Synchronization of stochastic Ca2+ release units creates a rhythmic Ca2+ clock in cardiac pacemaker cells

Biophysical Journal

Volumn 100, Issue 2, 2011, Pages 271-283

  Maltsev, Anna V ^a   Maltsev, Victor A ^a   Mikheev, Maxim ^a   Maltseva, Larissa A ^a   Sirenko, Syevda G ^a   Lakatta, Edward G ^a   Stern, Michael D ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORYCTOLAGUS CUNICULUS;

EID: 78751682678     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.11.081     Document Type: Article

References (33)

1. 2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Cardiovasc. Res. 77:274-284.
2. 2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ. Res. 106:659-673.
3. Noble, D. 1960. Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations. Nature. 188:495-497.
4. 2+ release contributes to automaticity in cat atrial pacemaker cells. J. Physiol. 524:415-422.
5. 2+ exchanger: molecular partners in pacemaker regulation. Circ. Res. 88:1254-1258.
6. 2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ. Res. 94:802-809.
7. Maltsev, V. A., T. M. Vinogradova, and E. G. Lakatta. 2006. The emergence of a general theory of the initiation and strength of the heartbeat. J. Pharmacol. Sci. 100:338-369.
8. 2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ. Res. 99:979-987.
9. Maltsev, V. A., T. M. Vinogradova,..., M. D. Stern. 2004. Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process. Biophys. J. 86:2596-2605.
10. 2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am. J. Physiol. Heart Circ. Physiol. 296: H594-H615.
11. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ. Res. 90:73-79.
12. 2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ. Res. 98:505-514.
13. (KACH). Am. J. Physiol. Heart Circ. Physiol. 297: H949-H959.
14. Györke, S., I. Györke,..., T. F. Wiesner. 2002. Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. Front. Biosci. 7: d1454-d1463.
15. Bers, D. M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd Ed. Kluwer Academic, Norwell, MA.
16. Cheng, H., W. J. Lederer, and M. B. Cannell. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 262:740-744.
17. 2+ rise in late diastole of rabbit sinoatrial node cells: characterization in two dimensions. Biophys. J. (Supplement): 76a (Abstract).
18. 2+ channel. Proc. Natl. Acad. Sci. USA. 106:18028-18033.
19. 2+/calmodulin-dependent protein kinase II activation. Circ. Res. 87:760-767.
20. Lyashkov, A. E., M. Juhaszova,..., E. G. Lakatta. 2007. Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circ. Res. 100:1723-1731.
21. Levine, J. D., P. Funes,..., J. C. Hall. 2002. Signal analysis of behavioral and molecular cycles. BMC Neurosci. 3:1-25.
22. Honjo, H., M. R. Boyett,..., J. Toyama. 1996. Correlation between electrical activity and the size of rabbit sino-atrial node cells. J. Physiol. 496:795-808.
23. 2+ handling proteins in rabbit sinoatrial node. J. Histochem. Cytochem. 50:311-324.
24. Rigg, L., B. M. Heath,..., D. A. Terrar. 2000. Localisation and functional significance of ryanodine receptors during β-adrenoceptor stimulation in the guinea-pig sino-atrial node. Cardiovasc. Res. 48:254-264.
25. Stern, M. D., L. S. Song,..., E. Ríos. 1999. Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors. J. Gen. Physiol. 113:469-489.
26. 2+ release in cardiac myocytes. Circ. Res. 91:414-420.
27. 2+ blinks: rapid nanoscopic store calcium signaling. Proc. Natl. Acad. Sci. USA. 102:3099-3104.
28. Kurata, Y., I. Hisatome,..., T. Shibamoto. 2002. Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. Am. J. Physiol. Heart Circ. Physiol. 283: H2074-H2101.
29. Tsien, R. W., R. S. Kass, and R. Weingart. 1979. Cellular and subcellular mechanisms of cardiac pacemaker oscillations. J. Exp. Biol. 81:205-215.
30. Fabiato, A., and F. Fabiato. 1972. Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. Circ. Res. 31:293-307.
31. Fabiato, A., and F. Fabiato. 1978. Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat, and frog hearts and from fetal and new-born rat ventricles. Ann. N. Y. Acad. Sci. 307:491-522.
32. 2+ release in the heart. Cardiovasc. Res. 26:193-214.
33. Ter Keurs, H. E., and P. A. Boyden. 2007. Calcium and arrhythmogenesis. Physiol. Rev. 87:457-506.