New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

Journal of Molecular and Cellular Cardiology

Volumn 62, Issue , 2013, Pages 80-89

  Yaniv, Yael ^a   Sirenko, Syevda ^a   Ziman, Bruce D ^a   Spurgeon, Harold A ^a   Maltsev, Victor A ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Ca2+ cycling; Ion channels; Physiology; Sarcoplasmic reticulum; Sinoatrial nodal pacemaker cells

Indexed keywords

CYCLOPIAZONIC ACID; IVABRADINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SERCA2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRADYCARDIA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART AUTOMATICITY; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; HEART RATE; NONHUMAN; PACEMAKER NERVE CELL; PRIORITY JOURNAL; RABBIT; SARCOPLASMIC RETICULUM; SINUS NODE; THEORETICAL MODEL;

50% DECAY TIME OF INTRACELLULAR CA(2+); 90% DECAY TIME OF INTRACELLULAR CA(2+); AC; ACTION POTENTIAL; ADENYLYL-CYCLASES; AP; CA(2+) CYCLING; CPA; CYCLOPIAZONIC ACID; ION CHANNELS; IVA; IVABRADINE; LCR; LOCAL CA(2+) RELEASE; M; MAXIMUM DIASTOLIC DEPOLARIZATION; MDP; MEMBRANE; PHOSPHOLAMBAN; PHYSIOLOGY; PKA; PLB; PROTEIN KINASE A; SANC; SARCOPLASMIC RETICULUM; SINOATRIAL NODAL PACEMAKER CELLS; SINOATRIAL-NODE CELLS; SR; T-50(C); T-90(C);

ANIMALS; BENZAZEPINES; BRADYCARDIA; CALCIUM; INDOLES; MODELS, BIOLOGICAL; MODELS, THEORETICAL; RABBITS; SARCOPLASMIC RETICULUM; SINOATRIAL NODE;

EID: 84880888765     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.04.026     Document Type: Article

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