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Volumn 181, Issue 3, 1996, Pages 245-272

Ion currents underlying sinoatrial node pacemaker activity: A new single cell mathematical model

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; POTASSIUM ION; SODIUM ION;

EID: 0030573669     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0129     Document Type: Article
Times cited : (112)

References (97)
  • 1
    • 0026524968 scopus 로고
    • Delayed rectification in single cells isolated from guinea pig sinoatrial node
    • ANUMONWO, J. M. B., FREEMAN, L. C., KWOK, W. M. & KASS, R. S. (1992). Delayed rectification in single cells isolated from guinea pig sinoatrial node. Am. J. Physiol. 262, H921-H925.
    • (1992) Am. J. Physiol. , vol.262
    • Anumonwo, J.M.B.1    Freeman, L.C.2    Kwok, W.M.3    Kass, R.S.4
  • 2
    • 0001087650 scopus 로고
    • Cardiac resting and pacemaker potentials
    • Fozzard, H. A., Haber, E., Jennings, R. B., Katz, A. M. & Morgan, H. E., eds 2nd edn. New York: Raven
    • BAUMGARTEN, C. M. & FOZZARD, H. A. (1992). Cardiac resting and pacemaker potentials. In: The Heart and Cardiovascular System (Fozzard, H. A., Haber, E., Jennings, R. B., Katz, A. M. & Morgan, H. E., eds) 2nd edn, pp. 963-1001. New York: Raven.
    • (1992) The Heart and Cardiovascular System , pp. 963-1001
    • Baumgarten, C.M.1    Fozzard, H.A.2
  • 3
    • 0023763779 scopus 로고
    • Õorphology of the sinus and atrioventricular nodes and their innervation
    • Mazgalev, T., Dreifus, L. S. & Michelson, E. L., eds. New York: Allan R. Liss
    • BHARATI, S. & LEV, M. (1988). Õorphology of the sinus and atrioventricular nodes and their innervation. In: Electrophysiology of the Sinoatrial and Atrioventricular Nodes (Mazgalev, T., Dreifus, L. S. & Michelson, E. L., eds) pp. 3-14. New York: Allan R. Liss.
    • (1988) Electrophysiology of the Sinoatrial and Atrioventricular Nodes , pp. 3-14
    • Bharati, S.1    Lev, M.2
  • 4
    • 0020170638 scopus 로고
    • A mathematical model of primary pacemaking cell in sa node of the heart
    • BRISTOW, D. G. & CLARK, J. W. (1982). A mathematical model of primary pacemaking cell in SA node of the heart. Am. J. Physiol. 243, H207-H218.
    • (1982) Am. J. Physiol. , vol.243
    • Bristow, D.G.1    Clark, J.W.2
  • 6
    • 0025236532 scopus 로고
    • Does a background inward current normally contribute to the pacemaker potential in rabbit sino-atrial node cells?
    • BROWN, H. F. & DENYER, J. C. (1990). Does a background inward current normally contribute to the pacemaker potential in rabbit sino-atrial node cells? (Abstract). J. Physiol. (Lond.) 423, 62P.
    • (1990) J. Physiol. (Lond.) , vol.423
    • Brown, H.F.1    Denyer, J.C.2
  • 8
    • 0002524144 scopus 로고
    • Calcium currents
    • Langer, G. A., ed. New York: Raven
    • CAMPBELL, D. L. & GILES, W. R. (1990). Calcium currents. In: Calcium and the Heart (Langer, G. A., ed.) pp. 27-83. New York: Raven.
    • (1990) Calcium and the Heart , pp. 27-83
    • Campbell, D.L.1    Giles, W.R.2
  • 9
    • 0026553443 scopus 로고
    • Ionic current mechanisms generating vertebrate primary cardiac pacemaker activity at the single cell level: An integrative view
    • CAMPBELL, D. L., RASMUSSON, R. L. & STRAUSS, H. C. (1992). Ionic current mechanisms generating vertebrate primary cardiac pacemaker activity at the single cell level: an integrative view. Annu. Rev. Physiol. 54, 279-302.
    • (1992) Annu. Rev. Physiol. , vol.54 , pp. 279-302
    • Campbell, D.L.1    Rasmusson, R.L.2    Strauss, H.C.3
  • 11
    • 0018910556 scopus 로고
    • Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres
    • COLATSKY, T. J. (1980). Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres. J. Physiol. (Lond.) 305, 215-234.
