An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

Journal of Physiology

Volumn 590, Issue 18, 2012, Pages 4483-4499

  Severi, Stefano ^a   Fantini, Matteo ^a   Charawi, Lara A ^b   Difrancesco, Dario ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL COMPARTMENTALIZATION; COMPUTER SIMULATION; CONTROLLED STUDY; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART RATE; INTRACELLULAR TRANSPORT; ION EXCHANGE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SINUS NODE MEMBRANE POTENTIAL;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; HEART RATE; MODELS, CARDIOVASCULAR; RABBITS; SINOATRIAL NODE;

EID: 84866390214     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.229435     Document Type: Article

References (66)

1. Altomare C, Terragni B, Brioschi C, Milanesi R, Pagliuca C, Viscomi C, Moroni A, Baruscotti M & DiFrancesco D (2003). Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol 549, 347-359.
2. 2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol 579, 147-160.
3. Barbuti A, Baruscotti M & DiFrancesco D (2007). The pacemaker current: from basics to the clinics. J Cardiovasc Electrophysiol 18, 342-347.
4. Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A & DiFrancesco D (2011). Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A 108, 1705-1710.
5. 2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ Res 99, 979-987.
6. 2+ exchanger : molecular partners in pacemaker regulation. Circ Res 88, 1254-1258.
7. Bois P, Bescond J, Renaudon B & Lenfant J (1996). Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol 118, 1051-1057.
8. f channels by ivabradine. J Gen Physiol 120, 1-13.
9. Bucchi A, Baruscotti M, Robinson RB & DiFrancesco D (2007). Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current. J Mol Cell Cardiol 43, 39-48.
10. + activity and pacemaker potential in rabbit SA node cells. Am J Physiol Heart Circ Physiol 276, H205-H214.
11. Demir SS, Clark JW, Murphey CR & Giles WR (1994). A mathematical model of a rabbit sinoatrial node cell. Am J physiol Cell Physiol 266, C832-C852.
12. + block of the hyperpolarization-activated current if. J Physiol 429, 401-409.
13. DiFrancesco D (1993). Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 55, 455-472.
14. DiFrancesco D (2010). The role of the funny current in pacemaker activity. Circ Res 106, 434-446.
15. DiFrancesco D, Ducouret P & Robinson RB (1989). Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science 243, 669-671.
16. f) in cells isolated from the rabbit sino-atrial node. J Physiol 377, 61-88.
17. DiFrancesco D & Noble D (1982). Implications of the reinterpretation of iK2 for the modelling of the electrical activity of the pacemaker tissues in the heart. In Cardiac Rate and Rhythm: Physiological, Morphological and Developmental Aspects, ed. Boumann LN & Jongsma HJ, pp. 93-128. TheHague: Martinus Nijhoff.
18. DiFrancesco D & Noble D (1985). A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307, 353-398.
19. DiFrancesco D & Noble D (2012). The funny current has a major pacemaking role in the sinus node. Heart Rhythm 9, 299-301.
20. f) induced by acetylcholine in rabbit sino-atrial node myocytes. J Physiol 405, 477-491.
21. Dokos S, Celler B & Lovell N (1996). Vagal control of sinoatrial rhythm: a mathematical model. J Theor Biol 182, 21-44.
22. Fermini B & Nathan RD (1991). Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes. Am J Physiol Heart Circ Physiol 260, H735-H743.
23. Garny A, Noble D, Hunter PJ & Kohl P (2009). Cellular Open Resource (COR): current status and future directions. Philos Transact A Math Phys Eng Sci 367, 1885-1905.
24. Hagiwara N, Irisawa H & Kameyama M (1988). Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol 395, 233-253.
25. Heath BM & Terrar DA (1996). Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea-pig isolated ventricular myocytes. Exp Physiol 81, 587-603.
26. Himeno Y, Sarai N, Matsuoka S & Noma A (2008). Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study. J Physiol Sci 58, 53-65.
27. 2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. Am J Physiol Heart Circ Physiol 300, H251-H261.
28. Honjo H, Boyett MR, Kodama I & Toyama J (1996). Correlation between electrical activity and the size of rabbit sino-atrial node cells. J Physiol 496, 795-808.
29. Kawano S & Hiraoka M (1991). Transient outward currents and action potential alterations in rabbit ventricular myocytes. J Mol Cell Cardiol 23, 681-693.
