, Ricci C, Bianco E, Vitali-Serdoz L, Gnecchi-Ruscone T, et al. Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation. J Am Coll Cardiol. 2012;60:1323-1329.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 1323-1329
-
-
Cappato, R.1
Castelvecchio, S.2
Ricci, C.3
Bianco, E.4
Vitali-Serdoz, L.5
Gnecchi-Ruscone, T.6
-
74
-
-
84861551026
-
Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity
-
Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, et al. Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity. PLoS One. 2012;7:e37582.
-
(2012)
PLoS One
, vol.7
-
-
Yaniv, Y.1
Spurgeon, H.A.2
Lyashkov, A.E.3
Yang, D.4
Ziman, B.D.5
Maltsev, V.A.6
-
75
-
-
84889080115
-
Pacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory
-
Yaniv Y, Lakatta EG. Pacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory. J Cardiovasc Electrophysiol. 2013;24:E28-E29.
-
(2013)
J Cardiovasc Electrophysiol
, vol.24
-
-
Yaniv, Y.1
Lakatta, E.G.2
-
76
-
-
84866390214
-
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation
-
Severi S, Fantini M, Charawi LA, DiFrancesco D. An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation. J Physiol. 2012;590:4483-4499.
-
(2012)
J Physiol
, vol.590
, pp. 4483-4499
-
-
Severi, S.1
Fantini, M.2
Charawi, L.A.3
DiFrancesco, D.4
-
78
-
-
69249150907
-
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca2+ cycling and IKACh
-
Lyashkov AE, Vinogradova TM, Zahanich I, Li Y, Younes A, Nuss HB, et al. Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca2+ cycling and IKACh. Am J Physiol Heart Circ Physiol. 2009;297:H949-H959.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Lyashkov, A.E.1
Vinogradova, T.M.2
Zahanich, I.3
Li, Y.4
Younes, A.5
Nuss, H.B.6
-
79
-
-
0030573669
-
Ion currents underlying sinoatrial node pacemaker activity: A new single cell mathematical model
-
DOI 10.1006/jtbi.1996.0129
-
Dokos S, Celler B, Lovell N. Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model. J Theor Biol. 1996;181:245-272. (Pubitemid 26315750)
-
(1996)
Journal of Theoretical Biology
, vol.181
, Issue.3
, pp. 245-272
-
-
Dokos, S.1
Celler, B.2
Lovell, N.3
-
80
-
-
0033858925
-
Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node
-
Zhang H, Holden AV, Kodama I, Honjo H, Lei M, Varghese T, et al. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol. 2000; 279:H397-H421. (Pubitemid 30616684)
-
(2000)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.279
, Issue.1
-
-
Zhang, H.1
Holden, A.V.2
Kodama, I.3
Honjo, H.4
Lei, M.5
Varghese, T.6
Boyett, M.R.7
-
81
-
-
84902205507
-
Experimental and in silico studies of the kinetics and magnitude of PKA activation in live sinoatrial node pacemaker cell
-
Abstract
-
Yaniv Y, Ganesan A, Yang D, Ziman BD, Zhang J, Lakatta EG. Experimental and in silico studies of the kinetics and magnitude of PKA activation in live sinoatrial node pacemaker cell. J Mol Cell Cardiol. 2013;65 Supplement (Abstract).
-
(2013)
J Mol Cell Cardiol
, Issue.SUPPL.
, pp. 65
-
-
Yaniv, Y.1
Ganesan, A.2
Yang, D.3
Ziman, B.D.4
Zhang, J.5
Lakatta, E.G.6
-
82
-
-
80053222653
-
Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand
-
Yaniv Y, Juhaszova M, Lyashkov AE, Spurgeon HA, Sollott SJ, Lakatta EG. Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand. J Mol Cell Cardiol. 2011;51:740-748.
-
(2011)
J Mol Cell Cardiol
, vol.51
, pp. 740-748
-
-
Yaniv, Y.1
Juhaszova, M.2
Lyashkov, A.E.3
Spurgeon, H.A.4
Sollott, S.J.5
Lakatta, E.G.6
-
83
-
-
84878766631
-
Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand
-
Yaniv Y, Spurgeon HA, Ziman BD, Lyashkov AE, Lakatta EG. Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand. Am J Physiol Heart Circ Physiol. 2013;304:H1428-H1438.