    • (1980) J. Physiol. (Lond.) , vol.305 , pp. 215-234
    • Colatsky, T.J.1
  • 12
    • 0028360947 scopus 로고
    • Gating of the squid sodium channel at positive potentials: II. Single channels reveal two open states
    • CORREA, A. M. & BEZANILLA, F. (1994). Gating of the squid sodium channel at positive potentials: II. Single channels reveal two open states. Biophys. J. 66, 1864-1878.
    • (1994) Biophys. J. , vol.66 , pp. 1864-1878
    • Correa, A.M.1    Bezanilla, F.2
  • 13
    • 0011877971 scopus 로고
    • Some aspects of the interrelationship between ions and electrical activity in specialized tissue of the heart
    • Paes de Carvalho, A., De Mello, W. C. & Hoffman, B. F., eds. New York: Elsevier
    • DE MELLO, W. C. (1961). Some aspects of the interrelationship between ions and electrical activity in specialized tissue of the heart. In: The Specialized Tissues of the Heart (Paes de Carvalho, A., De Mello, W. C. & Hoffman, B. F., eds) pp. 95-106. New York: Elsevier.
    • (1961) The Specialized Tissues of the Heart , pp. 95-106
    • De Mello, W.C.1
  • 15
    • 0025082937 scopus 로고
    • Rabbit sino-atrial node cells: Isolation and electrophysiological properties
    • DENYER, J. C. & BROWN, H. F. (1990a). Rabbit sino-atrial node cells: isolation and electrophysiological properties. J. Physiol. (Lond.) 428, 405-424.
    • (1990) J. Physiol. (Lond.) , vol.428 , pp. 405-424
    • Denyer, J.C.1    Brown, H.F.2
  • 17
    • 0022422465 scopus 로고
    • A model of cardiac electrical activity incorporating ionic pumps and concentration changes
    • DIFRANCESCO, D. & NOBLE, D. (1985). A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Phil. Trans. R. Soc. Lond. B 307, 353-398.
    • (1985) Phil. Trans. R. Soc. Lond. B , vol.307 , pp. 353-398
    • DiFrancesco, D.1    Noble, D.2
  • 19
    • 0001867931 scopus 로고
    • f and its contribution to cardiac pacemaking
    • Jacklet, J. W., ed. New York: Marcel Dekker
    • f and its contribution to cardiac pacemaking. In: Neuronal and cellular oscillators (Jacklet, J. W., ed.) pp. 31-57. New York: Marcel Dekker.
    • (1989) Neuronal and Cellular Oscillators , pp. 31-57
    • DiFrancesco, D.1    Noble, D.2
  • 20
    • 0025977991 scopus 로고
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J. Physiol. (Lond.) 434, 23-40.
    • (1991) J. Physiol. (Lond.) , vol.434 , pp. 23-40
    • DiFrancesco, D.1
  • 21
    • 0027530224 scopus 로고
    • Pacemaker mechanisms in cardiac tissue
    • DIFRANCESCO, D. (1993). Pacemaker mechanisms in cardiac tissue. Annu. Rev. Physiol. 55, 455-472.
    • (1993) Annu. Rev. Physiol. , vol.55 , pp. 455-472
    • DiFrancesco, D.1
  • 22
    • 0024601835 scopus 로고
    • Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp
    • DOERR, T., DENGER, R. & TRAUTWEIN, W. (1989). Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflügers. Arch. 413, 599-603.
    • (1989) Pflügers. Arch. , vol.413 , pp. 599-603
    • Doerr, T.1    Denger, R.2    Trautwein, W.3
  • 23
    • 0025364711 scopus 로고
    • Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp
    • DOERR, T., DENGER, R., DOERR, A. & TRAUTWEIN, W. (1990). Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflügers. Arch. 416, 230-237.
    • (1990) Pflügers. Arch. , vol.416 , pp. 230-237
    • Doerr, T.1    Denger, R.2    Doerr, A.3    Trautwein, W.4
  • 24
    • 0027624491 scopus 로고
    • Modification of DiFrancesco-Noble equations to simulate the effects of vagal stimulation on in-vivo mammalian sinoatrial node electrical activity
    • DOKOS, S., CELLER, B. G. & LOVELL, N. H. (1993). Modification of DiFrancesco-Noble Equations to simulate the effects of vagal stimulation on in-vivo mammalian sinoatrial node electrical activity. Ann. Biomed. Eng. 21, 321-335.
