Ca2+-Stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2

Circulation

Volumn 126, Issue 5, 2012, Pages 528-536

  Boink, Gerard J J ^a,b,c   Nearing, Bruce D ^d   Shlapakova, Iryna N ^a   Duan, Lian ^a,e,f   Kryukova, Yelena ^a   Bobkov, Yevgeniy ^a   Tan, Hanno L ^b,c   Cohen, Ira S ^g   Danilo, Peter ^a   Robinson, Richard B ^a   Verrier, Richard L ^d   Rosen, Michael R ^a,g  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d HARVARD MEDICAL SCHOOL   (United States)

^e CHINESE PLA GENERAL HOSPITAL   (China)

^f SECOND MILITARY MEDICAL UNIVERSITY   (China)

^g STONY BROOK UNIVERSITY   (United States)

Author keywords

gene therapy; heart rate; pacemaker, artificial

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 1; CYCLIC NUCLEOTIDE GATED CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL 2; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL HEART PACEMAKER; ATRIOVENTRICULAR BLOCK; GENE CONSTRUCT; GENE THERAPY; HEART PACING; HEART RATE VARIABILITY; HOLTER MONITORING; NONHUMAN; PACEMAKER; PARASYMPATHETIC FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ADENYLATE CYCLASE; ANIMALS; ATRIOVENTRICULAR BLOCK; BENZAZEPINES; CATHETER ABLATION; CIRCADIAN RHYTHM; DOGS; ELECTROCARDIOGRAPHY; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HEART CONDUCTION SYSTEM; HEART RATE; ION CHANNELS; MODELS, ANIMAL; POTASSIUM CHANNEL BLOCKERS;

EID: 84864487119     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.083584     Document Type: Article

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