Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the If pacemaker current

Journal of Physiology

Volumn 582, Issue 3, 2007, Pages 1195-1203

  Mattick, Paul ^a   Parrington, John ^a   Odia, Efe ^a   Simpson, Alasdair ^a   Collins, Thomas ^a   Terrar, Derek ^a  

^a OX1 3QT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FORSKOLIN; MESSENGER RNA; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; PHOSPHODIESTERASE; ADENYLATE CYCLASE 1; UNCLASSIFIED DRUG; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CALCIUM; DRUG DERIVATIVE; EGTAZIC ACID; ISOENZYME; PRIMER DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; HEART BEAT; HEART MUSCLE CELL; HEART VENTRICLE WALL; HYPERPOLARIZATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS NODE; SINUS NODE MEMBRANE POTENTIAL; AC1 GENE; CALCIUM CELL LEVEL; CONFOCAL MICROSCOPY; GENE EXPRESSION REGULATION; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART VENTRICLE; IMMUNOFLUORESCENCE TEST; PROTEIN LOCALIZATION; REGULATORY MECHANISM; ANIMAL; BIOLOGICAL RHYTHM; DRUG EFFECT; ELECTROPHYSIOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

ADENYLATE CYCLASE; ANIMALS; BIOLOGICAL CLOCKS; CALCIUM; DNA PRIMERS; EGTAZIC ACID; ELECTROPHYSIOLOGY; FORSKOLIN; GUINEA PIGS; ISOENZYMES; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SINOATRIAL NODE;

EID: 34547107585     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.133439     Document Type: Article

References (22)

1. h channels. Nat Neurosci 3, 133-141.
2. 2+ current in guinea-pig ventricular myocytes, mediated by Gβγ-dependent activation of adenylyl cyclase. J Physiol 536, 677-692.
3. Chang F, Gao J, Tromba C, Cohen I & DiFrancesco D (1990). Acetylcholine reverses effects of β-agonists on pacemaker current in canine cardiac Purkinje fibers but has no direct action. A difference between primary and secondary pacemakers. Circ Res 66, 633-636.
4. DiFrancesco D & Tortora P (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351, 145-147.
5. f) induced by acetylcholine in rabbit sino-atrial node myocytes. J Physiol 405, 477-491.
6. f) in rabbit sino-atrial node myocytes. J Physiol 405, 493-510.
7. 2+ entry sites. J Biol Chem 271, 12438-12444.
8. 2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells. J Physiol 409, 121-141.
9. Hescheler J, Kameyama M & Trautwein W (1986). On the mechanism of muscarinic inhibition of the cardiac Ca current. Pflugers Arch 407, 182-189.
10. Katsushika S, Chen L, Kawabe J, Nilakantan R, Halnon NJ, Homcy CJ & Ishikawa Y (1992). Cloning and characterization of a sixth adenylyl cyclase isoform: Types V and VI constitute a subgroup within the mammalian adenylyl cyclase family. Proc Natl Acad Sci U S A 89, 8774-8778.
11. Petit-Jacques J, Bois P, Bescond J & Lenfant J (1993). Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes. Pflugers Arch 423, 21-27.
12. Premont RT, Chen J, Ma HW, Ponnapalli M & Iyengar R (1992). Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc Natl Acad Sci U S A 89, 9809-9813.
13. Rigg L, Heath BM, Cui Y & Terrar DA (2000). Localisation and functional significance of ryanodine receptors during β-adrenoceptor stimulation in the guinea-pig sino-atrial node. Cardiovasc Res 48, 254-264.
14. f) by calcium and calmodulin in the guinea-pig sino-atrial node. Cardiovasc Res 57, 497-504.
15. 2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. J Physiol 571, 639-649.
16. Seamon KB, Daly JW, Metzger H, de Souza NJ & Reden J (1983). Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem 26, 436-439.
17. 2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 98, 505-514.
18. Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA & Tibbs GR (2001). Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805-810.
19. Wang H & Storm DR (2003). Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system. Mol Pharmacol 63, 463-468.
20. Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC, Muglia LJ & Storm DR (1999). Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23, 787-798.
21. 2+-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A 89, 6716-6720.
22. Zaza A, Micheletti M, Brioschi A & Rocchetti M (1997). Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes. J Physiol 505, 677-688.