Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Monfredi, Oliver ^a,b   Maltseva, Larissa A ^a   Spurgeon, Harold A ^a   Boyett, Mark R ^b   Lakatta, Edward G ^a   Maltsev, Victor A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CONTROLLED STUDY; DIASTOLE; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; MALE; MAXIMUM DIASTOLIC POTENTIAL; NONHUMAN; PATCH CLAMP; PERIODICITY; SINGLE CELL ANALYSIS; SINUS NODE; ANIMAL; CELL CULTURE; CYTOLOGY; LEPORIDAE; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; VOLTAGE SENSITIVE DYE IMAGING;

ORYCTOLAGUS CUNICULUS;

CALCIUM; CALCIUM CHANNEL; DIVALENT CATION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CATIONS, DIVALENT; CELLS, CULTURED; MALE; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PERIODICITY; RABBITS; SINOATRIAL NODE; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84879548903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067247     Document Type: Article

References (19)

1. Costa M, Goldberger AL, Peng CK, (2005) Broken asymmetry of the human heartbeat: loss of time irreversibility in aging and disease. Phys Rev Lett 95: 198102.
2. Wilders R, Jongsma HJ, (1993) Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node. Biophys J 65: 2601-2613.
3. Opthof T, VanGinneken AC, Bouman LN, Jongsma HJ, (1987) The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial node. J Mol Cell Cardiol 19: 923-934.
4. Lakatta EG, Maltsev VA, Vinogradova TM, (2010) A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 106: 659-673.
5. Cheng H, Lederer WJ, Cannell MB, (1993) Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740-744.
6. Vinogradova TM, Zhou YY, Maltsev V, Lyashkov A, Stern M, et al. (2004) Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ Res 94: 802-809.
7. Vinogradova TM, Brochet DX, Sirenko S, Li Y, Spurgeon H, et al. (2010) Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells. Circ Res 107: 767-775.
8. Bogdanov KY, Vinogradova TM, Lakatta EG, (2001) Sinoatrial nodal cell ryanodine receptor and Na+-Ca2+ exchanger: molecular partners in pacemaker regulation. Circ Res 88: 1254-1258.
9. Bogdanov KY, Maltsev VA, Vinogradova TM, Lyashkov AE, Spurgeon HA, et al. (2006) Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ Res 99: 979-987.
10. Vinogradova TM, Zhou YY, Bogdanov KY, Yang D, Kuschel M, et al. (2000) Sinoatrial node pacemaker activity requires Ca2+/calmodulin-dependent protein kinase II activation. Circ Res 87: 760-767.
11. Fan JS, Palade P, (1998) Perforated patch recording with beta-escin. Pflugers Arch 436: 1021-1023.
12. Lyashkov AE, Juhaszova M, Dobrzynski H, Vinogradova TM, Maltsev VA, et al. (2007) Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circ Res 100: 1723-1731.
13. Maltsev VA, Vinogradova TM, Bogdanov KY, Lakatta EG, Stern MD, (2004) Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process. Biophys J 86: 2596-2605.
14. Joung B, Tang L, Maruyama M, Han S, Chen Z, et al. (2009) Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation 119: 788-796.
15. Wilders R, (2007) Computer modelling of the sinoatrial node. Med Biol Eng Comput 45: 189-207.
16. Maltsev AV, Maltsev VA, Mikheev M, Maltseva LA, Sirenko SG, et al. (2011) Synchronization of stochastic Ca2+ release units creates a rhythmic Ca2+ clock in cardiac pacemaker cells. Biophysical J 100: 271-283.
17. Kim JJ, Nemec J, Papp R, Strongin R, Abramson JJ, et al. (2013) Bradycardia alters Ca2+ dynamics enhancing dispersion of repolarization and arrhythmia risk. Am J Physiol Heart Circ Physiol 304: H848-860.
18. Neco P, Torrente AG, Mesirca P, Zorio E, Liu N, et al. (2012) Paradoxical effect of increased diastolic Ca2+ release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circulation 126: 392-401.
19. Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, et al. (2011) Beat-to-beat Ca2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm. J Mol Cell Cardiol 51: 902-905.