    • (1993) Ann. Biomed. Eng. , vol.21 , pp. 321-335
    • Dokos, S.1    Celler, B.G.2    Lovell, N.H.3
  • 25
    • 0030573811 scopus 로고    scopus 로고
    • Vagal control of sinoatrial rhythm: A mathematical model
    • in press
    • DOKOS, S., CELLER, B. G. & LOVELL, N. H. (1996). Vagal control of sinoatrial rhythm: a mathematical model. J. theor. Biol. (in press).
    • (1996) J. Theor. Biol.
    • Dokos, S.1    Celler, B.G.2    Lovell, N.H.3
  • 26
    • 0023394125 scopus 로고
    • Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells
    • DROUHARD, J.-P. & ROBERGE, F. A. (1987). Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells. Comput. Biomed. Res. 20, 333-350.
    • (1987) Comput. Biomed. Res. , vol.20 , pp. 333-350
    • Drouhard, J.-P.1    Roberge, F.A.2
  • 27
    • 0025828731 scopus 로고
    • The cytosolic calcium transient modulates the action potential of rat ventricular myocytes
    • DUBELL, W. H., BOYETT, M. R., SPURGEON, H. A., TALO, A., STERN, M. D. & LAKATTA, E. G. (1991). The cytosolic calcium transient modulates the action potential of rat ventricular myocytes. J. Physiol. (Lond.) 436, 347-369.
    • (1991) J. Physiol. (Lond.) , vol.436 , pp. 347-369
    • Dubell, W.H.1    Boyett, M.R.2    Spurgeon, H.A.3    Talo, A.4    Stern, M.D.5    Lakatta, E.G.6
  • 28
    • 0025351530 scopus 로고
    • A model of the single atrial cell: Relation between calcium current and calcium release
    • EARM, Y. E. & NOBLE, D. (1990). A model of the single atrial cell: relation between calcium current and calcium release. Proc. R. Soc. Lond. Biol. 240, 83-96.
    • (1990) Proc. R. Soc. Lond. Biol. , vol.240 , pp. 83-96
    • Earm, Y.E.1    Noble, D.2
  • 29
    • 0026345738 scopus 로고
    • 2+-buffer concentration and stimulus interval on the voltage dependence and timecourse of calcium-release-dependent inward current in rabbit atrial myocytes
    • 2+-buffer concentration and stimulus interval on the voltage dependence and timecourse of calcium-release-dependent inward current in rabbit atrial myocytes. Proc. R. Soc. Lond. Biol. 246, 285-292.
    • (1991) Proc. R. Soc. Lond. Biol. , vol.246 , pp. 285-292
    • Earm, Y.E.1    Ho, W.K.2    So, I.3
  • 30
    • 0023262627 scopus 로고
    • Acetylcholine and the mammalian 'slow-inward' current: A computer investigation
    • EGAN, T. M. & NOBLE, S. J. (1987). Acetylcholine and the mammalian 'slow-inward' current: a computer investigation. Proc. Roy. Soc. Lond. 230, 315-337.
    • (1987) Proc. Roy. Soc. Lond. , vol.230 , pp. 315-337
    • Egan, T.M.1    Noble, S.J.2
  • 31
    • 0026873382 scopus 로고
    • + conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells
    • + conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells. Pflügers Arch. 421, 97-99.
    • (1992) Pflügers Arch. , vol.421 , pp. 97-99
    • Frace, A.M.1    Maruoka, F.2    Noma, A.3
  • 32
    • 0021867974 scopus 로고
    • Voltage dependence of Na/K pump current in isolated heart cells
    • GADSBY, D. C., KIMURA, J. & NOMA, A. (1985). Voltage dependence of Na/K pump current in isolated heart cells. Nature 315, 63-65.
    • (1985) Nature , vol.315 , pp. 63-65
    • Gadsby, D.C.1    Kimura, J.2    Noma, A.3
  • 34
    • 0023874297 scopus 로고
    • Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells
    • HAGIWARA, N., IRISAWA, H. & KAMEYAMA, M. (1988). Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. (Lond.) 395, 233-253.
    • (1988) J. Physiol. (Lond.) , vol.395 , pp. 233-253
    • Hagiwara, N.1    Irisawa, H.2    Kameyama, M.3
  • 35
    • 0003222194 scopus 로고
    • Na-Ca exchange current in sinoatrial node cell of rabbit.