-
(2013)
Am J Physiol Heart Circ Physiol
, vol.304
-
-
Yaniv, Y.1
Spurgeon, H.A.2
Ziman, B.D.3
Lyashkov, A.E.4
Lakatta, E.G.5
-
84
-
-
80051936634
-
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
-
De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011;476:336-340.
-
(2011)
Nature
, vol.476
, pp. 336-340
-
-
De Stefani, D.1
Raffaello, A.2
Teardo, E.3
Szabo, I.4
Rizzuto, R.5
-
85
-
-
76249133414
-
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
-
Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci U S A. 2009;107:436-441.
-
(2009)
Proc Natl Acad Sci U S A
, vol.107
, pp. 436-441
-
-
Palty, R.1
Silverman, W.F.2
Hershfinkel, M.3
Caporale, T.4
Sensi, S.L.5
Parnis, J.6
-
86
-
-
84884415229
-
Age-related changes of myocardial ATP supply and demand mechanisms
-
Yaniv Y, Juhaszova M, Sollott SJ. Age-related changes of myocardial ATP supply and demand mechanisms. Trends Endocrinol Metab. 2013;24:495-505.
-
(2013)
Trends Endocrinol Metab
, vol.24
, pp. 495-505
-
-
Yaniv, Y.1
Juhaszova, M.2
Sollott, S.J.3
-
87
-
-
77649175105
-
Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives
-
Yaniv Y, Juhaszova M, Nuss HB, Wang S, Zorov DB, Lakatta EG, et al. Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives. Ann N Y Acad Sci. 2010;1188:133-142.
-
(2010)
Ann N Y Acad Sci
, vol.1188
, pp. 133-142
-
-
Yaniv, Y.1
Juhaszova, M.2
Nuss, H.B.3
Wang, S.4
Zorov, D.B.5
Lakatta, E.G.6
-
88
-
-
84902155309
-
cAMP/PKA-dependent phosphorylation signaling controls both pacemaker cell rate and energetics: Experimental evidence and in silco testing
-
Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, et al. cAMP/PKA-dependent phosphorylation signaling controls both pacemaker cell rate and energetics: experimental evidence and in silco testing. Heart Rhythm. 2013;10:S53.
-
(2013)
Heart Rhythm
, vol.10
-
-
Yaniv, Y.1
Spurgeon, H.A.2
Lyashkov, A.E.3
Yang, D.4
Ziman, B.D.5
Maltsev, V.A.6
-
89
-
-
73849164199
-
A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials
-
Noble D. A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J Physiol. 1962;160:317-352.
-
(1962)
J Physiol
, vol.160
, pp. 317-352
-
-
Noble, D.1
-
90
-
-
0016826011
-
Reconstruction of the electrical activity of cardiac Purkinje fibres
-
McAllister RE, Noble D, Tsien RW. Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol. 1975;251:1-59.
-
(1975)
J Physiol
, vol.251
, pp. 1-59
-
-
McAllister, R.E.1
Noble, D.2
Tsien, R.W.3
-
91
-
-
0021226282
-
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations
-
Noble D, Noble SJ. A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations. Proc R Soc Lond B Biol Sci. 1984;222:295-304. (Pubitemid 14046738)
-
(1984)
Proceedings of the Royal Society of London - Biological Sciences
, vol.222
, Issue.1228
, pp. 295-304
-
-
Noble, D.1
Noble, S.J.2
-
92
-
-
0017370379
-
Reconstruction of the action potential of ventricular myocardial fibres
-
Beeler GW, Reuter H. Reconstruction of the action potential of ventricular myocardial fibres. J Physiol. 1977;268:177-210. (Pubitemid 8115094)
-
(1977)
Journal of Physiology
, vol.268
, Issue.1
, pp. 177-210
-
-
Beeler, G.W.1
Reuter, H.2
-
93
-
-
0022422465
-
A model of cardiac electrical activity incorporating ionic pumps and concentration changes
-
DiFrancesco D, Noble D. A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci. 1985;307:353-398.