30. Ke Y, Lei M, Collins TP, Rakovic S, Mattick PAD, Yamasaki M, Brodie MS, Terrar DA & Solaro RJ (2007). Regulation of L-Type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res 100, 1317-1327.
31. Kurata Y, Hisatome I, Imanishi S & Shibamoto T (2002). Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. Am J Physiol Heart Circ Physiol 283, H2074-H2101.
32. Lakatta EG & DiFrancesco D (2009). What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol 47, 157-170.
33. 2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 106, 659-673.
34. Lei M & Brown HF (1996). Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells. Exp Physiol 81, 725-741.
35. Lei M, Cooper PJ, Camelliti P & Kohl P (2002). Role of the 293b-sensitive, slowly activating delayed rectifier potassium current, iKs, in pacemaker activity of rabbit isolated sino-atrial node cells. Cardiovasc Res 53, 68-79.
36. 2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am J Physiol Heart Circ Physiol 296, H594-H615.
37. Maltsev VA & Lakatta EG (2010). A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins. Am J Physiol Heart Circ Physiol 298, H2010-H2023.
38. Maltsev VA & Lakatta EG (2012). The funny current in the context of the coupled-clock pacemaker cell system. Heart Rhythm 9, 302-307.
39. McAllister RE, Noble D & Tsien RW (1975). Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol 251, 1-59.
40. 2-adrenoceptors are not functionally coupled to L-type calcium current. J Cardiovasc Electrophysiol 10, 1240-1251.
41. Nakayama T, Kurachi Y, Noma A & Irisawa H (1984). Action potential and membrane currents of single pacemaker cells of the rabbit heart. Pflugers Arch 402, 248-257.
42. +, UL-FS-49, and ZD-7288 within sinoatrial node. Am j Physiol Heart Circ Physiol 272, H2782-H2792.
43. Nilius B (1986). Possible functional significance of a novel type of cardiac Ca channel. Biomed Biochim Acta 45, K37-K45.
44. Noble D, DiFrancesco D & Denyer JC (1989). Ionic mechanisms in normal and abnormal cardiac pacemaker activity. In Neuronal and Cellular Oscillators, ed. Jacklet JW, pp. 59-85.
45. Noble D, Noble PJ & Fink M (2010). Competing oscillators in cardiac pacemaking. Circ Res 106, 1791-1797.
46. Noble D & Noble SJ (1984). A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations. Proc R Soc Lond B Biol Sci 222, 295-304.
47. + current in sinoatrial node pacemaker activity. Am J Physiol Heart Circ Physiol 269, H453-H462.
48. Quayle JM, Standen NB & Stanfield PR (1988). The voltage-dependent block of ATP-sensitive potassium channels of frog skeletal muscle by caesium and barium ions. J Physiol 405, 677-697.
49. Rosen MR, Nargeot J & Salama G (2012). The case for the funny current and the calcium clock. Heart Rhythm 9, 616-618.
50. K(ACh)via different pathways in rabbit sino-atrial node cells. J Mol Cell Cardiol 29, 969-975.
51. Sakai R, Hagiwara N, Matsuda N, Kassanuki H & Hosoda S (1996). Sodium-potassium pump current in rabbit sino-atrial node cells. J Physiol 490, 51-62.
52. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96, 195-215.
53. Sarai N, Matsuoka S, Kuratomi S, Ono K & Noma A (2003). Role of individual ionic current systems in the SA node hypothesized by a model study. Jpn J Physiol 53, 125-134.
54. Severi S, Corsi C, Rocchetti M & Zaza A (2009). Mechanisms of β-adrenergic modulation of IKs in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 96, 3862-3872.
55. Shibasaki T (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol 387, 227-250.
56. Thollon C, Cambarrat C, Vian J, Prost JF, Peglion JL & Vilaine JP (1994). Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br J Pharmacol 112, 37-42.
57. f in single cells from rabbit sino-atrial node. J Physiol 434, 57-83.
58. Verkerk AO & Wilders R (2010). Relative importance of funny current in human versus rabbit sinoatrial node. J Mol Cell Cardiol 48, 799-801.
59. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res 90, 73-79.
60. 2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 98, 505-514.
61. Wilders R (2007). Computer modelling of the sinoatrial node. Med Biol Eng Comput 45, 189-207.
62. Ks). Comput Cardiol 37, 629-631.
63. Wilders R, Jongsma HJ & van Ginneken AC (1991). Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models. Biophys J 60, 1202-1216.
64. 2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node. J Physiol 491, 347-355.
65. Zeng J & Rudy Y (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys J 68, 949-964.
66. Zhang H, Holden AV, Kodama I, Honjo H, Lei M, Varghese T & Boyett MR (2000). Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol Heart Circ Physiol 279, H397-H421.