    • HAGIWARA, N. & IRISAWA, H. (1988). Na-Ca exchange current in sinoatrial node cell of rabbit. (Abstract). Circulation Suppl. 78, 490a.
    • (1988) Circulation , Issue.SUPPL. 78
    • Hagiwara, N.1    Irisawa, H.2
  • 36
    • 0026530016 scopus 로고
    • Background current in sino-atrial node cells of the rabbit heart
    • HAGIWARA, N., IRISAWA, H., KASANUKI, H. & HOSODA, S. (1992). Background current in sino-atrial node cells of the rabbit heart. J. Physiol. (Lond.) 448, 53-72.
    • (1992) J. Physiol. (Lond.) , vol.448 , pp. 53-72
    • Hagiwara, N.1    Irisawa, H.2    Kasanuki, H.3    Hosoda, S.4
  • 37
    • 0026581889 scopus 로고
    • The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes
    • HARRISON, S. M., MCCALL, E. & BOYETT, M. R. (1992). The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes. J. Physiol. (Lond.) 449, 517-550.
    • (1992) J. Physiol. (Lond.) , vol.449 , pp. 517-550
    • Harrison, S.M.1    McCall, E.2    Boyett, M.R.3
  • 38
    • 0023662820 scopus 로고
    • Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: Reconstruction of basic cellular mechanisms
    • HILGEMANN, D. W. & NOBLE, D. (1987). Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Proc. Roy. Soc. Lond. B 230, 163-205.
    • (1987) Proc. Roy. Soc. Lond. B , vol.230 , pp. 163-205
    • Hilgemann, D.W.1    Noble, D.2
  • 39
    • 0024224146 scopus 로고
    • Numerical approximations of sodium-calcium exchange
    • HILGEMANN, D. W. (1988). Numerical approximations of sodium-calcium exchange. Prog. Biophys. Mol. Biol. 51, 1-45.
    • (1988) Prog. Biophys. Mol. Biol. , vol.51 , pp. 1-45
    • Hilgemann, D.W.1
  • 40
    • 0027303739 scopus 로고
    • Internal K ions modulate the action of external cations on hyperpolarization-activated inward current in rabbit isolated sinoatrial node cells
    • HO, W.-K., BROWN, H. F. & NOBLE, D. (1993). Internal K ions modulate the action of external cations on hyperpolarization-activated inward current in rabbit isolated sinoatrial node cells. Pflügers Arch. 424, 308-314.
    • (1993) Pflügers Arch. , vol.424 , pp. 308-314
    • Ho, W.-K.1    Brown, H.F.2    Noble, D.3
  • 42
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • HODGKIN, A. L. & HUXLEY, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544.
    • (1952) J. Physiol. (Lond.) , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 43
    • 0027074563 scopus 로고
    • Desensitization to acetylcholine in single sinoatrial node cells isolated from rabbit hearts
    • HONJO, H., KODAMA, I., ZANG, W.-J. & BOYETT, M. R. (1992). Desensitization to acetylcholine in single sinoatrial node cells isolated from rabbit hearts. Am. J. Physiol. 263, H1779-H1789.
    • (1992) Am. J. Physiol. , vol.263
    • Honjo, H.1    Kodama, I.2    Zang, W.-J.3    Boyett, M.R.4
  • 44
    • 0000063474 scopus 로고
    • Correlation between action potential parameters and the size of single sinoatrial node cells isolated from rabbit hearts
    • HONJO, H. & BOYETT, M. R. (1992). Correlation between action potential parameters and the size of single sinoatrial node cells isolated from rabbit hearts (Abstract). J. Physiol. (Lond.) 452, 128P.
    • (1992) J. Physiol. (Lond.) , vol.452
    • Honjo, H.1    Boyett, M.R.2
  • 46
    • 0027509511 scopus 로고
    • Cardiac pacemaking in the sinoatrial node
    • IRISAWA, H., BROWN, H. F. & GILES, W. (1993). Cardiac pacemaking in the sinoatrial node. Physiol. Rev. 73, 197-227.
    • (1993) Physiol. Rev. , vol.73 , pp. 197-227
    • Irisawa, H.1    Brown, H.F.2    Giles, W.3
  • 49
    • 0021844035 scopus 로고
    • Regional differences in the electrical activity of the rabbit sinus node
    • KODAMA, I. & BOYETT, M. R. (1985). Regional differences in the electrical activity of the rabbit sinus node. Pflügers Arch. 404, 214-226.
