Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca2+ cycling and IKACh

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 3, 2009, Pages

  Lyashkov, Alexey E ^a   Vinogradova, Tatiana M ^a   Zahanich, Ihor ^a   Li, Yue ^a   Younes, Antoine ^a   Nuss, H Bradley ^a   Spurgeon, Harold A ^a   Maltsev, Victor A ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Ion channels; Protein kinase A phosphorylation; Signal transduction; Submembrane Ca2+ release

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; CALCIUM; CALCIUM CHANNEL L TYPE; CARBACHOL; CHOLINERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; PERTUSSIS TOXIN; PHOSPHOLAMBAN; POTASSIUM;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM SIGNALING; CHOLINERGIC SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERPOLARIZATION; IC 50; MEMBRANE CHANNEL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; RECEPTOR UPREGULATION; SARCOLEMMA; SARCOPLASMIC RETICULUM; SINUS NODE; SODIUM CALCIUM EXCHANGE;

ACTION POTENTIALS; ANIMALS; ATROPINE; BEE VENOMS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CESIUM; CHLORIDES; CHOLINERGIC AGONISTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; PARASYMPATHOLYTICS; PATCH-CLAMP TECHNIQUES; PERTUSSIS TOXIN; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; RABBITS; RECEPTORS, CHOLINERGIC; SINOATRIAL NODE; STOCHASTIC PROCESSES;

EID: 69249150907     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01340.2008     Document Type: Article

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