-
(1985)
Philos Trans R Soc Lond B Biol Sci
, vol.307
, pp. 353-398
-
-
DiFrancesco, D.1
Noble, D.2
-
94
-
-
77954212296
-
Competing oscillators in cardiac pacemaking: Historical background
-
Noble D, Noble PJ, Fink M. Competing oscillators in cardiac pacemaking: historical background. Circ Res. 2010;106:1791-1797.
-
(2010)
Circ Res
, vol.106
, pp. 1791-1797
-
-
Noble, D.1
Noble, P.J.2
Fink, M.3
-
95
-
-
0021133661
-
The slow inward current, i(si), in the rabbit sino-atrial node investigated by voltage clamp and computer simulation
-
Brown HF, Kimura J, Noble D, Noble SJ, Taupignon A. The slow inward current, isi, in the rabbit sino-atrial node investigated by voltage clamp and computer simulation. Proc R Soc Lond B Biol Sci. 1984;222:305-328. (Pubitemid 14046739)
-
(1984)
Proceedings of the Royal Society of London - Biological Sciences
, vol.222
, Issue.1228
, pp. 305-328
-
-
Brown, H.F.1
Kimura, J.2
Noble, D.3
-
96
-
-
34250820394
-
Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size
-
DOI 10.1161/CIRCRESAHA.107.153676
-
Lyashkov AE, Juhaszova M, Dobrzynski H, Vinogradova TM, Maltsev VA, Juhasz O, et al. Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circ Res. 2007;100:1723-1731 (Pubitemid 46987864)
-
(2007)
Circulation Research
, vol.100
, Issue.12
, pp. 1723-1731
-
-
Lyashkov, A.E.1
Juhaszova, M.2
Dobrzynski, H.3
Vinogradova, T.M.4
Maltsev, V.A.5
Juhasz, O.6
Spurgeon, H.A.7
Sollott, S.J.8
Lakatta, E.G.9
-
97
-
-
33644701769
-
2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node
-
DOI 10.1113/jphysiol.2005.100305
-
Sanders L, Rakovic S, Lowe M, Mattick PA, Terrar DA. Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. J Physiol. 2006;571:639-649. (Pubitemid 43329552)
-
(2006)
Journal of Physiology
, vol.571
, Issue.3
, pp. 639-649
-
-
Sanders, L.1
Rakovic, S.2
Lowe, M.3
Mattick, P.A.D.4
Terrar, D.A.5
-
98
-
-
0028144693
-
Intracellular calcium transients recorded with Fura-2 in spontaneously active myocytes isolated from the atrioventricular node of the rabbit heart
-
Hancox JC, Levi AJ, Brooksby P. Intracellular calcium transients recorded with Fura-2 in spontaneously active myocytes isolated from the atrioventricular node of the rabbit heart. Proc Biol Sci. 1994;255:99-105. (Pubitemid 24065821)
-
(1994)
Proceedings of the Royal Society B: Biological Sciences
, vol.255
, Issue.1343
, pp. 99-105
-
-
Hancox, J.C.1
Levi, A.J.2
Brooksby, P.3
-
99
-
-
78651302709
-
Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells
-
Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, et al. Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. Am J Physiol Heart Circ Physiol. 2011;300:H251-H261.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.300
-
-
Himeno, Y.1
Toyoda, F.2
Satoh, H.3
Amano, A.4
Cha, C.Y.5
Matsuura, H.6
-
100
-
-
79958025230
-
Validating the requirement for beat-to-beat coupling of the Ca clock and M clock in pacemaker cell normal automaticity
-
Maltsev VA, Vinogradova TM, Stern MD, Lakatta EG. Validating the requirement for beat-to-beat coupling of the Ca clock and M clock in pacemaker cell normal automaticity. Am J Physiol Heart Circ Physiol. 2011;300:H2323-H2324
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.300
-
-
Maltsev, V.A.1
Vinogradova, T.M.2
Stern, M.D.3
Lakatta, E.G.4
-
101
-
-
80055118338
-
Beat-to-beat Ca2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm
-
Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, Stern MD, et al. Beat-to-beat Ca2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm. J Mol Cell Cardiol. 2011;51:902-905.