    • (1985) Pflügers Arch. , vol.404 , pp. 214-226
    • Kodama, I.1    Boyett, M.R.2
  • 50
    • 0016840470 scopus 로고
    • Evidence for the existence of a rapid sodium channel in the membrane of rabbit sinoatrial node cells
    • KREITNER, D. (1975). Evidence for the existence of a rapid sodium channel in the membrane of rabbit sinoatrial node cells. J. Mol. Cell. Cardiol. 7, 655-662.
    • (1975) J. Mol. Cell. Cardiol. , vol.7 , pp. 655-662
    • Kreitner, D.1
  • 51
    • 0026715132 scopus 로고
    • Calcium transients caused by calcium entry are infuenced by the sarcoplasmic reticulum in guinea-pig atrial myocytes
    • LIPP, P., POTT, L., CALLEWAERT, G. & CARMELIET, E. (1992). Calcium transients caused by calcium entry are infuenced by the sarcoplasmic reticulum in guinea-pig atrial myocytes. J. Physiol. (Lond.) 454, 321-338.
    • (1992) J. Physiol. (Lond.) , vol.454 , pp. 321-338
    • Lipp, P.1    Pott, L.2    Callewaert, G.3    Carmeliet, E.4
  • 52
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
    • LUO, C.-H. & RUDY, Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 74, 1071-1096.
    • (1994) Circ. Res. , vol.74 , pp. 1071-1096
    • Luo, C.-H.1    Rudy, Y.2
  • 53
    • 0028101232 scopus 로고
    • Modeling state-dependent inactivation of membrane currents
    • MAROM, S. & ABBOTT, L. F. (1994). Modeling state-dependent inactivation of membrane currents. Biophys. J. 67, 515-520.
    • (1994) Biophys. J. , vol.67 , pp. 515-520
    • Marom, S.1    Abbott, L.F.2
  • 54
    • 84996019133 scopus 로고
    • On the structural identification of pacemaker cell types within the sinus node
    • Bouman, L. M. & Jongsma, H. L., eds. The Hague: Martinus Nijhoff
    • MASSON-PÉVET, M., BLEEKER, W. K., BESSELSEN, E., MACKAAY, A. J. C., JONGSMA, H. J. & BOUMAN, L. N. (1982). On the structural identification of pacemaker cell types within the sinus node. In: Cardiac Rate and Rhythm (Bouman, L. M. & Jongsma, H. L., eds) pp. 19-34. The Hague: Martinus Nijhoff.
    • (1982) Cardiac Rate and Rhythm , pp. 19-34
    • Masson-Pévet, M.1    Bleeker, W.K.2    Besselsen, E.3    Mackaay, A.J.C.4    Jongsma, H.J.5    Bouman, L.N.6
  • 56
    • 0023513790 scopus 로고
    • An analysis of the delayed outward current in single ventricular cells of the guinea-pig
    • MATSUURA, H., EHARA, T. & IMOTO, Y. (1987). An analysis of the delayed outward current in single ventricular cells of the guinea-pig. Pflügers Arch. 410, 596-603.
    • (1987) Pflügers Arch. , vol.410 , pp. 596-603
    • Matsuura, H.1    Ehara, T.2    Imoto, Y.3
  • 57
    • 0027082201 scopus 로고
    • Steady-state and dynamic properties of cardiac sodium-calcium exchange: Ion and voltage dependencies of the transport cycle
    • MATSUOKA, S. & HILGEMANN, D. W. (1992). Steady-state and dynamic properties of cardiac sodium-calcium exchange: Ion and voltage dependencies of the transport cycle. J. Gen. Physiol. 100, 963-1001.
    • (1992) J. Gen. Physiol. , vol.100 , pp. 963-1001
    • Matsuoka, S.1    Hilgemann, D.W.2
  • 58
    • 0024468374 scopus 로고
    • Influence of magnesium and extracellular calcium reduction on ouabain-treated sinoatrial node cells in rabbit heart
    • MIYAMAE, S. (1989). Influence of magnesium and extracellular calcium reduction on ouabain-treated sinoatrial node cells in rabbit heart. Pharmacol. Toxicol. 65, 192-197.
