Relevant use of Klotho in FGF19 subfamily signaling system in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 4, 2010, Pages 1666-1671

  Tomiyama, Ken Ichi ^a,b   Maeda, Ryota ^a,b   Urakawa, Itaru ^c   Yamazaki, Yuji ^c   Tanaka, Tomohiro ^a,b   Ito, Shinji ^a,b   Nabeshima, Yoko ^a,b   Tomita, Tsutomu ^a   Odori, Shinji ^a   Hosoda, Kiminori ^a   Nakao, Kazuwa ^a   Imura, Akihiro ^a,b   Nabeshima, Yo Ichi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Bile acid; Cholesterol; Cyp genes; Energy source; Mineral homeostasis

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; KLOTHO PROTEIN;

ARTICLE; GENE EXPRESSION; HOMEOSTASIS; HUMAN; IN VIVO STUDY; NEGATIVE FEEDBACK; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADIPOSE TISSUE; ANIMALS; BILE ACIDS AND SALTS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GLUCURONIDASE; LIVER; MICE; MICE, KNOCKOUT; PROTEIN BINDING; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; VITAMIN D;

MUS;

EID: 76549112800     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913986107     Document Type: Article

References (33)

1. Kuro-o M, et al. (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390:45-51.
2. Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y (2003) Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17:2393-2403.
3. Urakawa I, et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-774.
4. Imura A, et al. (2007) alpha-Klotho as a regulator of calcium homeostasis. Science 316: 1615-1618.
5. Nabeshima Y, Imura H (2008) alpha-Klotho: A regulator that integrates calcium homeostasis. Am J Nephrol 28:455-464.
6. Ito S, et al. (2000) Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev 98:115-119.
7. Ito S, et al. (2005) Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest 115:2202-2208.
8. Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137-174.
9. Goodwin B, et al. (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6:517-526.
10. Inagaki T, et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2:217-225.
11. Jones S (2008) Mini-review: Endocrine actions of fibroblast growth factor 19. Mol Pharm 5:42-48.
12. Itoh N, Ornitz DM (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563-569.
13. Itoh N, Ornitz DM (2008) Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 237:18-27.
14. Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N (1999) Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta 1444:148-151.
15. Nishimura T, Nakatake Y, Konishi M, Itoh N (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 1492:203-206.
16. Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest 115: 1627-1635.
17. Ogawa Y, et al. (2007) BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA 104:7432-7437.
18. Kurosu H, et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282:26687-26695.
19. Wu X, et al. (2007) Co-receptor requirements for fibroblast growth factor-19 signaling. J Biol Chem 282:29069-29072.
20. Suzuki M, et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22:1006-1014.
21. Kharitonenkov A, et al. (2008) FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J Cell Physiol 215:1-7.
22. Lin BC, Wang M, Blackmore C, Desnoyers LR (2007) Liver-specific activities of FGF19 require Klotho beta. J Biol Chem 282:27277-27284.
23. Hotta Y, et al. (2009) Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 150:4625-4633.
24. Potthoff MJ, et al. (2009) FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA 106:10853-10858.
25. Shimada T, et al. (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113: 561-568.
26. Powers CJ, McLeskey SW, Wellstein A (2000) Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 7:165-197.
27. Yu C, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 275:15482-15489.
28. Berglund ED, et al. (2009) Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology 150:4084-4093.
29. Xu J, et al. (2009) Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58:250-259.
30. Kurosu H, et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281:6120-6123.
31. Kolek OI, et al. (2005) 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: The final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 289:G1036-G1042.
32. Inagaki T, et al. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5:415-425.
33. Badman MK, et al. (2007) Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5:426-437.