-
(2011)
J Mol Cell Cardiol
, vol.51
, pp. 902-905
-
-
Yaniv, Y.1
Maltsev, V.A.2
Escobar, A.L.3
Spurgeon, H.A.4
Ziman, B.D.5
Stern, M.D.6
-
102
-
-
84885111752
-
Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca2+ cycling dynamics
-
Yaniv Y, Stern MD, Lakatta EG, Maltsev VA. Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca2+ cycling dynamics. Biophys J. 2013;105:1551-1561.
-
(2013)
Biophys J
, vol.105
, pp. 1551-1561
-
-
Yaniv, Y.1
Stern, M.D.2
Lakatta, E.G.3
Maltsev, V.A.4
-
103
-
-
0035201072
-
Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model
-
Hund TJ, Kucera JP, Otani NF, Rudy Y. Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model. Biophys J. 2001;81:3324-3331. (Pubitemid 33111479)
-
(2001)
Biophysical Journal
, vol.81
, Issue.6
, pp. 3324-3331
-
-
Hund, T.J.1
Kucera, J.P.2
Otani, N.F.3
Rudy, Y.4
-
104
-
-
0036084519
-
Time-dependent transients in an ionically based mathematical model of the canine atrial action potential
-
Kneller J, Ramirez RJ, Chartier D, Courtemanche M, Nattel S. Time-dependent transients in an ionically based mathematical model of the canine atrial action potential. Am J Physiol Heart Circ Physiol. 2002;282:H1437-H1451. (Pubitemid 34654898)
-
(2002)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.282
, Issue.4
-
-
Kneller, J.1
Ramirez, R.J.2
Chartier, D.3
Courtemanche, M.4
Nattel, S.5
-
105
-
-
21644489951
-
An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells
-
DOI 10.1152/ajpheart.00683.2004
-
Krogh-Madsen T, Schaffer P, Skriver AD, Taylor LK, Pelzmann B, Koidl B, et al. An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells. Am J Physiol Heart Circ Physiol. 2005;289:H398-H413. (Pubitemid 40934127)
-
(2005)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.289
, Issue.1
-
-
Krogh-Madsen, T.1
Schaffer, P.2
Skriver, A.D.3
Taylor, L.K.4
Pelzmann, B.5
Koidl, B.6
Guevara, M.R.7
-
106
-
-
0031558727
-
A discussion about the DiFrancesco-Noble model
-
DOI 10.1006/jtbi.1997.0486
-
Guan S, Lu Q, Huang K. A discussion about the DiFrancesco-Noble model. J Theor Biol. 1997;189:27-32. (Pubitemid 27510785)
-
(1997)
Journal of Theoretical Biology
, vol.189
, Issue.1
, pp. 27-32
-
-
Guan, S.1
Lu, Q.2
Huang, K.3
-
108
-
-
0032953771
-
+ activity and pacemaker potential in rabbit SA node cells
-
Choi HS, Wang DY, Noble D, Lee CO. Effect of isoprenaline, carbachol, and Cs+ on Na+ activity and pacemaker potential in rabbit SA node cells. Am J Physiol. 1999;276:H205-H214. (Pubitemid 29065639)
-
(1999)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.276
, Issue.1
-
-
Choi, H.S.1
Wang, D.Y.2
Noble, D.3
Lee, C.O.4
-
109
-
-
84878618238
-
Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: Theoretical study on influence of intracellular Na+ concentration
-
Kurata Y, Hisatome I, Tanida M, Shibamoto T. Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na+ concentration. Am J Physiol Heart Circ Physiol. 2013;304:H1337-H1351.
-
(2013)
Am J Physiol Heart Circ Physiol
, vol.304
-
-
Kurata, Y.1
Hisatome, I.2
Tanida, M.3
Shibamoto, T.4
-
110
-
-
77649275507
-
Considerations on the size of currents required for pacemaking
-
DiFrancesco D. Considerations on the size of currents required for pacemaking. J Mol Cell Cardiol. 2010;48:802-803.