    • (1989) Pharmacol. Toxicol. , vol.65 , pp. 192-197
    • Miyamae, S.1
  • 59
    • 0011805753 scopus 로고
    • Na/Ca exchange
    • New York: Raven Press
    • MULLINS, L. J. (1981). Na/Ca exchange. In: Ion Transport in the Heart pp. 20-43. New York: Raven Press.
    • (1981) Ion Transport in the Heart , pp. 20-43
    • Mullins, L.J.1
  • 60
    • 4243581239 scopus 로고
    • Role of a TTX-sensitive sodium current in primary pacemaker cells of the rabbit sinoatrial node
    • MURAMATSU, H. & NATHAN, R. D. (1992). Role of a TTX-sensitive sodium current in primary pacemaker cells of the rabbit sinoatrial node. (Abstract). Biophys. J. 61, A306.
    • (1992) Biophys. J. , vol.61
    • Muramatsu, H.1    Nathan, R.D.2
  • 61
    • 0002618638 scopus 로고
    • Parasympathetic control of SA node cell in rabbit heart - A model
    • Sideman, S. & Beyar, R., eds. Dordrecht: Martinus Nijhoff
    • MURPHEY, C. R. & CLARK, J. W., JR. (1987). Parasympathetic control of SA node cell in rabbit heart - a model. In: Activation, Metabolism and Perfusion of the Heart (Sideman, S. & Beyar, R., eds) pp. 41-59. Dordrecht: Martinus Nijhoff.
    • (1987) Activation, Metabolism and Perfusion of the Heart , pp. 41-59
    • Murphey, C.R.1    Clark J.W., Jr.2
  • 62
    • 0021719811 scopus 로고
    • Action potential and membrane currents of single cells of the rabbit heart
    • NAKAYAMA, T., KURACHI, Y., NOMA, A. & IRISAWA, H. (1984). Action potential and membrane currents of single cells of the rabbit heart. Pflügers Arch. 402, 248-257.
    • (1984) Pflügers Arch. , vol.402 , pp. 248-257
    • Nakayama, T.1    Kurachi, Y.2    Noma, A.3    Irisawa, H.4
  • 63
    • 0022495261 scopus 로고
    • Possible functional significance of a novel type of cardiac Ca channel
    • NILIUS, B. (1986). Possible functional significance of a novel type of cardiac Ca channel. Biomed. Biochim. Acta 45(8), K37-K45.
    • (1986) Biomed. Biochim. Acta , vol.45 , Issue.8
    • Nilius, B.1
  • 65
    • 0021226282 scopus 로고
    • A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations
    • NOBLE, D. & NOBLE, S. (1984). A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations. Proc. R. Soc. Lond. B 222, 295-304.
    • (1984) Proc. R. Soc. Lond. B , vol.222 , pp. 295-304
    • Noble, D.1    Noble, S.2
  • 66
    • 0021284516 scopus 로고
    • The surprising heart: A review of recent progress in cardiac electrophysiology
    • NOBLE, D. (1984). The surprising heart: A review of recent progress in cardiac electrophysiology. J. Physiol. (Lond.) 353, 1-50.
    • (1984) J. Physiol. (Lond.) , vol.353 , pp. 1-50
    • Noble, D.1
  • 67
    • 0002595356 scopus 로고
    • Ionic mechanisms in normal and abnormal cardiac pacemaker activity
    • Jacklet, J. W., ed. New York: Marcel Dekker
    • NOBLE, D., DIFRANCESCO, D. & DENYER, J. C. (1989). Ionic mechanisms in normal and abnormal cardiac pacemaker activity. In: Neuronal and cellular oscillators (Jacklet, J. W., ed) pp. 59-85. New York: Marcel Dekker.
    • (1989) Neuronal and Cellular Oscillators , pp. 59-85
    • Noble, D.1    DiFrancesco, D.2    Denyer, J.C.3
  • 68
  • 70
    • 0017060076 scopus 로고
    • Mechanisms underlying cessation of rabbit sinoatrial node pacemaker activity in high potassium solutions
    • NOMA, A. (1976). Mechanisms underlying cessation of rabbit sinoatrial node pacemaker activity in high potassium solutions. Jap. J. Physiol. 26, 619-630.
    • (1976) Jap. J. Physiol. , vol.26 , pp. 619-630
    • Noma, A.1
  • 71
    • 0018707367 scopus 로고
    • The effect of external potassium on the elementary conductance of the ACh-induced potassium channel in the sino-atrial node
    • NOMA, A., OSTERRIEDER, W. & TRAUTWEIN, W. (1979). The effect of external potassium on the elementary conductance of the ACh-induced potassium channel in the sino-atrial node. Pflügers Arch. 381, 263-269.
