Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate

Circulation Research

Volumn 112, Issue 2, 2013, Pages 309-317

  Gao, Zhan ^a   Rasmussen, Tyler P ^a,b   Li, Yue ^a   Kutschke, William ^a   Koval, Olha M ^a   Wu, Yiming ^a   Wu, Yuejin ^a   Hall, Duane D ^a   Joiner, Mei Ling A ^a   Wu, Xiang Qiong ^d   Swaminathan, Paari D ^a   Purohit, Anil ^a   Zimmerman, Kathy ^a   Weiss, Robert M ^a   Philipson, Kenneth D ^b,c   Song, Long Sheng ^a   Hund, Thomas J ^d   Anderson, Mark E ^a,b  

^a Cardiovascular Research Center   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

ion channel; L type Ca2+ channels; Na+ Ca2+ exchange; pacemaker current; sinoatrial node

Indexed keywords

CALCIUM CHANNEL L TYPE; DIHYDROPYRIDINE; ISOPRENALINE; IVABRADINE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; GENE DELETION; GENE EXPRESSION; HEART AUTOMATICITY; HEART RATE; HEART STRESS; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESTING HEART RATE; SINUS NODE;

ADRENERGIC BETA-AGONISTS; ANIMALS; HEART RATE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; REST; SINOATRIAL NODE; SODIUM-CALCIUM EXCHANGER;

EID: 84872867297     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300193     Document Type: Article

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