-
(2010)
J Mol Cell Cardiol
, vol.48
, pp. 802-803
-
-
DiFrancesco, D.1
-
111
-
-
6044275966
-
2+ exchanger
-
DOI 10.1152/ajpcell.00288.2004
-
Hilgemann DW. New insights into the molecular and cellular workings of the cardiac Na+/Ca2+ exchanger. Am J Physiol Cell Physiol. 2004;287:C1167-C1172. (Pubitemid 39382874)
-
(2004)
American Journal of Physiology - Cell Physiology
, vol.287
, Issue.5
-
-
Hilgemann, D.W.1
-
112
-
-
0034698064
-
Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells
-
Mitsuiye T, Shinagawa Y, Noma A. Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells. Circ Res. 2000;87:88-91. (Pubitemid 30616902)
-
(2000)
Circulation Research
, vol.87
, Issue.2
, pp. 88-91
-
-
Mitsuiye, T.1
Shinagawa, Y.2
Noma, A.3
-
113
-
-
40149107157
-
Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: A simulation study
-
DOI 10.2170/physiolsci.RP015207
-
Himeno Y, Sarai N, Matsuoka S, Noma A. Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study. J Physiol Sci. 2008;58:53-65. (Pubitemid 351329069)
-
(2008)
Journal of Physiological Sciences
, vol.58
, Issue.1
, pp. 53-65
-
-
Himeno, Y.1
Sarai, N.2
Matsuoka, S.3
Noma, A.4
-
114
-
-
80052338490
-
A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases
-
Kharche S, Yu J, Lei M, Zhang H. A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. Am J Physiol Heart Circ Physiol. 2011;301:H945-H963.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.301
-
-
Kharche, S.1
Yu, J.2
Lei, M.3
Zhang, H.4
-
116
-
-
0026733599
-
Theory of excitation-contraction coupling in cardiac muscle
-
Stern MD. Theory of excitation-contraction coupling in cardiac muscle. Biophys J. 1992;63:497-517.
-
(1992)
Biophys J
, vol.63
, pp. 497-517
-
-
Stern, M.D.1
-
117
-
-
78751682678
-
Synchronization of stochastic Ca2+ release units creates a rhythmic Ca2+ clock in cardiac pacemaker cells
-
Maltsev AV, Maltsev VA, Mikheev M, Maltseva LA, Sirenko SG, Lakatta EG, et al. Synchronization of stochastic Ca2+ release units creates a rhythmic Ca2+ clock in cardiac pacemaker cells. Biophys J. 2011;100:271-283.
-
(2011)
Biophys J
, vol.100
, pp. 271-283
-
-
Maltsev, A.V.1
Maltsev, V.A.2
Mikheev, M.3
Maltseva, L.A.4
Sirenko, S.G.5
Lakatta, E.G.6
-
118
-
-
70449578224
-
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel
-
Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, et al. Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc Natl Acad Sci U S A. 2009;106:18028-18033.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 18028-18033
-
-
Zhou, P.1
Zhao, Y.T.2
Guo, Y.B.3
Xu, S.M.4
Bai, S.H.5
Lakatta, E.G.6
-
119
-
-
84887193890
-
RyRNCX-SERCA local crosstalk ensures pacemaker cell function at rest and during the fight-or-flight reflex
-
Maltsev AV, Yaniv Y, Stern MD, Lakatta EG, Maltsev VA. RyRNCX-SERCA local crosstalk ensures pacemaker cell function at rest and during the fight-or-flight reflex. Circ Res. 2013;113:e94-e100.
-
(2013)
Circ Res
, vol.113
-
-
Maltsev, A.V.1
Yaniv, Y.2
Stern, M.D.3
Lakatta, E.G.4
Maltsev, V.A.5
-
120
-
-
84872867297
-
Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate
-
Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, et al. Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate. Circ Res. 2013;112:309-317.