    • (1979) Pflügers Arch. , vol.381 , pp. 263-269
    • Noma, A.1    Osterrieder, W.2    Trautwein, W.3
  • 73
    • 0018650314 scopus 로고
    • The efficient numerical solution of biological simulation problems
    • PLANT, R. E. (1979). The efficient numerical solution of biological simulation problems. Comput. Progr. in Biomed. 10, 1-15.
    • (1979) Comput. Progr. in Biomed. , vol.10 , pp. 1-15
    • Plant, R.E.1
  • 74
    • 0025357882 scopus 로고
    • High Na permeability of L-type Ca channels in isolated rabbit SA node cells
    • PORCIATTI, F. & DIFRANCESCO, D. (1990). High Na permeability of L-type Ca channels in isolated rabbit SA node cells. (Abstract). J. Physiol. (Lond.) 426, 18P.
    • (1990) J. Physiol. (Lond.) , vol.426
    • Porciatti, F.1    DiFrancesco, D.2
  • 75
    • 0027265420 scopus 로고
    • Ca channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells
    • RISSO, S. & DEFELICE, L. J. (1993). Ca channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells. Biophys. J. 65, 1006-1018.
    • (1993) Biophys. J. , vol.65 , pp. 1006-1018
    • Risso, S.1    DeFlice, L.J.2
  • 78
    • 0025351245 scopus 로고
    • + current. Differential sensitivity to block by class III antiarrhythmic agents
    • + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96, 195-215.
    • (1990) J. Gen. Physiol. , vol.96 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 80
    • 0028175615 scopus 로고
    • 2+ concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells
    • 2+ concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells. Gen. Pharmac. 25, 325-332.
    • (1994) Gen. Pharmac. , vol.25 , pp. 325-332
    • Satoh, H.1
  • 81
    • 0000327336 scopus 로고
    • Effect of calcium on the membrane potentials of single pacemaker fibres and atrial fibres in isolated rabbit atria
    • SEIFEN, E., SCHAER, H. & MARSHALL, J. M. (1964). Effect of calcium on the membrane potentials of single pacemaker fibres and atrial fibres in isolated rabbit atria. Nature 202, 1223-1224.
    • (1964) Nature , vol.202 , pp. 1223-1224
    • Seifen, E.1    Schaer, H.2    Marshall, J.M.3
  • 83
    • 0017612248 scopus 로고
    • The effect of Na, K and Cl ions on the resting membrane potential of sino-atrial node cell of the rabbit
    • SEYAMA, I. (1977). The effect of Na, K and Cl ions on the resting membrane potential of sino-atrial node cell of the rabbit. Jap. J. Physiol. 27, 577-588.
    • (1977) Jap. J. Physiol. , vol.27 , pp. 577-588
    • Seyama, I.1
  • 85
    • 0023162302 scopus 로고
    • Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart
    • SHIBASAKI, T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol. (Lond.) 387, 227-250.
    • (1987) J. Physiol. (Lond.) , vol.387 , pp. 227-250
    • Shibasaki, T.1
  • 86
    • 0026733599 scopus 로고
    • Theory of excitation-contraction coupling in cardiac muscle
    • STERN, M. D. (1992). Theory of excitation-contraction coupling in cardiac muscle. Biophys. J. 63, 497-517.
    • (1992) Biophys. J. , vol.63 , pp. 497-517
    • Stern, M.D.1
  • 87
    • 0014051226 scopus 로고
    • Interactions of K, Na, and vagal stimulation in the S-A node of the rabbit
    • TODA, N. & WEST, T. C. (1967a). Interactions of K, Na, and vagal stimulation in the S-A node of the rabbit. Am. J. Physiol. 212, 416-423.
    • (1967) Am. J. Physiol. , vol.212 , pp. 416-423
    • Toda, N.1    West, T.C.2
  • 88
    • 0014055190 scopus 로고
    • Interaction between Na, Ca, Mg, and vagal stimulation in the S-A node of the rabbit
    • TODA, N. & WEST, T. C. (1967b). Interaction between Na, Ca, Mg, and vagal stimulation in the S-A node of the rabbit. Am. J. Physiol. 212, 424-430.
