Regional differences in effects of 4-aminopyridine within the sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Boyett, M R ^a   Honjo, H ^b   Yamamoto, M ^c   Nikmaram, M R ^a   Niwa, R ^a,b   Kodama, L ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NAGOYA UNIVERSITY   (Japan)

^c IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cardiac; Heart; Pacemaking; Transient outward potassium current

Indexed keywords

4 AMINOPYRIDINE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; HEART ATRIOVENTRICULAR NODE; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART REPOLARIZATION; HEART VENTRICLE WALL; MYOFILAMENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; SINUS NODE;

EID: 0031754508     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.4.h1158     Document Type: Article

References (44)

1. Bleeker, W. K., A. J. C. Mackaay, M. Masson-Pevet, L. N. Bouman, and A. E. Becken Functional and morphological organization of the rabbit sinus node. Circ. Res. 46: 11-22, 1980.
2. Bonke, F. I. M. Electrotonic spread in the sinoatrial node of the rabbit heart. Pflügers Arch. 339: 17-23, 1973.
3. Boyett, M. R. Effect of rate-dependent changes in the transient outward current on the action potential in sheep Purkinje fibres. J. Physiol. (Land.) 319: 23-41, 1981.
4. Boyett, M. R., I. Kodama, R. Suzuki, and H. Honjo. A 4-aminopyridine-sensitive current controls action potential dura tion in the rabbit sinoatrial node. J. Physiol. (Land.) 497: 44P-45P, 1996.
5. 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes. J. Physiol. (Land.) 431: 689-712, 1990.
6. to-like potassium channel from ferret ventricle. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1383 -H1395, 1994.
7. Davies, N. W., A. I. Pettit, R. Agarwal, and N. B. Standen. The flickery block of ATP-dependent potassium channels of skeletal muscle by internal 4-aminopyridine. Pflügers Arch. 419: 25-31, 1991.
8. Denyer, J. C., and H. F. Brown. Rabbit sino-atrial node cells: isolation and electrophysiological properties. J. Physiol. (Land.) 428: 405-424, 1990.
9. to and action potential notch are smaller in left vs. right canine ventricular epicardium. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H548 -H561, 1996.
10. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ. Res. 79: 659-668, 1996.
11. + channel in the guinea-pig sinoatrial node. J. Physiol. (Lond.) 506: 54P, 1998.
12. Duivenvoorden, J. J., L. N. Bouman, F. F. Bukauskas, T. Opthof, and H. J. Jongsma. Phase dependency of electrotonic spread of hyperpolarizing current pulses in the rabbit sinoatrial node. J. Mol. Cell. Cardiol. 22: 415-427, 1990.
13. + channel current. Circ. Res. 73:210-216, 1993.
14. + current in cultured adult human atrial myocytes. Circ. Res. 80: 572-579, 1997.
15. + current in rat ventricle. J. Physiol. (Lond.) 500: 51-64, 1997.
16. Geller, J. C., and M. R. Rosen. Persistent T-wave changes after alteration of the ventricular activation sequence. New insights into cellular mechanisms of "cardiac memory." Circulation 88: 1811-1819, 1993.
17. Giles, W. R., and A. C. G. van Ginneken. A transient outward current in isolated cells from the crista terminalis of rabbit heart. J. Physiol. (Lond.) 368: 243-264, 1985.
18. Guo, J., K. Ono, and A. Noma. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. J. Physiol. (Lond.) 483: 1-13, 1995.
19. Honjo, H., M. R. Boyett, I. Kodama, and J. Toyama. Correla tion between electrical activity and the size of rabbit sinoatrial node cells. J. Physiol. (Lond.) 496: 795-808, 1996.
20. Irisawa, H., H. F. Brown, and W. Giles. Cardiac pacemaking in the sino-atrial node. Physiol. Rev. 73: 197-227, 1993.
21. + channel in rabbit sinoatrial node cells. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H443-H452, 1995.
22. Jeck, C. D., and P. A. Boyden. Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ. Res. 71: 1390-1403, 1992.