-
(2013)
Circ Res
, vol.112
, pp. 309-317
-
-
Gao, Z.1
Rasmussen, T.P.2
Li, Y.3
Kutschke, W.4
Koval, O.M.5
Wu, Y.6
-
121
-
-
84896707893
-
Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity
-
Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, et al. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8:e81633.
-
(2013)
PLoS One
, vol.8
-
-
Groenke, S.1
Larson, E.D.2
Alber, S.3
Zhang, R.4
Lamp, S.T.5
Ren, X.6
-
122
-
-
84883214925
-
The cardiac sodium-calcium exchanger NCX1 is a key player in initiation and maintenance of a stable heart rhythm
-
Herrmann S, Lipp P, Wiesen K, Stieber J, Nguyen H, Kaiser E, et al. The cardiac sodium-calcium exchanger NCX1 is a key player in initiation and maintenance of a stable heart rhythm. Cardiovasc Res. 2013;99:780-788.
-
(2013)
Cardiovasc Res
, vol.99
, pp. 780-788
-
-
Herrmann, S.1
Lipp, P.2
Wiesen, K.3
Stieber, J.4
Nguyen, H.5
Kaiser, E.6
-
123
-
-
84883213120
-
Life and death of a cardiac calcium spark
-
Stern MD, Rios E, Maltsev VA. Life and death of a cardiac calcium spark. J Gen Physiol. 2013;142:257-274.
-
(2013)
J Gen Physiol
, vol.142
, pp. 257-274
-
-
Stern, M.D.1
Rios, E.2
Maltsev, V.A.3
-
124
-
-
84901033045
-
Spatial imperfection encodes functional perfection: Success and failure of calcium release to propagate regulate pacemaker cell function
-
Maltsev VA, Maltsev AV, Lakatta EG, Stern MD. Spatial imperfection encodes functional perfection: success and failure of calcium release to propagate regulate pacemaker cell function. Biophys J. 2014;106:319a.
-
(2014)
Biophys J
, vol.106
-
-
Maltsev, V.A.1
Maltsev, A.V.2
Lakatta, E.G.3
Stern, M.D.4
-
125
-
-
84899552203
-
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in SA node cells
-
In press
-
Stern MD, Maltseva LA, Juhaszova M, Sollott SJ, Lakatta EG, Maltsev VA. Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in SA node cells. J Gen Physiol. 2014. In press.
-
(2014)
J Gen Physiol
-
-
Stern, M.D.1
Maltseva, L.A.2
Juhaszova, M.3
Sollott, S.J.4
Lakatta, E.G.5
Maltsev, V.A.6
-
126
-
-
33748974953
-
2+ exchanger inhibitors
-
DOI 10.1254/jphs.FMJ06002X2
-
Watanabe Y, Koide Y, Kimura J. Topics on the Na+/Ca2+ exchanger: pharmacological characterization of Na+/Ca2+ exchanger inhibitors. J Pharmacol Sci. 2006;102:7-16. (Pubitemid 44440960)
-
(2006)
Journal of Pharmacological Sciences
, vol.102
, Issue.1
, pp. 7-16
-
-
Watanabe, Y.1
Koide, Y.2
Kimura, J.3
-
127
-
-
84861901336
-
Criticality in intracellular calcium signaling in cardiac myocytes
-
Nivala M, Ko CY, Nivala M, Weiss JN, Qu Z. Criticality in intracellular calcium signaling in cardiac myocytes. Biophys J. 2012;102:2433-2442.
-
(2012)
Biophys J
, vol.102
, pp. 2433-2442
-
-
Nivala, M.1
Ko, C.Y.2
Nivala, M.3
Weiss, J.N.4
Qu, Z.5
-
129
-
-
0036182464
-
2+ handling proteins in rabbit sinoatrial node
-
Musa H, Lei M, Honjo H, Jones SA, Dobrzynski H, Lancaster MK, et al. Heterogeneous expression of Ca2+ handling proteins in rabbit sinoatrial node. J Histochem Cytochem. 2002;50:311-324. (Pubitemid 34171056)
-
(2002)
Journal of Histochemistry and Cytochemistry
, vol.50
, Issue.3
, pp. 311-324
-
-
Musa, H.1
Lei, M.2
Honjo, H.3
Jones, S.A.4
Dobrzynski, H.5
Lancaster, M.K.6
Takagishi, Y.7
Henderson, Z.8
Kodama, I.9
Boyett, M.R.10
-
130
-
-
84877792716
-
Yoga for the sinoatrial node: Sarcoplasmic reticulum calcium release confers flexibility
-
Cummins MA, Devenyi RA, Sobie EA. Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility. J Mol Cell Cardiol. 2013;60:161-163.