    • (1967) Am. J. Physiol. , vol.212 , pp. 424-430
    • Toda, N.1    West, T.C.2
  • 89
    • 0026088929 scopus 로고
    • Voltage clamp measurements of the hyperpolarization-activated inward current if in single cells from rabbit sino-atrial node
    • VAN GINNEKEN, A. C. G. & GILES, W. (1991). Voltage clamp measurements of the hyperpolarization-activated inward current if in single cells from rabbit sino-atrial node. J. Physiol. (Lond.) 434, 57-83.
    • (1991) J. Physiol. (Lond.) , vol.434 , pp. 57-83
    • Van Ginneken, A.C.G.1    Giles, W.2
  • 90
    • 0021920802 scopus 로고
    • Numerical integration in the reconstruction of cardiac action potentials using Hodgkin-Huxley-type models
    • VICTORRI, B., VINET, A., ROBERGE, F. A. & DROUHARD, J. P. (1983). Numerical integration in the reconstruction of cardiac action potentials using Hodgkin-Huxley-type models. Comp. Biomed. Res. 18, 10-23.
    • (1983) Comp. Biomed. Res. , vol.18 , pp. 10-23
    • Victorri, B.1    Vinet, A.2    Roberge, F.A.3    Drouhard, J.P.4
  • 91
    • 0025195168 scopus 로고
    • 2+] in mammalian ventricle: Dynamic control by cellular processes
    • 2+] in mammalian ventricle: Dynamic control by cellular processes. Ann. Rev. Physiol. 52, 467-485.
    • (1990) Ann. Rev. Physiol. , vol.52 , pp. 467-485
    • Wier, W.G.1
  • 92
    • 0025830164 scopus 로고
    • Pacemaker activity of the rabbit sinoatrial node: A comparison of mathematical models
    • WILDERS, R., JONGSMA, H. J. & VAN GINNEKEN, A. C. G. (1991). Pacemaker activity of the rabbit sinoatrial node: a comparison of mathematical models. Biophys. J. 60, 1202-1216.
    • (1991) Biophys. J. , vol.60 , pp. 1202-1216
    • Wilders, R.1    Jongsma, H.J.2    Van Ginneken, A.C.G.3
  • 93
    • 0027136258 scopus 로고
    • Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node
    • WILDERS, R. & JONGSMA, H. J. (1993). Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node. Biophys. J. 65, 2601-2613.
    • (1993) Biophys. J. , vol.65 , pp. 2601-2613
    • Wilders, R.1    Jongsma, H.J.2
  • 94
    • 0019277122 scopus 로고
    • Reconstruction of SA node pacemaker potential based on the voltage clamp experiments
    • YANAGIHARA, K., NOMA, A. & IRISAWA, H. (1980). Reconstruction of SA node pacemaker potential based on the voltage clamp experiments. Jpn. J. Physiol. 30, 841-857.
    • (1980) Jpn. J. Physiol. , vol.30 , pp. 841-857
    • Yanagihara, K.1    Noma, A.2    Irisawa, H.3
  • 95
    • 0018837655 scopus 로고
    • Inward current activated during hyperpolarization in the rabbit sinoatrial node cell
    • YANAGIHARA, K. & IRISAWA, H. (1980a). Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflügers Arch. 385, 11-19.
    • (1980) Pflügers Arch. , vol.385 , pp. 11-19
    • Yanagihara, K.1    Irisawa, H.2
  • 96
    • 0019269829 scopus 로고
    • Potassium current during the pacemaker depolarization in rabbit sinoatrial node cell
    • YANAGIHARA, K. & IRISAWA, H. (1980b). Potassium current during the pacemaker depolarization in rabbit sinoatrial node cell. Pflügers Arch. 388, 255-260.
    • (1980) Pflügers Arch. , vol.388 , pp. 255-260
    • Yanagihara, K.1    Irisawa, H.2
  • 97
    • 4243605122 scopus 로고
    • Is hyperpolarization-activated inward current the "pacemaker" current in the sinoatrial node?
    • ZOU, A., POWELL, R. A. & NATHAN, R. D. (1994). Is hyperpolarization-activated inward current the "pacemaker" current in the sinoatrial node? (Abstract). Biophys. J. 66, A84.
    • (1994) Biophys. J. , vol.66
    • Zou, A.1    Powell, R.A.2    Nathan, R.D.3


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