Beat-to-beat Ca 2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 6, 2011, Pages 902-905

  Yaniv, Yael ^a   Maltsev, Victor A ^a   Escobar, Ariel L ^b   Spurgeon, Harold A ^a   Ziman, Bruce D ^a   Stern, Michael D ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b University of California   (United States)

Author keywords

Arrhythmia; Ca2+ excitation contraction coupling; Ca 2+ cycling; Pacemaker Ca2+ clock; Pacemaker cell automaticity

Indexed keywords

BUFFER; CALCIUM ION; EGTAZIC ACID;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DEPOLARIZATION; DIASTOLE; DIASTOLIC DEPOLARIZATION; FLASH PHOTOLYSIS; HEART AUTOMATICITY; HEART BEAT; NONHUMAN; PHOTOLYSIS; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SINOATRIAL NODAL CELL ACTION POTENTIAL FIRING RATE; SINUS NODE;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL CLOCKS; CALCIUM; EXCITATION CONTRACTION COUPLING; RABBITS; SINOATRIAL NODE;

EID: 80055118338     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.08.029     Document Type: Article

References (8)

1. Lakatta E.G., Maltsev V.A., Vinogradova T.M. A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 2010, 106(4):659-673.
2. Noble D., Noble P.J., Fink M. Competing oscillators in cardiac pacemaking: historical background. Circ Res 2010, 106(12):1791-1797.
3. Himeno Y., Toyoda F., Satoh H., Amano A., Cha C.Y., Matsuura H., et al. Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. Am J Physiol Heart Circ Physiol 2010, 300(1):H251-H261.
4. Sobie E.A., Kao J.P., Lederer W.J. Novel approach to real-time flash photolysis and confocal [Ca2+] imaging. Pflugers Arch 2007, 454(4):663-673.
5. Diaz M.E., Trafford A.W., Eisner D.A. The effects of exogenous calcium buffers on the systolic calcium transient in rat ventricular myocytes. Biophys J 2001, 80(4):1915-1925.
6. Escobar A.L., Velez P., Kim A.M., Cifuentes F., Fill M., Vergara J.L. Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis. Pflugers Arch 1997, 434(5):615-631.
7. Momotake A., Lindegger N., Niggli E., Barsotti R.J., Ellis-Davies G.C. The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nat Methods 2006, 3(1):35-40.
8. Maltsev V.A., Vinogradova T.M., Stern M.D., Lakatta E.G. Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity". Am J Physiol Heart Circ Physiol 2011, 300(6):H2323-H2324.