-
(2013)
J Mol Cell Cardiol
, vol.60
, pp. 161-163
-
-
Cummins, M.A.1
Devenyi, R.A.2
Sobie, E.A.3
-
131
-
-
0348012925
-
Alternative to Hand-Tuning Conductance-Based Models: Construction and Analysis of Databases of Model Neurons
-
DOI 10.1152/jn.00641.2003
-
Prinz AA, Billimoria CP, Marder E. Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons. J Neurophysiol. 2003;90:3998-4015. (Pubitemid 37541930)
-
(2003)
Journal of Neurophysiology
, vol.90
, Issue.6
, pp. 3998-4015
-
-
Prinz, A.A.1
Billimoria, C.P.2
Marder, E.3
-
132
-
-
13744259954
-
Similar network activity from disparate circuit parameters
-
DOI 10.1038/nn1352
-
Prinz AA, Bucher D, Marder E. Similar network activity from disparate circuit parameters. Nat Neurosci. 2004;7:1345-1352. (Pubitemid 41057757)
-
(2004)
Nature Neuroscience
, vol.7
, Issue.12
, pp. 1345-1352
-
-
Prinz, A.A.1
Bucher, D.2
Marder, E.3
-
134
-
-
84861786241
-
Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models
-
Kurata Y, Hisatome I, Shibamoto T. Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models. Am J Physiol Heart Circ Physiol. 2012;302:H2285-H2300.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
-
-
Kurata, Y.1
Hisatome, I.2
Shibamoto, T.3
-
135
-
-
84864487119
-
Ca2+-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2
-
Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, et al. Ca2+-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation. 2012;126:528-536.
-
(2012)
Circulation
, vol.126
, pp. 528-536
-
-
Boink, G.J.1
Nearing, B.D.2
Shlapakova, I.N.3
Duan, L.4
Kryukova, Y.5
Bobkov, Y.6
-
137
-
-
78651240683
-
Determinants of heterogeneity, excitation and conduction in the sinoatrial node: A model study
-
Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput Biol. 2010;6:e1001041.
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Oren, R.V.1
Clancy, C.E.2
-
138
-
-
80054932960
-
Spatiotemporal control of heart rate in a rabbit heart
-
Lang D, Petrov V, Lou Q, Osipov G, Efimov IR. Spatiotemporal control of heart rate in a rabbit heart. J Electrocardiol. 2011; 44:626-634.
-
(2011)
J Electrocardiol
, vol.44
, pp. 626-634
-
-
Lang, D.1
Petrov, V.2
Lou, Q.3
Osipov, G.4
Efimov, I.R.5
-
139
-
-
84878618708
-
Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: A computational analysis
-
Wolf RM, Glynn P, Hashemi S, Zarei K, Mitchell CC, Anderson ME, et al. Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis. Am J Physiol Heart Circ Physiol. 2013;304:H1253-H1266.
-
(2013)
Am J Physiol Heart Circ Physiol
, vol.304
-
-
Wolf, R.M.1
Glynn, P.2
Hashemi, S.3
Zarei, K.4
Mitchell, C.C.5
Anderson, M.E.6
-
140
-
-
79961015131
-
Oxidized CaMKII causes cardiac sinus node dysfunction in mice
-
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, et al. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011;121:3277-3288.
-
(2011)
J Clin Invest
, vol.121
, pp. 3277-3288
-
-
Swaminathan, P.D.1
Purohit, A.2
Soni, S.3
Voigt, N.4
Singh, M.V.5
Glukhov, A.V.6
|