Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

Journal of Molecular and Cellular Cardiology

Volumn 66, Issue , 2014, Pages 106-115

  Sirenko, Syevda ^a   Maltsev, Victor A ^a   Maltseva, Larissa A ^a   Yang, Dongmei ^a   Lukyanenko, Yevgeniya ^a   Vinogradova, Tatiana M ^a   Jones, Larry R ^b   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium clock; Calcium cycling; Cardiac ventricular myocytes; Protein phosphorylation; Spontaneous local calcium releases

Indexed keywords

CALCIUM ION; CYCLIC AMP; PHOSPHODIESTERASE; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERCA 2; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; ANTIBODY; CALCIUM; CALCIUM BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOBUTYLMETHYLXANTHINE; STRONTIUM;

ANIMAL CELL; ARTICLE; BIOLOGICAL RHYTHM; CALCIUM CLOCK; CALCIUM METABOLISM; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; HEART VENTRICLE ARRHYTHMIA; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; ACTION POTENTIAL; ANIMAL; AP; ARTIFICIAL HEART PACEMAKER; CA(2+); CALCIUM CYCLING; CARDIAC VENTRICULAR MYOCYTES; CYTOLOGY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; ISOBUTYL-1-METHYLXANTHINE; LCR; LOCAL CA(2+) RELEASES; METABOLISM; PDE; PHOSPHORYLATION; PKA; PLB; PP; PROTEIN PHOSPHATASES; RABBIT; RYANODINE RECEPTORS; RYRS; SANC; SERCA-2; SIGNAL TRANSDUCTION; SINOATRIAL NODE CELLS; SINUS NODE; SPONTANEOUS LOCAL CALCIUM RELEASES; SR CA(2+) PUMP; VENTRICULAR MYOCYTES; VM; Β-ADRENERGIC RECEPTOR STIMULATION; Β-ARS;

ORYCTOLAGUS CUNICULUS;

ACTION POTENTIAL; AP; CA(2+); CALCIUM; CALCIUM CLOCK; CALCIUM CYCLING; CARDIAC VENTRICULAR MYOCYTES; IBMX; ISOBUTYL-1-METHYLXANTHINE; LCR; LOCAL CA(2+) RELEASES; PDE; PHOSPHODIESTERASE; PHOSPHOLAMBAN; PKA; PLB; PP; PROTEIN KINASE A; PROTEIN PHOSPHATASES; PROTEIN PHOSPHORYLATION; RYANODINE RECEPTORS; RYRS; SANC; SARCOPLASMIC RETICULUM; SERCA-2; SINOATRIAL NODE CELLS; SPONTANEOUS LOCAL CALCIUM RELEASES; SR; SR CA(2+) PUMP; VENTRICULAR MYOCYTES; VM; Β-ADRENERGIC RECEPTOR STIMULATION; Β-ARS;

ANIMALS; ANTIBODIES; BIOLOGICAL CLOCKS; CALCIUM; CALCIUM-BINDING PROTEINS; CYCLIC AMP; GENE EXPRESSION REGULATION; HEART VENTRICLES; MYOCYTES, CARDIAC; PACEMAKER, ARTIFICIAL; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORYLATION; PROTEIN BINDING; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; SINOATRIAL NODE;

EID: 84889589464     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.11.011     Document Type: Article

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