23. Kaab, S., B. Nuss, N. Chiamvimonvat, B. O'Rourke, P. H. Pak, D. A. Kas, E. Marban, and G. F. Tomaselli. Ionic mechanism of action potential prolongation in ventricular myo cytes from dogs with pacing-induced heart failure. Circ. Res. 78: 262-273, 1996.
24. Kentish, J. C., and M. R. Boyett. A simple electronic circuit for monitoring changes in the duration of the action potential. Pflügers Arch. 398: 233-235, 1983.
25. Kirchhof, C. J. H. J., F. I. M. Bonke, M. A. Allessie, and W. J. E. P. Lammers. The influence of the atrial myocardium on impulse formation in the rabbit sinus node. Pflügers Arch. 410: 198-203, 1987.
26. Kodama, I., and M. R. Boyett. Regional differences in the electrical activity of the rabbit sinus node. Pflügers Arch. 404: 214-226,1985.
27. Kodama, I., M. R. Boyett, R. Suzuki, H. Honjo, and J. Toyama. Regional differences in the response of the isolated sinoatrial node of the rabbit to vagal stimulation. J. Physiol. (Land.) 495: 785-801, 1996.
28. + currents in pacemaker activity in the sinoatrial node. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H2793-H2806, 1997.
29. Kreitner, D. Electrophysiological study of the two main pacemaker mechanisms in the rabbit sinus node. Cardiovasc. Res. 19: 304-318, 1985.
30. Liu, D.-W., G. A. Gintant, and C. Antzelevitch. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ. Res. 72: 671-687, 1993.
31. Meszaros, J., K. O. Ryder, and G. Hart. Transient outward current in catecholamine-induced cardiac hypertrophy in the rat. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H2360-H2367, 1996.
32. Nakayama, T., and H. Irisawa. Transient outward current carried by potassium and sodium in quiescent atrioventricular node cells of rabbits. Circ. Res. 57: 65-73, 1985.
33. Nathan, R. D. Two electrophysiologically distinct types of cultured pacemaker cells from rabbit sinoatrial node. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H325-H329, 1986.
34. Navarro-Polanco, R. A., and J. A. Sanchez-Chapula. 4-Aminopyridine activates potassium currents by activation of a muscarinic receptor in feline atrial myocytes. J. Physiol. (Land.) 498: 663-678, 1997.
35. +, UL-FS-49 and ZD-7288 within the sinoatrial node. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H2782-H2792, 1997.
36. Oosthoek, P. W., S. Viragh, A. E. M. Mayen, M. J. A. van Kempen, W. H. Lamers, and A. F. M. Moorman. Immunohistochemical delineation of the conduction system. I. The sinoatrial node. Circ. Res. 73: 473-481, 1993.
37. Opthof, T. The mammalian sinoatrial node. Cardiovasc. Drugs Ther. 1: 573-597, 1988.
38. Opthof, T., B. de Jonge, H. J. Jongsma, and L. N. Bouman. Functional morphology of the mammalian sinuatrial node. Eur. Heart J. 8: 1249-1259, 1987.
39. Opthof, T., A. C. G. van Ginneken, L. N. Bouman, and H. J. Jongsma. The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial node. J. Mol. Cell. Cardiol. 19: 923-934, 1987.
40. Schuessler, R. B., J. P. Boineau, and B. I. Bromberg. Origin of the sinus impulse. J. Cardiovasc. Electrophysiol. 7: 263-274, 1996.
41. Shibata, E. F., il Drury, H. Refsum, V. Aldrete, and W. Giles. Contribution of transient outward current to repolarization in human atrium. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1773-H1781, 1989.
42. Van Bogaert, P.-P., and D. J. Snyders. Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibres. P flügers Arch. 394: 230-238, 1982.
43. Yamashita, T., T. Nakajima, H. Hazama, E. Hamada, Y. Murakawa, K. Sawada, and M. Omata. Regional differences in transient outward current density and inhomogeneities of repolarization in rabbit right atrium. Circulation 92:3061-3069, 1995.
44. Yue, L., J. Feng, G.-R. Li, and S. Nattel. Characterization of an ultrarapid delayed rectifier potassium channel in canine atrial repolarization. J. Physiol. (Land.) 496: 647-662, 1996.